Result of FASTA (omim) for
pFN21AE6285
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6285, 279 aa
1>>>pF1KE6285 279 - 279 aa - 279 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0335+/-0.000367; mu= 16.6479+/- 0.023
mean_var=67.4449+/-14.061, 0's: 0 Z-trim(112.8): 12 B-trim: 0 in 0/50
Lambda= 0.156171
statistics sampled from 21911 (21923) to 21911 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.65), E-opt: 0.2 (0.257), width: 16
Scan time: 5.650
The best scores are: opt bits E(85289)
NP_001670 (OMIM: 601867) sodium/potassium-transpor ( 279) 1896 436.1 3.5e-122
NP_001669 (OMIM: 182331) sodium/potassium-transpor ( 290) 597 143.4 4.6e-34
NP_000696 (OMIM: 137217) potassium-transporting AT ( 291) 457 111.9 1.4e-24
NP_001290192 (OMIM: 182331) sodium/potassium-trans ( 208) 419 103.2 4.2e-22
NP_001668 (OMIM: 145500,182330) sodium/potassium-t ( 303) 317 80.4 4.7e-15
>>NP_001670 (OMIM: 601867) sodium/potassium-transporting (279 aa)
initn: 1896 init1: 1896 opt: 1896 Z-score: 2314.5 bits: 436.1 E(85289): 3.5e-122
Smith-Waterman score: 1896; 100.0% identity (100.0% similar) in 279 aa overlap (1-279:1-279)
10 20 30 40 50 60
pF1KE6 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN
190 200 210 220 230 240
250 260 270
pF1KE6 NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
:::::::::::::::::::::::::::::::::::::::
NP_001 NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
250 260 270
>>NP_001669 (OMIM: 182331) sodium/potassium-transporting (290 aa)
initn: 817 init1: 385 opt: 597 Z-score: 732.5 bits: 143.4 E(85289): 4.6e-34
Smith-Waterman score: 863; 47.6% identity (73.6% similar) in 288 aa overlap (3-275:4-285)
10 20 30 40 50
pF1KE6 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMW
..:::: .: . ::: :..:: : .:.:::. ::..::::::::::::.:.:..:::
NP_001 MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMW
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 VMLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPY--
:::::..:..:::.:.. .::::. :: . :. . :: :. ... :.:::.::
NP_001 VMLQTVSDHTPKYQDRLATPGLMIRPK-TENLDVIVNVSDTESWDQHVQKLNKFLEPYND
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 TLEEQKNLTVCPDGALFEQ--KGPVYV---ACQFPISLLQACSGMNDPD-FGYSQGNPCI
... ::: :: : .:: .: . :::: . : :::..: .::: :.::.
NP_001 SIQAQKN-DVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCV
120 130 140 150 160 170
180 190 200 210 220
pF1KE6 LVKMNRIIGLKPEGVPRID--CVSKN----EDIPNVAVYPHNGMIDLKYFPYYGKKLHVG
..::::.:.. . .. :..: :.. : ...: :: ::: ::::::::.::.
NP_001 FIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVN
180 190 200 210 220 230
230 240 250 260 270
pF1KE6 YLQPLVAVQ-VSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
: ::::::. .. .:: ::.:::.:. .::. ..:.:::: ::: ::.
NP_001 YTQPLVAVKFLNVTPNV---EVNVECRIN-AANIATDDERDKFAGRVAFKLRINKT
240 250 260 270 280 290
>>NP_000696 (OMIM: 137217) potassium-transporting ATPase (291 aa)
initn: 580 init1: 237 opt: 457 Z-score: 562.0 bits: 111.9 E(85289): 1.4e-24
Smith-Waterman score: 632; 35.4% identity (67.0% similar) in 285 aa overlap (5-275:6-287)
10 20 30 40 50
pF1KE6 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMW
:::. .: . :.. . .:: ::..:::: . : : :.:..:: ...::.. ..
NP_000 MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 VMLQTLNDEVPKYRDQIPSPGLMVFPKPV--TALEYTFSRSDPTSYAGYIEDLKKFLKPY
:..::.. .: :.::. :::. . : .:: ... :: ..: . :. :: :
NP_000 VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 TLEEQKNLTVCPDGALFEQ---KGPVYV--ACQFPISLLQACSGMNDPDFGYSQGNPCIL
. :.. : . : : ..: .. .:.: ..:: :::. ::.::. .:.::..
NP_000 SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI
130 140 150 160 170 180
180 190 200 210 220
pF1KE6 VKMNRIIGLKPEG--VPRIDC--VSKNEDI--P-NVAVYPHNGMIDLKYFPYYGKKLHVG
.:::::. . : . .::.:: ... ... : .: :: :: ..:.:::::::: .
NP_000 IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH
190 200 210 220 230 240
230 240 250 260 270
pF1KE6 YLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
: .::::... : :. ::.. ::. . .. .. .: . :.: ::.
NP_000 YSNPLVAAKLLNIPRNA--EVAIVCKV-MAEHVTFNNPHDPYEGKVEFKLKIEK
250 260 270 280 290
>>NP_001290192 (OMIM: 182331) sodium/potassium-transport (208 aa)
initn: 468 init1: 153 opt: 419 Z-score: 517.8 bits: 103.2 E(85289): 4.2e-22
Smith-Waterman score: 502; 42.6% identity (67.5% similar) in 209 aa overlap (82-275:1-203)
60 70 80 90 100 110
pF1KE6 ALFSFTMWVMLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLK
:. :: . :. . :: :. ... :.
NP_001 MIRPK-TENLDVIVNVSDTESWDQHVQKLN
10 20
120 130 140 150 160
pF1KE6 KFLKPY--TLEEQKNLTVCPDGALFEQ--KGPVYV---ACQFPISLLQACSGMNDPD-FG
:::.:: ... ::: :: : .:: .: . :::: . : :::..: .:
NP_001 KFLEPYNDSIQAQKN-DVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYG
30 40 50 60 70 80
170 180 190 200 210
pF1KE6 YSQGNPCILVKMNRIIGLKPEGVPRID--CVSKN----EDIPNVAVYPHNGMIDLKYFPY
:: :.::...::::.:.. . .. :..: :.. : ...: :: ::: ::::
NP_001 YSTGQPCVFIKMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPY
90 100 110 120 130 140
220 230 240 250 260 270
pF1KE6 YGKKLHVGYLQPLVAVQ-VSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKIT
::::.::.: ::::::. .. .:: ::.:::.:. .::. ..:.:::: ::: ::.
NP_001 YGKKFHVNYTQPLVAVKFLNVTPNV---EVNVECRIN-AANIATDDERDKFAGRVAFKLR
150 160 170 180 190 200
pF1KE6 ARA
NP_001 INKT
>>NP_001668 (OMIM: 145500,182330) sodium/potassium-trans (303 aa)
initn: 580 init1: 241 opt: 317 Z-score: 391.3 bits: 80.4 E(85289): 4.7e-15
Smith-Waterman score: 603; 36.6% identity (60.4% similar) in 298 aa overlap (16-279:12-303)
10 20 30 40 50 60
pF1KE6 MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
:: ::.: ::::::. :: :::::..::: ::..: :. :
NP_001 MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQV
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
:: :... : :.:.. ::: .:. . : .: .:: :: .:. .. .::. :
NP_001 MLLTISEFKPTYQDRVAPPGLTQIPQ-IQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDS
60 70 80 90 100 110
130 140 150 160
pF1KE6 EQKNLTV---CPD--------GALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNP
:.. . : : : . ...: : :.: . : :::.:: .::..:.:
NP_001 AQRDDMIFEDCGDVPSEPKERGDFNHERGERKV-CRFKLEWLGNCSGLNDETYGYKEGKP
120 130 140 150 160 170
170 180 190 200
pF1KE6 CILVKMNRIIGLKP--------EGVPR---------IDCVSK-NEDIPNVAVYPHNGM--
::..:.::..:.:: : : ..:..: .:: .:. . :.
NP_001 CIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGN
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE6 ---IDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDK
. :.:.::::: :. :::::.::: :. . :. .::: : :. . ...:.
NP_001 SPGFPLQYYPYYGKLLQPKYLQPLLAVQ--FTNLTMDTEIRIECKAYGE-NI-GYSEKDR
240 250 260 270 280 290
270
pF1KE6 FLGRVMFKITARA
: :: :: ...
NP_001 FQGRFDVKIEVKS
300
279 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:47:08 2016 done: Tue Nov 8 11:47:09 2016
Total Scan time: 5.650 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]