Result of FASTA (ccds) for
pFN21AE6271
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6271, 182 aa
1>>>pF1KE6271 182 - 182 aa - 182 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0283+/-0.000922; mu= 13.7889+/- 0.055
mean_var=59.4141+/-12.186, 0's: 0 Z-trim(104.2): 58 B-trim: 7 in 1/46
Lambda= 0.166391
statistics sampled from 7712 (7770) to 7712 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.239), width: 16
Scan time: 1.470
The best scores are: opt bits E(32554)
CCDS55225.1 ADAM18 gene_id:8749|Hs108|chr8 ( 182) 1206 297.8 2.4e-81
CCDS83287.1 ADAM18 gene_id:8749|Hs108|chr8 ( 715) 1168 289.0 4.2e-78
CCDS6113.1 ADAM18 gene_id:8749|Hs108|chr8 ( 739) 1168 289.0 4.3e-78
CCDS64883.1 ADAM2 gene_id:2515|Hs108|chr8 ( 672) 486 125.3 7.6e-29
CCDS64882.1 ADAM2 gene_id:2515|Hs108|chr8 ( 716) 486 125.3 8e-29
CCDS34884.1 ADAM2 gene_id:2515|Hs108|chr8 ( 735) 486 125.3 8.2e-29
CCDS47846.1 ADAM32 gene_id:203102|Hs108|chr8 ( 787) 473 122.2 7.6e-28
CCDS83286.1 ADAM32 gene_id:203102|Hs108|chr8 ( 688) 404 105.6 6.5e-23
CCDS6112.1 ADAM9 gene_id:8754|Hs108|chr8 ( 819) 344 91.3 1.6e-18
CCDS907.1 ADAM30 gene_id:11085|Hs108|chr1 ( 790) 258 70.6 2.6e-12
CCDS3823.1 ADAM29 gene_id:11086|Hs108|chr4 ( 820) 254 69.7 5.2e-12
CCDS32111.1 ADAM20 gene_id:8748|Hs108|chr14 ( 776) 247 68.0 1.6e-11
>>CCDS55225.1 ADAM18 gene_id:8749|Hs108|chr8 (182 aa)
initn: 1206 init1: 1206 opt: 1206 Z-score: 1573.9 bits: 297.8 E(32554): 2.4e-81
Smith-Waterman score: 1206; 100.0% identity (100.0% similar) in 182 aa overlap (1-182:1-182)
10 20 30 40 50 60
pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS55 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL
130 140 150 160 170 180
pF1KE6 ML
::
CCDS55 ML
>>CCDS83287.1 ADAM18 gene_id:8749|Hs108|chr8 (715 aa)
initn: 1189 init1: 1168 opt: 1168 Z-score: 1515.7 bits: 289.0 E(32554): 4.2e-78
Smith-Waterman score: 1168; 99.4% identity (100.0% similar) in 175 aa overlap (1-175:1-175)
10 20 30 40 50 60
pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS83 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS83 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::.
CCDS83 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSK
130 140 150 160 170 180
pF1KE6 ML
CCDS83 LLPQYLEIYIIVEKALMFTQFKLTVILSSLELWSNENQISTSGDADDILQRFLAWKRDYL
190 200 210 220 230 240
>>CCDS6113.1 ADAM18 gene_id:8749|Hs108|chr8 (739 aa)
initn: 1189 init1: 1168 opt: 1168 Z-score: 1515.5 bits: 289.0 E(32554): 4.3e-78
Smith-Waterman score: 1168; 99.4% identity (100.0% similar) in 175 aa overlap (1-175:1-175)
10 20 30 40 50 60
pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS61 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS61 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::.
CCDS61 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQIKNLSK
130 140 150 160 170 180
pF1KE6 ML
CCDS61 LLPQYLEIYIIVEKALYDYMGSEMMAVTQKIVQVIGLVNTMFTQFKLTVILSSLELWSNE
190 200 210 220 230 240
>>CCDS64883.1 ADAM2 gene_id:2515|Hs108|chr8 (672 aa)
initn: 468 init1: 468 opt: 486 Z-score: 631.3 bits: 125.3 E(32554): 7.6e-29
Smith-Waterman score: 486; 45.0% identity (74.0% similar) in 169 aa overlap (1-169:1-167)
10 20 30 40 50 60
pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
:. .: ::. :: :. . ... ...:::.::.: .: : . : :.:.:.:::..:
CCDS64 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
...:::.:: ::.:. :: .. .. :. :::::: .:.: : .: :.:::: :::
CCDS64 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL
::.::::::.:::. :::.:::.:.. .::. : . : ..: .:.
CCDS64 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEPQQDFAK
130 140 150 160 170
pF1KE6 ML
CCDS64 YIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIA
180 190 200 210 220 230
>>CCDS64882.1 ADAM2 gene_id:2515|Hs108|chr8 (716 aa)
initn: 468 init1: 468 opt: 486 Z-score: 630.9 bits: 125.3 E(32554): 8e-29
Smith-Waterman score: 486; 45.0% identity (74.0% similar) in 169 aa overlap (1-169:1-167)
10 20 30 40 50 60
pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
:. .: ::. :: :. . ... ...:::.::.: .: : . : :.:.:.:::..:
CCDS64 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
...:::.:: ::.:. :: .. .. :. :::::: .:.: : .: :.:::: :::
CCDS64 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL
::.::::::.:::. :::.:::.:.. .::. : . : ..: .:.
CCDS64 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEYNHMGSD
130 140 150 160 170
pF1KE6 ML
CCDS64 TTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSY
180 190 200 210 220 230
>>CCDS34884.1 ADAM2 gene_id:2515|Hs108|chr8 (735 aa)
initn: 468 init1: 468 opt: 486 Z-score: 630.7 bits: 125.3 E(32554): 8.2e-29
Smith-Waterman score: 486; 45.0% identity (74.0% similar) in 169 aa overlap (1-169:1-167)
10 20 30 40 50 60
pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL
:. .: ::. :: :. . ... ...:::.::.: .: : . : :.:.:.:::..:
CCDS34 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF
...:::.:: ::.:. :: .. .. :. :::::: .:.: : .: :.:::: :::
CCDS34 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL
::.::::::.:::. :::.:::.:.. .::. : . : ..: .:.
CCDS34 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEPQQDFAK
130 140 150 160 170
pF1KE6 ML
CCDS34 YIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIA
180 190 200 210 220 230
>>CCDS47846.1 ADAM32 gene_id:203102|Hs108|chr8 (787 aa)
initn: 420 init1: 310 opt: 473 Z-score: 613.4 bits: 122.2 E(32554): 7.6e-28
Smith-Waterman score: 473; 44.1% identity (76.5% similar) in 170 aa overlap (1-166:1-165)
10 20 30 40 50
pF1KE6 MFLLLALLTEL-GRLQAHEGSEGIFLHVTVPRKIKSN---DSEVSERKMIYIITIDGQPY
:: : ::. : : : .. : .. .:....:.::..: .::. ... ::: :: . :
CCDS47 MFRLWLLLAGLCGLLASRPGFQNSLLQIVIPEKIQTNTNDSSEIEYEQISYIIPIDEKLY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 TLHLGKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRG
:.:: .. :: .::..: ::. ::... : .. .:.::: .:.:.:::: ::::::
CCDS47 TVHLKQRYFLADNFMIYLYNQ-GSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRG
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 FLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVT
.:::::.::::::.::...:.:..:..::.: ...:. .. : :.::
CCDS47 ILQFENVSYGIEPLESAVEFQHVLYKLKNEDNDIAIF-IDRS---LKEQPMDDNIFISEK
120 130 140 150 160 170
180
pF1KE6 VIILML
CCDS47 SEPAVPDLFPLYLEMHIVVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSS
180 190 200 210 220 230
>>CCDS83286.1 ADAM32 gene_id:203102|Hs108|chr8 (688 aa)
initn: 401 init1: 304 opt: 404 Z-score: 524.8 bits: 105.6 E(32554): 6.5e-23
Smith-Waterman score: 404; 48.0% identity (79.7% similar) in 123 aa overlap (44-166:55-172)
20 30 40 50 60 70
pF1KE6 LQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHLGKQSFLPQNFLVY
.. ::: :: . ::.:: .. :: .::..:
CCDS83 LPAGSPEAAPCSASGCCWPGSAASWRQDPEQISYIIPIDEKLYTVHLKQRYFLADNFMIY
30 40 50 60 70 80
80 90 100 110 120 130
pF1KE6 TYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVESS
::. ::... : .. .:.::: .:.:.:::: ::::::.:::::.::::::.::.
CCDS83 LYNQ-GSMNTYSSDIQTQCYYQGNIEGYPDSMVTLSTCSGLRGILQFENVSYGIEPLESA
90 100 110 120 130 140
140 150 160 170 180
pF1KE6 ARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIILML
..:.:..:..::.: ...:. .. : :.::
CCDS83 VEFQHVLYKLKNEDNDIAIF-IDRS---LKEQPMDDNIFISEKSEPAVPDLFPLYLEMHI
150 160 170 180 190
CCDS83 VVDKTLYDYWGSDSMIVTNKVIEIVGLANSMFTQFKVTIVLSSLELWSDENKISTVGEAD
200 210 220 230 240 250
>>CCDS6112.1 ADAM9 gene_id:8754|Hs108|chr8 (819 aa)
initn: 334 init1: 306 opt: 344 Z-score: 445.8 bits: 91.3 E(32554): 1.6e-18
Smith-Waterman score: 344; 46.2% identity (78.8% similar) in 104 aa overlap (43-145:64-167)
20 30 40 50 60 70
pF1KE6 RLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHLGK-QSFLPQNFL
... :.: .:. . .:: . ...::..:.
CCDS61 FQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFV
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE6 VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVE
:::::. :.: . : .. ::::.::. :: ..:: : ::::.:..:: ::::::..
CCDS61 VYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQ
100 110 120 130 140 150
140 150 160 170 180
pF1KE6 SSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIILML
.:..::::::.: .
CCDS61 NSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRY
160 170 180 190 200 210
>>CCDS907.1 ADAM30 gene_id:11085|Hs108|chr1 (790 aa)
initn: 116 init1: 116 opt: 258 Z-score: 334.5 bits: 70.6 E(32554): 2.6e-12
Smith-Waterman score: 258; 32.2% identity (65.0% similar) in 177 aa overlap (1-168:13-187)
10 20 30 40
pF1KE6 MFLLLA---LLTELGR-LQAHEGSEGIFLHVTVPRKIKSNDSEVSE--
..:::. :: ::. . : .: .::.:.:. : .::.
CCDS90 MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKL-SFRGEVQGVV
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 RKMIYIITIDGQPYTLHL-GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEF
. :.. . :. ..::: :. .::... :....: : : ::. :.:.: . :
CCDS90 SPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKES
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 PNSFVTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHI
.: .:.: : .:::: .... : :::...: :::..: .:... . .. ... ..:
CCDS90 LDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI
120 130 140 150 160 170
170 180
pF1KE6 -WQKDQPYKVPLNSQVTVIILML
:: ::.
CCDS90 EWQM-APYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMD
180 190 200 210 220 230
182 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:39:54 2016 done: Tue Nov 8 11:39:55 2016
Total Scan time: 1.470 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]