Result of FASTA (omim) for
pFN21AE6256
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6256, 209 aa
1>>>pF1KE6256 209 - 209 aa - 209 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2473+/-0.000392; mu= 13.3873+/- 0.024
mean_var=56.2458+/-11.450, 0's: 0 Z-trim(112.2): 25 B-trim: 570 in 2/47
Lambda= 0.171013
statistics sampled from 20986 (21011) to 20986 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.246), width: 16
Scan time: 4.990
The best scores are: opt bits E(85289)
NP_057517 (OMIM: 608949) glycolipid transfer prote ( 209) 1379 348.3 5.4e-96
XP_011536736 (OMIM: 608949) PREDICTED: glycolipid ( 168) 1021 259.9 1.7e-69
XP_016868235 (OMIM: 608639) PREDICTED: pleckstrin ( 320) 364 97.9 1.9e-20
XP_016868236 (OMIM: 608639) PREDICTED: pleckstrin ( 320) 364 97.9 1.9e-20
XP_011513898 (OMIM: 608639) PREDICTED: pleckstrin ( 350) 364 97.9 2.1e-20
NP_001183955 (OMIM: 608639) pleckstrin homology do ( 519) 364 98.0 2.9e-20
XP_016868233 (OMIM: 608639) PREDICTED: pleckstrin ( 491) 311 84.9 2.4e-16
XP_011513893 (OMIM: 608639) PREDICTED: pleckstrin ( 491) 311 84.9 2.4e-16
XP_011513896 (OMIM: 608639) PREDICTED: pleckstrin ( 455) 309 84.4 3.2e-16
NP_001183956 (OMIM: 608639) pleckstrin homology do ( 459) 309 84.4 3.2e-16
XP_011513894 (OMIM: 608639) PREDICTED: pleckstrin ( 475) 309 84.4 3.3e-16
XP_016868238 (OMIM: 608639) PREDICTED: pleckstrin ( 260) 255 71.0 2e-12
XP_016868237 (OMIM: 608639) PREDICTED: pleckstrin ( 290) 255 71.0 2.2e-12
XP_011513897 (OMIM: 608639) PREDICTED: pleckstrin ( 439) 255 71.1 3.2e-12
NP_116028 (OMIM: 608639) pleckstrin homology domai ( 440) 255 71.1 3.2e-12
XP_016868234 (OMIM: 608639) PREDICTED: pleckstrin ( 441) 255 71.1 3.2e-12
XP_005249954 (OMIM: 608639) PREDICTED: pleckstrin ( 459) 255 71.1 3.3e-12
XP_011540502 (OMIM: 615467) PREDICTED: ceramide-1- ( 214) 156 46.5 3.7e-05
NP_001025056 (OMIM: 615467) ceramide-1-phosphate t ( 214) 156 46.5 3.7e-05
XP_005244858 (OMIM: 615467) PREDICTED: ceramide-1- ( 214) 156 46.5 3.7e-05
XP_005244859 (OMIM: 615467) PREDICTED: ceramide-1- ( 151) 122 38.1 0.0091
>>NP_057517 (OMIM: 608949) glycolipid transfer protein [ (209 aa)
initn: 1379 init1: 1379 opt: 1379 Z-score: 1844.4 bits: 348.3 E(85289): 5.4e-96
Smith-Waterman score: 1379; 100.0% identity (100.0% similar) in 209 aa overlap (1-209:1-209)
10 20 30 40 50 60
pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 DTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 DTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 PNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKI
130 140 150 160 170 180
190 200
pF1KE6 RLFLVNYTATIDVIYEMYTQMNAELNYKV
:::::::::::::::::::::::::::::
NP_057 RLFLVNYTATIDVIYEMYTQMNAELNYKV
190 200
>>XP_011536736 (OMIM: 608949) PREDICTED: glycolipid tran (168 aa)
initn: 1042 init1: 1021 opt: 1021 Z-score: 1368.6 bits: 259.9 E(85289): 1.7e-69
Smith-Waterman score: 1021; 98.1% identity (98.7% similar) in 159 aa overlap (51-209:10-168)
30 40 50 60 70 80
pF1KE6 GPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEM
:. ::::::::::::::::::::::::::
XP_011 MTATSGLPPGSYKKIKAVYDTNPAKFRTLQNILEVEKEM
10 20 30
90 100 110 120 130 140
pF1KE6 YGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYH
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE6 GWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQ
100 110 120 130 140 150
pF1KE6 MNAELNYKV
:::::::::
XP_011 MNAELNYKV
160
>>XP_016868235 (OMIM: 608639) PREDICTED: pleckstrin homo (320 aa)
initn: 352 init1: 142 opt: 364 Z-score: 488.1 bits: 97.9 E(85289): 1.9e-20
Smith-Waterman score: 364; 36.5% identity (62.0% similar) in 192 aa overlap (15-198:128-312)
10 20 30 40
pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP
:. : : :: . . : .: :: ::.:
XP_016 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP
100 110 120 130 140 150
50 60 70 80 90 100
pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI
.: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:.
XP_016 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL
160 170 180 190 200 210
110 120 130 140 150 160
pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA
. :: . .::.: :.. ..:: .:...:::.:. .: :: ::: ::. :
XP_016 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAA
220 230 240 250 260 270
170 180 190 200
pF1KE6 LSKGQNVTEEECL-----EKIRLFLVNYT---ATIDVIYEMYTQMNAELNYKV
:. .. ..: . . . :.: . : .:..::..
XP_016 LTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV
280 290 300 310 320
>>XP_016868236 (OMIM: 608639) PREDICTED: pleckstrin homo (320 aa)
initn: 352 init1: 142 opt: 364 Z-score: 488.1 bits: 97.9 E(85289): 1.9e-20
Smith-Waterman score: 364; 36.5% identity (62.0% similar) in 192 aa overlap (15-198:128-312)
10 20 30 40
pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP
:. : : :: . . : .: :: ::.:
XP_016 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP
100 110 120 130 140 150
50 60 70 80 90 100
pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI
.: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:.
XP_016 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL
160 170 180 190 200 210
110 120 130 140 150 160
pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA
. :: . .::.: :.. ..:: .:...:::.:. .: :: ::: ::. :
XP_016 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAA
220 230 240 250 260 270
170 180 190 200
pF1KE6 LSKGQNVTEEECL-----EKIRLFLVNYT---ATIDVIYEMYTQMNAELNYKV
:. .. ..: . . . :.: . : .:..::..
XP_016 LTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV
280 290 300 310 320
>>XP_011513898 (OMIM: 608639) PREDICTED: pleckstrin homo (350 aa)
initn: 352 init1: 142 opt: 364 Z-score: 487.4 bits: 97.9 E(85289): 2.1e-20
Smith-Waterman score: 364; 36.5% identity (62.0% similar) in 192 aa overlap (15-198:158-342)
10 20 30 40
pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP
:. : : :: . . : .: :: ::.:
XP_011 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP
130 140 150 160 170 180
50 60 70 80 90 100
pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI
.: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:.
XP_011 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL
190 200 210 220 230 240
110 120 130 140 150 160
pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA
. :: . .::.: :.. ..:: .:...:::.:. .: :: ::: ::. :
XP_011 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAA
250 260 270 280 290 300
170 180 190 200
pF1KE6 LSKGQNVTEEECL-----EKIRLFLVNYT---ATIDVIYEMYTQMNAELNYKV
:. .. ..: . . . :.: . : .:..::..
XP_011 LTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV
310 320 330 340 350
>>NP_001183955 (OMIM: 608639) pleckstrin homology domain (519 aa)
initn: 352 init1: 142 opt: 364 Z-score: 484.7 bits: 98.0 E(85289): 2.9e-20
Smith-Waterman score: 364; 36.5% identity (62.0% similar) in 192 aa overlap (15-198:327-511)
10 20 30 40
pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP
:. : : :: . . : .: :: ::.:
NP_001 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP
300 310 320 330 340 350
50 60 70 80 90 100
pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI
.: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:.
NP_001 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL
360 370 380 390 400 410
110 120 130 140 150 160
pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA
. :: . .::.: :.. ..:: .:...:::.:. .: :: ::: ::. :
NP_001 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFALALRAAPSYEDFVAA
420 430 440 450 460
170 180 190 200
pF1KE6 LSKGQNVTEEECL-----EKIRLFLVNYT---ATIDVIYEMYTQMNAELNYKV
:. .. ..: . . . :.: . : .:..::..
NP_001 LTVKEGDHQKEAFSIGMQRDLSLYLPAMEKQLAILDTLYEVHGLESDEVV
470 480 490 500 510
>>XP_016868233 (OMIM: 608639) PREDICTED: pleckstrin homo (491 aa)
initn: 303 init1: 142 opt: 311 Z-score: 414.4 bits: 84.9 E(85289): 2.4e-16
Smith-Waterman score: 311; 39.9% identity (62.8% similar) in 148 aa overlap (15-157:327-467)
10 20 30 40
pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP
:. : : :: . . : .: :: ::.:
XP_016 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP
300 310 320 330 340 350
50 60 70 80 90 100
pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI
.: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:.
XP_016 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL
360 370 380 390 400 410
110 120 130 140 150
pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIF----QAALYAA-PYKS
. :: . .::.: :.. ..:: .:...:::.:. .: : : .: ::
XP_016 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFAVLDQMKLQTAHPYLQ
420 430 440 450 460
160 170 180 190 200
pF1KE6 DFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV
XP_016 YTLNNHNGYHVAIGHLLCTRHS
470 480 490
>>XP_011513893 (OMIM: 608639) PREDICTED: pleckstrin homo (491 aa)
initn: 303 init1: 142 opt: 311 Z-score: 414.4 bits: 84.9 E(85289): 2.4e-16
Smith-Waterman score: 311; 39.9% identity (62.8% similar) in 148 aa overlap (15-157:327-467)
10 20 30 40
pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP
:. : : :: . . : .: :: ::.:
XP_011 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP
300 310 320 330 340 350
50 60 70 80 90 100
pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI
.: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:.
XP_011 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL
360 370 380 390 400 410
110 120 130 140 150
pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIF----QAALYAA-PYKS
. :: . .::.: :.. ..:: .:...:::.:. .: : : .: ::
XP_011 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFAVLDQMKLQTAHPYLQ
420 430 440 450 460
160 170 180 190 200
pF1KE6 DFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV
XP_011 YTLNNHNGYHVAIGHLLCTRHS
470 480 490
>>XP_011513896 (OMIM: 608639) PREDICTED: pleckstrin homo (455 aa)
initn: 303 init1: 142 opt: 309 Z-score: 412.3 bits: 84.4 E(85289): 3.2e-16
Smith-Waterman score: 309; 40.3% identity (64.9% similar) in 134 aa overlap (15-148:327-453)
10 20 30 40
pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP
:. : : :: . . : .: :: ::.:
XP_011 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP
300 310 320 330 340 350
50 60 70 80 90 100
pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI
.: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:.
XP_011 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL
360 370 380 390 400 410
110 120 130 140 150 160
pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA
. :: . .::.: :.. ..:: .:...:::.:. .:
XP_011 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFAV
420 430 440 450
170 180 190 200
pF1KE6 LSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV
>>NP_001183956 (OMIM: 608639) pleckstrin homology domain (459 aa)
initn: 303 init1: 142 opt: 309 Z-score: 412.2 bits: 84.4 E(85289): 3.2e-16
Smith-Waterman score: 309; 40.3% identity (64.9% similar) in 134 aa overlap (15-148:327-453)
10 20 30 40
pF1KE6 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTP
:. : : :: . . : .: :: ::.:
NP_001 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP
300 310 320 330 340 350
50 60 70 80 90 100
pF1KE6 IKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFI
.: :. ::: :.. : :: .: :::.:. : : :. . .:: ::.::::::.:.
NP_001 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQV-RNSATEALLWLKRGLKFL
360 370 380 390 400 410
110 120 130 140 150 160
pF1KE6 QVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKA
. :: . .::.: :.. ..:: .:...:::.:. .:
NP_001 KGFLTEVKNGEKD------IQTALNNAYGKTLRQHHGWVVRGVFAGHTNV
420 430 440 450
170 180 190 200
pF1KE6 LSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV
209 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:31:52 2016 done: Tue Nov 8 11:31:53 2016
Total Scan time: 4.990 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]