Result of FASTA (omim) for
pFN21AE6229
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6229, 193 aa
1>>>pF1KE6229 193 - 193 aa - 193 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1479+/-0.000376; mu= 13.4204+/- 0.023
mean_var=54.3114+/-10.797, 0's: 0 Z-trim(110.8): 42 B-trim: 0 in 0/53
Lambda= 0.174032
statistics sampled from 19201 (19247) to 19201 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.226), width: 16
Scan time: 4.760
The best scores are: opt bits E(85289)
NP_001275 (OMIM: 601507) AP-3 complex subunit sigm ( 193) 1260 324.3 7.3e-89
NP_001002924 (OMIM: 601507) AP-3 complex subunit s ( 171) 1102 284.7 5.7e-77
NP_005820 (OMIM: 602416) AP-3 complex subunit sigm ( 193) 1089 281.4 6.1e-76
NP_001305022 (OMIM: 601507) AP-3 complex subunit s ( 162) 994 257.5 7.9e-69
XP_016864513 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 994 257.6 1.2e-68
XP_011541438 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 994 257.6 1.2e-68
NP_001305023 (OMIM: 601507) AP-3 complex subunit s ( 157) 775 202.5 2.8e-52
NP_001305019 (OMIM: 601507) AP-3 complex subunit s ( 125) 657 172.9 1.9e-43
NP_001305020 (OMIM: 601507) AP-3 complex subunit s ( 169) 608 160.6 1.2e-39
XP_016864514 (OMIM: 601507) PREDICTED: AP-3 comple ( 238) 608 160.7 1.7e-39
NP_004060 (OMIM: 600740,602242) AP-2 complex subun ( 142) 365 99.6 2.4e-21
NP_001288007 (OMIM: 600740,602242) AP-2 complex su ( 156) 359 98.1 7.6e-21
NP_001288010 (OMIM: 600740,602242) AP-2 complex su ( 144) 358 97.8 8.4e-21
NP_001288005 (OMIM: 600740,602242) AP-2 complex su ( 158) 358 97.8 9.1e-21
XP_011524726 (OMIM: 600740,602242) PREDICTED: AP-2 ( 158) 352 96.3 2.6e-20
XP_011524725 (OMIM: 600740,602242) PREDICTED: AP-2 ( 172) 352 96.4 2.8e-20
NP_001259000 (OMIM: 300629) AP-1 complex subunit s ( 160) 348 95.3 5.3e-20
XP_016885415 (OMIM: 300629) PREDICTED: AP-1 comple ( 189) 347 95.1 7.3e-20
XP_016885414 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 347 95.1 7.7e-20
XP_011543901 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 347 95.1 7.7e-20
NP_003907 (OMIM: 300629) AP-1 complex subunit sigm ( 157) 344 94.3 1e-19
NP_001274 (OMIM: 603531,609313) AP-1 complex subun ( 158) 343 94.1 1.2e-19
XP_005274671 (OMIM: 300629) PREDICTED: AP-1 comple ( 195) 342 93.9 1.8e-19
NP_001241657 (OMIM: 607243,614067) AP-4 complex su ( 144) 336 92.3 3.9e-19
NP_001241658 (OMIM: 607243,614067) AP-4 complex su ( 144) 336 92.3 3.9e-19
NP_001121598 (OMIM: 607243,614067) AP-4 complex su ( 144) 336 92.3 3.9e-19
NP_001034658 (OMIM: 615781,616106) AP-1 complex su ( 154) 321 88.6 5.6e-18
NP_001241656 (OMIM: 607243,614067) AP-4 complex su ( 149) 233 66.5 2.4e-11
XP_011534674 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 233 66.5 2.6e-11
XP_011534673 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 233 66.5 2.6e-11
NP_009008 (OMIM: 607243,614067) AP-4 complex subun ( 159) 233 66.5 2.6e-11
XP_005267350 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 233 66.5 2.6e-11
NP_001241655 (OMIM: 607243,614067) AP-4 complex su ( 135) 213 61.4 7.2e-10
XP_011508902 (OMIM: 615781,616106) PREDICTED: AP-1 ( 108) 207 59.9 1.7e-09
NP_057513 (OMIM: 615526) coatomer subunit zeta-2 [ ( 210) 186 54.7 1.2e-07
NP_067586 (OMIM: 600740,602242) AP-2 complex subun ( 104) 158 47.6 8.2e-06
NP_001258664 (OMIM: 615472) coatomer subunit zeta- ( 160) 154 46.6 2.4e-05
NP_057141 (OMIM: 615472) coatomer subunit zeta-1 i ( 177) 154 46.6 2.6e-05
XP_016874486 (OMIM: 615472) PREDICTED: coatomer su ( 180) 154 46.6 2.7e-05
NP_001258665 (OMIM: 615472) coatomer subunit zeta- ( 185) 154 46.7 2.8e-05
>>NP_001275 (OMIM: 601507) AP-3 complex subunit sigma-1 (193 aa)
initn: 1260 init1: 1260 opt: 1260 Z-score: 1716.4 bits: 324.3 E(85289): 7.3e-89
Smith-Waterman score: 1260; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193)
10 20 30 40 50 60
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
130 140 150 160 170 180
190
pF1KE6 DISIKVPNLPSFK
:::::::::::::
NP_001 DISIKVPNLPSFK
190
>>NP_001002924 (OMIM: 601507) AP-3 complex subunit sigma (171 aa)
initn: 1102 init1: 1102 opt: 1102 Z-score: 1502.8 bits: 284.7 E(85289): 5.7e-77
Smith-Waterman score: 1102; 100.0% identity (100.0% similar) in 170 aa overlap (24-193:2-171)
10 20 30 40 50 60
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
:::::::::::::::::::::::::::::::::::::
NP_001 MSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30
70 80 90 100 110 120
pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
100 110 120 130 140 150
190
pF1KE6 DISIKVPNLPSFK
:::::::::::::
NP_001 DISIKVPNLPSFK
160 170
>>NP_005820 (OMIM: 602416) AP-3 complex subunit sigma-2 (193 aa)
initn: 1107 init1: 1089 opt: 1089 Z-score: 1484.3 bits: 281.4 E(85289): 6.1e-76
Smith-Waterman score: 1089; 84.4% identity (94.8% similar) in 192 aa overlap (1-192:1-192)
10 20 30 40 50 60
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
::.:::.::::::::: .::: . :. ::::.::::::: :::.:.::::::: ::::::
NP_005 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
:::::::::::::::::::::::::::::::::::::::::::::::::::.:::: ::
NP_005 YKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
:.:::::::::::::::.::.:::.:::::.::..:::::::::::.::::::::::::
NP_005 QEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIG
130 140 150 160 170 180
190
pF1KE6 DISIKVPNLPSFK
:..:::::: .:
NP_005 DLNIKVPNLSQFV
190
>>NP_001305022 (OMIM: 601507) AP-3 complex subunit sigma (162 aa)
initn: 990 init1: 990 opt: 994 Z-score: 1356.6 bits: 257.5 E(85289): 7.9e-69
Smith-Waterman score: 994; 96.2% identity (98.1% similar) in 158 aa overlap (1-158:1-158)
10 20 30 40 50 60
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
:::::::::::::::::::::::::::::::. . .:
NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSETFIFQSPRQDR
130 140 150 160
190
pF1KE6 DISIKVPNLPSFK
>>XP_016864513 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa)
initn: 990 init1: 990 opt: 994 Z-score: 1353.3 bits: 257.6 E(85289): 1.2e-68
Smith-Waterman score: 994; 96.2% identity (98.1% similar) in 158 aa overlap (1-158:101-258)
10 20 30
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQ
::::::::::::::::::::::::::::::
XP_016 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ
80 90 100 110 120 130
40 50 60 70 80 90
pF1KE6 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI
140 150 160 170 180 190
100 110 120 130 140 150
pF1KE6 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS
200 210 220 230 240 250
160 170 180 190
pF1KE6 EAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK
:. . .:
XP_016 ETFIFQSPRQDR
260
>>XP_011541438 (OMIM: 601507) PREDICTED: AP-3 complex su (262 aa)
initn: 990 init1: 990 opt: 994 Z-score: 1353.3 bits: 257.6 E(85289): 1.2e-68
Smith-Waterman score: 994; 96.2% identity (98.1% similar) in 158 aa overlap (1-158:101-258)
10 20 30
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQ
::::::::::::::::::::::::::::::
XP_011 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ
80 90 100 110 120 130
40 50 60 70 80 90
pF1KE6 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI
140 150 160 170 180 190
100 110 120 130 140 150
pF1KE6 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS
200 210 220 230 240 250
160 170 180 190
pF1KE6 EAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK
:. . .:
XP_011 ETFIFQSPRQDR
260
>>NP_001305023 (OMIM: 601507) AP-3 complex subunit sigma (157 aa)
initn: 793 init1: 775 opt: 775 Z-score: 1059.7 bits: 202.5 E(85289): 2.8e-52
Smith-Waterman score: 957; 81.3% identity (81.3% similar) in 193 aa overlap (1-193:1-157)
10 20 30 40 50 60
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDK-----
70 80 90 100 110
130 140 150 160 170 180
pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
:::::::::::::::::::::::::::::
NP_001 -------------------------------AGLAGAPARAVSAVKNMNLPEIPRNINIG
120 130 140
190
pF1KE6 DISIKVPNLPSFK
:::::::::::::
NP_001 DISIKVPNLPSFK
150
>>NP_001305019 (OMIM: 601507) AP-3 complex subunit sigma (125 aa)
initn: 801 init1: 657 opt: 657 Z-score: 901.2 bits: 172.9 E(85289): 1.9e-43
Smith-Waterman score: 669; 64.8% identity (64.8% similar) in 193 aa overlap (1-193:1-125)
10 20 30 40 50 60
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
:::::::::::::::::::::::
NP_001 MIKAILIFNNHGKPRLSKFYQPY-------------------------------------
10 20
70 80 90 100 110 120
pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
:::::::::::::::::::::::::::::
NP_001 -------------------------------VFVETLDKCFENVCELDLIFHVDKVHNIL
30 40 50
130 140 150 160 170 180
pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
60 70 80 90 100 110
190
pF1KE6 DISIKVPNLPSFK
:::::::::::::
NP_001 DISIKVPNLPSFK
120
>>NP_001305020 (OMIM: 601507) AP-3 complex subunit sigma (169 aa)
initn: 608 init1: 608 opt: 608 Z-score: 832.6 bits: 160.6 E(85289): 1.2e-39
Smith-Waterman score: 1036; 87.6% identity (87.6% similar) in 193 aa overlap (1-193:1-169)
10 20 30 40 50 60
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNIL
:::::::::::::::::::::::::::::::: ::::
NP_001 NKLIYRHYATLYFVFCVDSSESELGILDLIQV------------------------HNIL
70 80 90
130 140 150 160 170 180
pF1KE6 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPEIPRNINIG
100 110 120 130 140 150
190
pF1KE6 DISIKVPNLPSFK
:::::::::::::
NP_001 DISIKVPNLPSFK
160
>>XP_016864514 (OMIM: 601507) PREDICTED: AP-3 complex su (238 aa)
initn: 608 init1: 608 opt: 608 Z-score: 830.2 bits: 160.7 E(85289): 1.7e-39
Smith-Waterman score: 770; 81.0% identity (82.9% similar) in 158 aa overlap (1-158:101-234)
10 20 30
pF1KE6 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQ
::::::::::::::::::::::::::::::
XP_016 GRIAGEITRRGSRARPRPGPQCPPGRPGTAMIKAILIFNNHGKPRLSKFYQPYSEDTQQQ
80 90 100 110 120 130
40 50 60 70 80 90
pF1KE6 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLI
140 150 160 170 180 190
100 110 120 130 140 150
pF1KE6 QVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS
:: ::::::::::::::::::::::::::::::::::
XP_016 QV------------------------HNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKS
200 210 220
160 170 180 190
pF1KE6 EAGLAGAPARAVSAVKNMNLPEIPRNINIGDISIKVPNLPSFK
:. . .:
XP_016 ETFIFQSPRQDR
230
193 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:17:01 2016 done: Tue Nov 8 11:17:02 2016
Total Scan time: 4.760 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]