Result of FASTA (omim) for
pFN21AE6228
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6228, 260 aa
1>>>pF1KE6228 260 - 260 aa - 260 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1128+/-0.00034; mu= 15.5972+/- 0.021
mean_var=63.2657+/-12.504, 0's: 0 Z-trim(114.7): 28 B-trim: 0 in 0/54
Lambda= 0.161246
statistics sampled from 24681 (24707) to 24681 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.29), width: 16
Scan time: 5.700
The best scores are: opt bits E(85289)
NP_001035517 (OMIM: 138760,614033) hydroxyacylglut ( 260) 1757 417.2 1.5e-116
NP_005317 (OMIM: 138760,614033) hydroxyacylglutath ( 308) 1757 417.2 1.8e-116
XP_016878684 (OMIM: 138760,614033) PREDICTED: hydr ( 258) 1538 366.2 3.3e-101
XP_011520771 (OMIM: 138760,614033) PREDICTED: hydr ( 306) 1538 366.2 3.8e-101
NP_072094 (OMIM: 118800,609023) probable hydrolase ( 361) 647 159.0 1.1e-38
NP_056303 (OMIM: 118800,609023) probable hydrolase ( 385) 647 159.0 1.1e-38
NP_001273178 (OMIM: 138760,614033) hydroxyacylglut ( 236) 631 155.2 1e-37
XP_011520772 (OMIM: 138760,614033) PREDICTED: hydr ( 236) 631 155.2 1e-37
XP_016859261 (OMIM: 118800,609023) PREDICTED: prob ( 332) 430 108.5 1.6e-23
XP_016859260 (OMIM: 118800,609023) PREDICTED: prob ( 356) 430 108.5 1.7e-23
NP_055112 (OMIM: 602473,608451) persulfide dioxyge ( 254) 252 67.0 3.7e-11
XP_005258744 (OMIM: 602473,608451) PREDICTED: pers ( 227) 251 66.8 4e-11
NP_001307797 (OMIM: 602473,608451) persulfide diox ( 131) 147 42.4 0.00048
NP_001307798 (OMIM: 602473,608451) persulfide diox ( 156) 145 42.0 0.00077
>>NP_001035517 (OMIM: 138760,614033) hydroxyacylglutathi (260 aa)
initn: 1757 init1: 1757 opt: 1757 Z-score: 2213.3 bits: 417.2 E(85289): 1.5e-116
Smith-Waterman score: 1757; 100.0% identity (100.0% similar) in 260 aa overlap (1-260:1-260)
10 20 30 40 50 60
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 KFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETD
190 200 210 220 230 240
250 260
pF1KE6 PVTTMRAVRREKDQFKMPRD
::::::::::::::::::::
NP_001 PVTTMRAVRREKDQFKMPRD
250 260
>>NP_005317 (OMIM: 138760,614033) hydroxyacylglutathione (308 aa)
initn: 1757 init1: 1757 opt: 1757 Z-score: 2212.2 bits: 417.2 E(85289): 1.8e-116
Smith-Waterman score: 1757; 100.0% identity (100.0% similar) in 260 aa overlap (1-260:49-308)
10 20 30
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP
::::::::::::::::::::::::::::::
NP_005 ACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDP
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD
140 150 160 170 180 190
160 170 180 190 200 210
pF1KE6 EMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPT
200 210 220 230 240 250
220 230 240 250 260
pF1KE6 VPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
260 270 280 290 300
>>XP_016878684 (OMIM: 138760,614033) PREDICTED: hydroxya (258 aa)
initn: 1536 init1: 1536 opt: 1538 Z-score: 1938.0 bits: 366.2 E(85289): 3.3e-101
Smith-Waterman score: 1538; 95.0% identity (96.3% similar) in 241 aa overlap (1-241:1-241)
10 20 30 40 50 60
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 KFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETD
::::::::::::::::::::::::::::::::::::::::::::::: . : ..
XP_016 KFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVSGPGSSGGRGSAQ
190 200 210 220 230 240
250 260
pF1KE6 PVTTMRAVRREKDQFKMPRD
:
XP_016 PAARCWPPQGEDGAAARR
250
>>XP_011520771 (OMIM: 138760,614033) PREDICTED: hydroxya (306 aa)
initn: 1536 init1: 1536 opt: 1538 Z-score: 1936.9 bits: 366.2 E(85289): 3.8e-101
Smith-Waterman score: 1538; 95.0% identity (96.3% similar) in 241 aa overlap (1-241:49-289)
10 20 30
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP
::::::::::::::::::::::::::::::
XP_011 ACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDP
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD
140 150 160 170 180 190
160 170 180 190 200 210
pF1KE6 EMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPT
200 210 220 230 240 250
220 230 240 250 260
pF1KE6 VPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
::::::::::::::::: . : ..:
XP_011 VPSTLAEEFTYNPFMRVSGPGSSGGRGSAQPAARCWPPQGEDGAAARR
260 270 280 290 300
>>NP_072094 (OMIM: 118800,609023) probable hydrolase PNK (361 aa)
initn: 550 init1: 324 opt: 647 Z-score: 815.6 bits: 159.0 E(85289): 1.1e-38
Smith-Waterman score: 648; 40.6% identity (69.2% similar) in 266 aa overlap (1-256:95-359)
10 20 30
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP
.:: .:.:.::: ::.:: ... :. :::
NP_072 GYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDP
70 80 90 100 110 120
40 50 60 70 80
pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGG-DDRIGALTHKI
.:. : . .:.:: :...: ::.::::.:::. : . . .:::. .: : ::: .
NP_072 SDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPL
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE6 THLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTA
: ....:: :... :::: ::.::. :... . : .:.:: ::..:::. .::.:
NP_072 CHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNA
190 200 210 220 230 240
150 160 170 180 190 200
pF1KE6 DEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEP
. : ..: ::: : :: .. ::::. .:: :: ::: : : ..:. :.... .
NP_072 ETMLSSLDTVLG-LGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKG
250 260 270 280 290 300
210 220 230 240 250 260
pF1KE6 TVPSTLAEEFTYNPFMRVREKTVQQH-------AGETDP--VTTMRAVRREKDQFKMPRD
: ::::.:: .::::.:.. ..:. .:. : . .. .:: ::. :
NP_072 TCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK
310 320 330 340 350 360
>>NP_056303 (OMIM: 118800,609023) probable hydrolase PNK (385 aa)
initn: 550 init1: 324 opt: 647 Z-score: 815.2 bits: 159.0 E(85289): 1.1e-38
Smith-Waterman score: 648; 40.6% identity (69.2% similar) in 266 aa overlap (1-256:119-383)
10 20 30
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP
.:: .:.:.::: ::.:: ... :. :::
NP_056 GYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDP
90 100 110 120 130 140
40 50 60 70 80
pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGG-DDRIGALTHKI
.:. : . .:.:: :...: ::.::::.:::. : . . .:::. .: : ::: .
NP_056 SDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPL
150 160 170 180 190 200
90 100 110 120 130 140
pF1KE6 THLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTA
: ....:: :... :::: ::.::. :... . : .:.:: ::..:::. .::.:
NP_056 CHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCGRTFEGNA
210 220 230 240 250 260
150 160 170 180 190 200
pF1KE6 DEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEP
. : ..: ::: : :: .. ::::. .:: :: ::: : : ..:. :.... .
NP_056 ETMLSSLDTVLG-LGDDTLLWPGHEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKG
270 280 290 300 310 320
210 220 230 240 250 260
pF1KE6 TVPSTLAEEFTYNPFMRVREKTVQQH-------AGETDP--VTTMRAVRREKDQFKMPRD
: ::::.:: .::::.:.. ..:. .:. : . .. .:: ::. :
NP_056 TCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK
330 340 350 360 370 380
>>NP_001273178 (OMIM: 138760,614033) hydroxyacylglutathi (236 aa)
initn: 631 init1: 631 opt: 631 Z-score: 798.2 bits: 155.2 E(85289): 1e-37
Smith-Waterman score: 631; 100.0% identity (100.0% similar) in 97 aa overlap (1-97:49-145)
10 20 30
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP
::::::::::::::::::::::::::::::
NP_001 ACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDP
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD
:::::::
NP_001 HLSTLQVTPCLWLAAGSSMKGLRMRCVKLCWRSWAGSPRTQESTVATSTPSTTSSLHATW
140 150 160 170 180 190
>>XP_011520772 (OMIM: 138760,614033) PREDICTED: hydroxya (236 aa)
initn: 631 init1: 631 opt: 631 Z-score: 798.2 bits: 155.2 E(85289): 1e-37
Smith-Waterman score: 631; 100.0% identity (100.0% similar) in 97 aa overlap (1-97:49-145)
10 20 30
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP
::::::::::::::::::::::::::::::
XP_011 ACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDP
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKIT
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 HLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTAD
:::::::
XP_011 HLSTLQVTPCLWLAAGSSMKGLRMRCVKLCWRSWAGSPRTQESTVATSTPSTTSSLHATW
140 150 160 170 180 190
>>XP_016859261 (OMIM: 118800,609023) PREDICTED: probable (332 aa)
initn: 587 init1: 246 opt: 430 Z-score: 543.3 bits: 108.5 E(85289): 1.6e-23
Smith-Waterman score: 522; 36.1% identity (61.7% similar) in 266 aa overlap (1-256:95-330)
10 20 30
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP
.:: .:.:.::: ::.:: ... :. :::
XP_016 GYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDP
70 80 90 100 110 120
40 50 60 70 80
pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGG-DDRIGALTHKI
.:. : . .:.:: :...: ::.::::.:::. : . . .:::. .: : ::: .
XP_016 SDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPL
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE6 THLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTA
: ....:: :... :::: ::.::. :... . : .:.:: ::..:::
XP_016 CHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCG-------
190 200 210 220 230
150 160 170 180 190 200
pF1KE6 DEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEP
:::. .:: :: ::: : : ..:. :.... .
XP_016 -----------------------HEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKG
240 250 260 270
210 220 230 240 250 260
pF1KE6 TVPSTLAEEFTYNPFMRVREKTVQQH-------AGETDP--VTTMRAVRREKDQFKMPRD
: ::::.:: .::::.:.. ..:. .:. : . .. .:: ::. :
XP_016 TCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK
280 290 300 310 320 330
>>XP_016859260 (OMIM: 118800,609023) PREDICTED: probable (356 aa)
initn: 587 init1: 246 opt: 430 Z-score: 542.9 bits: 108.5 E(85289): 1.7e-23
Smith-Waterman score: 522; 36.1% identity (61.7% similar) in 266 aa overlap (1-256:119-354)
10 20 30
pF1KE6 MKVEVLPALTDNYMYLVIDDETKEAAIVDP
.:: .:.:.::: ::.:: ... :. :::
XP_016 GYLFYRQQLRRARNRYPKGHSKTQPRLFNGVKVLPIPVLSDNYSYLIIDTQAQLAVAVDP
90 100 110 120 130 140
40 50 60 70 80
pF1KE6 VQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGG-DDRIGALTHKI
.:. : . .:.:: :...: ::.::::.:::. : . . .:::. .: : ::: .
XP_016 SDPRAVQASIEKEGVTLVAILCTHKHWDHSGGNRDLSRRHRDCRVYGSPQDGIPYLTHPL
150 160 170 180 190 200
90 100 110 120 130 140
pF1KE6 THLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTA
: ....:: :... :::: ::.::. :... . : .:.:: ::..:::
XP_016 CHQDVVSVGRLQIRALATPGHTQGHLVYLLDGEPYKGPSCLFSGDLLFLSGCG-------
210 220 230 240 250 260
150 160 170 180 190 200
pF1KE6 DEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEP
:::. .:: :: ::: : : ..:. :.... .
XP_016 -----------------------HEYAEENLGFAGVVEPENLARERKMQWVQRQRLERKG
270 280 290
210 220 230 240 250 260
pF1KE6 TVPSTLAEEFTYNPFMRVREKTVQQH-------AGETDP--VTTMRAVRREKDQFKMPRD
: ::::.:: .::::.:.. ..:. .:. : . .. .:: ::. :
XP_016 TCPSTLGEERSYNPFLRTHCLALQEALGPGPGPTGDDDYSRAQLLEELRRLKDMHKSK
300 310 320 330 340 350
260 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:16:22 2016 done: Tue Nov 8 11:16:23 2016
Total Scan time: 5.700 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]