Result of FASTA (omim) for
pFN21AE6226
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6226, 211 aa
1>>>pF1KE6226 211 - 211 aa - 211 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2613+/-0.000344; mu= 14.1002+/- 0.022
mean_var=74.7072+/-14.965, 0's: 0 Z-trim(116.2): 79 B-trim: 737 in 1/55
Lambda= 0.148386
statistics sampled from 27105 (27193) to 27105 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.319), width: 16
Scan time: 5.150
The best scores are: opt bits E(85289)
NP_060416 (OMIM: 614505,614557) peptidyl-prolyl ci ( 211) 1438 316.7 1.7e-86
NP_001128684 (OMIM: 607062) peptidyl-prolyl cis-tr ( 221) 698 158.3 8.7e-39
NP_851939 (OMIM: 607062) peptidyl-prolyl cis-trans ( 222) 696 157.9 1.2e-38
XP_005246695 (OMIM: 607062) PREDICTED: peptidyl-pr ( 181) 364 86.8 2.5e-17
XP_011509651 (OMIM: 607062) PREDICTED: peptidyl-pr ( 114) 349 83.4 1.6e-16
XP_011509650 (OMIM: 607062) PREDICTED: peptidyl-pr ( 115) 349 83.4 1.6e-16
NP_476433 (OMIM: 186946) peptidyl-prolyl cis-trans ( 142) 346 82.8 3e-16
NP_004461 (OMIM: 186946) peptidyl-prolyl cis-trans ( 142) 346 82.8 3e-16
XP_005273905 (OMIM: 186946) PREDICTED: peptidyl-pr ( 142) 346 82.8 3e-16
NP_001128680 (OMIM: 186946) peptidyl-prolyl cis-tr ( 142) 346 82.8 3e-16
NP_001271272 (OMIM: 616257) peptidyl-prolyl cis-tr ( 338) 315 76.5 5.9e-14
NP_009201 (OMIM: 616257) peptidyl-prolyl cis-trans ( 570) 315 76.6 8.8e-14
NP_001271270 (OMIM: 616257) peptidyl-prolyl cis-tr ( 623) 315 76.7 9.4e-14
XP_011523402 (OMIM: 259450,607063,610968) PREDICTE ( 510) 308 75.1 2.3e-13
NP_068758 (OMIM: 259450,607063,610968) peptidyl-pr ( 582) 308 75.1 2.5e-13
XP_011523401 (OMIM: 259450,607063,610968) PREDICTE ( 601) 308 75.1 2.6e-13
XP_011513417 (OMIM: 616257) PREDICTED: peptidyl-pr ( 359) 298 72.8 7.6e-13
NP_463460 (OMIM: 186945) peptidyl-prolyl cis-trans ( 108) 252 62.6 2.8e-10
NP_000792 (OMIM: 186945) peptidyl-prolyl cis-trans ( 108) 252 62.6 2.8e-10
XP_011534867 (OMIM: 186947) PREDICTED: peptidyl-pr ( 191) 229 57.9 1.3e-08
NP_002004 (OMIM: 186947) peptidyl-prolyl cis-trans ( 224) 229 57.9 1.5e-08
NP_004107 (OMIM: 600620) peptidyl-prolyl cis-trans ( 108) 217 55.1 5e-08
NP_057678 (OMIM: 610571) peptidyl-prolyl cis-trans ( 201) 211 54.0 2e-07
NP_001139249 (OMIM: 602623,608516) peptidyl-prolyl ( 268) 210 53.9 2.9e-07
NP_004108 (OMIM: 602623,608516) peptidyl-prolyl ci ( 457) 210 54.1 4.3e-07
NP_001139248 (OMIM: 602623,608516) peptidyl-prolyl ( 457) 210 54.1 4.3e-07
NP_001139247 (OMIM: 602623,608516) peptidyl-prolyl ( 457) 210 54.1 4.3e-07
NP_001137254 (OMIM: 610571) peptidyl-prolyl cis-tr ( 146) 196 50.7 1.4e-06
XP_011519231 (OMIM: 600611) PREDICTED: peptidyl-pr ( 414) 200 51.9 1.8e-06
NP_002005 (OMIM: 600611) peptidyl-prolyl cis-trans ( 459) 200 51.9 1.9e-06
XP_016859085 (OMIM: 600620) PREDICTED: peptidyl-pr ( 79) 184 48.0 5.2e-06
XP_016859082 (OMIM: 600620) PREDICTED: peptidyl-pr ( 79) 184 48.0 5.2e-06
XP_016859084 (OMIM: 600620) PREDICTED: peptidyl-pr ( 79) 184 48.0 5.2e-06
NP_001309893 (OMIM: 600620) peptidyl-prolyl cis-tr ( 79) 184 48.0 5.2e-06
NP_001309892 (OMIM: 600620) peptidyl-prolyl cis-tr ( 79) 184 48.0 5.2e-06
XP_016859083 (OMIM: 600620) PREDICTED: peptidyl-pr ( 79) 184 48.0 5.2e-06
XP_016876582 (OMIM: 186947) PREDICTED: peptidyl-pr ( 196) 182 47.8 1.4e-05
XP_016876581 (OMIM: 186947) PREDICTED: peptidyl-pr ( 229) 182 47.9 1.6e-05
XP_016868231 (OMIM: 604839) PREDICTED: inactive pe ( 266) 149 40.8 0.0024
XP_016868230 (OMIM: 604839) PREDICTED: inactive pe ( 317) 149 40.9 0.0028
NP_001128683 (OMIM: 604839) inactive peptidyl-prol ( 322) 149 40.9 0.0028
NP_003593 (OMIM: 604839) inactive peptidyl-prolyl ( 327) 149 40.9 0.0028
XP_006716216 (OMIM: 604839) PREDICTED: inactive pe ( 282) 140 38.9 0.0096
>>NP_060416 (OMIM: 614505,614557) peptidyl-prolyl cis-tr (211 aa)
initn: 1438 init1: 1438 opt: 1438 Z-score: 1673.7 bits: 316.7 E(85289): 1.7e-86
Smith-Waterman score: 1438; 100.0% identity (100.0% similar) in 211 aa overlap (1-211:1-211)
10 20 30 40 50 60
pF1KE6 MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKIP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 PESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHH
130 140 150 160 170 180
190 200 210
pF1KE6 DALVEDIFDKEDEDKDGFISAREFTYKHDEL
:::::::::::::::::::::::::::::::
NP_060 DALVEDIFDKEDEDKDGFISAREFTYKHDEL
190 200 210
>>NP_001128684 (OMIM: 607062) peptidyl-prolyl cis-trans (221 aa)
initn: 692 init1: 360 opt: 698 Z-score: 817.3 bits: 158.3 E(85289): 8.7e-39
Smith-Waterman score: 698; 48.3% identity (77.7% similar) in 211 aa overlap (3-211:15-221)
10 20 30 40
pF1KE6 MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLM
..::. ::... :::::::..: : . .: :::.
NP_001 MPKTMHFLFRFIVFFYLWG----LFTAQRQKKEESTEEVKIEVLHRPENCSKTSKKGDLL
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 LVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPA
.::.::: :::: :. .. .:.:.: ::.::. ...:: : .. :: :::::..:::.
NP_001 NAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAMTDMCPGEKRKVVIPPS
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 LGYGKEG-KGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKE
..::::: .:::::..::::.:.: . .:::: :.:...:...: .::: :.. ::..:
NP_001 FAYGKEGYEGKIPPDATLIFEIELYAVTKGPRSIETFKQIDMDNDRQLSKAEINLYLQRE
120 130 140 150 160 170
170 180 190 200 210
pF1KE6 FEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFT-YKHDEL
::: ..:..::..:::: :.:.: ::::: .:.. :.::::
NP_001 FEKDEKPRDKSYQDAVLEDIFKKNDHDGDGFISPKEYNVYQHDEL
180 190 200 210 220
>>NP_851939 (OMIM: 607062) peptidyl-prolyl cis-trans iso (222 aa)
initn: 692 init1: 360 opt: 696 Z-score: 815.0 bits: 157.9 E(85289): 1.2e-38
Smith-Waterman score: 696; 48.1% identity (77.4% similar) in 212 aa overlap (3-211:15-222)
10 20 30 40
pF1KE6 MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLM
..::. ::... :::::::..: : . .: :::.
NP_851 MPKTMHFLFRFIVFFYLWG----LFTAQRQKKEESTEEVKIEVLHRPENCSKTSKKGDLL
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 LVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPA
.::.::: :::: :. .. .:.:.: ::.::. ...:: : .. :: :::::..:::.
NP_851 NAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAMTDMCPGEKRKVVIPPS
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 LGYGKEG--KGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKK
..::::: .:::::..::::.:.: . .:::: :.:...:...: .::: :.. ::..
NP_851 FAYGKEGYAEGKIPPDATLIFEIELYAVTKGPRSIETFKQIDMDNDRQLSKAEINLYLQR
120 130 140 150 160 170
170 180 190 200 210
pF1KE6 EFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFT-YKHDEL
:::: ..:..::..:::: :.:.: ::::: .:.. :.::::
NP_851 EFEKDEKPRDKSYQDAVLEDIFKKNDHDGDGFISPKEYNVYQHDEL
180 190 200 210 220
>>XP_005246695 (OMIM: 607062) PREDICTED: peptidyl-prolyl (181 aa)
initn: 363 init1: 363 opt: 364 Z-score: 432.1 bits: 86.8 E(85289): 2.5e-17
Smith-Waterman score: 364; 45.7% identity (72.4% similar) in 116 aa overlap (3-118:63-174)
10 20 30
pF1KE6 MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVL
..::. ::... :::::::
XP_005 GARVTRGRESSVLLEPMPKTMHFLFRFIVFFYLWG----LFTAQRQKKEESTEEVKIEVL
40 50 60 70 80
40 50 60 70 80 90
pF1KE6 QKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGL
..: : . .: :::. .::.::: :::: :. .. .:.:.: ::.::. ...:: : ..
XP_005 HRPENCSKTSKKGDLLNAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAM
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE6 KGMCVGEKRKLIIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDD
:: :::::..:::...::::: :
XP_005 TDMCPGEKRKVVIPPSFAYGKEGYDKPLLAKGI
150 160 170 180
>>XP_011509651 (OMIM: 607062) PREDICTED: peptidyl-prolyl (114 aa)
initn: 346 init1: 321 opt: 349 Z-score: 417.5 bits: 83.4 E(85289): 1.6e-16
Smith-Waterman score: 349; 51.5% identity (83.5% similar) in 97 aa overlap (116-211:18-114)
90 100 110 120 130 140
pF1KE6 KGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQ
.:::::..::::.:.: . .:::: :.:.
XP_011 MPIMTATWLKTARNSTAEGKIPPDATLIFEIELYAVTKGPRSIETFK
10 20 30 40
150 160 170 180 190 200
pF1KE6 EMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFT
..:...: .::: :.. ::..:::: ..:..::..:::: :.:.: ::::: .:..
XP_011 QIDMDNDRQLSKAEINLYLQREFEKDEKPRDKSYQDAVLEDIFKKNDHDGDGFISPKEYN
50 60 70 80 90 100
210
pF1KE6 -YKHDEL
:.::::
XP_011 VYQHDEL
110
>>XP_011509650 (OMIM: 607062) PREDICTED: peptidyl-prolyl (115 aa)
initn: 346 init1: 321 opt: 349 Z-score: 417.5 bits: 83.4 E(85289): 1.6e-16
Smith-Waterman score: 349; 51.5% identity (83.5% similar) in 97 aa overlap (116-211:19-115)
90 100 110 120 130 140
pF1KE6 KGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQ
.:::::..::::.:.: . .:::: :.:.
XP_011 MPIMTATWLKTARNSTAAEGKIPPDATLIFEIELYAVTKGPRSIETFK
10 20 30 40
150 160 170 180 190 200
pF1KE6 EMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFT
..:...: .::: :.. ::..:::: ..:..::..:::: :.:.: ::::: .:..
XP_011 QIDMDNDRQLSKAEINLYLQREFEKDEKPRDKSYQDAVLEDIFKKNDHDGDGFISPKEYN
50 60 70 80 90 100
210
pF1KE6 -YKHDEL
:.::::
XP_011 VYQHDEL
110
>>NP_476433 (OMIM: 186946) peptidyl-prolyl cis-trans iso (142 aa)
initn: 302 init1: 208 opt: 346 Z-score: 412.7 bits: 82.8 E(85289): 3e-16
Smith-Waterman score: 346; 43.9% identity (68.3% similar) in 139 aa overlap (1-134:1-136)
10 20 30 40 50
pF1KE6 MRL--FLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFI--CHRKTKGGDLMLVHYEGYL
::: : .::.. .... : : . :... : . : :.. ::.. .:: : :
NP_476 MRLSWFRVLTVLSICLSAVATATGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 EKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGK
: ::. : :. .: ::. :.:: ...::::::: ::: ::::::.:: ::::..:
NP_476 E-DGTEFDSSLPQN--QPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGA
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 G-KIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVV
::: .::.:...::.:
NP_476 PPKIPGGATLVFEVELLKIERRTEL
120 130 140
>>NP_004461 (OMIM: 186946) peptidyl-prolyl cis-trans iso (142 aa)
initn: 302 init1: 208 opt: 346 Z-score: 412.7 bits: 82.8 E(85289): 3e-16
Smith-Waterman score: 346; 43.9% identity (68.3% similar) in 139 aa overlap (1-134:1-136)
10 20 30 40 50
pF1KE6 MRL--FLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFI--CHRKTKGGDLMLVHYEGYL
::: : .::.. .... : : . :... : . : :.. ::.. .:: : :
NP_004 MRLSWFRVLTVLSICLSAVATATGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 EKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGK
: ::. : :. .: ::. :.:: ...::::::: ::: ::::::.:: ::::..:
NP_004 E-DGTEFDSSLPQN--QPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGA
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 G-KIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVV
::: .::.:...::.:
NP_004 PPKIPGGATLVFEVELLKIERRTEL
120 130 140
>>XP_005273905 (OMIM: 186946) PREDICTED: peptidyl-prolyl (142 aa)
initn: 302 init1: 208 opt: 346 Z-score: 412.7 bits: 82.8 E(85289): 3e-16
Smith-Waterman score: 346; 43.9% identity (68.3% similar) in 139 aa overlap (1-134:1-136)
10 20 30 40 50
pF1KE6 MRL--FLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFI--CHRKTKGGDLMLVHYEGYL
::: : .::.. .... : : . :... : . : :.. ::.. .:: : :
XP_005 MRLSWFRVLTVLSICLSAVATATGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 EKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGK
: ::. : :. .: ::. :.:: ...::::::: ::: ::::::.:: ::::..:
XP_005 E-DGTEFDSSLPQN--QPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGA
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 G-KIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVV
::: .::.:...::.:
XP_005 PPKIPGGATLVFEVELLKIERRTEL
120 130 140
>>NP_001128680 (OMIM: 186946) peptidyl-prolyl cis-trans (142 aa)
initn: 302 init1: 208 opt: 346 Z-score: 412.7 bits: 82.8 E(85289): 3e-16
Smith-Waterman score: 346; 43.9% identity (68.3% similar) in 139 aa overlap (1-134:1-136)
10 20 30 40 50
pF1KE6 MRL--FLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFI--CHRKTKGGDLMLVHYEGYL
::: : .::.. .... : : . :... : . : :.. ::.. .:: : :
NP_001 MRLSWFRVLTVLSICLSAVATATGAEGKRKLQIGVKKRVDHCPIKSRKGDVLHMHYTGKL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 EKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGK
: ::. : :. .: ::. :.:: ...::::::: ::: ::::::.:: ::::..:
NP_001 E-DGTEFDSSLPQN--QPFVFSLGTGQVIKGWDQGLLGMCEGEKRKLVIPSELGYGERGA
70 80 90 100 110
120 130 140 150 160 170
pF1KE6 G-KIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVV
::: .::.:...::.:
NP_001 PPKIPGGATLVFEVELLKIERRTEL
120 130 140
211 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:15:23 2016 done: Tue Nov 8 11:15:24 2016
Total Scan time: 5.150 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]