Result of FASTA (omim) for
pFN21AE6224
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6224, 270 aa
1>>>pF1KE6224 270 - 270 aa - 270 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3698+/-0.0003; mu= 15.7825+/- 0.019
mean_var=83.8179+/-16.604, 0's: 0 Z-trim(118.2): 177 B-trim: 29 in 1/56
Lambda= 0.140090
statistics sampled from 30747 (30950) to 30747 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.732), E-opt: 0.2 (0.363), width: 16
Scan time: 6.020
The best scores are: opt bits E(85289)
NP_005657 (OMIM: 600889) complement factor H-relat ( 270) 1929 399.0 4.7e-111
XP_011507760 (OMIM: 600889) PREDICTED: complement ( 266) 1876 388.3 7.7e-108
XP_011507761 (OMIM: 600889) PREDICTED: complement ( 250) 1808 374.6 1e-103
XP_005245170 (OMIM: 600889) PREDICTED: complement ( 205) 1325 276.9 2.1e-74
XP_011507762 (OMIM: 600889) PREDICTED: complement ( 201) 1272 266.2 3.5e-71
NP_002104 (OMIM: 134371,235400,603075) complement ( 330) 1201 252.0 1.1e-66
NP_001160096 (OMIM: 235400,603075,605336) compleme ( 269) 1028 216.9 3.1e-56
XP_016856598 (OMIM: 600889) PREDICTED: complement ( 211) 980 207.2 2.1e-53
XP_011507759 (OMIM: 134371,235400,603075) PREDICTE ( 265) 943 199.8 4.5e-51
NP_110414 (OMIM: 608593,614809) complement factor ( 569) 929 197.2 5.7e-50
NP_001299601 (OMIM: 600889) complement factor H-re ( 146) 907 192.3 4.4e-49
XP_016855599 (OMIM: 605337) PREDICTED: complement ( 519) 895 190.3 6.2e-48
XP_011508322 (OMIM: 608593,614809) PREDICTED: comp ( 572) 851 181.4 3.2e-45
NP_000177 (OMIM: 126700,134370,235400,609814,61069 (1231) 826 176.7 1.9e-43
NP_066303 (OMIM: 235400,603075,605336) complement ( 330) 784 167.7 2.5e-41
NP_006675 (OMIM: 605337) complement factor H-relat ( 331) 756 162.0 1.3e-39
XP_016855603 (OMIM: 605337) PREDICTED: complement ( 387) 756 162.1 1.4e-39
XP_006711192 (OMIM: 605337) PREDICTED: complement ( 570) 756 162.2 1.9e-39
NP_001188480 (OMIM: 605337) complement factor H-re ( 577) 756 162.2 1.9e-39
NP_001188479 (OMIM: 605337) complement factor H-re ( 578) 756 162.2 1.9e-39
XP_016855600 (OMIM: 605337) PREDICTED: complement ( 519) 538 118.2 3.2e-26
XP_016855602 (OMIM: 605337) PREDICTED: complement ( 458) 534 117.3 5.2e-26
XP_016855601 (OMIM: 605337) PREDICTED: complement ( 468) 534 117.3 5.3e-26
XP_011507588 (OMIM: 134580,613235) PREDICTED: coag ( 628) 448 100.0 1.1e-20
NP_001985 (OMIM: 134580,613235) coagulation factor ( 661) 448 100.0 1.2e-20
XP_011507586 (OMIM: 134580,613235) PREDICTED: coag ( 675) 448 100.1 1.2e-20
XP_011507585 (OMIM: 134580,613235) PREDICTED: coag ( 676) 448 100.1 1.2e-20
XP_016856597 (OMIM: 126700,134370,235400,609814,61 ( 446) 435 97.3 5.3e-20
NP_001014975 (OMIM: 126700,134370,235400,609814,61 ( 449) 435 97.3 5.4e-20
NP_000565 (OMIM: 125240,613793) complement decay-a ( 381) 256 61.0 3.7e-09
NP_001287833 (OMIM: 125240,613793) complement deca ( 384) 256 61.0 3.7e-09
XP_016855956 (OMIM: 125240,613793) PREDICTED: comp ( 412) 256 61.1 3.9e-09
NP_001287832 (OMIM: 125240,613793) complement deca ( 439) 256 61.1 4.1e-09
NP_001108224 (OMIM: 125240,613793) complement deca ( 440) 256 61.1 4.1e-09
NP_001287831 (OMIM: 125240,613793) complement deca ( 444) 256 61.1 4.1e-09
XP_005273309 (OMIM: 120830) PREDICTED: C4b-binding ( 597) 254 60.8 6.8e-09
NP_000706 (OMIM: 120830) C4b-binding protein alpha ( 597) 254 60.8 6.8e-09
XP_005273308 (OMIM: 120830) PREDICTED: C4b-binding ( 597) 254 60.8 6.8e-09
NP_000033 (OMIM: 138700) beta-2-glycoprotein 1 pre ( 345) 249 59.6 9.1e-09
XP_016856799 (OMIM: 120920,612922) PREDICTED: memb ( 348) 229 55.6 1.5e-07
NP_758860 (OMIM: 120920,612922) membrane cofactor ( 349) 229 55.6 1.5e-07
NP_758871 (OMIM: 120920,612922) membrane cofactor ( 355) 229 55.6 1.5e-07
NP_758862 (OMIM: 120920,612922) membrane cofactor ( 362) 229 55.6 1.6e-07
XP_016856798 (OMIM: 120920,612922) PREDICTED: memb ( 363) 229 55.6 1.6e-07
NP_758863 (OMIM: 120920,612922) membrane cofactor ( 369) 229 55.6 1.6e-07
XP_011507866 (OMIM: 120920,612922) PREDICTED: memb ( 370) 229 55.6 1.6e-07
NP_758861 (OMIM: 120920,612922) membrane cofactor ( 377) 229 55.6 1.6e-07
XP_016856797 (OMIM: 120920,612922) PREDICTED: memb ( 378) 229 55.6 1.6e-07
NP_722548 (OMIM: 120920,612922) membrane cofactor ( 384) 229 55.6 1.6e-07
XP_011507865 (OMIM: 120920,612922) PREDICTED: memb ( 385) 229 55.6 1.6e-07
>>NP_005657 (OMIM: 600889) complement factor H-related p (270 aa)
initn: 1929 init1: 1929 opt: 1929 Z-score: 2114.8 bits: 399.0 E(85289): 4.7e-111
Smith-Waterman score: 1929; 100.0% identity (100.0% similar) in 270 aa overlap (1-270:1-270)
10 20 30 40 50 60
pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
190 200 210 220 230 240
250 260 270
pF1KE6 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
::::::::::::::::::::::::::::::
NP_005 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
250 260 270
>>XP_011507760 (OMIM: 600889) PREDICTED: complement fact (266 aa)
initn: 1880 init1: 991 opt: 1876 Z-score: 2057.0 bits: 388.3 E(85289): 7.7e-108
Smith-Waterman score: 1876; 98.1% identity (98.5% similar) in 270 aa overlap (1-270:1-266)
10 20 30 40 50 60
pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
::::::::::::::::::: .::::::::::::::::::::::::::::::::::::
XP_011 QNNENNISCVERGWSTPPK----FSAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
130 140 150 160 170
190 200 210 220 230 240
pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
180 190 200 210 220 230
250 260 270
pF1KE6 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
::::::::::::::::::::::::::::::
XP_011 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
240 250 260
>>XP_011507761 (OMIM: 600889) PREDICTED: complement fact (250 aa)
initn: 1808 init1: 1808 opt: 1808 Z-score: 1983.1 bits: 374.6 E(85289): 1e-103
Smith-Waterman score: 1808; 100.0% identity (100.0% similar) in 250 aa overlap (21-270:1-250)
10 20 30 40 50 60
pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
::::::::::::::::::::::::::::::::::::::::
XP_011 MFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
10 20 30 40
70 80 90 100 110 120
pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
170 180 190 200 210 220
250 260 270
pF1KE6 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
::::::::::::::::::::::::::::::
XP_011 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
230 240 250
>>XP_005245170 (OMIM: 600889) PREDICTED: complement fact (205 aa)
initn: 1325 init1: 1325 opt: 1325 Z-score: 1456.7 bits: 276.9 E(85289): 2.1e-74
Smith-Waterman score: 1325; 100.0% identity (100.0% similar) in 185 aa overlap (86-270:21-205)
60 70 80 90 100 110
pF1KE6 EYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICN
::::::::::::::::::::::::::::::
XP_005 MWLLVSVILISRISSVGGEGLCFFPFVENGHSESSGQTHLEGDTVQIICN
10 20 30 40 50
120 130 140 150 160 170
pF1KE6 TGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVE
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE6 YQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD
120 130 140 150 160 170
240 250 260 270
pF1KE6 IVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
:::::::::::::::::::::::::::::::::::
XP_005 IVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
180 190 200
>>XP_011507762 (OMIM: 600889) PREDICTED: complement fact (201 aa)
initn: 1381 init1: 903 opt: 1272 Z-score: 1398.9 bits: 266.2 E(85289): 3.5e-71
Smith-Waterman score: 1272; 97.3% identity (97.8% similar) in 185 aa overlap (86-270:21-201)
60 70 80 90 100 110
pF1KE6 EYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICN
::::::::::::::::::::::::::::::
XP_011 MWLLVSVILISRISSVGGEGLCFFPFVENGHSESSGQTHLEGDTVQIICN
10 20 30 40 50
120 130 140 150 160 170
pF1KE6 TGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVE
:::::::::::::::::::::::: .:::::::::::::::::::::::::::::::
XP_011 TGYRLQNNENNISCVERGWSTPPK----FSAEKCGPPPPIDNGDITSFLLSVYAPGSSVE
60 70 80 90 100
180 190 200 210 220 230
pF1KE6 YQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD
110 120 130 140 150 160
240 250 260 270
pF1KE6 IVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
:::::::::::::::::::::::::::::::::::
XP_011 IVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
170 180 190 200
>>NP_002104 (OMIM: 134371,235400,603075) complement fact (330 aa)
initn: 1669 init1: 1008 opt: 1201 Z-score: 1318.5 bits: 252.0 E(85289): 1.1e-66
Smith-Waterman score: 1460; 74.1% identity (77.7% similar) in 301 aa overlap (1-242:1-301)
10 20 30 40 50 60
pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_002 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
70 80 90 100 110 120
130 140
pF1KE6 QNNENNISCVERGWSTPPKCRST-----------------------ISAE----------
::::::::::::::::::::::: :.:
NP_002 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY
130 140 150 160 170 180
150 160 170 180
pF1KE6 --------------------------KCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL
:::::::::::::::: ::::::.::::::::::
NP_002 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL
190 200 210 220 230 240
190 200 210 220 230 240
pF1KE6 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC
::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::. .::::
NP_002 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC
250 260 270 280 290 300
250 260 270
pF1KE6 KSGYHPTKSHSFRAMCQNGKLVYPSCEEK
:
NP_002 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
310 320 330
>>NP_001160096 (OMIM: 235400,603075,605336) complement f (269 aa)
initn: 1211 init1: 965 opt: 1028 Z-score: 1130.7 bits: 216.9 E(85289): 3.1e-56
Smith-Waterman score: 1028; 48.0% identity (77.0% similar) in 269 aa overlap (1-268:1-269)
10 20 30 40 50 60
pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
: ::..::: .: ..:.. :::: :.:: :. :. .:. : .:. . : :. .:
NP_001 MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
.:: :.: : :...::::. ::: :.::..:::.... :. ..:..... :. :: :
NP_001 TPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
. .....:.:.::: :.: . :.:::::::::.::: :::::.::.: : ::::::
NP_001 PKAQTTVTCTEKGWSPTPRCIRVNSSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQCQP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
:.:.:.: .:: ::.:::::.:. ::.:..: :.: ::::: ...: :..::: .::.
NP_001 YYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTIEFM
190 200 210 220 230 240
250 260 270
pF1KE6 CKSGYHPTKS-HSFRAMCQNGKLVYPSCEEK
:: ::. . : ::.:.:..: . :: ::
NP_001 CKLGYNANTSILSFQAVCREGIVEYPRCE
250 260
>>XP_016856598 (OMIM: 600889) PREDICTED: complement fact (211 aa)
initn: 909 init1: 909 opt: 980 Z-score: 1079.7 bits: 207.2 E(85289): 2.1e-53
Smith-Waterman score: 1377; 78.1% identity (78.1% similar) in 270 aa overlap (1-270:1-211)
10 20 30 40 50 60
pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::::::::::::::
XP_016 SPSKSFWTRITCAEEGWSPTPKCL------------------------------------
70 80
130 140 150 160 170 180
pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
:::::::::::::::::::::::::::::::::::::
XP_016 -----------------------ISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
90 100 110 120
190 200 210 220 230 240
pF1KE6 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
130 140 150 160 170 180
250 260 270
pF1KE6 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
::::::::::::::::::::::::::::::
XP_016 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
190 200 210
>>XP_011507759 (OMIM: 134371,235400,603075) PREDICTED: c (265 aa)
initn: 1078 init1: 599 opt: 943 Z-score: 1038.0 bits: 199.8 E(85289): 4.5e-51
Smith-Waterman score: 966; 62.0% identity (70.2% similar) in 245 aa overlap (86-270:21-265)
60 70 80 90 100 110
pF1KE6 EYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICN
::::::::::::::::::::::::::::::
XP_011 MWLLVSVILISRISSVGGEGLCFFPFVENGHSESSGQTHLEGDTVQIICN
10 20 30 40 50
120 130 140
pF1KE6 TGYRLQNNENNISCVERGWSTPPKCRST-----------------------ISAE-----
:::::::::::::::::::::::::::: :.:
XP_011 TGYRLQNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYE
60 70 80 90 100 110
150 160 170
pF1KE6 -------------------------------KCGPPPPIDNGDITSFLLSVYAPGSSVEY
:::::::::::::::: ::::::.:::::
XP_011 CRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEY
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 QCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDI
:::::::::::..::::::::::::::: :::::.::::.::: :.:: .:::: :::.
XP_011 QCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGES
180 190 200 210 220 230
240 250 260 270
pF1KE6 VEFVCKSGYH-PTKSHSFRAMCQNGKLVYPSCEEK
.::::: ::. ..::..:. : .::: ::.: ..
XP_011 AEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR
240 250 260
>>NP_110414 (OMIM: 608593,614809) complement factor H-re (569 aa)
initn: 1476 init1: 857 opt: 929 Z-score: 1018.2 bits: 197.2 E(85289): 5.7e-50
Smith-Waterman score: 929; 53.5% identity (72.2% similar) in 273 aa overlap (1-270:1-265)
10 20 30 40 50 60
pF1KE6 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
: :: :::::: .:.::::. .::::::.::.::::: :.::::::::::::::::::::
NP_110 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
::::::::::::.::::::::::::.: ::::.:::::::: ::::::::::::::: :
NP_110 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQC-Q
::::.::::::::::::: : ... .: : : : : : :. ....: .
NP_110 QNNEKNISCVERGWSTPPIC--SFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRK
130 140 150 160 170
180 190 200 210 220 230
pF1KE6 NLYQLEGNNQITCRNGQWSEP-PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVE
:: .. :.... : . :: : : . : ..: ... :... ..::
NP_110 NLIRV-GSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEE-YGHN-EVVE
180 190 200 210 220 230
240 250 260 270
pF1KE6 FVCKSGYHPTKSHSFRAMCQNGK-LVYPSCEEK
. :. .. . . .: .:. . :.: :.
NP_110 YDCNPNF--IINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVS
240 250 260 270 280 290
NP_110 VEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHN
300 310 320 330 340 350
>--
initn: 566 init1: 490 opt: 657 Z-score: 721.1 bits: 142.2 E(85289): 2e-33
Smith-Waterman score: 657; 42.1% identity (67.5% similar) in 228 aa overlap (47-268:345-569)
20 30 40 50 60 70
pF1KE6 GGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG
.:. : .. . . . . . .: .
NP_110 IWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGK
320 330 340 350 360 370
80 90 100 110 120 130
pF1KE6 WSPTPKCL--RLCFFPF---VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVE
:.: : : : : . :... .. .. .:. : ..:. .: : . .. : : .
NP_110 WNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKE-IVCKD
380 390 400 410 420 430
140 150 160 170 180 190
pF1KE6 RGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQIT
:.. :.: . :. ::::: :.::: ::: :::: :::.: :.::..:.:.:. .:
NP_110 GRWQSLPRC--VESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVT
440 450 460 470 480 490
200 210 220 230 240 250
pF1KE6 CRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPT-KS
::: ::::::.::::::.:.: :.: ::.::: :. :::..::: ::: :: .. .:
NP_110 CRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISS
500 510 520 530 540 550
260 270
pF1KE6 HSFRAMCQNGKLVYPSCEEK
:::.::.::. :: ::
NP_110 PPFRAICQEGKFEYPICE
560
270 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:14:17 2016 done: Tue Nov 8 11:14:18 2016
Total Scan time: 6.020 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]