Result of FASTA (omim) for
pFN21AE6185
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6185, 164 aa
1>>>pF1KE6185 164 - 164 aa - 164 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9372+/-0.00033; mu= 13.8167+/- 0.020
mean_var=54.4997+/-10.962, 0's: 0 Z-trim(113.6): 64 B-trim: 0 in 0/53
Lambda= 0.173731
statistics sampled from 22983 (23047) to 22983 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.27), width: 16
Scan time: 4.600
The best scores are: opt bits E(85289)
NP_001034658 (OMIM: 615781,616106) AP-1 complex su ( 154) 933 241.5 4.3e-64
NP_003907 (OMIM: 300629) AP-1 complex subunit sigm ( 157) 776 202.1 3.1e-52
NP_001259000 (OMIM: 300629) AP-1 complex subunit s ( 160) 768 200.1 1.3e-51
XP_005274671 (OMIM: 300629) PREDICTED: AP-1 comple ( 195) 767 199.9 1.8e-51
XP_016885415 (OMIM: 300629) PREDICTED: AP-1 comple ( 189) 766 199.7 2.1e-51
NP_001274 (OMIM: 603531,609313) AP-1 complex subun ( 158) 761 198.4 4.2e-51
XP_016885414 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 762 198.7 4.4e-51
XP_011543901 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 762 198.7 4.4e-51
XP_011508902 (OMIM: 615781,616106) PREDICTED: AP-1 ( 108) 647 169.7 1.2e-42
NP_004060 (OMIM: 600740,602242) AP-2 complex subun ( 142) 453 121.2 6.6e-28
NP_001288010 (OMIM: 600740,602242) AP-2 complex su ( 144) 446 119.4 2.3e-27
NP_001288005 (OMIM: 600740,602242) AP-2 complex su ( 158) 446 119.4 2.5e-27
NP_001121598 (OMIM: 607243,614067) AP-4 complex su ( 144) 366 99.4 2.5e-21
NP_001241658 (OMIM: 607243,614067) AP-4 complex su ( 144) 366 99.4 2.5e-21
NP_001241657 (OMIM: 607243,614067) AP-4 complex su ( 144) 366 99.4 2.5e-21
NP_005820 (OMIM: 602416) AP-3 complex subunit sigm ( 193) 348 94.9 7.2e-20
NP_001305022 (OMIM: 601507) AP-3 complex subunit s ( 162) 322 88.4 5.7e-18
XP_016864513 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 322 88.5 8.6e-18
XP_011541438 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 322 88.5 8.6e-18
NP_001275 (OMIM: 601507) AP-3 complex subunit sigm ( 193) 319 87.6 1.1e-17
NP_001288007 (OMIM: 600740,602242) AP-2 complex su ( 156) 311 85.6 3.7e-17
XP_011524726 (OMIM: 600740,602242) PREDICTED: AP-2 ( 158) 311 85.6 3.8e-17
XP_011524725 (OMIM: 600740,602242) PREDICTED: AP-2 ( 172) 311 85.6 4e-17
NP_001241656 (OMIM: 607243,614067) AP-4 complex su ( 149) 291 80.6 1.2e-15
XP_005267350 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 289 80.1 1.7e-15
XP_011534674 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 289 80.1 1.7e-15
XP_011534673 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 289 80.1 1.7e-15
NP_009008 (OMIM: 607243,614067) AP-4 complex subun ( 159) 289 80.1 1.7e-15
NP_001241655 (OMIM: 607243,614067) AP-4 complex su ( 135) 268 74.8 5.8e-14
NP_001305023 (OMIM: 601507) AP-3 complex subunit s ( 157) 268 74.8 6.6e-14
NP_001002924 (OMIM: 601507) AP-3 complex subunit s ( 171) 260 72.8 2.8e-13
NP_067586 (OMIM: 600740,602242) AP-2 complex subun ( 104) 185 53.9 8.4e-08
NP_001305020 (OMIM: 601507) AP-3 complex subunit s ( 169) 167 49.5 2.9e-06
XP_016864514 (OMIM: 601507) PREDICTED: AP-3 comple ( 238) 167 49.6 3.9e-06
NP_001305019 (OMIM: 601507) AP-3 complex subunit s ( 125) 158 47.2 1.1e-05
NP_001258664 (OMIM: 615472) coatomer subunit zeta- ( 160) 154 46.3 2.7e-05
NP_057141 (OMIM: 615472) coatomer subunit zeta-1 i ( 177) 153 46.0 3.5e-05
NP_001258665 (OMIM: 615472) coatomer subunit zeta- ( 185) 153 46.0 3.6e-05
XP_016874486 (OMIM: 615472) PREDICTED: coatomer su ( 180) 152 45.8 4.2e-05
NP_001258663 (OMIM: 615472) coatomer subunit zeta- ( 154) 139 42.5 0.00035
NP_057513 (OMIM: 615526) coatomer subunit zeta-2 [ ( 210) 135 41.5 0.00091
NP_001020376 (OMIM: 601024) AP-2 complex subunit m ( 433) 127 39.7 0.0068
NP_004059 (OMIM: 601024) AP-2 complex subunit mu i ( 435) 127 39.7 0.0068
>>NP_001034658 (OMIM: 615781,616106) AP-1 complex subuni (154 aa)
initn: 933 init1: 933 opt: 933 Z-score: 1271.6 bits: 241.5 E(85289): 4.3e-64
Smith-Waterman score: 933; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143)
10 20 30 40 50 60
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG
70 80 90 100 110 120
130 140 150 160
pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA
:::::::::::::::::::::::
NP_001 GEIQETSKKIAVKAIEDSDMLQETMEEYMNKPTF
130 140 150
>>NP_003907 (OMIM: 300629) AP-1 complex subunit sigma-2 (157 aa)
initn: 776 init1: 776 opt: 776 Z-score: 1058.8 bits: 202.1 E(85289): 3.1e-52
Smith-Waterman score: 776; 74.3% identity (93.2% similar) in 148 aa overlap (2-149:1-148)
10 20 30 40 50 60
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK
..:.:::::::::::::::. : :::.::::::.:: .:.: . ::..:..::.:::
NP_003 MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYK
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG
::::::::::::.:::::.::::.::::::::::::.::::::::::::::::::::..:
NP_003 RYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLG
60 70 80 90 100 110
130 140 150 160
pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA
::.:::::: ..::::..:.:::. .::
NP_003 GEVQETSKKNVLKAIEQADLLQEEAETPRSVLEEIGLT
120 130 140 150
>>NP_001259000 (OMIM: 300629) AP-1 complex subunit sigma (160 aa)
initn: 783 init1: 751 opt: 768 Z-score: 1047.9 bits: 200.1 E(85289): 1.3e-51
Smith-Waterman score: 768; 70.7% identity (89.8% similar) in 157 aa overlap (2-158:1-152)
10 20 30 40 50 60
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK
..:.:::::::::::::::. : :::.::::::.:: .:.: . ::..:..::.:::
NP_001 MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYK
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG
::::::::::::.:::::.::::.::::::::::::.::::::::::::::::::::..:
NP_001 RYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLG
60 70 80 90 100 110
130 140 150 160
pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA
::.:::::: ..::::..:.:::. ... :::
NP_001 GEVQETSKKNVLKAIEQADLLQED-----AKEAETPRSVLEEIGLT
120 130 140 150 160
>>XP_005274671 (OMIM: 300629) PREDICTED: AP-1 complex su (195 aa)
initn: 786 init1: 754 opt: 767 Z-score: 1045.2 bits: 199.9 E(85289): 1.8e-51
Smith-Waterman score: 767; 75.7% identity (93.8% similar) in 144 aa overlap (2-145:43-186)
10 20 30
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKI
..:.:::::::::::::::. : :::.:::
XP_005 SLPQHGDRGFPFAAAAAAGQAPPRPRPAAAMQFMLLFSRQGKLRLQKWYVPLSDKEKKKI
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELL
:::.:: .:.: . ::..:..::.:::::::::::::::.:::::.::::.:::::::
XP_005 TRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 DKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENRLSPRGR
:::::.::::::::::::::::::::..:::.:::::: ..::::..:.::: :
XP_005 DKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEPRHEYFNV
140 150 160 170 180 190
160
pF1KE6 DCSEPRSCHCTLA
XP_005 PVY
>>XP_016885415 (OMIM: 300629) PREDICTED: AP-1 complex su (189 aa)
initn: 785 init1: 753 opt: 766 Z-score: 1044.0 bits: 199.7 E(85289): 2.1e-51
Smith-Waterman score: 766; 74.7% identity (93.8% similar) in 146 aa overlap (2-147:43-188)
10 20 30
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKI
..:.:::::::::::::::. : :::.:::
XP_016 SLPQHGDRGFPFAAAAAAGQAPPRPRPAAAMQFMLLFSRQGKLRLQKWYVPLSDKEKKKI
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELL
:::.:: .:.: . ::..:..::.:::::::::::::::.:::::.::::.:::::::
XP_016 TRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 DKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENRLSPRGR
:::::.::::::::::::::::::::..:::.:::::: ..::::..:.:::. .:
XP_016 DKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQESFFSS
140 150 160 170 180
160
pF1KE6 DCSEPRSCHCTLA
>>NP_001274 (OMIM: 603531,609313) AP-1 complex subunit s (158 aa)
initn: 761 init1: 761 opt: 761 Z-score: 1038.5 bits: 198.4 E(85289): 4.2e-51
Smith-Waterman score: 761; 71.1% identity (94.0% similar) in 149 aa overlap (1-149:1-149)
10 20 30 40 50 60
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK
:..:.:::::::::::::::.. ::::::..::..:..:.: . ::..:..::.:::
NP_001 MMRFMLLFSRQGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFLEWRDLKVVYK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG
::::::::::::.:::::.:::..::::::::::::.::::::::::::::::::::..:
NP_001 RYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLMG
70 80 90 100 110 120
130 140 150 160
pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA
:..:.:::: ..::::..:.:::. :::
NP_001 GDVQDTSKKSVLKAIEQADLLQEEDESPRSVLEEMGLA
130 140 150
>>XP_016885414 (OMIM: 300629) PREDICTED: AP-1 complex su (202 aa)
initn: 762 init1: 762 opt: 762 Z-score: 1038.2 bits: 198.7 E(85289): 4.4e-51
Smith-Waterman score: 762; 76.1% identity (94.4% similar) in 142 aa overlap (2-143:43-184)
10 20 30
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKI
..:.:::::::::::::::. : :::.:::
XP_016 SLPQHGDRGFPFAAAAAAGQAPPRPRPAAAMQFMLLFSRQGKLRLQKWYVPLSDKEKKKI
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELL
:::.:: .:.: . ::..:..::.:::::::::::::::.:::::.::::.:::::::
XP_016 TRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 DKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENRLSPRGR
:::::.::::::::::::::::::::..:::.:::::: ..::::..:.:::
XP_016 DKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEKTETMYHS
140 150 160 170 180 190
160
pF1KE6 DCSEPRSCHCTLA
XP_016 KSFIGFKKAY
200
>>XP_011543901 (OMIM: 300629) PREDICTED: AP-1 complex su (202 aa)
initn: 762 init1: 762 opt: 762 Z-score: 1038.2 bits: 198.7 E(85289): 4.4e-51
Smith-Waterman score: 762; 76.1% identity (94.4% similar) in 142 aa overlap (2-143:43-184)
10 20 30
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKI
..:.:::::::::::::::. : :::.:::
XP_011 SLPQHGDRGFPFAAAAAAGQAPPRPRPAAAMQFMLLFSRQGKLRLQKWYVPLSDKEKKKI
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELL
:::.:: .:.: . ::..:..::.:::::::::::::::.:::::.::::.:::::::
XP_011 TRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 DKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENRLSPRGR
:::::.::::::::::::::::::::..:::.:::::: ..::::..:.:::
XP_011 DKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEKTETMYHS
140 150 160 170 180 190
160
pF1KE6 DCSEPRSCHCTLA
XP_011 KSFIGFKKAY
200
>>XP_011508902 (OMIM: 615781,616106) PREDICTED: AP-1 com (108 aa)
initn: 647 init1: 647 opt: 647 Z-score: 886.6 bits: 169.7 E(85289): 1.2e-42
Smith-Waterman score: 647; 98.0% identity (99.0% similar) in 100 aa overlap (1-100:1-100)
10 20 30 40 50 60
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG
:::::::::::::::::::::::::::::::::::::. :
XP_011 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNTMEEYMNKPTF
70 80 90 100
130 140 150 160
pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA
>>NP_004060 (OMIM: 600740,602242) AP-2 complex subunit s (142 aa)
initn: 467 init1: 452 opt: 453 Z-score: 622.0 bits: 121.2 E(85289): 6.6e-28
Smith-Waterman score: 453; 44.4% identity (78.9% similar) in 142 aa overlap (1-142:1-139)
10 20 30 40 50 60
pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK
::.:::. .: :: :: :::. . : :..:. .:. .. : . ..::.....:..:.
NP_004 MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG
:::.:::: .. .::.: :: .: .::.:..:: ::::::..::: :.: ..::....
NP_004 RYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLA
70 80 90 100 110 120
130 140 150 160
pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA
:::.:::. .:.... :::
NP_004 GEIRETSQ---TKVLKQLLMLQSLE
130 140
164 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 10:10:32 2016 done: Tue Nov 8 10:10:33 2016
Total Scan time: 4.600 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]