Result of FASTA (omim) for
pFN21AE5754
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5754, 736 aa
1>>>pF1KE5754 736 - 736 aa - 736 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.1353+/-0.000461; mu= 6.0185+/- 0.029
mean_var=134.1959+/-27.021, 0's: 0 Z-trim(113.1): 23 B-trim: 501 in 2/56
Lambda= 0.110715
statistics sampled from 22204 (22223) to 22204 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.261), width: 16
Scan time: 11.370
The best scores are: opt bits E(85289)
NP_075045 (OMIM: 616865) poly(A) polymerase gamma ( 736) 4845 786.2 0
XP_005264558 (OMIM: 616865) PREDICTED: poly(A) pol ( 692) 4565 741.4 2.8e-213
XP_005264557 (OMIM: 616865) PREDICTED: poly(A) pol ( 714) 4392 713.8 6e-205
XP_016860212 (OMIM: 616865) PREDICTED: poly(A) pol ( 498) 3288 537.4 5.2e-152
XP_011531343 (OMIM: 616865) PREDICTED: poly(A) pol ( 498) 3288 537.4 5.2e-152
XP_016860213 (OMIM: 616865) PREDICTED: poly(A) pol ( 476) 2835 465.0 3e-130
NP_001280556 (OMIM: 605553) poly(A) polymerase alp ( 744) 2827 463.8 1.1e-129
NP_116021 (OMIM: 605553) poly(A) polymerase alpha ( 745) 2817 462.2 3.3e-129
XP_016876424 (OMIM: 605553) PREDICTED: poly(A) pol ( 723) 2782 456.6 1.6e-127
XP_005267338 (OMIM: 605553) PREDICTED: poly(A) pol ( 724) 2780 456.3 2e-127
XP_016876425 (OMIM: 605553) PREDICTED: poly(A) pol ( 698) 2775 455.5 3.3e-127
XP_005267339 (OMIM: 605553) PREDICTED: poly(A) pol ( 699) 2773 455.2 4.1e-127
NP_064529 (OMIM: 607436) poly(A) polymerase beta [ ( 637) 2540 418.0 6e-116
NP_001280561 (OMIM: 605553) poly(A) polymerase alp ( 495) 1549 259.6 2.1e-68
NP_001280557 (OMIM: 605553) poly(A) polymerase alp ( 495) 1549 259.6 2.1e-68
NP_001238935 (OMIM: 605553) poly(A) polymerase alp ( 285) 1457 244.9 3.5e-64
NP_001238936 (OMIM: 605553) poly(A) polymerase alp ( 238) 994 170.9 5.4e-42
>>NP_075045 (OMIM: 616865) poly(A) polymerase gamma [Hom (736 aa)
initn: 4845 init1: 4845 opt: 4845 Z-score: 4191.3 bits: 786.2 E(85289): 0
Smith-Waterman score: 4845; 100.0% identity (100.0% similar) in 736 aa overlap (1-736:1-736)
10 20 30 40 50 60
pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE5 VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
670 680 690 700 710 720
730
pF1KE5 NNIRVIKNSIRLTLNR
::::::::::::::::
NP_075 NNIRVIKNSIRLTLNR
730
>>XP_005264558 (OMIM: 616865) PREDICTED: poly(A) polymer (692 aa)
initn: 4565 init1: 4565 opt: 4565 Z-score: 3950.0 bits: 741.4 E(85289): 2.8e-213
Smith-Waterman score: 4565; 100.0% identity (100.0% similar) in 692 aa overlap (45-736:1-692)
20 30 40 50 60 70
pF1KE5 QQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKLNNLVKEW
::::::::::::::::::::::::::::::
XP_005 MKPFGVFEDEEELNHRLVVLGKLNNLVKEW
10 20 30
80 90 100 110 120 130
pF1KE5 ISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFE
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE5 KLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDNLDLRDDSRLRSLDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDNLDLRDDSRLRSLDI
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE5 RCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVAR
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE5 TCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPI
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE5 ITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYI
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE5 VLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVS
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE5 MWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHH
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE5 YLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPS
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE5 VGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNV
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE5 IPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDP
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE5 RTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTL
640 650 660 670 680 690
pF1KE5 NR
::
XP_005 NR
>>XP_005264557 (OMIM: 616865) PREDICTED: poly(A) polymer (714 aa)
initn: 4693 init1: 4381 opt: 4392 Z-score: 3800.5 bits: 713.8 E(85289): 6e-205
Smith-Waterman score: 4653; 97.0% identity (97.0% similar) in 736 aa overlap (1-736:1-714)
10 20 30 40 50 60
pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE5 VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
::: :::::::::::::::::::::::::::::::::::
XP_005 VEK----------------------DAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
670 680 690
730
pF1KE5 NNIRVIKNSIRLTLNR
::::::::::::::::
XP_005 NNIRVIKNSIRLTLNR
700 710
>>XP_016860212 (OMIM: 616865) PREDICTED: poly(A) polymer (498 aa)
initn: 3288 init1: 3288 opt: 3288 Z-score: 2850.0 bits: 537.4 E(85289): 5.2e-152
Smith-Waterman score: 3288; 100.0% identity (100.0% similar) in 498 aa overlap (239-736:1-498)
210 220 230 240 250 260
pF1KE5 ILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLV
::::::::::::::::::::::::::::::
XP_016 MLGFLGGVSWAMLVARTCQLYPNAAASTLV
10 20 30
270 280 290 300 310 320
pF1KE5 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV
40 50 60 70 80 90
330 340 350 360 370 380
pF1KE5 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE
100 110 120 130 140 150
390 400 410 420 430 440
pF1KE5 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA
160 170 180 190 200 210
450 460 470 480 490 500
pF1KE5 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS
220 230 240 250 260 270
510 520 530 540 550 560
pF1KE5 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV
280 290 300 310 320 330
570 580 590 600 610 620
pF1KE5 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ
340 350 360 370 380 390
630 640 650 660 670 680
pF1KE5 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI
400 410 420 430 440 450
690 700 710 720 730
pF1KE5 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
460 470 480 490
>>XP_011531343 (OMIM: 616865) PREDICTED: poly(A) polymer (498 aa)
initn: 3288 init1: 3288 opt: 3288 Z-score: 2850.0 bits: 537.4 E(85289): 5.2e-152
Smith-Waterman score: 3288; 100.0% identity (100.0% similar) in 498 aa overlap (239-736:1-498)
210 220 230 240 250 260
pF1KE5 ILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLV
::::::::::::::::::::::::::::::
XP_011 MLGFLGGVSWAMLVARTCQLYPNAAASTLV
10 20 30
270 280 290 300 310 320
pF1KE5 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV
40 50 60 70 80 90
330 340 350 360 370 380
pF1KE5 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE
100 110 120 130 140 150
390 400 410 420 430 440
pF1KE5 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA
160 170 180 190 200 210
450 460 470 480 490 500
pF1KE5 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS
220 230 240 250 260 270
510 520 530 540 550 560
pF1KE5 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV
280 290 300 310 320 330
570 580 590 600 610 620
pF1KE5 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ
340 350 360 370 380 390
630 640 650 660 670 680
pF1KE5 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI
400 410 420 430 440 450
690 700 710 720 730
pF1KE5 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
460 470 480 490
>>XP_016860213 (OMIM: 616865) PREDICTED: poly(A) polymer (476 aa)
initn: 3136 init1: 2824 opt: 2835 Z-score: 2459.3 bits: 465.0 E(85289): 3e-130
Smith-Waterman score: 3096; 95.6% identity (95.6% similar) in 498 aa overlap (239-736:1-476)
210 220 230 240 250 260
pF1KE5 ILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLV
::::::::::::::::::::::::::::::
XP_016 MLGFLGGVSWAMLVARTCQLYPNAAASTLV
10 20 30
270 280 290 300 310 320
pF1KE5 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV
40 50 60 70 80 90
330 340 350 360 370 380
pF1KE5 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE
100 110 120 130 140 150
390 400 410 420 430 440
pF1KE5 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA
160 170 180 190 200 210
450 460 470 480 490 500
pF1KE5 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS
220 230 240 250 260 270
510 520 530 540 550 560
pF1KE5 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV
280 290 300 310 320 330
570 580 590 600 610 620
pF1KE5 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ
340 350 360 370 380 390
630 640 650 660 670 680
pF1KE5 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI
::::::::::::::::::::::::::::::::::: :::
XP_016 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEK----------------------DAI
400 410 420
690 700 710 720 730
pF1KE5 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
430 440 450 460 470
>>NP_001280556 (OMIM: 605553) poly(A) polymerase alpha i (744 aa)
initn: 2792 init1: 2677 opt: 2827 Z-score: 2449.2 bits: 463.8 E(85289): 1.1e-129
Smith-Waterman score: 2846; 61.1% identity (78.8% similar) in 746 aa overlap (12-736:13-744)
10 20 30 40 50
pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH
.: :::::::::::::.::: : . :::::...:::::::.::::..
NP_001 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA
:...:::::::::::: ..::::::: ::. .::::::::::::::::::::::::::::
NP_001 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD
::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: .
NP_001 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM
.::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::.
NP_001 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW
::::::::::::::::::::::: :::::::::::::::::::::::::::: :::::::
NP_001 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK
::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..:::
NP_001 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS
:.: :::::::.::::: ::: ::...::::::::::::.:::.::.:::::::::::::
NP_001 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG
::. ::. ... .:: .:..:...::.:....::::::::::::::::: : .:..
NP_001 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN
::: : :::.::::. :: ..::::::.: : : .:..: :: : :.::
NP_001 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN
490 500 510 520 530
540 550 560 570 580
pF1KE5 GTPFNSPASKSD-SP--SVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVI-------GA
. ::.: . :: : : .. :: :: ... .. : .:.: . :.
NP_001 SMSVPSPTSATKTSPLNSSGSSQGNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGGT
540 550 560 570 580
590 600 610 620 630 640
pF1KE5 KVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP----
. .: .:.. :.. : .:.: : :...: ..:. .: . :: ::
NP_001 SSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVGV
590 600 610 620 630 640
650 660 670 680 690
pF1KE5 KRSHSPSIDGTPKRLKDVEKFIR-----LESTFKDPRTAEERKRKSVDAIGGESMPIPTI
::. :: . .::. : : : . .: :.:. ... .:.. .
NP_001 KRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAAS
650 660 670 680 690 700
700 710 720 730
pF1KE5 DTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
. .: : .: : . .::: : ::::::.: :::
NP_001 LLASQKT-SSTDLSDIPA-LPANPIPVIKNSIKLRLNR
710 720 730 740
>>NP_116021 (OMIM: 605553) poly(A) polymerase alpha isof (745 aa)
initn: 2784 init1: 2669 opt: 2817 Z-score: 2440.6 bits: 462.2 E(85289): 3.3e-129
Smith-Waterman score: 2844; 61.2% identity (78.8% similar) in 747 aa overlap (12-736:13-745)
10 20 30 40 50
pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH
.: :::::::::::::.::: : . :::::...:::::::.::::..
NP_116 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA
:...:::::::::::: ..::::::: ::. .::::::::::::::::::::::::::::
NP_116 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD
::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: .
NP_116 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM
.::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::.
NP_116 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW
::::::::::::::::::::::: :::::::::::::::::::::::::::: :::::::
NP_116 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK
::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..:::
NP_116 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS
:.: :::::::.::::: ::: ::...::::::::::::.:::.::.:::::::::::::
NP_116 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG
::. ::. ... .:: .:..:...::.:....::::::::::::::::: : .:..
NP_116 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN
::: : :::.::::. :: ..::::::.: : : .:..: :: : :.::
NP_116 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN
490 500 510 520 530
540 550 560 570 580
pF1KE5 GTPFNSPASKSD-SP--SVGETE-RNSAEPAAVIVEKPLSVPPAQGLSIPVI-------G
. ::.: . :: : : .. ::: :: ... .. : .:.: . :
NP_116 SMSVPSPTSATKTSPLNSSGSSQGRNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGG
540 550 560 570 580
590 600 610 620 630 640
pF1KE5 AKVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP---
.. .: .:.. :.. : .:.: : :...: ..:. .: . :: ::
NP_116 TSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVG
590 600 610 620 630 640
650 660 670 680 690
pF1KE5 -KRSHSPSIDGTPKRLKDVEKFIR-----LESTFKDPRTAEERKRKSVDAIGGESMPIPT
::. :: . .::. : : : . .: :.:. ... .:.. .
NP_116 VKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAA
650 660 670 680 690 700
700 710 720 730
pF1KE5 IDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
. .: : .: : . .::: : ::::::.: :::
NP_116 SLLASQKT-SSTDLSDIPA-LPANPIPVIKNSIKLRLNR
710 720 730 740
>>XP_016876424 (OMIM: 605553) PREDICTED: poly(A) polymer (723 aa)
initn: 2828 init1: 2677 opt: 2782 Z-score: 2410.6 bits: 456.6 E(85289): 1.6e-127
Smith-Waterman score: 2833; 61.3% identity (78.8% similar) in 741 aa overlap (12-736:13-723)
10 20 30 40 50
pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH
.: :::::::::::::.::: : . :::::...:::::::.::::..
XP_016 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA
:...:::::::::::: ..::::::: ::. .::::::::::::::::::::::::::::
XP_016 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD
::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: .
XP_016 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM
.::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::.
XP_016 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW
::::::::::::::::::::::: :::::::::::::::::::::::::::: :::::::
XP_016 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK
::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..:::
XP_016 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS
:.: :::::::.::::: ::: ::...::::::::::::.:::.::.:::::::::::::
XP_016 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG
::. ::. ... .:: .:..:...::.:....::::::::::::::::: : .:..
XP_016 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN
::: : :::.::::. :: ..::::::.: : : .:..: :: : :.::
XP_016 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN
490 500 510 520 530
540 550 560 570 580
pF1KE5 GTPFNSPASKSD-SP--SVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVI-------GA
. ::.: . :: : : .. :: :: ... .. : .:.: . :.
XP_016 SMSVPSPTSATKTSPLNSSGSSQGNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGGT
540 550 560 570 580
590 600 610 620 630 640
pF1KE5 KVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP----
. .: .:.. :.. : .:.: : :...: ..:. .: . :: ::
XP_016 SSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVGV
590 600 610 620 630 640
650 660 670 680 690 700
pF1KE5 KRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRK
::. :: . .::. : :. . :.. . .: . .. .:.:
XP_016 KRTSSPHKEESPKKTKTEEEQLDTETSTTQSETIQT---------------AASLLASQK
650 660 670 680 690
710 720 730
pF1KE5 KRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
: .: : . .::: : ::::::.: :::
XP_016 TS--STDLSDIPA-LPANPIPVIKNSIKLRLNR
700 710 720
>>XP_005267338 (OMIM: 605553) PREDICTED: poly(A) polymer (724 aa)
initn: 2779 init1: 2669 opt: 2780 Z-score: 2408.8 bits: 456.3 E(85289): 2e-127
Smith-Waterman score: 2831; 61.3% identity (78.8% similar) in 742 aa overlap (12-736:13-724)
10 20 30 40 50
pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH
.: :::::::::::::.::: : . :::::...:::::::.::::..
XP_005 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA
:...:::::::::::: ..::::::: ::. .::::::::::::::::::::::::::::
XP_005 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD
::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: .
XP_005 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM
.::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::.
XP_005 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW
::::::::::::::::::::::: :::::::::::::::::::::::::::: :::::::
XP_005 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK
::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..:::
XP_005 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS
:.: :::::::.::::: ::: ::...::::::::::::.:::.::.:::::::::::::
XP_005 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG
::. ::. ... .:: .:..:...::.:....::::::::::::::::: : .:..
XP_005 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN
::: : :::.::::. :: ..::::::.: : : .:..: :: : :.::
XP_005 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN
490 500 510 520 530
540 550 560 570 580
pF1KE5 GTPFNSPASKSD-SP--SVGETE-RNSAEPAAVIVEKPLSVPPAQGLSIPVI-------G
. ::.: . :: : : .. ::: :: ... .. : .:.: . :
XP_005 SMSVPSPTSATKTSPLNSSGSSQGRNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGG
540 550 560 570 580
590 600 610 620 630 640
pF1KE5 AKVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP---
.. .: .:.. :.. : .:.: : :...: ..:. .: . :: ::
XP_005 TSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVG
590 600 610 620 630 640
650 660 670 680 690 700
pF1KE5 -KRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSR
::. :: . .::. : :. . :.. . .: . .. .:.
XP_005 VKRTSSPHKEESPKKTKTEEEQLDTETSTTQSETIQT---------------AASLLASQ
650 660 670 680 690
710 720 730
pF1KE5 KKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR
: : .: : . .::: : ::::::.: :::
XP_005 KTS--STDLSDIPA-LPANPIPVIKNSIKLRLNR
700 710 720
736 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:22:27 2016 done: Tue Nov 8 06:22:29 2016
Total Scan time: 11.370 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]