Result of FASTA (omim) for
pFN21AE5722
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5722, 870 aa
1>>>pF1KE5722 870 - 870 aa - 870 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.2209+/-0.000584; mu= 7.3117+/- 0.036
mean_var=273.2006+/-63.015, 0's: 0 Z-trim(113.3): 446 B-trim: 1035 in 2/56
Lambda= 0.077595
statistics sampled from 21927 (22520) to 21927 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.264), width: 16
Scan time: 8.570
The best scores are: opt bits E(85289)
NP_001355 (OMIM: 603583) disks large homolog 2 iso ( 870) 5787 663.1 1.6e-189
XP_011543084 (OMIM: 603583) PREDICTED: disks large ( 891) 5685 651.7 4.5e-186
NP_001136171 (OMIM: 603583) disks large homolog 2 ( 975) 5685 651.7 4.7e-186
XP_011543080 (OMIM: 603583) PREDICTED: disks large (1025) 5685 651.7 4.9e-186
XP_016872763 (OMIM: 603583) PREDICTED: disks large ( 866) 5543 635.7 2.7e-181
NP_001193698 (OMIM: 603583) disks large homolog 2 ( 909) 5332 612.2 3.6e-174
XP_005273867 (OMIM: 603583) PREDICTED: disks large ( 837) 5318 610.5 1e-173
XP_016872771 (OMIM: 603583) PREDICTED: disks large ( 811) 5082 584.1 8.8e-166
XP_016872756 (OMIM: 603583) PREDICTED: disks large ( 884) 4380 505.6 4.2e-142
XP_016872757 (OMIM: 603583) PREDICTED: disks large ( 883) 4362 503.6 1.7e-141
XP_016872758 (OMIM: 603583) PREDICTED: disks large ( 880) 4299 496.5 2.3e-139
XP_016872753 (OMIM: 603583) PREDICTED: disks large ( 904) 4285 494.9 6.8e-139
XP_016872754 (OMIM: 603583) PREDICTED: disks large ( 903) 4278 494.2 1.2e-138
XP_016872752 (OMIM: 603583) PREDICTED: disks large ( 905) 4278 494.2 1.2e-138
XP_016872747 (OMIM: 603583) PREDICTED: disks large ( 985) 4278 494.2 1.2e-138
XP_016872745 (OMIM: 603583) PREDICTED: disks large (1026) 4278 494.2 1.3e-138
XP_016872744 (OMIM: 603583) PREDICTED: disks large (1026) 4278 494.2 1.3e-138
XP_016872743 (OMIM: 603583) PREDICTED: disks large (1039) 4278 494.2 1.3e-138
XP_016872746 (OMIM: 603583) PREDICTED: disks large (1025) 4272 493.6 2e-138
NP_001287912 (OMIM: 603583) disks large homolog 2 ( 852) 4158 480.7 1.3e-134
XP_016872765 (OMIM: 603583) PREDICTED: disks large ( 848) 4077 471.6 6.7e-132
XP_016872760 (OMIM: 603583) PREDICTED: disks large ( 872) 4063 470.1 2e-131
XP_016872761 (OMIM: 603583) PREDICTED: disks large ( 871) 4056 469.3 3.5e-131
XP_016872759 (OMIM: 603583) PREDICTED: disks large ( 873) 4056 469.3 3.5e-131
XP_016872748 (OMIM: 603583) PREDICTED: disks large ( 969) 4056 469.3 3.7e-131
XP_011543082 (OMIM: 603583) PREDICTED: disks large (1007) 4056 469.4 3.8e-131
XP_016872749 (OMIM: 603583) PREDICTED: disks large ( 968) 4050 468.7 5.9e-131
XP_016872751 (OMIM: 603583) PREDICTED: disks large ( 923) 3925 454.7 9.4e-127
XP_016872766 (OMIM: 603583) PREDICTED: disks large ( 842) 3916 453.6 1.8e-126
XP_016872773 (OMIM: 603583) PREDICTED: disks large ( 801) 3794 439.9 2.2e-122
XP_016872755 (OMIM: 603583) PREDICTED: disks large ( 891) 3703 429.8 2.8e-119
XP_016872772 (OMIM: 603583) PREDICTED: disks large ( 810) 3694 428.7 5.2e-119
XP_005273868 (OMIM: 603583) PREDICTED: disks large ( 819) 3689 428.2 7.8e-119
XP_016872775 (OMIM: 603583) PREDICTED: disks large ( 757) 3418 397.8 1e-109
XP_016872764 (OMIM: 603583) PREDICTED: disks large ( 857) 3183 371.6 9e-102
XP_016884811 (OMIM: 300189,300850) PREDICTED: disk ( 498) 2475 292.0 4.6e-78
XP_011529185 (OMIM: 300189,300850) PREDICTED: disk ( 835) 2475 292.3 6.4e-78
XP_016884812 (OMIM: 300189,300850) PREDICTED: disk ( 494) 2341 277.0 1.5e-73
XP_006724689 (OMIM: 300189,300850) PREDICTED: disk ( 831) 2341 277.3 2.1e-73
XP_016872774 (OMIM: 603583) PREDICTED: disks large ( 796) 2182 259.5 4.6e-68
XP_016872770 (OMIM: 603583) PREDICTED: disks large ( 820) 2168 257.9 1.4e-67
XP_016872768 (OMIM: 603583) PREDICTED: disks large ( 821) 2161 257.1 2.4e-67
XP_016872750 (OMIM: 603583) PREDICTED: disks large ( 955) 2161 257.2 2.7e-67
XP_016872769 (OMIM: 603583) PREDICTED: disks large ( 820) 2155 256.4 3.9e-67
XP_016872767 (OMIM: 603583) PREDICTED: disks large ( 839) 1808 217.6 1.9e-55
XP_016872762 (OMIM: 603583) PREDICTED: disks large ( 871) 1808 217.6 2e-55
XP_011543090 (OMIM: 603583) PREDICTED: disks large ( 767) 1794 216.0 5.4e-55
NP_001136172 (OMIM: 603583) disks large homolog 2 ( 749) 1680 203.2 3.7e-51
XP_011510811 (OMIM: 601014) PREDICTED: disks large ( 554) 1606 194.8 9.5e-49
XP_011510807 (OMIM: 601014) PREDICTED: disks large ( 871) 1606 195.0 1.3e-48
>>NP_001355 (OMIM: 603583) disks large homolog 2 isoform (870 aa)
initn: 5787 init1: 5787 opt: 5787 Z-score: 3523.5 bits: 663.1 E(85289): 1.6e-189
Smith-Waterman score: 5787; 100.0% identity (100.0% similar) in 870 aa overlap (1-870:1-870)
10 20 30 40 50 60
pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE5 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE5 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE5 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG
790 800 810 820 830 840
850 860 870
pF1KE5 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
::::::::::::::::::::::::::::::
NP_001 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
850 860 870
>>XP_011543084 (OMIM: 603583) PREDICTED: disks large hom (891 aa)
initn: 5685 init1: 5685 opt: 5685 Z-score: 3461.6 bits: 651.7 E(85289): 4.5e-186
Smith-Waterman score: 5685; 100.0% identity (100.0% similar) in 856 aa overlap (15-870:36-891)
10 20 30 40
pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHV
::::::::::::::::::::::::::::::
XP_011 IVTTKQNQGRCPAQNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE5 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE5 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE5 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE5 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE5 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE5 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE5 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE5 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE5 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE5 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE5 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI
790 800 810 820 830 840
830 840 850 860 870
pF1KE5 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
850 860 870 880 890
>>NP_001136171 (OMIM: 603583) disks large homolog 2 isof (975 aa)
initn: 5685 init1: 5685 opt: 5685 Z-score: 3461.2 bits: 651.7 E(85289): 4.7e-186
Smith-Waterman score: 5685; 100.0% identity (100.0% similar) in 856 aa overlap (15-870:120-975)
10 20 30 40
pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHV
::::::::::::::::::::::::::::::
NP_001 DETTTQNQGRCPAQNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHV
90 100 110 120 130 140
50 60 70 80 90 100
pF1KE5 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG
150 160 170 180 190 200
110 120 130 140 150 160
pF1KE5 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS
210 220 230 240 250 260
170 180 190 200 210 220
pF1KE5 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV
270 280 290 300 310 320
230 240 250 260 270 280
pF1KE5 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM
330 340 350 360 370 380
290 300 310 320 330 340
pF1KE5 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP
390 400 410 420 430 440
350 360 370 380 390 400
pF1KE5 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ
450 460 470 480 490 500
410 420 430 440 450 460
pF1KE5 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG
510 520 530 540 550 560
470 480 490 500 510 520
pF1KE5 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM
570 580 590 600 610 620
530 540 550 560 570 580
pF1KE5 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV
630 640 650 660 670 680
590 600 610 620 630 640
pF1KE5 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF
690 700 710 720 730 740
650 660 670 680 690 700
pF1KE5 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK
750 760 770 780 790 800
710 720 730 740 750 760
pF1KE5 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF
810 820 830 840 850 860
770 780 790 800 810 820
pF1KE5 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI
870 880 890 900 910 920
830 840 850 860 870
pF1KE5 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
930 940 950 960 970
>>XP_011543080 (OMIM: 603583) PREDICTED: disks large hom (1025 aa)
initn: 5685 init1: 5685 opt: 5685 Z-score: 3460.9 bits: 651.7 E(85289): 4.9e-186
Smith-Waterman score: 5685; 100.0% identity (100.0% similar) in 856 aa overlap (15-870:170-1025)
10 20 30 40
pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHV
::::::::::::::::::::::::::::::
XP_011 DETTTQNQGRCPAQNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHV
140 150 160 170 180 190
50 60 70 80 90 100
pF1KE5 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERG
200 210 220 230 240 250
110 120 130 140 150 160
pF1KE5 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS
260 270 280 290 300 310
170 180 190 200 210 220
pF1KE5 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYV
320 330 340 350 360 370
230 240 250 260 270 280
pF1KE5 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYM
380 390 400 410 420 430
290 300 310 320 330 340
pF1KE5 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPP
440 450 460 470 480 490
350 360 370 380 390 400
pF1KE5 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ
500 510 520 530 540 550
410 420 430 440 450 460
pF1KE5 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRG
560 570 580 590 600 610
470 480 490 500 510 520
pF1KE5 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSM
620 630 640 650 660 670
530 540 550 560 570 580
pF1KE5 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRV
680 690 700 710 720 730
590 600 610 620 630 640
pF1KE5 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPF
740 750 760 770 780 790
650 660 670 680 690 700
pF1KE5 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDK
800 810 820 830 840 850
710 720 730 740 750 760
pF1KE5 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF
860 870 880 890 900 910
770 780 790 800 810 820
pF1KE5 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAI
920 930 940 950 960 970
830 840 850 860 870
pF1KE5 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
980 990 1000 1010 1020
>>XP_016872763 (OMIM: 603583) PREDICTED: disks large hom (866 aa)
initn: 5555 init1: 4158 opt: 5543 Z-score: 3375.9 bits: 635.7 E(85289): 2.7e-181
Smith-Waterman score: 5543; 96.7% identity (98.0% similar) in 870 aa overlap (1-870:1-866)
10 20 30 40 50 60
pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPER
::::::::::::::::::::::::::.. .. . : . ... :..:.: :
XP_016 RVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGY--GTKTLKHVSSNASDSESS--YR
610 620 630 640 650
670 680 690 700 710 720
pF1KE5 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYE
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE5 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNA
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE5 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQG
780 790 800 810 820 830
850 860 870
pF1KE5 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
::::::::::::::::::::::::::::::
XP_016 DTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
840 850 860
>>NP_001193698 (OMIM: 603583) disks large homolog 2 isof (909 aa)
initn: 5332 init1: 5332 opt: 5332 Z-score: 3248.0 bits: 612.2 E(85289): 3.6e-174
Smith-Waterman score: 5332; 99.8% identity (99.9% similar) in 806 aa overlap (65-870:104-909)
40 50 60 70 80 90
pF1KE5 EVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEY
:: .::::::::::::::::::::::::::
NP_001 WDSVRKSPHKTSTKGKGTCGEHCTCPHGWFSPAQASPAPIIVNTDTLDTIPYVNGTEIEY
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE5 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN
140 150 160 170 180 190
160 170 180 190 200 210
pF1KE5 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQ
200 210 220 230 240 250
220 230 240 250 260 270
pF1KE5 HIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL
260 270 280 290 300 310
280 290 300 310 320 330
pF1KE5 KVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHM
320 330 340 350 360 370
340 350 360 370 380 390
pF1KE5 LVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTS
380 390 400 410 420 430
400 410 420 430 440 450
pF1KE5 HSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGP
440 450 460 470 480 490
460 470 480 490 500 510
pF1KE5 ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHD
500 510 520 530 540 550
520 530 540 550 560 570
pF1KE5 LREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINAS
560 570 580 590 600 610
580 590 600 610 620 630
pF1KE5 DDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKK
620 630 640 650 660 670
640 650 660 670 680 690
pF1KE5 SFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRIN
680 690 700 710 720 730
700 710 720 730 740 750
pF1KE5 DDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNL
740 750 760 770 780 790
760 770 780 790 800 810
pF1KE5 YGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE
800 810 820 830 840 850
820 830 840 850 860 870
pF1KE5 QAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
860 870 880 890 900
>>XP_005273867 (OMIM: 603583) PREDICTED: disks large hom (837 aa)
initn: 5318 init1: 5318 opt: 5318 Z-score: 3239.9 bits: 610.5 E(85289): 1e-173
Smith-Waterman score: 5318; 99.8% identity (99.9% similar) in 804 aa overlap (67-870:34-837)
40 50 60 70 80 90
pF1KE5 RGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEF
. ::::::::::::::::::::::::::::
XP_005 PSVSRAENYQLLWDTIASLKQCEQAMQHAFIPASPAPIIVNTDTLDTIPYVNGTEIEYEF
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE5 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV
70 80 90 100 110 120
160 170 180 190 200 210
pF1KE5 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI
130 140 150 160 170 180
220 230 240 250 260 270
pF1KE5 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV
190 200 210 220 230 240
280 290 300 310 320 330
pF1KE5 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV
250 260 270 280 290 300
340 350 360 370 380 390
pF1KE5 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS
310 320 330 340 350 360
400 410 420 430 440 450
pF1KE5 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPAD
370 380 390 400 410 420
460 470 480 490 500 510
pF1KE5 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR
430 440 450 460 470 480
520 530 540 550 560 570
pF1KE5 EQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDD
490 500 510 520 530 540
580 590 600 610 620 630
pF1KE5 EWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSF
550 560 570 580 590 600
640 650 660 670 680 690
pF1KE5 IFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD
610 620 630 640 650 660
700 710 720 730 740 750
pF1KE5 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG
670 680 690 700 710 720
760 770 780 790 800 810
pF1KE5 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA
730 740 750 760 770 780
820 830 840 850 860 870
pF1KE5 KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
790 800 810 820 830
>>XP_016872771 (OMIM: 603583) PREDICTED: disks large hom (811 aa)
initn: 5082 init1: 5082 opt: 5082 Z-score: 3097.3 bits: 584.1 E(85289): 8.8e-166
Smith-Waterman score: 5082; 99.7% identity (99.9% similar) in 769 aa overlap (67-835:34-802)
40 50 60 70 80 90
pF1KE5 RGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEF
. ::::::::::::::::::::::::::::
XP_016 PSVSRAENYQLLWDTIASLKQCEQAMQHAFIPASPAPIIVNTDTLDTIPYVNGTEIEYEF
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE5 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV
70 80 90 100 110 120
160 170 180 190 200 210
pF1KE5 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI
130 140 150 160 170 180
220 230 240 250 260 270
pF1KE5 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV
190 200 210 220 230 240
280 290 300 310 320 330
pF1KE5 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV
250 260 270 280 290 300
340 350 360 370 380 390
pF1KE5 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHS
310 320 330 340 350 360
400 410 420 430 440 450
pF1KE5 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPAD
370 380 390 400 410 420
460 470 480 490 500 510
pF1KE5 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLR
430 440 450 460 470 480
520 530 540 550 560 570
pF1KE5 EQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDD
490 500 510 520 530 540
580 590 600 610 620 630
pF1KE5 EWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSF
550 560 570 580 590 600
640 650 660 670 680 690
pF1KE5 IFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD
610 620 630 640 650 660
700 710 720 730 740 750
pF1KE5 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG
670 680 690 700 710 720
760 770 780 790 800 810
pF1KE5 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA
730 740 750 760 770 780
820 830 840 850 860 870
pF1KE5 KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
:::::::::::::::::::
XP_016 KKTYDRAIKLEQEFGEYFTGKFTFTLVV
790 800 810
>>XP_016872756 (OMIM: 603583) PREDICTED: disks large hom (884 aa)
initn: 6188 init1: 4380 opt: 4380 Z-score: 2672.1 bits: 505.6 E(85289): 4.2e-142
Smith-Waterman score: 5749; 98.4% identity (98.4% similar) in 884 aa overlap (1-870:1-884)
10 20 30 40 50 60
pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
550 560 570 580 590 600
610 620 630 640 650
pF1KE5 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPE-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPEQ
610 620 630 640 650 660
660 670 680 690 700
pF1KE5 -------------RGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFG
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVSSNASDSESSYRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFG
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE5 SCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE5 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKL
790 800 810 820 830 840
830 840 850 860 870
pF1KE5 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
850 860 870 880
>>XP_016872757 (OMIM: 603583) PREDICTED: disks large hom (883 aa)
initn: 6174 init1: 4278 opt: 4362 Z-score: 2661.3 bits: 503.6 E(85289): 1.7e-141
Smith-Waterman score: 5731; 98.3% identity (98.3% similar) in 884 aa overlap (1-870:1-883)
10 20 30 40 50 60
pF1KE5 MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
:::::::::::::: :::::::::::::::::::::::::::::::::::::::::::::
XP_016 MFFACYCALRTNVK-YRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVL
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPH
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQ
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE5 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE5 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPAS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE5 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPR
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE5 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE5 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLY
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE5 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKR
540 550 560 570 580 590
610 620 630 640 650
pF1KE5 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPE-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPEQ
600 610 620 630 640 650
660 670 680 690 700
pF1KE5 -------------RGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFG
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVSSNASDSESSYRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFG
660 670 680 690 700 710
710 720 730 740 750 760
pF1KE5 SCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVA
720 730 740 750 760 770
770 780 790 800 810 820
pF1KE5 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKL
780 790 800 810 820 830
830 840 850 860 870
pF1KE5 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
840 850 860 870 880
870 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:05:13 2016 done: Tue Nov 8 06:05:15 2016
Total Scan time: 8.570 Total Display time: 0.190
Function used was FASTA [36.3.4 Apr, 2011]