Result of FASTA (omim) for
pFN21AE5687
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5687, 562 aa
1>>>pF1KE5687 562 - 562 aa - 562 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.8549+/-0.000531; mu= -13.8822+/- 0.033
mean_var=496.1118+/-103.036, 0's: 0 Z-trim(121.4): 283 B-trim: 1534 in 1/61
Lambda= 0.057582
statistics sampled from 37711 (38001) to 37711 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.446), width: 16
Scan time: 9.690
The best scores are: opt bits E(85289)
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 3845 334.1 7.4e-91
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 3801 330.4 9.2e-90
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 2962 260.7 8.5e-69
NP_001193719 (OMIM: 610050) transmembrane protease ( 491) 2842 250.7 8e-66
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 995 97.3 1.2e-19
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 995 97.3 1.2e-19
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 995 97.3 1.3e-19
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 976 95.6 3.1e-19
NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 935 92.2 3.6e-18
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 919 90.9 9.3e-18
XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 918 90.9 1e-17
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 914 90.5 1.2e-17
NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 900 89.3 2.7e-17
NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 900 89.3 2.7e-17
NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 897 89.1 3.1e-17
NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 888 88.3 5e-17
XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 883 88.0 7.8e-17
XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 883 88.0 7.8e-17
XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 871 86.9 1.5e-16
XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 871 86.9 1.5e-16
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 823 82.9 2.2e-15
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 819 82.5 2.3e-15
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 823 82.9 2.3e-15
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 823 83.0 2.3e-15
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 819 82.6 2.9e-15
NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 788 79.9 1.3e-14
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 757 77.5 1e-13
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 757 77.5 1e-13
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 757 77.6 1.3e-13
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 757 77.6 1.4e-13
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 757 77.6 1.4e-13
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 735 75.9 5.6e-13
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 735 75.9 5.7e-13
NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 728 75.4 1e-12
XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 727 75.3 1.1e-12
XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 727 75.3 1.1e-12
XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 727 75.3 1.1e-12
XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 727 75.3 1.1e-12
XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 727 75.3 1.1e-12
XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 727 75.3 1.1e-12
XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 717 74.2 1.2e-12
XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 717 74.3 1.3e-12
XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 717 74.3 1.3e-12
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 704 72.9 1.7e-12
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 709 73.6 2.1e-12
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 700 72.6 2.3e-12
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 700 72.6 2.3e-12
XP_011530198 (OMIM: 610399) PREDICTED: transmembra ( 345) 692 72.0 3.6e-12
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 703 73.2 3.7e-12
NP_054777 (OMIM: 610399) transmembrane protease se ( 423) 692 72.0 4.2e-12
>>NP_001070731 (OMIM: 610050) transmembrane protease ser (567 aa)
initn: 3547 init1: 3547 opt: 3845 Z-score: 1752.2 bits: 334.1 E(85289): 7.4e-91
Smith-Waterman score: 3845; 99.1% identity (99.1% similar) in 567 aa overlap (1-562:1-567)
10 20 30 40 50 60
pF1KE5 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS
10 20 30 40 50 60
70 80 90 100 110
pF1KE5 PAGTPPGRASPGRASPAQASPA-----RASPALASLSRSSSGRSSSARSASVTTSPTRVY
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK
490 500 510 520 530 540
540 550 560
pF1KE5 PGVYTKVTEVLPWIYSKMESEVRFRKS
:::::::::::::::::::::::::::
NP_001 PGVYTKVTEVLPWIYSKMESEVRFRKS
550 560
>>NP_001231924 (OMIM: 610050) transmembrane protease ser (563 aa)
initn: 3503 init1: 3503 opt: 3801 Z-score: 1732.5 bits: 330.4 E(85289): 9.2e-90
Smith-Waterman score: 3801; 99.1% identity (99.1% similar) in 560 aa overlap (1-555:1-560)
10 20 30 40 50 60
pF1KE5 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS
10 20 30 40 50 60
70 80 90 100 110
pF1KE5 PAGTPPGRASPGRASPAQASPA-----RASPALASLSRSSSGRSSSARSASVTTSPTRVY
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE5 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK
490 500 510 520 530 540
540 550 560
pF1KE5 PGVYTKVTEVLPWIYSKMESEVRFRKS
::::::::::::::::::::
NP_001 PGVYTKVTEVLPWIYSKMESSAG
550 560
>>NP_001193718 (OMIM: 610050) transmembrane protease ser (532 aa)
initn: 2900 init1: 2900 opt: 2962 Z-score: 1356.1 bits: 260.7 E(85289): 8.5e-69
Smith-Waterman score: 3532; 92.8% identity (92.8% similar) in 567 aa overlap (1-562:1-532)
10 20 30 40 50 60
pF1KE5 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS
10 20 30 40 50 60
70 80 90 100 110
pF1KE5 PAGTPPGRASPGRASPAQASPA-----RASPALASLSRSSSGRSSSARSASVTTSPTRVY
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV
::::::::::::::::::::::::::::::
NP_001 LVRATPVGAVPIRSSPARSAPATRATRESP------------------------------
130 140 150
180 190 200 210 220 230
pF1KE5 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----VQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS
160 170 180 190 200
240 250 260 270 280 290
pF1KE5 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH
210 220 230 240 250 260
300 310 320 330 340 350
pF1KE5 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE5 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE5 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC
390 400 410 420 430 440
480 490 500 510 520 530
pF1KE5 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK
450 460 470 480 490 500
540 550 560
pF1KE5 PGVYTKVTEVLPWIYSKMESEVRFRKS
:::::::::::::::::::::::::::
NP_001 PGVYTKVTEVLPWIYSKMESEVRFRKS
510 520 530
>>NP_001193719 (OMIM: 610050) transmembrane protease ser (491 aa)
initn: 2539 init1: 2539 opt: 2842 Z-score: 1302.7 bits: 250.7 E(85289): 8e-66
Smith-Waterman score: 2842; 97.2% identity (97.7% similar) in 436 aa overlap (1-431:1-434)
10 20 30 40 50 60
pF1KE5 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS
10 20 30 40 50 60
70 80 90 100 110
pF1KE5 PAGTPPGRASPGRASPAQASPA-----RASPALASLSRSSSGRSSSARSASVTTSPTRVY
:::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE5 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC
:::::::.. : :
NP_001 SKPLTLSGE--GICTPRSPAPQPQHPLQPSHLSASVNSYPGPKASAGQKSKTLKDPYMEH
430 440 450 460 470
>>XP_011528033 (OMIM: 602060) PREDICTED: transmembrane p (492 aa)
initn: 882 init1: 497 opt: 995 Z-score: 473.5 bits: 97.3 E(85289): 1.2e-19
Smith-Waterman score: 1009; 35.4% identity (63.4% similar) in 492 aa overlap (86-556:9-491)
60 70 80 90 100 110
pF1KE5 PAQASPAGTPPGRASPGRASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY
::.. .. . . . :. :. :: ::
XP_011 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPT-VY
10 20 30
120 130 140 150 160
pF1KE5 LVRA-----TPVGAVPIRSSPARSAPATRATRESP-GTSLPKFTWREGQKQLPLIGCVLL
:. .:: : : :.. . .:: :: . : . : : : :.
XP_011 EVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTL-GTFLV
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE5 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK
::...:. :. . ...::. .. .: . . :::: : :: :::. .
XP_011 GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE5 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS
.:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... :.
XP_011 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT
160 170 180 190 200 210
290 300 310 320 330
pF1KE5 T-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGALASDSKWPWQVSLH
. : ..:..:. : :. .::.: ::. ..: :::: : . ::::::::
XP_011 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE5 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE
..:.:::..: .:..::::: :: :.. : ..:: . .:. . .
XP_011 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE5 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET
.: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.:
XP_011 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE5 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ
::: : ..: ::. ..::. :::. .:: :.::: :.:. :::::::::::: .
XP_011 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK
400 410 420 430 440
520 530 540 550 560
pF1KE5 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS
:: :.: : ::::.::.. .:::: .: ::: .:...
XP_011 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
450 460 470 480 490
>>NP_005647 (OMIM: 602060) transmembrane protease serine (492 aa)
initn: 882 init1: 497 opt: 995 Z-score: 473.5 bits: 97.3 E(85289): 1.2e-19
Smith-Waterman score: 1009; 35.4% identity (63.4% similar) in 492 aa overlap (86-556:9-491)
60 70 80 90 100 110
pF1KE5 PAQASPAGTPPGRASPGRASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY
::.. .. . . . :. :. :: ::
NP_005 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPT-VY
10 20 30
120 130 140 150 160
pF1KE5 LVRA-----TPVGAVPIRSSPARSAPATRATRESP-GTSLPKFTWREGQKQLPLIGCVLL
:. .:: : : :.. . .:: :: . : . : : : :.
NP_005 EVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTL-GTFLV
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE5 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK
::...:. :. . ...::. .. .: . . :::: : :: :::. .
NP_005 GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE5 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS
.:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... :.
NP_005 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT
160 170 180 190 200 210
290 300 310 320 330
pF1KE5 T-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGALASDSKWPWQVSLH
. : ..:..:. : :. .::.: ::. ..: :::: : . ::::::::
NP_005 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE5 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE
..:.:::..: .:..::::: :: :.. : ..:: . .:. . .
NP_005 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE5 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET
.: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.:
NP_005 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE5 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ
::: : ..: ::. ..::. :::. .:: :.::: :.:. :::::::::::: .
NP_005 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK
400 410 420 430 440
520 530 540 550 560
pF1KE5 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS
:: :.: : ::::.::.. .:::: .: ::: .:...
NP_005 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
450 460 470 480 490
>>NP_001128571 (OMIM: 602060) transmembrane protease ser (529 aa)
initn: 882 init1: 497 opt: 995 Z-score: 473.1 bits: 97.3 E(85289): 1.3e-19
Smith-Waterman score: 1009; 35.4% identity (63.4% similar) in 492 aa overlap (86-556:46-528)
60 70 80 90 100 110
pF1KE5 PAQASPAGTPPGRASPGRASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY
::.. .. . . . :. :. :: ::
NP_001 GAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPT-VY
20 30 40 50 60 70
120 130 140 150 160
pF1KE5 LVRA-----TPVGAVPIRSSPARSAPATRATRESP-GTSLPKFTWREGQKQLPLIGCVLL
:. .:: : : :.. . .:: :: . : . : : : :.
NP_001 EVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTL-GTFLV
80 90 100 110 120 130
170 180 190 200 210 220
pF1KE5 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK
::...:. :. . ...::. .. .: . . :::: : :: :::. .
NP_001 GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN
140 150 160 170 180 190
230 240 250 260 270 280
pF1KE5 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS
.:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... :.
NP_001 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT
200 210 220 230 240 250
290 300 310 320 330
pF1KE5 T-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGALASDSKWPWQVSLH
. : ..:..:. : :. .::.: ::. ..: :::: : . ::::::::
NP_001 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH
260 270 280 290 300 310
340 350 360 370 380 390
pF1KE5 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE
..:.:::..: .:..::::: :: :.. : ..:: . .:. . .
NP_001 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK
320 330 340 350 360
400 410 420 430 440 450
pF1KE5 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET
.: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.:
NP_001 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK
370 380 390 400 410 420
460 470 480 490 500 510
pF1KE5 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ
::: : ..: ::. ..::. :::. .:: :.::: :.:. :::::::::::: .
NP_001 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK
430 440 450 460 470 480
520 530 540 550 560
pF1KE5 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS
:: :.: : ::::.::.. .:::: .: ::: .:...
NP_001 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
490 500 510 520
>>XP_011528035 (OMIM: 602060) PREDICTED: transmembrane p (384 aa)
initn: 866 init1: 497 opt: 976 Z-score: 466.4 bits: 95.6 E(85289): 3.1e-19
Smith-Waterman score: 982; 38.9% identity (67.8% similar) in 373 aa overlap (198-556:17-383)
170 180 190 200 210 220
pF1KE5 LLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWD
.: . . :::: : :: :::.
XP_011 MGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGP
10 20 30 40
230 240 250 260 270 280
pF1KE5 KSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYN
. .:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... :
XP_011 NFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLN
50 60 70 80 90 100
290 300 310 320 330
pF1KE5 ST-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGALASDSKWPWQVSL
.. : ..:..:. : :. .::.: ::. ..: :::: : . :::::::
XP_011 TSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSL
110 120 130 140 150 160
340 350 360 370 380 390
pF1KE5 HFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IA
: ..:.:::..: .:..::::: :: :.. : ..:: . .:. .
XP_011 HVQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
170 180 190 200 210 220
400 410 420 430 440 450
pF1KE5 EIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRE
..: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.:
XP_011 KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE
230 240 250 260 270 280
460 470 480 490 500 510
pF1KE5 TDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCE
::: : ..: ::. ..::. :::. .:: :.::: :.:. ::::::::::::
XP_011 KG-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTS
290 300 310 320 330 340
520 530 540 550 560
pF1KE5 QNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS
.:: :.: : ::::.::.. .:::: .: ::: .:...
XP_011 KNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
350 360 370 380
>>NP_001077416 (OMIM: 606565) transmembrane protease ser (432 aa)
initn: 819 init1: 323 opt: 935 Z-score: 447.3 bits: 92.2 E(85289): 3.6e-18
Smith-Waterman score: 935; 35.2% identity (64.5% similar) in 420 aa overlap (149-557:24-432)
120 130 140 150 160 170
pF1KE5 ATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVVSLI
.: :.: . .:.: .:: .: .. ..
NP_001 MLQDPDSDQPLNSLDVKPLRKPRIPMETFR--KVGIPII-IALLSLASIIIVV
10 20 30 40 50
180 190 200 210 220
pF1KE5 ILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCV-----------RFDWD
.:.. . . . . :.. . ::: .:: : :: :: :.. :
NP_001 VLIKVILDKYYFLCGQPLHFIPRKQL-CDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKD
60 70 80 90 100
230 240 250 260 270 280
pF1KE5 KSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYN
.: :.. .... .:. : .:.... .: .:.:.:. :..:.. . . : . .
NP_001 RSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYS---RAVEIGPDQDLDVVEITENS
110 120 130 140 150 160
290 300 310 320 330 340
pF1KE5 STIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICG
. .. . : : .::.: :: : :.::: :: ..::::::... :.::
NP_001 QELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCG
170 180 190 200 210 220
350 360 370 380 390 400
pF1KE5 GTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDD
:...: .::::::::: .. . .::: ::...: ..: : :::. : .:.
NP_001 GSILDPHWVLTAAHCF--RKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN
230 240 250 260 270 280
410 420 430 440 450 460
pF1KE5 YDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQV
:::::.:. :::.:. ..: :::. . .. :: :.: :... : : .: ...:
NP_001 -DIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASV
290 300 310 320 330 340
470 480 490 500 510 520
pF1KE5 NLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWG
..:: .:: .:.. .: .::::: .:: :.:::::::::. :...:...:..:::
NP_001 QVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLM-YQSDQWHVVGIVSWG
350 360 370 380 390 400
530 540 550 560
pF1KE5 TGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS
::: . :::::::. : :::. ..:.
NP_001 YGCGGPSTPGVYTKVSAYLNWIYNVWKAEL
410 420 430
>>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa)
initn: 927 init1: 388 opt: 919 Z-score: 439.8 bits: 90.9 E(85289): 9.3e-18
Smith-Waterman score: 1007; 37.9% identity (65.8% similar) in 409 aa overlap (163-558:53-452)
140 150 160 170 180 190
pF1KE5 RSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVVSLIILFQFWQGHTGIRY
.:: . :..::...: : :. .:
NP_001 DLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDC----SGKYR
30 40 50 60 70
200 210 220 230 240 250
pF1KE5 KEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDS
.. .: . .::::: ::: :: ::: ....:......: : .::..:.
NP_001 CRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAAS--WKTMCSDDWKGH
80 90 100 110 120 130
260 270 280 290 300
pF1KE5 YSEKTCQQLGFESAHRTTEVAHRDFANSFS--ILRYNSTIQE----SLH-----RSECPS
:.. .: :::: : . .. .. ..: .. . . . .:: : : :
NP_001 YANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCAS
140 150 160 170 180 190
310 320 330 340 350 360
pF1KE5 QRYISLQCSHCGLR-AMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAA
. ..:::. :: : ....::::: .. :.::::.::.: :.:::..: :..:::
NP_001 GHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAA
200 210 220 230 240 250
370 380 390 400 410
pF1KE5 HCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAE-IIINSNYTDEEDDYDIALMRLSKPL
:: . . ..: . .: .: . : . ..: :. .:.: .. :::::.:. ::
NP_001 HCVYDLY--LPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPL
260 270 280 290 300 310
420 430 440 450 460 470
pF1KE5 TLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYL
:.. :.:.::: ..: ...:: .:.: :.. : .:: : .. : ::. : ::
NP_001 TFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGD-ASPVLNHAAVPLISNKICNHRD
320 330 340 350 360 370
480 490 500 510 520 530
pF1KE5 VYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVY
:: . ..: :.::: : :: :::::::::::::.. : :.:.::.: ::.. ::::::
NP_001 VYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVY
380 390 400 410 420 430
540 550 560
pF1KE5 TKVTEVLPWIYSKMESEVRFRKS
:.:: : ::. .:: ...
NP_001 TRVTSFLDWIHEQMERDLKT
440 450
562 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:51:57 2016 done: Tue Nov 8 05:51:59 2016
Total Scan time: 9.690 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]