Result of FASTA (omim) for
pFN21AE5681
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5681, 522 aa
1>>>pF1KE5681 522 - 522 aa - 522 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2257+/-0.000348; mu= 18.8185+/- 0.022
mean_var=75.1442+/-15.215, 0's: 0 Z-trim(115.6): 126 B-trim: 491 in 1/53
Lambda= 0.147954
statistics sampled from 26039 (26171) to 26039 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.307), width: 16
Scan time: 9.390
The best scores are: opt bits E(85289)
NP_000503 (OMIM: 253000,612222) N-acetylgalactosam ( 522) 3665 791.9 0
XP_005256358 (OMIM: 253000,612222) PREDICTED: N-ac ( 575) 3443 744.5 1.9e-214
NP_001310473 (OMIM: 253000,612222) N-acetylgalacto ( 528) 3403 736.0 6.6e-212
XP_011521284 (OMIM: 253000,612222) PREDICTED: N-ac ( 581) 3181 688.6 1.3e-197
XP_016878601 (OMIM: 253000,612222) PREDICTED: N-ac ( 508) 3180 688.4 1.4e-197
XP_016878600 (OMIM: 253000,612222) PREDICTED: N-ac ( 511) 3176 687.5 2.5e-197
NP_001310472 (OMIM: 253000,612222) N-acetylgalacto ( 337) 2350 511.1 2.1e-144
XP_016878602 (OMIM: 253000,612222) PREDICTED: N-ac ( 390) 2128 463.7 4.4e-130
NP_001078896 (OMIM: 250100,607574) arylsulfatase A ( 509) 958 214.1 8.2e-55
NP_001078895 (OMIM: 250100,607574) arylsulfatase A ( 509) 958 214.1 8.2e-55
NP_001078894 (OMIM: 250100,607574) arylsulfatase A ( 509) 958 214.1 8.2e-55
NP_000478 (OMIM: 250100,607574) arylsulfatase A is ( 509) 958 214.1 8.2e-55
XP_016884289 (OMIM: 250100,607574) PREDICTED: aryl ( 547) 906 203.0 1.9e-51
XP_011528993 (OMIM: 250100,607574) PREDICTED: aryl ( 387) 862 193.5 9.7e-49
NP_001078897 (OMIM: 250100,607574) arylsulfatase A ( 423) 570 131.2 6e-30
XP_011528992 (OMIM: 250100,607574) PREDICTED: aryl ( 423) 570 131.2 6e-30
XP_005274578 (OMIM: 300180,302950) PREDICTED: aryl ( 535) 552 127.4 1e-28
NP_001269560 (OMIM: 300180,302950) arylsulfatase E ( 544) 552 127.4 1.1e-28
XP_011522842 (OMIM: 610008) PREDICTED: arylsulfata ( 551) 548 126.6 1.9e-28
XP_011541694 (OMIM: 253200,611542) PREDICTED: aryl ( 405) 537 124.1 7.7e-28
NP_942002 (OMIM: 253200,611542) arylsulfatase B is ( 413) 537 124.1 7.8e-28
XP_011541693 (OMIM: 253200,611542) PREDICTED: aryl ( 442) 537 124.2 8.2e-28
XP_016864960 (OMIM: 253200,611542) PREDICTED: aryl ( 451) 537 124.2 8.4e-28
XP_011541692 (OMIM: 253200,611542) PREDICTED: aryl ( 533) 537 124.2 9.5e-28
NP_000037 (OMIM: 253200,611542) arylsulfatase B is ( 533) 537 124.2 9.5e-28
XP_011541695 (OMIM: 253200,611542) PREDICTED: aryl ( 382) 530 122.6 2.1e-27
XP_016879857 (OMIM: 610008) PREDICTED: arylsulfata ( 413) 495 115.2 3.9e-25
XP_011522847 (OMIM: 610008) PREDICTED: arylsulfata ( 413) 495 115.2 3.9e-25
XP_011522846 (OMIM: 610008) PREDICTED: arylsulfata ( 427) 495 115.2 4e-25
XP_011522845 (OMIM: 610008) PREDICTED: arylsulfata ( 427) 495 115.2 4e-25
XP_016879855 (OMIM: 610008) PREDICTED: arylsulfata ( 461) 487 113.5 1.4e-24
XP_016879856 (OMIM: 610008) PREDICTED: arylsulfata ( 461) 487 113.5 1.4e-24
XP_011522843 (OMIM: 610008) PREDICTED: arylsulfata ( 488) 487 113.5 1.5e-24
XP_011522844 (OMIM: 610008) PREDICTED: arylsulfata ( 488) 487 113.5 1.5e-24
XP_016879850 (OMIM: 610008) PREDICTED: arylsulfata ( 525) 487 113.5 1.5e-24
XP_016879854 (OMIM: 610008) PREDICTED: arylsulfata ( 525) 487 113.5 1.5e-24
XP_005257227 (OMIM: 610008) PREDICTED: arylsulfata ( 525) 487 113.5 1.5e-24
XP_016879853 (OMIM: 610008) PREDICTED: arylsulfata ( 525) 487 113.5 1.5e-24
NP_055775 (OMIM: 610008) arylsulfatase G [Homo sap ( 525) 487 113.5 1.5e-24
NP_001254656 (OMIM: 610008) arylsulfatase G [Homo ( 525) 487 113.5 1.5e-24
XP_016879851 (OMIM: 610008) PREDICTED: arylsulfata ( 525) 487 113.5 1.5e-24
XP_016879852 (OMIM: 610008) PREDICTED: arylsulfata ( 525) 487 113.5 1.5e-24
XP_011522837 (OMIM: 610008) PREDICTED: arylsulfata ( 552) 487 113.6 1.6e-24
XP_006721840 (OMIM: 610008) PREDICTED: arylsulfata ( 552) 487 113.6 1.6e-24
XP_011522839 (OMIM: 610008) PREDICTED: arylsulfata ( 552) 487 113.6 1.6e-24
XP_011522838 (OMIM: 610008) PREDICTED: arylsulfata ( 552) 487 113.6 1.6e-24
XP_016879849 (OMIM: 610008) PREDICTED: arylsulfata ( 552) 487 113.6 1.6e-24
XP_011522840 (OMIM: 610008) PREDICTED: arylsulfata ( 552) 487 113.6 1.6e-24
XP_006721842 (OMIM: 610008) PREDICTED: arylsulfata ( 329) 476 111.0 5.5e-24
XP_005257229 (OMIM: 610008) PREDICTED: arylsulfata ( 344) 476 111.1 5.6e-24
>>NP_000503 (OMIM: 253000,612222) N-acetylgalactosamine- (522 aa)
initn: 3665 init1: 3665 opt: 3665 Z-score: 4227.7 bits: 791.9 E(85289): 0
Smith-Waterman score: 3665; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522)
10 20 30 40 50 60
pF1KE5 MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 EQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 YRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 ASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 RAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 GQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALV
430 440 450 460 470 480
490 500 510 520
pF1KE5 PAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH
::::::::::::::::::::::::::::::::::::::::::
NP_000 PAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH
490 500 510 520
>>XP_005256358 (OMIM: 253000,612222) PREDICTED: N-acetyl (575 aa)
initn: 3437 init1: 3437 opt: 3443 Z-score: 3971.0 bits: 744.5 E(85289): 1.9e-214
Smith-Waterman score: 3443; 96.2% identity (96.5% similar) in 521 aa overlap (1-515:1-519)
10 20 30 40 50 60
pF1KE5 MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 EQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 YRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 ASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 RAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 GQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALV
430 440 450 460 470 480
490 500 510 520
pF1KE5 PAQPQLNVCNWAVMNWAPPGC------EKLGKCLTPPESIPKKCLWSH
:::::::::::::: :: .: : : :. :
XP_005 PAQPQLNVCNWAVM--APTQSSTSVQPDKTRPCSPPVEKRPHHASIGQKHKHRRASKVSL
490 500 510 520 530
XP_005 KSVFRPQRMRRRLVQPWGPQQSGPLRSSFSVPCLGVP
540 550 560 570
>>NP_001310473 (OMIM: 253000,612222) N-acetylgalactosami (528 aa)
initn: 3403 init1: 3403 opt: 3403 Z-score: 3925.4 bits: 736.0 E(85289): 6.6e-212
Smith-Waterman score: 3403; 99.8% identity (100.0% similar) in 483 aa overlap (40-522:46-528)
10 20 30 40 50 60
pF1KE5 WWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLF
.:::::::::::::::::::::::::::::
NP_001 PHLKTKQKWRRKTAWADRGAAPSCTHAGDAEMGWGDLGVYGEPSRETPNLDRMAAEGLLF
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE5 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE5 KAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGR
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE5 YYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTS
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE5 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE5 KQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE5 PTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTT
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE5 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVC
440 450 460 470 480 490
490 500 510 520
pF1KE5 NWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH
:::::::::::::::::::::::::::::::::
NP_001 NWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH
500 510 520
>>XP_011521284 (OMIM: 253000,612222) PREDICTED: N-acetyl (581 aa)
initn: 3175 init1: 3175 opt: 3181 Z-score: 3668.7 bits: 688.6 E(85289): 1.3e-197
Smith-Waterman score: 3181; 95.6% identity (96.3% similar) in 482 aa overlap (40-515:46-525)
10 20 30 40 50 60
pF1KE5 WWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLF
.:::::::::::::::::::::::::::::
XP_011 PHLKTKQKWRRKTAWADRGAAPSCTHAGDAEMGWGDLGVYGEPSRETPNLDRMAAEGLLF
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE5 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE5 KAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGR
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE5 YYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTS
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE5 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE5 KQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE5 PTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTT
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE5 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVC
440 450 460 470 480 490
490 500 510 520
pF1KE5 NWAVMNWAPPGC------EKLGKCLTPPESIPKKCLWSH
::::: :: .: : : :. :
XP_011 NWAVM--APTQSSTSVQPDKTRPCSPPVEKRPHHASIGQKHKHRRASKVSLKSVFRPQRM
500 510 520 530 540 550
XP_011 RRRLVQPWGPQQSGPLRSSFSVPCLGVP
560 570 580
>>XP_016878601 (OMIM: 253000,612222) PREDICTED: N-acetyl (508 aa)
initn: 3175 init1: 3175 opt: 3180 Z-score: 3668.4 bits: 688.4 E(85289): 1.4e-197
Smith-Waterman score: 3180; 99.1% identity (99.3% similar) in 459 aa overlap (40-498:46-504)
10 20 30 40 50 60
pF1KE5 WWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLF
.:::::::::::::::::::::::::::::
XP_016 PHLKTKQKWRRKTAWADRGAAPSCTHAGDAEMGWGDLGVYGEPSRETPNLDRMAAEGLLF
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE5 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE5 KAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGR
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE5 YYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTS
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE5 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE5 KQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE5 PTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTT
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE5 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVC
440 450 460 470 480 490
490 500 510 520
pF1KE5 NWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH
::::: :
XP_016 NWAVMPQRPSHQT
500
>>XP_016878600 (OMIM: 253000,612222) PREDICTED: N-acetyl (511 aa)
initn: 3175 init1: 3175 opt: 3176 Z-score: 3663.7 bits: 687.5 E(85289): 2.5e-197
Smith-Waterman score: 3176; 98.3% identity (98.9% similar) in 465 aa overlap (40-504:46-506)
10 20 30 40 50 60
pF1KE5 WWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLF
.:::::::::::::::::::::::::::::
XP_016 PHLKTKQKWRRKTAWADRGAAPSCTHAGDAEMGWGDLGVYGEPSRETPNLDRMAAEGLLF
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE5 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLK
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE5 KAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGR
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE5 YYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTS
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE5 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCG
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE5 KQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLL
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE5 PTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTT
380 390 400 410 420 430
430 440 450 460 470 480
pF1KE5 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVC
440 450 460 470 480 490
490 500 510 520
pF1KE5 NWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH
::::: .: :. :
XP_016 NWAVM--GP--CDDLQTPGL
500 510
>>NP_001310472 (OMIM: 253000,612222) N-acetylgalactosami (337 aa)
initn: 2350 init1: 2350 opt: 2350 Z-score: 2713.4 bits: 511.1 E(85289): 2.1e-144
Smith-Waterman score: 2350; 100.0% identity (100.0% similar) in 337 aa overlap (186-522:1-337)
160 170 180 190 200 210
pF1KE5 FDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALD
::::::::::::::::::::::::::::::
NP_001 MVGRYYEEFPINLKTGEANLTQIYLQEALD
10 20 30
220 230 240 250 260 270
pF1KE5 FIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDL
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE5 HVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQV
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE5 SHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATL
160 170 180 190 200 210
400 410 420 430 440 450
pF1KE5 GQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLS
220 230 240 250 260 270
460 470 480 490 500 510
pF1KE5 FASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIP
280 290 300 310 320 330
520
pF1KE5 KKCLWSH
:::::::
NP_001 KKCLWSH
>>XP_016878602 (OMIM: 253000,612222) PREDICTED: N-acetyl (390 aa)
initn: 2122 init1: 2122 opt: 2128 Z-score: 2456.4 bits: 463.7 E(85289): 4.4e-130
Smith-Waterman score: 2128; 94.0% identity (94.6% similar) in 336 aa overlap (186-515:1-334)
160 170 180 190 200 210
pF1KE5 FDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALD
::::::::::::::::::::::::::::::
XP_016 MVGRYYEEFPINLKTGEANLTQIYLQEALD
10 20 30
220 230 240 250 260 270
pF1KE5 FIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDL
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE5 HVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQV
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE5 SHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATL
160 170 180 190 200 210
400 410 420 430 440 450
pF1KE5 GQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLS
220 230 240 250 260 270
460 470 480 490 500
pF1KE5 FASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGC------EKLGKCLT
::::::::::::::::::::::::::::::::::::::: :: .: :
XP_016 FASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVM--APTQSSTSVQPDKTRPCSP
280 290 300 310 320
510 520
pF1KE5 PPESIPKKCLWSH
: :. :
XP_016 PVEKRPHHASIGQKHKHRRASKVSLKSVFRPQRMRRRLVQPWGPQQSGPLRSSFSVPCLG
330 340 350 360 370 380
>>NP_001078896 (OMIM: 250100,607574) arylsulfatase A iso (509 aa)
initn: 709 init1: 323 opt: 958 Z-score: 1105.1 bits: 214.1 E(85289): 8.2e-55
Smith-Waterman score: 968; 37.3% identity (60.5% similar) in 534 aa overlap (13-512:9-506)
10 20 30 40 50 60
pF1KE5 MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD
:::.: :::.... .::::.:.. ::.:.:::: ::.:: :::::
NP_001 MSMGAPRSLLLAL-AAGLAVA---RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLD
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS
..:: :: : .:: ::.::::::::::::.: :.: .. .:. ::.:
NP_001 QLAAGGLRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYP------GVLVPSS-RGGLPLE
60 70 80 90 100
130 140 150 160 170
pF1KE5 EQLLPELLKKAGYVSKIVGKWHLGHRPQ--FHPLKHGFDEWFGSPNCH-FGPYDNKA--R
: . :.: ::.. ..:::::: :. : : ..:: ...: : : :: .: .
NP_001 EVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFP
110 120 130 140 150 160
180 190 200 210 220
pF1KE5 PNIPVYRDWEMVGRYYEEFPINLKTGEAN------LTQIYLQEALDFI---KRQARHHPF
: : .. : . ::.. ::. : :. : :.. .:: : ::
NP_001 PATPCDGGCDQ-GLVPIPLLANLSV-EAQPPWLPGLEARYMAFAHDLMADAQRQDR--PF
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE5 FLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFT
:::.: :: : .... : : :: .::.. :.: ..: .. . :: . ..:.:.::
NP_001 FLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE5 SDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLF
.::: . .:: .: . ::: ::.:::.::::::.::::.. : :.:.:.: .::.
NP_001 ADNGPETMRMS-RGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLL
290 300 310 320 330
350 360 370 380 390
pF1KE5 TTSLALAGLTPPSDRAIDGLNLLPTLL-QGRLMDRPIFYY-------RGDTLMAATLGQH
: :::: .: . ..::..: : :: :. . .:.: :: ..:. :..
NP_001 PTLAALAG-APLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRG--VFAVRTGKY
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE5 KAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPL----
::::.: .. . : . :..:.: . ::.. :..:::: . :
NP_001 KAHFFTQGSAHSDTTAD-PAC--HASSSLTAH------EPPLLYDLSKDPGENYNLLGGV
400 410 420 430 440
460 470 480 490 500
pF1KE5 SFASAEYQEALSRITSVVQQHQEALV--PAQ------PQLNVCNWAVMNWAPPGCEKLGK
. :. : .::... . : . :.. :.: : :..: :::
NP_001 AGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQIC-------CHPGCTPRPA
450 460 470 480 490 500
510 520
pF1KE5 CLTPPESIPKKCLWSH
: :.
NP_001 CCHCPDPHA
>>NP_001078895 (OMIM: 250100,607574) arylsulfatase A iso (509 aa)
initn: 709 init1: 323 opt: 958 Z-score: 1105.1 bits: 214.1 E(85289): 8.2e-55
Smith-Waterman score: 968; 37.3% identity (60.5% similar) in 534 aa overlap (13-512:9-506)
10 20 30 40 50 60
pF1KE5 MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD
:::.: :::.... .::::.:.. ::.:.:::: ::.:: :::::
NP_001 MSMGAPRSLLLAL-AAGLAVA---RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLD
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS
..:: :: : .:: ::.::::::::::::.: :.: .. .:. ::.:
NP_001 QLAAGGLRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYP------GVLVPSS-RGGLPLE
60 70 80 90 100
130 140 150 160 170
pF1KE5 EQLLPELLKKAGYVSKIVGKWHLGHRPQ--FHPLKHGFDEWFGSPNCH-FGPYDNKA--R
: . :.: ::.. ..:::::: :. : : ..:: ...: : : :: .: .
NP_001 EVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFP
110 120 130 140 150 160
180 190 200 210 220
pF1KE5 PNIPVYRDWEMVGRYYEEFPINLKTGEAN------LTQIYLQEALDFI---KRQARHHPF
: : .. : . ::.. ::. : :. : :.. .:: : ::
NP_001 PATPCDGGCDQ-GLVPIPLLANLSV-EAQPPWLPGLEARYMAFAHDLMADAQRQDR--PF
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE5 FLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFT
:::.: :: : .... : : :: .::.. :.: ..: .. . :: . ..:.:.::
NP_001 FLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFT
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE5 SDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLF
.::: . .:: .: . ::: ::.:::.::::::.::::.. : :.:.:.: .::.
NP_001 ADNGPETMRMS-RGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLL
290 300 310 320 330
350 360 370 380 390
pF1KE5 TTSLALAGLTPPSDRAIDGLNLLPTLL-QGRLMDRPIFYY-------RGDTLMAATLGQH
: :::: .: . ..::..: : :: :. . .:.: :: ..:. :..
NP_001 PTLAALAG-APLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRG--VFAVRTGKY
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE5 KAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPL----
::::.: .. . : . :..:.: . ::.. :..:::: . :
NP_001 KAHFFTQGSAHSDTTAD-PAC--HASSSLTAH------EPPLLYDLSKDPGENYNLLGGV
400 410 420 430 440
460 470 480 490 500
pF1KE5 SFASAEYQEALSRITSVVQQHQEALV--PAQ------PQLNVCNWAVMNWAPPGCEKLGK
. :. : .::... . : . :.. :.: : :..: :::
NP_001 AGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQIC-------CHPGCTPRPA
450 460 470 480 490 500
510 520
pF1KE5 CLTPPESIPKKCLWSH
: :.
NP_001 CCHCPDPHA
522 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:48:54 2016 done: Tue Nov 8 05:48:55 2016
Total Scan time: 9.390 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]