Result of FASTA (omim) for
pFN21AE5674
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5674, 556 aa
1>>>pF1KE5674 556 - 556 aa - 556 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4234+/-0.000355; mu= 18.7690+/- 0.022
mean_var=79.1361+/-16.101, 0's: 0 Z-trim(114.2): 29 B-trim: 0 in 0/56
Lambda= 0.144174
statistics sampled from 23904 (23919) to 23904 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.28), width: 16
Scan time: 9.070
The best scores are: opt bits E(85289)
XP_006722020 (OMIM: 604311) PREDICTED: mediator of ( 616) 3633 765.6 0
NP_004765 (OMIM: 604311) mediator of RNA polymeras (1581) 3635 766.3 0
XP_005257522 (OMIM: 604311) PREDICTED: mediator of (1409) 2507 531.6 6.2e-150
XP_016880268 (OMIM: 604311) PREDICTED: mediator of (1362) 2194 466.5 2.4e-130
>>XP_006722020 (OMIM: 604311) PREDICTED: mediator of RNA (616 aa)
initn: 3633 init1: 3633 opt: 3633 Z-score: 4083.6 bits: 765.6 E(85289): 0
Smith-Waterman score: 3633; 100.0% identity (100.0% similar) in 547 aa overlap (1-547:1-547)
10 20 30 40 50 60
pF1KE5 MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
490 500 510 520 530 540
550
pF1KE5 PPASSPGSKNPELGSG
:::::::
XP_006 PPASSPGEPGLNCFTLPENQGALHFSTGWRRRGRINQAWDTSLLSRCTHSSVSKEGKDMK
550 560 570 580 590 600
>>NP_004765 (OMIM: 604311) mediator of RNA polymerase II (1581 aa)
initn: 3674 init1: 3633 opt: 3635 Z-score: 4080.1 bits: 766.3 E(85289): 0
Smith-Waterman score: 3635; 98.2% identity (98.8% similar) in 560 aa overlap (1-555:1-560)
10 20 30 40 50 60
pF1KE5 MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
490 500 510 520 530 540
550
pF1KE5 PPASSPG-----SKNPELGSG
::::::: ..:: :.
NP_004 PPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQ
550 560 570 580 590 600
>>XP_005257522 (OMIM: 604311) PREDICTED: mediator of RNA (1409 aa)
initn: 2546 init1: 2505 opt: 2507 Z-score: 2812.8 bits: 531.6 E(85289): 6.2e-150
Smith-Waterman score: 2507; 97.4% identity (98.2% similar) in 388 aa overlap (173-555:1-388)
150 160 170 180 190 200
pF1KE5 REKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDK
::::::::::::::::::::::::::::::
XP_005 MYLALQSLEQDLSKMAIMYWKATNAGPLDK
10 20 30
210 220 230 240 250 260
pF1KE5 ILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGT
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE5 SAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQ
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE5 NCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPL
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE5 PDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEV
220 230 240 250 260 270
450 460 470 480 490 500
pF1KE5 CPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCM
280 290 300 310 320 330
510 520 530 540 550
pF1KE5 SIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPG-----SKNPELGSG
::::::::::::::::::::::::::::::::::::::::::::: ..:: :.
XP_005 SIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTT
340 350 360 370 380 390
XP_005 PTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSP
400 410 420 430 440 450
>>XP_016880268 (OMIM: 604311) PREDICTED: mediator of RNA (1362 aa)
initn: 2233 init1: 2192 opt: 2194 Z-score: 2461.1 bits: 466.5 E(85289): 2.4e-130
Smith-Waterman score: 2194; 97.1% identity (97.9% similar) in 341 aa overlap (220-555:1-341)
190 200 210 220 230 240
pF1KE5 MYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSR
::::::::::::::::::::::::::::::
XP_016 MNLKYYVSPSDLLDDKTASPIILHENNVSR
10 20 30
250 260 270 280 290 300
pF1KE5 SLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQ
40 50 60 70 80 90
310 320 330 340 350 360
pF1KE5 PIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPG
100 110 120 130 140 150
370 380 390 400 410 420
pF1KE5 QQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTI
160 170 180 190 200 210
430 440 450 460 470 480
pF1KE5 LKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALIC
220 230 240 250 260 270
490 500 510 520 530 540
pF1KE5 TDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPG--
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYG
280 290 300 310 320 330
550
pF1KE5 ---SKNPELGSG
..:: :.
XP_016 MTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQ
340 350 360 370 380 390
556 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:44:14 2016 done: Tue Nov 8 05:44:15 2016
Total Scan time: 9.070 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]