Result of FASTA (omim) for
pFN21AE5668
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5668, 528 aa
1>>>pF1KE5668 528 - 528 aa - 528 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1256+/-0.000401; mu= 19.3479+/- 0.025
mean_var=69.1332+/-13.514, 0's: 0 Z-trim(111.8): 47 B-trim: 22 in 1/50
Lambda= 0.154252
statistics sampled from 20416 (20462) to 20416 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.599), E-opt: 0.2 (0.24), width: 16
Scan time: 8.200
The best scores are: opt bits E(85289)
NP_001086 (OMIM: 602866) acid-sensing ion channel ( 528) 3621 815.3 0
XP_011536654 (OMIM: 602866) PREDICTED: acid-sensin ( 529) 3609 812.7 0
NP_064423 (OMIM: 602866) acid-sensing ion channel ( 574) 2971 670.7 3.2e-192
NP_001243759 (OMIM: 602866) acid-sensing ion chann ( 562) 2522 570.8 3.8e-162
XP_011536653 (OMIM: 602866) PREDICTED: acid-sensin ( 559) 2385 540.3 5.7e-153
XP_011536652 (OMIM: 602866) PREDICTED: acid-sensin ( 560) 2373 537.6 3.6e-152
NP_001085 (OMIM: 601784) acid-sensing ion channel ( 512) 2356 533.8 4.7e-151
NP_899233 (OMIM: 601784) acid-sensing ion channel ( 563) 1975 449.1 1.7e-125
NP_061144 (OMIM: 606715) acid-sensing ion channel ( 666) 1472 337.2 9.5e-92
XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320) 1245 286.4 8.6e-77
NP_004760 (OMIM: 611741) acid-sensing ion channel ( 531) 1006 233.4 1.3e-60
NP_064718 (OMIM: 611741) acid-sensing ion channel ( 543) 1006 233.4 1.3e-60
NP_064717 (OMIM: 611741) acid-sensing ion channel ( 549) 1006 233.4 1.3e-60
NP_059115 (OMIM: 616693) acid-sensing ion channel ( 505) 643 152.6 2.6e-36
NP_878267 (OMIM: 606715) acid-sensing ion channel ( 647) 583 139.3 3.3e-32
XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 479 116.1 2.4e-25
NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649) 275 70.8 1.4e-11
NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669) 248 64.8 9.5e-10
NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692) 248 64.8 9.7e-10
NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728) 248 64.8 1e-09
XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623) 210 56.3 3.1e-07
NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640) 208 55.9 4.4e-07
XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646) 208 55.9 4.4e-07
XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651) 208 55.9 4.4e-07
XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659) 208 55.9 4.5e-07
XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 174 48.3 8.3e-05
XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 174 48.3 8.3e-05
XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696) 174 48.3 8.9e-05
XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704) 174 48.3 8.9e-05
XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732) 174 48.3 9.2e-05
XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736) 174 48.3 9.3e-05
XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749) 174 48.4 9.4e-05
XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757) 174 48.4 9.5e-05
XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760) 174 48.4 9.5e-05
XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764) 174 48.4 9.5e-05
XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795) 174 48.4 9.8e-05
NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802) 174 48.4 9.9e-05
XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810) 174 48.4 0.0001
XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816) 174 48.4 0.0001
XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827) 174 48.4 0.0001
XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846) 174 48.4 0.0001
XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851) 174 48.4 0.0001
XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859) 174 48.4 0.0001
XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 174 48.4 0.00011
XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 174 48.4 0.00011
>>NP_001086 (OMIM: 602866) acid-sensing ion channel 1 is (528 aa)
initn: 3621 init1: 3621 opt: 3621 Z-score: 4354.2 bits: 815.3 E(85289): 0
Smith-Waterman score: 3621; 100.0% identity (100.0% similar) in 528 aa overlap (1-528:1-528)
10 20 30 40 50 60
pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA
430 440 450 460 470 480
490 500 510 520
pF1KE5 DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
490 500 510 520
>>XP_011536654 (OMIM: 602866) PREDICTED: acid-sensing io (529 aa)
initn: 1908 init1: 1908 opt: 3609 Z-score: 4339.7 bits: 812.7 E(85289): 0
Smith-Waterman score: 3609; 99.8% identity (99.8% similar) in 529 aa overlap (1-528:1-529)
10 20 30 40 50 60
pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
190 200 210 220 230 240
250 260 270 280 290
pF1KE5 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQR-LIYLPPPWGTCKAVTMDSDL
::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_011 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRQLIYLPPPWGTCKAVTMDSDL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE5 DFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQE
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE5 YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYET
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 IEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSS
430 440 450 460 470 480
480 490 500 510 520
pF1KE5 ADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
490 500 510 520
>>NP_064423 (OMIM: 602866) acid-sensing ion channel 1 is (574 aa)
initn: 2971 init1: 2971 opt: 2971 Z-score: 3571.9 bits: 670.7 E(85289): 3.2e-192
Smith-Waterman score: 3406; 91.8% identity (91.8% similar) in 560 aa overlap (1-514:1-560)
10 20 30 40 50 60
pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
370 380 390 400 410 420
430
pF1KE5 EQKKAYEIAGLLG----------------------------------------------D
::::::::::::: :
NP_064 EQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGD
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE5 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 IGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRH
490 500 510 520 530 540
500 510 520
pF1KE5 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
::::::::::::::::::::
NP_064 NPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
550 560 570
>>NP_001243759 (OMIM: 602866) acid-sensing ion channel 1 (562 aa)
initn: 2814 init1: 2515 opt: 2522 Z-score: 3032.0 bits: 570.8 E(85289): 3.8e-162
Smith-Waterman score: 2794; 78.9% identity (88.7% similar) in 522 aa overlap (7-528:53-562)
10 20 30
pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSY
.: : .:... :::.: :::: :::
NP_001 DIWGPHHHQQQQDISESEEEEEEKEKEAVRKEASEGHSPMDLVAFANSCTLHGTNHIFVE
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE5 ERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLN
. ...:::. :. .:...:: .:: ::. : ::: :.:::...:.:::::::: :
NP_001 GGPGPRQVLWAVAFVLALGAFLCQVGDRVAYYLSYPHVTLLNEVATTELAFPAVTLCNTN
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE5 EFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMRE
:.::.: :: . . .:.: .. . : . .: ..:. .:::...
NP_001 AVRLSQLSYPDLLYLAPMLGL--DESDDPGVPLAPPGP----------EAFSGEPFNLHR
150 160 170 180 190
160 170 180 190 200 210
pF1KE5 FYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN
::.:. : ..:::: : ..: :. ..:.:::::::::::::::::::::::::::::::
NP_001 FYNRSCHRLEDMLLYCSYQGGPCGPHNFSVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGN
200 210 220 230 240 250
220 230 240 250 260 270
pF1KE5 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
260 270 280 290 300 310
280 290 300 310 320 330
pF1KE5 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY
320 330 340 350 360 370
340 350 360 370 380 390
pF1KE5 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK
380 390 400 410 420 430
400 410 420 430 440 450
pF1KE5 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDY
440 450 460 470 480 490
460 470 480 490 500 510
pF1KE5 AYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPH
500 510 520 530 540 550
520
pF1KE5 HPARGTFEDFTC
::::::::::::
NP_001 HPARGTFEDFTC
560
>>XP_011536653 (OMIM: 602866) PREDICTED: acid-sensing io (559 aa)
initn: 2380 init1: 2380 opt: 2385 Z-score: 2867.3 bits: 540.3 E(85289): 5.7e-153
Smith-Waterman score: 3549; 94.5% identity (94.5% similar) in 559 aa overlap (1-528:1-559)
10 20 30 40 50 60
pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
130 140 150 160 170 180
190 200
pF1KE5 AEDFKV-------------------------------VFTRYGKCYTFNSGRDGRPRLKT
:::::: :::::::::::::::::::::::
XP_011 AEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEKQVFTRYGKCYTFNSGRDGRPRLKT
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE5 MKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGF
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE5 QTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVH
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE5 MPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKY
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE5 LAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILT
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE5 VLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTY
490 500 510 520 530 540
510 520
pF1KE5 AANILPHHPARGTFEDFTC
:::::::::::::::::::
XP_011 AANILPHHPARGTFEDFTC
550
>>XP_011536652 (OMIM: 602866) PREDICTED: acid-sensing io (560 aa)
initn: 2963 init1: 1733 opt: 2373 Z-score: 2852.9 bits: 537.6 E(85289): 3.6e-152
Smith-Waterman score: 3537; 94.3% identity (94.3% similar) in 560 aa overlap (1-528:1-560)
10 20 30 40 50 60
pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
130 140 150 160 170 180
190 200
pF1KE5 AEDFKV-------------------------------VFTRYGKCYTFNSGRDGRPRLKT
:::::: :::::::::::::::::::::::
XP_011 AEDFKVKPMQVAKELRRCTLPGTVFQGTQRARKGEKQVFTRYGKCYTFNSGRDGRPRLKT
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE5 MKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGF
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE5 QTFVACQEQR-LIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMV
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTFVACQEQRQLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMV
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE5 HMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAK
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE5 YLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASIL
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE5 TVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMT
490 500 510 520 530 540
510 520
pF1KE5 YAANILPHHPARGTFEDFTC
::::::::::::::::::::
XP_011 YAANILPHHPARGTFEDFTC
550 560
>>NP_001085 (OMIM: 601784) acid-sensing ion channel 2 is (512 aa)
initn: 1378 init1: 1378 opt: 2356 Z-score: 2833.0 bits: 533.8 E(85289): 4.7e-151
Smith-Waterman score: 2387; 66.1% identity (84.8% similar) in 528 aa overlap (1-528:1-512)
10 20 30 40 50 60
pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
:.:: : :..:: ::: ::..:::::. ::: : :...:.:::. :.:::..::
NP_001 MDLKESPSE-GSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVE
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
.:::.::: :.::::.:::.:..:.:::::::::: ::::... :::::::::::::.
NP_001 SSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDV
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
.::: ..:: . :: :..::::. .::: :.: :: :.:::..::.: :.:.:. :.
NP_001 NLQIPDPHLADPSVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECG
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
.:: .:::.::::: ::::.::.: : :.:::::::::::::::::::::.::::.::.
NP_001 HQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETT
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE5 FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
::::.:::::::.:::::..:::::::::::::: ::::: ::::::: :.. : ::
NP_001 FEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM--GLD
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE5 FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
:: ::::::::::::::.::::::::::::::::.:::::.::::.::: .:.:::..:
NP_001 FFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNY
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE5 CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
:.:. :::::::.:::::::::::.::::: :::::::.::.:::::::::::.::::::
NP_001 CLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETI
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE5 EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA
:::::::.:.:::::::::::::::::::.:::::: ::.::.:: :: ..:
NP_001 EQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLL--DLLGKEEDEGSH
420 430 440 450 460 470
490 500 510 520
pF1KE5 DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
:..:. :... .: .....:. : . . ::.:...:
NP_001 DENVS----------TCDTMPNHSETISHTVNV-PLQTTLGTLEEIAC
480 490 500 510
>>NP_899233 (OMIM: 601784) acid-sensing ion channel 2 is (563 aa)
initn: 1235 init1: 979 opt: 1975 Z-score: 2374.1 bits: 449.1 E(85289): 1.7e-125
Smith-Waterman score: 2022; 59.8% identity (79.5% similar) in 517 aa overlap (23-528:62-563)
10 20 30 40
pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLS----LKRALWAL
: . :::: :. . . . .::::.:
NP_899 LAAAGQPGGGRGGERALQGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWVL
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE5 CFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDL
: :...:: ..:. :.. . :.. . . :: :::::.:: : .:: ..::.::
NP_899 AFCTSFGLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE5 YHAGELLALL-NNRYEIP---DTQMADEKQLEILQDKANFRSF-KPKPFN--MREFYDRA
:.::. :.:: :: : . .:: . . .. :.:: : :. :. :.::
NP_899 YYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRL
160 170 180 190 200 210
170 180 190 200 210 220
pF1KE5 GHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIM
::...::::::..:::.:. ..:. :::.::::: ::::.::.: : :.:::::::::::
NP_899 GHQLEDMLLSCKYRGELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIM
220 230 240 250 260 270
230 240 250 260 270 280
pF1KE5 LDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLI
::::::::::.::::.::.::::.:::::::.:::::..:::::::::::::: :::::
NP_899 LDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLT
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE5 YLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQ
::::::: :.. : :::: ::::::::::::::.::::::::::::::::.:::::
NP_899 YLPPPWGECRSSEMG--LDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQ
340 350 360 370 380
350 360 370 380 390 400
pF1KE5 YKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYI
.::::.::: .:.:::..::.:. :::::::.:::::::::::.::::: :::::::.::
NP_899 HKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYI
390 400 410 420 430 440
410 420 430 440 450 460
pF1KE5 GENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVI
.:::::::::::.:::::::::::::.:.:::::::::::::::::::.:::::: ::.:
NP_899 SENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELI
450 460 470 480 490 500
470 480 490 500 510 520
pF1KE5 KHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARG
:.:: :: ..: :..:. :... .: .....:. : . . :
NP_899 KEKLL--DLLGKEEDEGSHDENVST----------CDTMPNHSETISHTVNV-PLQTTLG
510 520 530 540 550
pF1KE5 TFEDFTC
:.:...:
NP_899 TLEEIAC
560
>>NP_061144 (OMIM: 606715) acid-sensing ion channel 4 is (666 aa)
initn: 1129 init1: 865 opt: 1472 Z-score: 1768.2 bits: 337.2 E(85289): 9.5e-92
Smith-Waterman score: 1675; 49.7% identity (73.7% similar) in 525 aa overlap (12-528:163-666)
10 20 30 40
pF1KE5 MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSL
:. : .. .:::.::::::.. . .:
NP_061 VCKIKFAEEDAKPKEKEAGDEQSLLGAVAPGAAPRDLATFASTSTLHGLGRACGPGPHGL
140 150 160 170 180 190
50 60 70 80 90 100
pF1KE5 KRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLT-FPAVTLCNLNEFRF
.:.:::: .: :::..: . .. :. :.. .: .: . .. ::::::::.:.::
NP_061 RRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPAAPAPVAGFPAVTLCNINRFRH
200 210 220 230 240 250
110 120 130 140 150 160
pF1KE5 SQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDR
: .: :..: ..: .: : . .. :..: :.: .: .. .:
NP_061 SALSDADIFHLANLTGL-------PPKDRDGHR-------AAGLRY--PEP-DMVDILNR
260 270 280 290
170 180 190 200 210 220
pF1KE5 AGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEI
.::.. ::: ::.: :. ::: .:.::.::::::::::. : : : . :: :.::::
NP_061 TGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFNA--DPRSSLPSRAGGMGSGLEI
300 310 320 330 340 350
230 240 250 260 270 280
pF1KE5 MLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRL
::::::.::::.: ::.::::::::.::::::.:::.: ::::::.:::::::.::::::
NP_061 MLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRL
360 370 380 390 400 410
290 300 310 320 330
pF1KE5 IYLPPPWGTCKAVTM--DSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCT
::: :::.:.: . . .:. ...::..:::. :: . ... :.::::::::. :
NP_061 TYLPQPWGNCRAESELREPELQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICP
420 430 440 450 460 470
340 350 360 370 380 390
pF1KE5 PEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSE
:. : :::: .:: : . : : ::::::::::.:::.::...::.:::.:.:..:
NP_061 PNIYIECADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNE
480 490 500 510 520 530
400 410 420 430 440 450
pF1KE5 QYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAY
:: ::.::::.:::.:. :..::. :: ...::::.::::::::::::::.::..:: :
NP_061 TYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIY
540 550 560 570 580 590
460 470 480 490 500 510
pF1KE5 EVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHH-
:: .: : . : :.:. .:.:...:...:: : ::. : ....::.:
NP_061 EVSWDRLKRVWRRPKTPLRTSTGGISTLGLQELKEQSPCPS-RGRVEG-GGVSSLLPNHH
600 610 620 630 640 650
520
pF1KE5 ----PARGTFEDFTC
: : ::::.:
NP_061 HPHGPPGGLFEDFAC
660
>>XP_016859928 (OMIM: 606715) PREDICTED: acid-sensing io (320 aa)
initn: 1257 init1: 739 opt: 1245 Z-score: 1499.7 bits: 286.4 E(85289): 8.6e-77
Smith-Waterman score: 1245; 56.4% identity (79.1% similar) in 321 aa overlap (215-528:2-320)
190 200 210 220 230 240
pF1KE5 KVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAG
:.::::::::::.::::.: ::.:::::::
XP_016 MGSGLEIMLDIQQEEYLPIWRETNETSFEAG
10 20 30
250 260 270 280 290 300
pF1KE5 IKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTM--DSDLDFF
:.::::::.:::.: ::::::.:::::::.:::::: ::: :::.:.: . . .:. .
XP_016 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRAESELREPELQGY
40 50 60 70 80 90
310 320 330 340 350 360
pF1KE5 DSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCV
..::..:::. :: . ... :.::::::::. : :. : :::: .:: : . :
XP_016 SAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCF
100 110 120 130 140 150
370 380 390 400 410 420
pF1KE5 CEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQ
: ::::::::::.:::.::...::.:::.:.:..: :: ::.::::.:::.:. :..::
XP_016 CPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQ
160 170 180 190 200 210
430 440 450 460 470 480
pF1KE5 KKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADK
. :: ...::::.::::::::::::::.::..:: ::: .: : . : :.:.
XP_016 RAAYGLSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKRVWRRPKTPLRTSTGG
220 230 240 250 260 270
490 500 510 520
pF1KE5 GVALSLDDVKRHNPCESLRGHPAGMTYAANILPHH-----PARGTFEDFTC
.:.:...:...:: : ::. : ....::.: : : ::::.:
XP_016 ISTLGLQELKEQSPCPS-RGRVEGGG-VSSLLPNHHHPHGPPGGLFEDFAC
280 290 300 310 320
528 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:42:19 2016 done: Tue Nov 8 05:42:20 2016
Total Scan time: 8.200 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]