Result of FASTA (omim) for
pFN21AE5667
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5667, 523 aa
1>>>pF1KE5667 523 - 523 aa - 523 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9207+/-0.000502; mu= 9.8017+/- 0.031
mean_var=95.5551+/-19.136, 0's: 0 Z-trim(109.1): 45 B-trim: 12 in 1/54
Lambda= 0.131204
statistics sampled from 17174 (17214) to 17174 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.537), E-opt: 0.2 (0.202), width: 16
Scan time: 6.540
The best scores are: opt bits E(85289)
NP_001245378 (OMIM: 604669) polycystic kidney dise ( 523) 3469 667.8 2.2e-191
XP_016864832 (OMIM: 604669) PREDICTED: polycystic ( 604) 2589 501.2 3.5e-141
NP_055201 (OMIM: 604669) polycystic kidney disease ( 613) 2589 501.2 3.6e-141
NP_001287850 (OMIM: 604669) polycystic kidney dise ( 624) 2589 501.2 3.6e-141
XP_011541620 (OMIM: 604669) PREDICTED: polycystic ( 590) 2295 445.6 1.9e-124
NP_001245377 (OMIM: 604669) polycystic kidney dise ( 602) 2199 427.4 5.8e-119
XP_016864833 (OMIM: 604669) PREDICTED: polycystic ( 564) 2188 425.3 2.3e-118
XP_011541623 (OMIM: 604669) PREDICTED: polycystic ( 564) 2188 425.3 2.3e-118
NP_000288 (OMIM: 173910,613095) polycystin-2 [Homo ( 968) 1231 244.2 1.3e-63
NP_001240766 (OMIM: 604532) polycystic kidney dise ( 758) 1221 242.3 3.8e-63
NP_057196 (OMIM: 604532) polycystic kidney disease ( 805) 1221 242.3 4.1e-63
XP_016864834 (OMIM: 604669) PREDICTED: polycystic ( 550) 1173 233.2 1.6e-60
XP_011530331 (OMIM: 173910,613095) PREDICTED: poly ( 728) 1136 226.2 2.6e-58
XP_016872364 (OMIM: 604532) PREDICTED: polycystic ( 710) 1129 224.9 6.3e-58
XP_011538625 (OMIM: 604532) PREDICTED: polycystic ( 710) 1129 224.9 6.3e-58
XP_011538627 (OMIM: 604532) PREDICTED: polycystic ( 687) 1106 220.5 1.3e-56
XP_011530332 (OMIM: 173910,613095) PREDICTED: poly ( 688) 983 197.3 1.3e-49
XP_016872365 (OMIM: 604532) PREDICTED: polycystic ( 649) 483 102.6 3.8e-21
XP_011530330 (OMIM: 173910,613095) PREDICTED: poly ( 893) 463 98.9 6.9e-20
NP_001265354 (OMIM: 607894) polycystic kidney dise (1774) 439 94.4 3e-18
NP_443124 (OMIM: 607894) polycystic kidney disease (2459) 439 94.5 4.1e-18
XP_005255427 (OMIM: 173900,601313) PREDICTED: poly (3288) 238 56.4 1.5e-06
XP_016878774 (OMIM: 173900,601313) PREDICTED: poly (3327) 238 56.4 1.5e-06
XP_011520839 (OMIM: 173900,601313) PREDICTED: poly (3329) 238 56.4 1.5e-06
XP_011520837 (OMIM: 173900,601313) PREDICTED: poly (3603) 238 56.5 1.6e-06
NP_612152 (OMIM: 609721) polycystic kidney disease (2849) 236 56.0 1.7e-06
XP_016867287 (OMIM: 609721) PREDICTED: polycystic (2920) 236 56.0 1.7e-06
XP_011520836 (OMIM: 173900,601313) PREDICTED: poly (4241) 238 56.5 1.9e-06
XP_011520834 (OMIM: 173900,601313) PREDICTED: poly (4287) 238 56.5 1.9e-06
NP_000287 (OMIM: 173900,601313) polycystin-1 isofo (4302) 238 56.5 1.9e-06
NP_001009944 (OMIM: 173900,601313) polycystin-1 is (4303) 238 56.5 1.9e-06
XP_011520832 (OMIM: 173900,601313) PREDICTED: poly (4311) 238 56.5 1.9e-06
XP_011520831 (OMIM: 173900,601313) PREDICTED: poly (4320) 238 56.5 1.9e-06
XP_011520830 (OMIM: 173900,601313) PREDICTED: poly (4321) 238 56.5 1.9e-06
NP_006062 (OMIM: 604670) polycystic kidney disease (2253) 206 50.3 7.1e-05
>>NP_001245378 (OMIM: 604669) polycystic kidney disease (523 aa)
initn: 3469 init1: 3469 opt: 3469 Z-score: 3556.9 bits: 667.8 E(85289): 2.2e-191
Smith-Waterman score: 3469; 99.8% identity (99.8% similar) in 523 aa overlap (1-523:1-523)
10 20 30 40 50 60
pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 LACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKN
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
NP_001 LACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 VLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEI
430 440 450 460 470 480
490 500 510 520
pF1KE5 QDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
:::::::::::::::::::::::::::::::::::::::::::
NP_001 QDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
490 500 510 520
>>XP_016864832 (OMIM: 604669) PREDICTED: polycystic kidn (604 aa)
initn: 3026 init1: 2576 opt: 2589 Z-score: 2655.6 bits: 501.2 E(85289): 3.5e-141
Smith-Waterman score: 2815; 81.6% identity (81.6% similar) in 555 aa overlap (1-454:1-555)
10 20 30 40 50 60
pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
310 320 330 340 350 360
370 380
pF1KE5 LACWHIYYNNIIAITIFFAWIK--------------------------------------
::::::::::::::::::::::
XP_016 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA
370 380 390 400 410 420
pF1KE5 ------------------------------------------------------------
XP_016 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF
430 440 450 460 470 480
390 400 410 420 430
pF1KE5 ---NMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_016 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
490 500 510 520 530 540
440 450 460 470 480 490
pF1KE5 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA
:::::::::::::::
XP_016 GSGDLAEQARREGFDENRQSLTLSPRLEQRCDSGLNILQTENQVILLPQPPKYLGLHANT
550 560 570 580 590 600
>>NP_055201 (OMIM: 604669) polycystic kidney disease 2-l (613 aa)
initn: 3278 init1: 2576 opt: 2589 Z-score: 2655.5 bits: 501.2 E(85289): 3.6e-141
Smith-Waterman score: 2815; 81.6% identity (81.6% similar) in 555 aa overlap (1-454:1-555)
10 20 30 40 50 60
pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
310 320 330 340 350 360
370 380
pF1KE5 LACWHIYYNNIIAITIFFAWIK--------------------------------------
::::::::::::::::::::::
NP_055 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA
370 380 390 400 410 420
pF1KE5 ------------------------------------------------------------
NP_055 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF
430 440 450 460 470 480
390 400 410 420 430
pF1KE5 ---NMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_055 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
490 500 510 520 530 540
440 450 460 470 480 490
pF1KE5 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA
:::::::::::::::
NP_055 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRDGTTTK
550 560 570 580 590 600
>--
initn: 285 init1: 265 opt: 265 Z-score: 278.1 bits: 61.3 E(85289): 9.4e-09
Smith-Waterman score: 265; 97.5% identity (100.0% similar) in 40 aa overlap (455-494:556-595)
430 440 450 460 470 480
pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
::::::::::::::::::::::::::::::
NP_055 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
530 540 550 560 570 580
490 500 510 520
pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
:::::::::.
NP_055 QPVTQEEFRDGTTTKYKMRFSECLTKRI
590 600 610
>>NP_001287850 (OMIM: 604669) polycystic kidney disease (624 aa)
initn: 3455 init1: 2576 opt: 2589 Z-score: 2655.4 bits: 501.2 E(85289): 3.6e-141
Smith-Waterman score: 2815; 81.6% identity (81.6% similar) in 555 aa overlap (1-454:1-555)
10 20 30 40 50 60
pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
310 320 330 340 350 360
370 380
pF1KE5 LACWHIYYNNIIAITIFFAWIK--------------------------------------
::::::::::::::::::::::
NP_001 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA
370 380 390 400 410 420
pF1KE5 ------------------------------------------------------------
NP_001 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF
430 440 450 460 470 480
390 400 410 420 430
pF1KE5 ---NMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
490 500 510 520 530 540
440 450 460 470 480 490
pF1KE5 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA
:::::::::::::::
NP_001 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA
550 560 570 580 590 600
>--
initn: 442 init1: 442 opt: 442 Z-score: 459.0 bits: 94.8 E(85289): 7.9e-19
Smith-Waterman score: 442; 100.0% identity (100.0% similar) in 69 aa overlap (455-523:556-624)
430 440 450 460 470 480
pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
::::::::::::::::::::::::::::::
NP_001 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
530 540 550 560 570 580
490 500 510 520
pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
:::::::::::::::::::::::::::::::::::::::
NP_001 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
590 600 610 620
>>XP_011541620 (OMIM: 604669) PREDICTED: polycystic kidn (590 aa)
initn: 3222 init1: 2282 opt: 2295 Z-score: 2355.1 bits: 445.6 E(85289): 1.9e-124
Smith-Waterman score: 2521; 79.8% identity (80.0% similar) in 511 aa overlap (45-454:11-521)
20 30 40 50 60 70
pF1KE5 HKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEE
.:::::::::::::::::::::::::::::
XP_011 MAEASRWHRGVTFGMVNPHMYYLNKVMSSLFLDTSVPGEE
10 20 30 40
80 90 100 110 120 130
pF1KE5 RTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQL
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE5 KVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGV
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE5 YRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEF
170 180 190 200 210 220
260 270 280 290 300 310
pF1KE5 PATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKS
230 240 250 260 270 280
320 330 340 350 360 370
pF1KE5 IWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAI
290 300 310 320 330 340
380
pF1KE5 TIFFAWIK----------------------------------------------------
::::::::
XP_011 TIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVD
350 360 370 380 390 400
390
pF1KE5 -------------------------------------------------NMFLAIINDTY
:::::::::::
XP_011 DFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTY
410 420 430 440 450 460
400 410 420 430 440 450
pF1KE5 SEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGF
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGF
470 480 490 500 510 520
460 470 480 490 500 510
pF1KE5 DENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKL
:
XP_011 DENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKL
530 540 550 560 570 580
>--
initn: 442 init1: 442 opt: 442 Z-score: 459.4 bits: 94.8 E(85289): 7.5e-19
Smith-Waterman score: 442; 100.0% identity (100.0% similar) in 69 aa overlap (455-523:522-590)
430 440 450 460 470 480
pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
::::::::::::::::::::::::::::::
XP_011 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
500 510 520 530 540 550
490 500 510 520
pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
:::::::::::::::::::::::::::::::::::::::
XP_011 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
560 570 580 590
>>NP_001245377 (OMIM: 604669) polycystic kidney disease (602 aa)
initn: 3078 init1: 2199 opt: 2199 Z-score: 2256.7 bits: 427.4 E(85289): 5.8e-119
Smith-Waterman score: 2765; 78.5% identity (78.5% similar) in 577 aa overlap (1-476:1-555)
10 20 30 40 50 60
pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
:::::::::::::::::::::::::: ::::::::::::
NP_001 VKKIKEFKSAYFKSIWNWLELLLLLL----------------------LKSTEKYSDFYF
310 320 330
370 380
pF1KE5 LACWHIYYNNIIAITIFFAWIK--------------------------------------
::::::::::::::::::::::
NP_001 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA
340 350 360 370 380 390
pF1KE5 ------------------------------------------------------------
NP_001 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF
400 410 420 430 440 450
390 400 410 420 430
pF1KE5 ---NMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
460 470 480 490 500 510
440 450 460 470 480 490
pF1KE5 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA
:::::::::::::::::::::::::::::::::::::
NP_001 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA
520 530 540 550 560 570
500 510 520
pF1KE5 VELEKELHYINLKLNQVVRKVSAL
NP_001 VELEKELHYINLKLNQVVRKVSAL
580 590 600
>--
initn: 294 init1: 294 opt: 294 Z-score: 307.9 bits: 66.8 E(85289): 2.1e-10
Smith-Waterman score: 294; 100.0% identity (100.0% similar) in 47 aa overlap (477-523:556-602)
450 460 470 480 490 500
pF1KE5 QARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKEL
::::::::::::::::::::::::::::::
NP_001 QARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKEL
530 540 550 560 570 580
510 520
pF1KE5 HYINLKLNQVVRKVSAL
:::::::::::::::::
NP_001 HYINLKLNQVVRKVSAL
590 600
>>XP_016864833 (OMIM: 604669) PREDICTED: polycystic kidn (564 aa)
initn: 3054 init1: 2175 opt: 2188 Z-score: 2245.9 bits: 425.3 E(85289): 2.3e-118
Smith-Waterman score: 2414; 79.4% identity (79.4% similar) in 495 aa overlap (61-454:1-495)
40 50 60 70 80 90
pF1KE5 ELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKF
::::::::::::::::::::::::::::::
XP_016 MSSLFLDTSVPGEERTNFKSIRSITDFWKF
10 20 30
100 110 120 130 140 150
pF1KE5 MEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE5 MSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSE
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE5 TKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVK
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE5 LLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVA
220 230 240 250 260 270
340 350 360 370 380
pF1KE5 VSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIK--------
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFN
280 290 300 310 320 330
pF1KE5 ------------------------------------------------------------
XP_016 KTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIV
340 350 360 370 380 390
390 400
pF1KE5 ---------------------------------NMFLAIINDTYSEVKADYSIGRRPDFE
::::::::::::::::::::::: :::
XP_016 LGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSIGRRLDFE
400 410 420 430 440 450
410 420 430 440 450 460
pF1KE5 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE
460 470 480 490 500 510
470 480 490 500 510 520
pF1KE5 RLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
XP_016 RLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
520 530 540 550 560
>--
initn: 442 init1: 442 opt: 442 Z-score: 459.8 bits: 94.8 E(85289): 7.2e-19
Smith-Waterman score: 442; 100.0% identity (100.0% similar) in 69 aa overlap (455-523:496-564)
430 440 450 460 470 480
pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
::::::::::::::::::::::::::::::
XP_016 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
470 480 490 500 510 520
490 500 510 520
pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
:::::::::::::::::::::::::::::::::::::::
XP_016 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
530 540 550 560
>>XP_011541623 (OMIM: 604669) PREDICTED: polycystic kidn (564 aa)
initn: 3054 init1: 2175 opt: 2188 Z-score: 2245.9 bits: 425.3 E(85289): 2.3e-118
Smith-Waterman score: 2414; 79.4% identity (79.4% similar) in 495 aa overlap (61-454:1-495)
40 50 60 70 80 90
pF1KE5 ELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKF
::::::::::::::::::::::::::::::
XP_011 MSSLFLDTSVPGEERTNFKSIRSITDFWKF
10 20 30
100 110 120 130 140 150
pF1KE5 MEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE5 MSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSE
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE5 TKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVK
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE5 LLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVA
220 230 240 250 260 270
340 350 360 370 380
pF1KE5 VSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIK--------
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFN
280 290 300 310 320 330
pF1KE5 ------------------------------------------------------------
XP_011 KTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIV
340 350 360 370 380 390
390 400
pF1KE5 ---------------------------------NMFLAIINDTYSEVKADYSIGRRPDFE
::::::::::::::::::::::: :::
XP_011 LGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSIGRRLDFE
400 410 420 430 440 450
410 420 430 440 450 460
pF1KE5 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE
460 470 480 490 500 510
470 480 490 500 510 520
pF1KE5 RLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
XP_011 RLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
520 530 540 550 560
>--
initn: 442 init1: 442 opt: 442 Z-score: 459.8 bits: 94.8 E(85289): 7.2e-19
Smith-Waterman score: 442; 100.0% identity (100.0% similar) in 69 aa overlap (455-523:496-564)
430 440 450 460 470 480
pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
::::::::::::::::::::::::::::::
XP_011 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY
470 480 490 500 510 520
490 500 510 520
pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
:::::::::::::::::::::::::::::::::::::::
XP_011 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL
530 540 550 560
>>NP_000288 (OMIM: 173910,613095) polycystin-2 [Homo sap (968 aa)
initn: 1183 init1: 582 opt: 1231 Z-score: 1263.1 bits: 244.2 E(85289): 1.3e-63
Smith-Waterman score: 1231; 45.0% identity (77.5% similar) in 382 aa overlap (21-401:213-591)
10 20 30 40 50
pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMV
.: . ..:.::. :..::: :::::.::.
NP_000 QPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMM
190 200 210 220 230 240
60 70 80 90 100 110
pF1KE5 NPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQL
. ..:: ...::.::::: : :.::::.. :. ::::: :: ::.:::: .::
NP_000 SSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTE
250 260 270 280 290 300
120 130 140 150 160 170
pF1KE5 YNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGL
. : : :.:::.::::::.:::.:::..:.. ..... ..::: :. ..:: . ::
NP_000 AD--NRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP
310 320 330 340 350 360
180 190 200 210 220
pF1KE5 QINTEWRYST-SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTR
. .: : :.. .. :. :::....: ..:: . ::... :: . .:. : :. ::::
NP_000 RNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR
370 380 390 400 410 420
230 240 250 260 270 280
pF1KE5 VIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITF
. :::::.::::.::::..::..:::::::.. :::: .::.:::. .:.:.:.::: :
NP_000 ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIF
430 440 450 460 470 480
290 300 310 320 330 340
pF1KE5 CIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL
:.:.: ....:. .:. : ::.:.:: :......: ::...: : . .. .:: :.:
NP_000 CFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLL-QFL
490 500 510 520 530
350 360 370 380 390 400
pF1KE5 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSEVKADYSIGRRPDFE
.. . . .: :: :.: .::: :.:.::.::: . . .: :.:.... .:
NP_000 EDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFG
540 550 560 570 580 590
410 420 430 440 450 460
pF1KE5 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE
NP_000 FAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPI
600 610 620 630 640 650
>--
initn: 150 init1: 101 opt: 201 Z-score: 209.4 bits: 49.3 E(85289): 6.3e-05
Smith-Waterman score: 201; 31.4% identity (66.7% similar) in 159 aa overlap (366-522:659-802)
340 350 360 370 380 390
pF1KE5 YYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSE
::..... . .:: . :::::::::::::
NP_000 FQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFV-FFMFFILL-NMFLAIINDTYSE
630 640 650 660 670 680
400 410 420 430 440 450
pF1KE5 VKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKT--KGSGDLAEQARREGF
::.: . .. ..::. .:...:...: :..::: :. ... .:.: : .:
NP_000 VKSDLA-QQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKL-------NF
690 700 710 720 730
460 470 480 490 500 510
pF1KE5 DENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKL
:: . :. . . ..: . ... :: : .:..: ... .:::: . ..:
NP_000 DELR-QDLKGKGHTDAEIEAIFTKYD-QDGDQELTEHEHQQM---RDDLEKEREDLDLDH
740 750 760 770 780 790
520
pF1KE5 NQVVRKVSAL
... : .:.
NP_000 SSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSI
800 810 820 830 840 850
>>NP_001240766 (OMIM: 604532) polycystic kidney disease (758 aa)
initn: 1051 init1: 819 opt: 1221 Z-score: 1254.6 bits: 242.3 E(85289): 3.8e-63
Smith-Waterman score: 1221; 45.9% identity (76.3% similar) in 379 aa overlap (21-398:46-421)
10 20 30 40 50
pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMV
.:. : :::.:::.:..::...:.::.::.
NP_001 ASISVKASEASLPCPLGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMT
20 30 40 50 60 70
60 70 80 90 100 110
pF1KE5 NPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQL
. :: .:::: ::: : :.. ..:..: :..::: : .::::..::: .:::::.:
NP_001 SSSAYYYTKVMSELFLHT--PSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSL
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE5 YNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGL
. . : :::::.::::::.:::::::..: :. .:. . :: :. .:. ::
NP_001 GH-GSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGP
140 150 160 170 180 190
180 190 200 210 220
pF1KE5 QINTEWRYSTSNTNSPW-HWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTR
.: : : ... . . ::: : : .::: . : :.. . . . :. . :. ::::
NP_001 FNGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTR
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE5 VIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITF
:.:::::.::::.::::..:::.::::::: . :::. .:::.:::: .:.::..::. :
NP_001 VVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIF
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE5 CIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL
:.:.: ....:. ... . :..:::: :.:...:: .:::.:. . .... :.:.::
NP_001 CVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLL
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE5 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSEVKADYSIGRRPDFE
.. . :.:: ::: :. :::. :...:::::: . .: :......
NP_001 QQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILG
380 390 400 410 420 430
410 420 430 440 450 460
pF1KE5 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE
NP_001 FAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPA
440 450 460 470 480 490
>--
initn: 147 init1: 93 opt: 191 Z-score: 200.9 bits: 47.4 E(85289): 0.00019
Smith-Waterman score: 191; 28.1% identity (62.3% similar) in 167 aa overlap (302-458:428-588)
280 290 300 310 320 330
pF1KE5 LRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAV
: : : .: .. . .: ::. .
NP_001 NLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVE
400 410 420 430 440 450
340 350 360 370 380
pF1KE5 SFNTYYN---VQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKNMFLAI
.:.:. . .:. ..::.. .. .. . . . : .. .::. . ::::::
NP_001 NFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTY----VFFVFFVLL-NMFLAI
460 470 480 490 500 510
390 400 410 420 430 440
pF1KE5 INDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSG------
::::::::: . . :.. ...:. ..::.:...: ..::.: . .. .:. .:
NP_001 INDTYSEVKEELA-GQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQF
520 530 540 550 560 570
450 460 470 480 490 500
pF1KE5 -DLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVE
:... :. : :.::
NP_001 EDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEK
580 590 600 610 620 630
523 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:41:43 2016 done: Tue Nov 8 05:41:44 2016
Total Scan time: 6.540 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]