Result of FASTA (omim) for
pFN21AE5642
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5642, 503 aa
1>>>pF1KE5642 503 - 503 aa - 503 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2203+/-0.000371; mu= 18.1538+/- 0.023
mean_var=64.1807+/-13.224, 0's: 0 Z-trim(112.3): 192 B-trim: 1098 in 1/52
Lambda= 0.160093
statistics sampled from 20904 (21116) to 20904 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.248), width: 16
Scan time: 7.230
The best scores are: opt bits E(85289)
NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 3343 781.2 0
NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502) 3325 777.1 0
NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 2982 697.8 1.8e-200
NP_000768 (OMIM: 145500,605325) cytochrome P450 3A ( 502) 2878 673.8 3.1e-193
XP_016867269 (OMIM: 124010) PREDICTED: cytochrome ( 449) 2788 653.0 5.1e-187
NP_001278759 (OMIM: 145500,605325) cytochrome P450 ( 492) 2770 648.9 9.9e-186
NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 2627 615.8 8.8e-176
NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504) 2615 613.1 6e-175
XP_016867270 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 2244 527.3 3e-149
NP_001278758 (OMIM: 145500,605325) cytochrome P450 ( 389) 2244 527.3 3e-149
XP_011514145 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 2244 527.3 3e-149
NP_476437 (OMIM: 606534) cytochrome P450 3A43 isof ( 420) 2189 514.6 2.2e-145
XP_016868032 (OMIM: 606534) PREDICTED: cytochrome ( 394) 2029 477.7 2.7e-134
XP_016868031 (OMIM: 606534) PREDICTED: cytochrome ( 394) 2029 477.7 2.7e-134
XP_006715922 (OMIM: 145500,605325) PREDICTED: cyto ( 381) 1918 452.0 1.4e-126
XP_016868034 (OMIM: 606534) PREDICTED: cytochrome ( 360) 1858 438.2 2e-122
XP_016868033 (OMIM: 606534) PREDICTED: cytochrome ( 360) 1858 438.2 2e-122
XP_016867271 (OMIM: 145500,605325) PREDICTED: cyto ( 322) 1840 434.0 3.2e-121
NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393) 1482 351.3 2.9e-96
NP_001159726 (OMIM: 231095,274180,614158) thrombox ( 466) 627 153.9 9.4e-37
XP_016868058 (OMIM: 231095,274180,614158) PREDICTE ( 472) 627 153.9 9.5e-37
NP_001300957 (OMIM: 231095,274180,614158) thrombox ( 514) 627 153.9 1e-36
NP_001052 (OMIM: 231095,274180,614158) thromboxane ( 534) 627 153.9 1.1e-36
NP_001124438 (OMIM: 231095,274180,614158) thrombox ( 534) 627 153.9 1.1e-36
NP_001159725 (OMIM: 231095,274180,614158) thrombox ( 580) 627 154.0 1.1e-36
NP_001177413 (OMIM: 145500,605325) cytochrome P450 ( 140) 595 146.2 5.8e-35
NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 593 146.1 2.3e-34
NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 585 144.2 7.5e-34
NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 585 144.2 8.4e-34
XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 575 141.9 4.3e-33
NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 573 141.5 5.9e-33
NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519) 571 141.0 8e-33
XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 569 140.5 1.1e-32
XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 569 140.5 1.1e-32
NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 569 140.5 1.1e-32
XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 563 139.1 2.7e-32
NP_001010969 (OMIM: 615341) cytochrome P450 4A22 i ( 519) 561 138.7 4e-32
NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 555 137.3 1e-31
XP_016868061 (OMIM: 231095,274180,614158) PREDICTE ( 411) 551 136.3 1.6e-31
XP_016868060 (OMIM: 231095,274180,614158) PREDICTE ( 418) 551 136.3 1.6e-31
XP_016868059 (OMIM: 231095,274180,614158) PREDICTE ( 451) 551 136.3 1.8e-31
NP_112246 (OMIM: 231095,274180,614158) thromboxane ( 460) 551 136.3 1.8e-31
XP_011514846 (OMIM: 231095,274180,614158) PREDICTE ( 463) 551 136.3 1.8e-31
NP_001186137 (OMIM: 601270) docosahexaenoic acid o ( 520) 551 136.4 2e-31
NP_000887 (OMIM: 601270) docosahexaenoic acid omeg ( 520) 551 136.4 2e-31
NP_001186138 (OMIM: 601270) docosahexaenoic acid o ( 520) 551 136.4 2e-31
XP_016882303 (OMIM: 601270) PREDICTED: docosahexae ( 520) 551 136.4 2e-31
XP_006722913 (OMIM: 611485) PREDICTED: cytochrome ( 375) 543 134.4 5.4e-31
XP_011526504 (OMIM: 611485) PREDICTED: cytochrome ( 375) 543 134.4 5.4e-31
XP_011526510 (OMIM: 611485) PREDICTED: cytochrome ( 375) 543 134.4 5.4e-31
>>NP_059488 (OMIM: 124010) cytochrome P450 3A4 isoform 1 (503 aa)
initn: 3343 init1: 3343 opt: 3343 Z-score: 4170.6 bits: 781.2 E(85289): 0
Smith-Waterman score: 3343; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_059 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
430 440 450 460 470 480
490 500
pF1KE5 GLLQPEKPVVLKVESRDGTVSGA
:::::::::::::::::::::::
NP_059 GLLQPEKPVVLKVESRDGTVSGA
490 500
>>NP_001189784 (OMIM: 124010) cytochrome P450 3A4 isofor (502 aa)
initn: 3323 init1: 1834 opt: 3325 Z-score: 4148.1 bits: 777.1 E(85289): 0
Smith-Waterman score: 3325; 99.6% identity (99.8% similar) in 503 aa overlap (1-503:1-502)
10 20 30 40 50 60
pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
::::::::::::::::::::::::::::::::::::::::::: .:::::::::::::::
NP_001 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSI-IFPFLIPILEVLNICV
190 200 210 220 230
250 260 270 280 290 300
pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
420 430 440 450 460 470
490 500
pF1KE5 GLLQPEKPVVLKVESRDGTVSGA
:::::::::::::::::::::::
NP_001 GLLQPEKPVVLKVESRDGTVSGA
480 490 500
>>NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo sap (503 aa)
initn: 2982 init1: 2982 opt: 2982 Z-score: 3719.9 bits: 697.8 E(85289): 1.8e-200
Smith-Waterman score: 2982; 88.5% identity (96.4% similar) in 503 aa overlap (1-503:1-503)
10 20 30 40 50 60
pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
: :::.::.::::::::::.:::::::..:::::::::::::::::::: ::..::. :
NP_000 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
::::.::: ::::.:: :::.::::::::::::::::::::::::::::::::::.::::
NP_000 DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
::::::::.:::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_000 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
:::::::::::.:::::::::::::::::::::. :::: ::: ::::: ::::.::: :
NP_000 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
:::.: .:: ::::..::.::..:::::::::::::::::::..:.:::::::::.::::
NP_000 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
:::::::::::::::::.::::::::::::.:.:::.:::::::::::::::.:::::::
NP_000 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
::::::::.::::::::::::::::::::::::::::::.::.:::::::::::::::::
NP_000 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
:::::::::::::::::::::::::::::.::::::.:::::::::::::::::::: .:
NP_000 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG
430 440 450 460 470 480
490 500
pF1KE5 GLLQPEKPVVLKVESRDGTVSGA
::: :::.:::.:::: :::::
NP_000 GLLLTEKPIVLKAESRDETVSGA
490 500
>>NP_000768 (OMIM: 145500,605325) cytochrome P450 3A5 is (502 aa)
initn: 2397 init1: 2397 opt: 2878 Z-score: 3590.1 bits: 673.8 E(85289): 3.1e-193
Smith-Waterman score: 2878; 84.3% identity (95.6% similar) in 502 aa overlap (1-502:1-501)
10 20 30 40 50 60
pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
: :::.::.::::::::::::::::::..:::::.::::::::::.:::.:::..:. :
NP_000 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
: ::.:::::.:: :.:: :::::::::.:.::::::::::::::: .:::::::::::.
NP_000 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
::::::::.:::::::::::::::: ::::::::::::::::::: ::::::::.:::::
NP_000 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
:::::.:::::::::::::::::::.:::.:.: ::::.:::: .:::: :..:.::. .
NP_000 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
::... ::: :::.:::.:::.: ::::.::::::::::::::::::::::::::.::::
NP_000 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
:::::::::::::::: .::::::::::::::.:::::::::::::::.:.:::::::::
NP_000 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
::::::::.:.::::.:::::::::.::::: .:.::.::::.:::::::::.: :::::
NP_000 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
:: ::.::::::::::.::::::::::::::::::::::::::::::::::::::::.
NP_000 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ
430 440 450 460 470
490 500
pF1KE5 GLLQPEKPVVLKVESRDGTVSGA
::::::::.::::.:::::.::
NP_000 GLLQPEKPIVLKVDSRDGTLSGE
480 490 500
>>XP_016867269 (OMIM: 124010) PREDICTED: cytochrome P450 (449 aa)
initn: 2783 init1: 2783 opt: 2788 Z-score: 3478.5 bits: 653.0 E(85289): 5.1e-187
Smith-Waterman score: 2788; 95.7% identity (97.3% similar) in 442 aa overlap (1-442:1-440)
10 20 30 40 50 60
pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERLE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
:.. .. : : . : . :
XP_016 KRKLQS--STIPTTYDEGHQLCPYGSSVSKM
430 440
>>NP_001278759 (OMIM: 145500,605325) cytochrome P450 3A5 (492 aa)
initn: 2287 init1: 2287 opt: 2770 Z-score: 3455.5 bits: 648.9 E(85289): 9.9e-186
Smith-Waterman score: 2770; 83.1% identity (95.1% similar) in 490 aa overlap (14-502:3-491)
10 20 30 40 50
pF1KE5 MALIPDLAMETWLLLAVSLVLLYL-YGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCM
:: . :.::.. :::..:::::.::::::::::.:::.:::..:.
NP_001 MQLLMLELLLLFIVYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWK
10 20 30 40
60 70 80 90 100 110
pF1KE5 FDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAIS
:: ::.:::::.:: :.:: :::::::::.:.::::::::::::::: .:::::::::::
NP_001 FDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAIS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE5 IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAY
.::::::::.:::::::::::::::: ::::::::::::::::::: ::::::::.::::
NP_001 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAY
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE5 SMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNIC
::::::.:::::::::::::::::::.:::.:.: ::::.:::: .:::: :..:.::.
NP_001 SMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVS
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE5 VFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQS
.::... ::: :::.:::.:::.: ::::.::::::::::::::::::::::::::.:::
NP_001 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE5 IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV
::::::::::::::::: .::::::::::::::.:::::::::::::::.:.::::::::
NP_001 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE5 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF
:::::::::.:.::::.:::::::::.::::: .:.::.::::.:::::::::.: ::::
NP_001 VNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE5 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSL
::: ::.::::::::::.::::::::::::::::::::::::::::::::::::::::.
NP_001 SKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT
410 420 430 440 450 460
480 490 500
pF1KE5 GGLLQPEKPVVLKVESRDGTVSGA
::::::::.::::.:::::.::
NP_001 QGLLQPEKPIVLKVDSRDGTLSGE
470 480 490
>>NP_476436 (OMIM: 606534) cytochrome P450 3A43 isoform (503 aa)
initn: 2627 init1: 2627 opt: 2627 Z-score: 3276.8 bits: 615.8 E(85289): 8.8e-176
Smith-Waterman score: 2627; 75.9% identity (93.0% similar) in 502 aa overlap (1-502:1-502)
10 20 30 40 50 60
pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
: :::..:::::.:.:.::::::.:::::: :::::::::::::::::.:: : .:. :
NP_476 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
: ::..:::..::.:.::::.:.: :::::::::::::::::::. :.::.::.:::.:.
NP_476 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
::::::::.:.::::.::: :.:::::::.: ::.:::.::.:::..: ..::: ::::.
NP_476 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
:::::.: ::::.::::::::::..: ::::..::::::.: :..:::: :..:.::: .
NP_476 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
::..::.::..:..:::::::.: :::::::.: ::::::::::.:::::::::::::::
NP_476 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
:.:::.:.:::..: ::::::::::::::::::::::::::::: :::...:::::::::
NP_476 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
::::::::.. :. ::::::.::::.:::::..::.: ::::.::::::::::: :::::
NP_476 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
:::::.:: : : :::.:::::::::::: :.:::.::.::::::::::::::::::.
NP_476 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL
430 440 450 460 470 480
490 500
pF1KE5 GLLQPEKPVVLKVESRDGTVSGA
.::::::.::::. ::: .::
NP_476 PILQPEKPIVLKVHLRDGITSGP
490 500
>>NP_073731 (OMIM: 606534) cytochrome P450 3A43 isoform (504 aa)
initn: 2613 init1: 2182 opt: 2615 Z-score: 3261.8 bits: 613.1 E(85289): 6e-175
Smith-Waterman score: 2615; 75.7% identity (92.8% similar) in 503 aa overlap (1-502:1-503)
10 20 30 40 50 60
pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
: :::..:::::.:.:.::::::.:::::: :::::::::::::::::.:: : .:. :
NP_073 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
: ::..:::..::.:.::::.:.: :::::::::::::::::::. :.::.::.:::.:.
NP_073 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
::::::::.:.::::.::: :.:::::::.: ::.:::.::.:::..: ..::: ::::.
NP_073 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
:::::.: ::::.::::::::::..: ::::..::::::.: :..:::: :..:.::: .
NP_073 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
::..::.::..:..:::::::.: :::::::.: ::::::::::.:::::::::::::::
NP_073 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
:.:::.:.:::..: ::::::::::::::::::::::::::::: :::...:::::::::
NP_073 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
310 320 330 340 350 360
370 380 390 400 410
pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPE-RF
::::::::.. :. ::::::.::::.:::::..::.: ::::.::::::::::: :: ::
NP_073 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE5 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSL
::::::.:: : : :::.:::::::::::: :.:::.::.::::::::::::::::::.
NP_073 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN
430 440 450 460 470 480
480 490 500
pF1KE5 GGLLQPEKPVVLKVESRDGTVSGA
.::::::.::::. ::: .::
NP_073 LPILQPEKPIVLKVHLRDGITSGP
490 500
>>XP_016867270 (OMIM: 145500,605325) PREDICTED: cytochro (389 aa)
initn: 1763 init1: 1763 opt: 2244 Z-score: 2800.4 bits: 527.3 E(85289): 3e-149
Smith-Waterman score: 2244; 85.6% identity (96.1% similar) in 389 aa overlap (114-502:1-388)
90 100 110 120 130 140
pF1KE5 ITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLK
::::::.::::::::.::::::::::::::
XP_016 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK
10 20 30
150 160 170 180 190 200
pF1KE5 EMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPF
:: ::::::::::::::::::: ::::::::.::::::::::.:::::::::::::::::
XP_016 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE5 VENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLED
::.:::.:.: ::::.:::: .:::: :..:.::. .::... ::: :::.:::.:::.:
XP_016 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE5 TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT
::::.::::::::::::::::::::::::::.:::::::::::::::::::: .:::::
XP_016 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE5 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI
:::::::::.:::::::::::::::.:.:::::::::::::::::.:.::::.:::::::
XP_016 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE5 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI
::.::::: .:.::.::::.:::::::::.: ::::::: ::.::::::::::.::::::
XP_016 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCI
280 290 300 310 320
450 460 470 480 490 500
pF1KE5 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA
::::::::::::::::::::::::::::::::::. ::::::::.::::.:::::.::
XP_016 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
330 340 350 360 370 380
>>NP_001278758 (OMIM: 145500,605325) cytochrome P450 3A5 (389 aa)
initn: 1763 init1: 1763 opt: 2244 Z-score: 2800.4 bits: 527.3 E(85289): 3e-149
Smith-Waterman score: 2244; 85.6% identity (96.1% similar) in 389 aa overlap (114-502:1-388)
90 100 110 120 130 140
pF1KE5 ITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLK
::::::.::::::::.::::::::::::::
NP_001 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK
10 20 30
150 160 170 180 190 200
pF1KE5 EMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPF
:: ::::::::::::::::::: ::::::::.::::::::::.:::::::::::::::::
NP_001 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE5 VENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLED
::.:::.:.: ::::.:::: .:::: :..:.::. .::... ::: :::.:::.:::.:
NP_001 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE5 TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT
::::.::::::::::::::::::::::::::.:::::::::::::::::::: .:::::
NP_001 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE5 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI
:::::::::.:::::::::::::::.:.:::::::::::::::::.:.::::.:::::::
NP_001 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE5 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI
::.::::: .:.::.::::.:::::::::.: ::::::: ::.::::::::::.::::::
NP_001 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCI
280 290 300 310 320
450 460 470 480 490 500
pF1KE5 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA
::::::::::::::::::::::::::::::::::. ::::::::.::::.:::::.::
NP_001 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
330 340 350 360 370 380
503 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:28:25 2016 done: Tue Nov 8 05:28:26 2016
Total Scan time: 7.230 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]