Result of FASTA (omim) for
pFN21AE5612
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5612, 511 aa
1>>>pF1KE5612 511 - 511 aa - 511 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9857+/-0.000403; mu= 19.7954+/- 0.025
mean_var=61.4509+/-12.846, 0's: 0 Z-trim(111.1): 30 B-trim: 1058 in 1/50
Lambda= 0.163610
statistics sampled from 19572 (19599) to 19572 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.597), E-opt: 0.2 (0.23), width: 16
Scan time: 8.810
The best scores are: opt bits E(85289)
NP_003108 (OMIM: 600930) hyaluronidase PH-20 isofo ( 511) 3499 834.8 0
NP_001167517 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 3377 806.0 0
NP_001167515 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 3377 806.0 0
NP_694859 (OMIM: 600930) hyaluronidase PH-20 isofo ( 509) 3377 806.0 0
NP_001167516 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 3377 806.0 0
XP_016867400 (OMIM: 604510) PREDICTED: hyaluronida ( 481) 1352 328.0 3.7e-89
XP_011514292 (OMIM: 604510) PREDICTED: hyaluronida ( 481) 1352 328.0 3.7e-89
NP_036401 (OMIM: 604510) hyaluronidase-4 [Homo sap ( 481) 1352 328.0 3.7e-89
XP_005265581 (OMIM: 603551) PREDICTED: hyaluronida ( 473) 1157 282.0 2.6e-75
XP_005265582 (OMIM: 603551) PREDICTED: hyaluronida ( 473) 1157 282.0 2.6e-75
NP_003764 (OMIM: 603551) hyaluronidase-2 precursor ( 473) 1157 282.0 2.6e-75
NP_149348 (OMIM: 603551) hyaluronidase-2 precursor ( 473) 1157 282.0 2.6e-75
XP_011531969 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 1130 275.6 2e-73
XP_011531971 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 1130 275.6 2e-73
NP_695013 (OMIM: 601492,607071) hyaluronidase-1 is ( 435) 1130 275.6 2e-73
NP_149349 (OMIM: 601492,607071) hyaluronidase-1 is ( 435) 1130 275.6 2e-73
XP_011531970 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 1130 275.6 2e-73
XP_011514293 (OMIM: 604510) PREDICTED: hyaluronida ( 451) 949 232.9 1.5e-60
NP_001186958 (OMIM: 604038) hyaluronidase-3 isofor ( 417) 920 226.0 1.6e-58
NP_003540 (OMIM: 604038) hyaluronidase-3 isoform 1 ( 417) 920 226.0 1.6e-58
NP_695014 (OMIM: 601492,607071) hyaluronidase-1 is ( 405) 772 191.1 5.3e-48
NP_695015 (OMIM: 601492,607071) hyaluronidase-1 is ( 253) 688 171.1 3.3e-42
NP_001186959 (OMIM: 604038) hyaluronidase-3 isofor ( 387) 674 168.0 4.7e-41
NP_695017 (OMIM: 601492,607071) hyaluronidase-1 is ( 176) 439 112.3 1.2e-24
NP_001186960 (OMIM: 604038) hyaluronidase-3 isofor ( 168) 356 92.7 9.3e-19
NP_001186961 (OMIM: 604038) hyaluronidase-3 isofor ( 138) 154 44.9 0.00018
>>NP_003108 (OMIM: 600930) hyaluronidase PH-20 isoform 1 (511 aa)
initn: 3499 init1: 3499 opt: 3499 Z-score: 4460.1 bits: 834.8 E(85289): 0
Smith-Waterman score: 3499; 100.0% identity (100.0% similar) in 511 aa overlap (1-511:1-511)
10 20 30 40 50 60
pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
430 440 450 460 470 480
490 500 510
pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF
:::::::::::::::::::::::::::::::
NP_003 FYNASPSTLSATMFIWRLEVWDQGISRIGFF
490 500 510
>>NP_001167517 (OMIM: 600930) hyaluronidase PH-20 isofor (509 aa)
initn: 3377 init1: 3377 opt: 3377 Z-score: 4304.5 bits: 806.0 E(85289): 0
Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 495 aa overlap (1-495:1-495)
10 20 30 40 50 60
pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
430 440 450 460 470 480
490 500 510
pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF
:::::::::::::::
NP_001 FYNASPSTLSATMFIVSILFLIISSVASL
490 500
>>NP_001167515 (OMIM: 600930) hyaluronidase PH-20 isofor (509 aa)
initn: 3377 init1: 3377 opt: 3377 Z-score: 4304.5 bits: 806.0 E(85289): 0
Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 495 aa overlap (1-495:1-495)
10 20 30 40 50 60
pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
430 440 450 460 470 480
490 500 510
pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF
:::::::::::::::
NP_001 FYNASPSTLSATMFIVSILFLIISSVASL
490 500
>>NP_694859 (OMIM: 600930) hyaluronidase PH-20 isoform 2 (509 aa)
initn: 3377 init1: 3377 opt: 3377 Z-score: 4304.5 bits: 806.0 E(85289): 0
Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 495 aa overlap (1-495:1-495)
10 20 30 40 50 60
pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
430 440 450 460 470 480
490 500 510
pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF
:::::::::::::::
NP_694 FYNASPSTLSATMFIVSILFLIISSVASL
490 500
>>NP_001167516 (OMIM: 600930) hyaluronidase PH-20 isofor (509 aa)
initn: 3377 init1: 3377 opt: 3377 Z-score: 4304.5 bits: 806.0 E(85289): 0
Smith-Waterman score: 3377; 100.0% identity (100.0% similar) in 495 aa overlap (1-495:1-495)
10 20 30 40 50 60
pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMET
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQI
430 440 450 460 470 480
490 500 510
pF1KE5 FYNASPSTLSATMFIWRLEVWDQGISRIGFF
:::::::::::::::
NP_001 FYNASPSTLSATMFIVSILFLIISSVASL
490 500
>>XP_016867400 (OMIM: 604510) PREDICTED: hyaluronidase-4 (481 aa)
initn: 1160 init1: 679 opt: 1352 Z-score: 1721.6 bits: 328.0 E(85289): 3.7e-89
Smith-Waterman score: 1352; 45.1% identity (72.0% similar) in 446 aa overlap (15-458:14-455)
10 20 30 40 50 60
pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
:. ... .. :... :. :. ::. :::::.. :
XP_016 MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQC
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
: :.. :....: :::: .: ::.::::::.::::::. : :: .:::.::.:::
XP_016 LIKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTS-QGVPINGGLPQNISL
60 70 80 90 100 110
130 140 150 160 170
pF1KE5 QDHLDKAKKDITFYMPVDNL-GMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQL
: ::.:: .::..:.:.... :.:::::: ::: :::::. ::::...: .:..... ..
XP_016 QVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 SLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCF
: :. :: ::...: :. :::::: ::. ::::::.:::.:.. :.:.:::
XP_016 SATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 NVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATL-YVRNRVREAIRVSKIPDAKSPL
. :. ::..:::::: :.:::::: . . . : . . ::.:..:.: . . :
XP_016 EDEVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYAL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 PVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYM
:::.:::. . :. : :::...:: :.::..::::.:::::: ... : .: . ...
XP_016 PVFVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFV
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE5 ETILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVR
. :. :: ::: ::..:: ::...: :::: ::. .:::::: .. :. . :.:::.
XP_016 SSDLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDGEFTVK
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE5 GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEP
:: . :: ... : : ::. : :: .. ..: :
XP_016 GKASDTDLAVMADTFSCHCYQGY---EGADCREIKTADGCSGVSPSPGSLMTLCLLLLAS
420 430 440 450 460 470
480 490 500 510
pF1KE5 QIFYNASPSTLSATMFIWRLEVWDQGISRIGFF
XP_016 YRSIQL
480
>>XP_011514292 (OMIM: 604510) PREDICTED: hyaluronidase-4 (481 aa)
initn: 1160 init1: 679 opt: 1352 Z-score: 1721.6 bits: 328.0 E(85289): 3.7e-89
Smith-Waterman score: 1352; 45.1% identity (72.0% similar) in 446 aa overlap (15-458:14-455)
10 20 30 40 50 60
pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
:. ... .. :... :. :. ::. :::::.. :
XP_011 MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQC
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
: :.. :....: :::: .: ::.::::::.::::::. : :: .:::.::.:::
XP_011 LIKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTS-QGVPINGGLPQNISL
60 70 80 90 100 110
130 140 150 160 170
pF1KE5 QDHLDKAKKDITFYMPVDNL-GMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQL
: ::.:: .::..:.:.... :.:::::: ::: :::::. ::::...: .:..... ..
XP_011 QVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 SLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCF
: :. :: ::...: :. :::::: ::. ::::::.:::.:.. :.:.:::
XP_011 SATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 NVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATL-YVRNRVREAIRVSKIPDAKSPL
. :. ::..:::::: :.:::::: . . . : . . ::.:..:.: . . :
XP_011 EDEVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYAL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 PVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYM
:::.:::. . :. : :::...:: :.::..::::.:::::: ... : .: . ...
XP_011 PVFVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFV
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE5 ETILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVR
. :. :: ::: ::..:: ::...: :::: ::. .:::::: .. :. . :.:::.
XP_011 SSDLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDGEFTVK
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE5 GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEP
:: . :: ... : : ::. : :: .. ..: :
XP_011 GKASDTDLAVMADTFSCHCYQGY---EGADCREIKTADGCSGVSPSPGSLMTLCLLLLAS
420 430 440 450 460 470
480 490 500 510
pF1KE5 QIFYNASPSTLSATMFIWRLEVWDQGISRIGFF
XP_011 YRSIQL
480
>>NP_036401 (OMIM: 604510) hyaluronidase-4 [Homo sapiens (481 aa)
initn: 1160 init1: 679 opt: 1352 Z-score: 1721.6 bits: 328.0 E(85289): 3.7e-89
Smith-Waterman score: 1352; 45.1% identity (72.0% similar) in 446 aa overlap (15-458:14-455)
10 20 30 40 50 60
pF1KE5 MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFC
:. ... .. :... :. :. ::. :::::.. :
NP_036 MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQC
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 LGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISL
: :.. :....: :::: .: ::.::::::.::::::. : :: .:::.::.:::
NP_036 LIKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTS-QGVPINGGLPQNISL
60 70 80 90 100 110
130 140 150 160 170
pF1KE5 QDHLDKAKKDITFYMPVDNL-GMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQL
: ::.:: .::..:.:.... :.:::::: ::: :::::. ::::...: .:..... ..
NP_036 QVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 SLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCF
: :. :: ::...: :. :::::: ::. ::::::.:::.:.. :.:.:::
NP_036 SATDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 NVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATL-YVRNRVREAIRVSKIPDAKSPL
. :. ::..:::::: :.:::::: . . . : . . ::.:..:.: . . :
NP_036 EDEVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYAL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 PVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYM
:::.:::. . :. : :::...:: :.::..::::.:::::: ... : .: . ...
NP_036 PVFVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFV
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE5 ETILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVR
. :. :: ::: ::..:: ::...: :::: ::. .:::::: .. :. . :.:::.
NP_036 SSDLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDGEFTVK
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE5 GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEP
:: . :: ... : : ::. : :: .. ..: :
NP_036 GKASDTDLAVMADTFSCHCYQGY---EGADCREIKTADGCSGVSPSPGSLMTLCLLLLAS
420 430 440 450 460 470
480 490 500 510
pF1KE5 QIFYNASPSTLSATMFIWRLEVWDQGISRIGFF
NP_036 YRSIQL
480
>>XP_005265581 (OMIM: 603551) PREDICTED: hyaluronidase-2 (473 aa)
initn: 977 init1: 531 opt: 1157 Z-score: 1473.0 bits: 282.0 E(85289): 2.6e-75
Smith-Waterman score: 1157; 40.3% identity (71.8% similar) in 412 aa overlap (34-438:21-430)
10 20 30 40 50 60
pF1KE5 LKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLGK
. :. :::.. . ::. ::..:.. : .
XP_005 MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPR
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 FDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDH
. :::.. :. .:: . ..:..:::: :::: :: .:: .: .:.::.::..:: :
XP_005 LKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDS-AGRSVHGGVPQNVSLWAH
60 70 80 90 100
130 140 150 160 170 180
pF1KE5 LDKAKKDITFYMPV-DNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLT
.: . :. . .. :.::::::.:::.:.:::. ::::. : .:: ... .
XP_005 RKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPD
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE5 EATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKK--PGYNGSCFN
. ...:. ::: :...:..::.. : .:: ::::.::::::::: : . .:.: : .
XP_005 RIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPD
170 180 190 200 210 220
250 260 270 280 290
pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLN-TQQSPVAATLYVRNRVREAIRVSKIPDAKSPLP
::. :::.:.::: :::::.::.::. : : . .: ::.::.::.. :. ::
XP_005 VEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALP
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE5 VFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYME
:...:: ... . : ::. .:. :.::..::::.:...:: . : ..: : .:.
XP_005 VYVFTRPTYSRR-LTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLT
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE5 TILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFA-IQLEKGGKFTVR
.: ::..::. :...::.. :. .: :.:.: ..: .:::. ..: . . :. .:
XP_005 RLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLR
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE5 --GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETE
:. . :..... .: :.::
XP_005 PVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALA
410 420 430 440 450 460
>>XP_005265582 (OMIM: 603551) PREDICTED: hyaluronidase-2 (473 aa)
initn: 977 init1: 531 opt: 1157 Z-score: 1473.0 bits: 282.0 E(85289): 2.6e-75
Smith-Waterman score: 1157; 40.3% identity (71.8% similar) in 412 aa overlap (34-438:21-430)
10 20 30 40 50 60
pF1KE5 LKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLGK
. :. :::.. . ::. ::..:.. : .
XP_005 MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPR
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 FDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDH
. :::.. :. .:: . ..:..:::: :::: :: .:: .: .:.::.::..:: :
XP_005 LKVPLDLNAFDVQASPNEGFVNQNITIFYRDRLGLYPRFDS-AGRSVHGGVPQNVSLWAH
60 70 80 90 100
130 140 150 160 170 180
pF1KE5 LDKAKKDITFYMPV-DNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLT
.: . :. . .. :.::::::.:::.:.:::. ::::. : .:: ... .
XP_005 RKMLQKRVEHYIRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPD
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE5 EATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKK--PGYNGSCFN
. ...:. ::: :...:..::.. : .:: ::::.::::::::: : . .:.: : .
XP_005 RIVKQAQYEFEFAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPD
170 180 190 200 210 220
250 260 270 280 290
pF1KE5 VEIKRNDDLSWLWNESTALYPSIYLN-TQQSPVAATLYVRNRVREAIRVSKIPDAKSPLP
::. :::.:.::: :::::.::.::. : : . .: ::.::.::.. :. ::
XP_005 VEVARNDQLAWLWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALP
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE5 VFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYME
:...:: ... . : ::. .:. :.::..::::.:...:: . : ..: : .:.
XP_005 VYVFTRPTYSRR-LTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLT
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE5 TILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFA-IQLEKGGKFTVR
.: ::..::. :...::.. :. .: :.:.: ..: .:::. ..: . . :. .:
XP_005 RLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLR
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE5 --GKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETE
:. . :..... .: :.::
XP_005 PVGELSWADIDHLQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALA
410 420 430 440 450 460
511 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:08:52 2016 done: Tue Nov 8 05:08:53 2016
Total Scan time: 8.810 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]