Result of FASTA (omim) for
pFN21AE5611
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5611, 492 aa
1>>>pF1KE5611 492 - 492 aa - 492 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0866+/-0.000366; mu= 18.8887+/- 0.023
mean_var=61.8564+/-13.213, 0's: 0 Z-trim(113.5): 42 B-trim: 1502 in 2/51
Lambda= 0.163073
statistics sampled from 22860 (22901) to 22860 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.269), width: 16
Scan time: 7.920
The best scores are: opt bits E(85289)
NP_037511 (OMIM: 610537) dipeptidyl peptidase 2 pr ( 492) 3381 804.2 0
XP_011516902 (OMIM: 610537) PREDICTED: dipeptidyl ( 484) 2945 701.6 1.3e-201
XP_011516901 (OMIM: 610537) PREDICTED: dipeptidyl ( 514) 2945 701.6 1.3e-201
XP_016870141 (OMIM: 610537) PREDICTED: dipeptidyl ( 436) 2599 620.2 3.7e-177
XP_005266132 (OMIM: 610537) PREDICTED: dipeptidyl ( 565) 2298 549.4 9.6e-156
XP_016870140 (OMIM: 610537) PREDICTED: dipeptidyl ( 458) 2163 517.6 2.9e-146
XP_006717146 (OMIM: 610537) PREDICTED: dipeptidyl ( 509) 1516 365.4 2.1e-100
NP_005031 (OMIM: 176785) lysosomal Pro-X carboxype ( 496) 1267 306.8 8.9e-83
NP_955450 (OMIM: 176785) lysosomal Pro-X carboxype ( 517) 1218 295.3 2.7e-79
XP_005274150 (OMIM: 176785) PREDICTED: lysosomal P ( 391) 1020 248.7 2.3e-65
NP_001306143 (OMIM: 176785) lysosomal Pro-X carbox ( 391) 1020 248.7 2.3e-65
NP_005856 (OMIM: 607169) thymus-specific serine pr ( 514) 632 157.5 8.6e-38
XP_016865651 (OMIM: 607169) PREDICTED: thymus-spec ( 454) 485 122.8 2e-27
XP_016865653 (OMIM: 607169) PREDICTED: thymus-spec ( 357) 381 98.3 3.8e-20
XP_016865652 (OMIM: 607169) PREDICTED: thymus-spec ( 417) 381 98.3 4.3e-20
XP_016865650 (OMIM: 607169) PREDICTED: thymus-spec ( 488) 307 81.0 8.6e-15
XP_016865654 (OMIM: 607169) PREDICTED: thymus-spec ( 257) 233 63.4 8.8e-10
>>NP_037511 (OMIM: 610537) dipeptidyl peptidase 2 prepro (492 aa)
initn: 3381 init1: 3381 opt: 3381 Z-score: 4295.0 bits: 804.2 E(85289): 0
Smith-Waterman score: 3381; 99.8% identity (100.0% similar) in 492 aa overlap (1-492:1-492)
10 20 30 40 50 60
pF1KE5 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQS
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_037 DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 AGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQ
430 440 450 460 470 480
490
pF1KE5 QPALRGGPRLSL
::::::::::::
NP_037 QPALRGGPRLSL
490
>>XP_011516902 (OMIM: 610537) PREDICTED: dipeptidyl pept (484 aa)
initn: 2945 init1: 2945 opt: 2945 Z-score: 3740.7 bits: 701.6 E(85289): 1.3e-201
Smith-Waterman score: 2945; 99.8% identity (100.0% similar) in 430 aa overlap (63-492:55-484)
40 50 60 70 80 90
pF1KE5 ERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSGFVA
::::::::::::::::::::::::::.:::
XP_011 PGALLPAASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVA
30 40 50 60 70 80
100 110 120 130 140 150
pF1KE5 ELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQ
90 100 110 120 130 140
160 170 180 190 200 210
pF1KE5 DAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQ
150 160 170 180 190 200
220 230 240 250 260 270
pF1KE5 SPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMM
210 220 230 240 250 260
280 290 300 310 320 330
pF1KE5 DYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSC
270 280 290 300 310 320
340 350 360 370 380 390
pF1KE5 ADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRP
330 340 350 360 370 380
400 410 420 430 440 450
pF1KE5 DWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHP
390 400 410 420 430 440
460 470 480 490
pF1KE5 EDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
::::::::::::::::::::::::::::::::::::::::
XP_011 EDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
450 460 470 480
>>XP_011516901 (OMIM: 610537) PREDICTED: dipeptidyl pept (514 aa)
initn: 3080 init1: 2945 opt: 2945 Z-score: 3740.4 bits: 701.6 E(85289): 1.3e-201
Smith-Waterman score: 3049; 89.9% identity (91.8% similar) in 514 aa overlap (1-492:1-514)
10 20 30 40 50
pF1KE5 MGSAPWAPVLLLALGLRGLQAGA--RRAPD----PGFQERFFQQRLDHFNFERFGNKTFP
::::::::::::::::::::::. :: : :. :: . . . :. . .:
XP_011 MGSAPWAPVLLLALGLRGLQAGGEWRRPPAHSPVPAPPLRFASPHSPQGPGPRLPGALLP
10 20 30 40 50 60
60 70 80 90
pF1KE5 ------------QRFLVSDR----FWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAER
:. : : ::::::::::::::::::::::::::.:::::::::
XP_011 AASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAER
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 GALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIA
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 FGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 DFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGC
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE5 GTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTS
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE5 FWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASV
430 440 450 460 470 480
460 470 480 490
pF1KE5 VEARKLEATIIGEWVKAARREQQPALRGGPRLSL
::::::::::::::::::::::::::::::::::
XP_011 VEARKLEATIIGEWVKAARREQQPALRGGPRLSL
490 500 510
>>XP_016870141 (OMIM: 610537) PREDICTED: dipeptidyl pept (436 aa)
initn: 2599 init1: 2599 opt: 2599 Z-score: 3301.5 bits: 620.2 E(85289): 3.7e-177
Smith-Waterman score: 2599; 99.7% identity (100.0% similar) in 380 aa overlap (1-380:1-380)
10 20 30 40 50 60
pF1KE5 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQS
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
XP_016 DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 SNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPW
::::::::::::::::::::
XP_016 SNNVTDMFPDLPFTDELRQRSQSRQQHHLLQREPGPLGRGRDSEEPECLSHRRHHPGGSA
370 380 390 400 410 420
>>XP_005266132 (OMIM: 610537) PREDICTED: dipeptidyl pept (565 aa)
initn: 2292 init1: 2292 opt: 2298 Z-score: 2917.1 bits: 549.4 E(85289): 9.6e-156
Smith-Waterman score: 2939; 85.9% identity (86.1% similar) in 524 aa overlap (42-492:42-565)
20 30 40 50 60 70
pF1KE5 LALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPI
::::::::::::::::::::::::::::::
XP_005 LALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPI
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE5 FFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTV
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
XP_005 FFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTV
80 90 100 110 120 130
140 150 160
pF1KE5 EQALADFAELLRALRRDLGAQDAPAIAFGG------------------------------
::::::::::::::::::::::::::::::
XP_005 EQALADFAELLRALRRDLGAQDAPAIAFGGRKPSHLSSQPPAQLGCAATLAAFPSESCTR
140 150 160 170 180 190
170
pF1KE5 -------------------------------------------SYGGMLSAYLRMKYPHL
:::::::::::::::::
XP_005 TWPRVGICGSQKCRPPCGTCGPLRRKRGNGVLGAAALTLCPSPSYGGMLSAYLRMKYPHL
200 210 220 230 240 250
180 190 200 210 220 230
pF1KE5 VAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDT
260 270 280 290 300 310
240 250 260 270 280 290
pF1KE5 VRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLS
320 330 340 350 360 370
300 310 320 330 340 350
pF1KE5 EAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLT
380 390 400 410 420 430
360 370 380 390 400 410
pF1KE5 FASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLD
440 450 460 470 480 490
420 430 440 450 460 470
pF1KE5 PWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARR
500 510 520 530 540 550
480 490
pF1KE5 EQQPALRGGPRLSL
::::::::::::::
XP_005 EQQPALRGGPRLSL
560
>--
initn: 286 init1: 286 opt: 286 Z-score: 358.9 bits: 76.1 E(85289): 3e-13
Smith-Waterman score: 286; 100.0% identity (100.0% similar) in 41 aa overlap (1-41:1-41)
10 20 30 40 50 60
pF1KE5 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
:::::::::::::::::::::::::::::::::::::::::
XP_005 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQS
XP_005 DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
70 80 90 100 110 120
>>XP_016870140 (OMIM: 610537) PREDICTED: dipeptidyl pept (458 aa)
initn: 2298 init1: 2163 opt: 2163 Z-score: 2746.8 bits: 517.6 E(85289): 2.9e-146
Smith-Waterman score: 2267; 87.1% identity (89.6% similar) in 402 aa overlap (1-380:1-402)
10 20 30 40 50
pF1KE5 MGSAPWAPVLLLALGLRGLQAGA--RRAPD----PGFQERFFQQRLDHFNFERFGNKTFP
::::::::::::::::::::::. :: : :. :: . . . :. . .:
XP_016 MGSAPWAPVLLLALGLRGLQAGGEWRRPPAHSPVPAPPLRFASPHSPQGPGPRLPGALLP
10 20 30 40 50 60
60 70 80 90
pF1KE5 ------------QRFLVSDR----FWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAER
:. : : ::::::::::::::::::::::::::.:::::::::
XP_016 AASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAER
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 GALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIA
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 FGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQ
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE5 GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE5 DFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGC
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE5 GTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTS
::::::::::::::::::::::::::::::::::::::::::
XP_016 GTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRSQSRQQHHLLQREPGPLG
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE5 FWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASV
XP_016 RGRDSEEPECLSHRRHHPGGSAPPRPQSLPPRRSCFRG
430 440 450
>>XP_006717146 (OMIM: 610537) PREDICTED: dipeptidyl pept (509 aa)
initn: 1510 init1: 1510 opt: 1516 Z-score: 1923.5 bits: 365.4 E(85289): 2.1e-100
Smith-Waterman score: 2157; 82.0% identity (82.3% similar) in 412 aa overlap (42-380:42-453)
20 30 40 50 60 70
pF1KE5 LALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPI
::::::::::::::::::::::::::::::
XP_006 LALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPI
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE5 FFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTV
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
XP_006 FFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTV
80 90 100 110 120 130
140 150 160
pF1KE5 EQALADFAELLRALRRDLGAQDAPAIAFGG------------------------------
::::::::::::::::::::::::::::::
XP_006 EQALADFAELLRALRRDLGAQDAPAIAFGGRKPSHLSSQPPAQLGCAATLAAFPSESCTR
140 150 160 170 180 190
170
pF1KE5 -------------------------------------------SYGGMLSAYLRMKYPHL
:::::::::::::::::
XP_006 TWPRVGICGSQKCRPPCGTCGPLRRKRGNGVLGAAALTLCPSPSYGGMLSAYLRMKYPHL
200 210 220 230 240 250
180 190 200 210 220 230
pF1KE5 VAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDT
260 270 280 290 300 310
240 250 260 270 280 290
pF1KE5 VRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLS
320 330 340 350 360 370
300 310 320 330 340 350
pF1KE5 EAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLT
380 390 400 410 420 430
360 370 380 390 400 410
pF1KE5 FASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLD
::::::::::::::::::::::
XP_006 FASNNVTDMFPDLPFTDELRQRSQSRQQHHLLQREPGPLGRGRDSEEPECLSHRRHHPGG
440 450 460 470 480 490
>--
initn: 286 init1: 286 opt: 286 Z-score: 359.6 bits: 76.0 E(85289): 2.7e-13
Smith-Waterman score: 286; 100.0% identity (100.0% similar) in 41 aa overlap (1-41:1-41)
10 20 30 40 50 60
pF1KE5 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
:::::::::::::::::::::::::::::::::::::::::
XP_006 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 DRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQS
XP_006 DRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQS
70 80 90 100 110 120
>>NP_005031 (OMIM: 176785) lysosomal Pro-X carboxypeptid (496 aa)
initn: 1210 init1: 425 opt: 1267 Z-score: 1607.1 bits: 306.8 E(85289): 8.9e-83
Smith-Waterman score: 1294; 42.6% identity (69.9% similar) in 488 aa overlap (4-474:15-486)
10 20 30 40
pF1KE5 MGSAPWAPVLLL----ALGLRGLQAGARRAPD--PGFQERFFQQRLDHF
:::: . : ::: : .. : ... .:::..:::
NP_005 MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHF
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 NFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLV
.:. ::: ::.::.:..: .. : :.::::::::. : ::.::. ..: : :.::
NP_005 GFNTV--KTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLV
70 80 90 100 110
110 120 130 140 150 160
pF1KE5 FAEHRYYGKSLPFGAQSTQRG-HTELLTVEQALADFAELLRALRRDL-GAQDAPAIAFGG
::::::::.::::: .: . . : ..:: ::::::::::.. :.: . ::.. :.::.::
NP_005 FAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE5 SYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVR
::::::.:..::::::.:.::::::::. : . :.. ::.::. ..:.:.....
NP_005 SYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIH
180 190 200 210 220 230
230 240 250 260 270
pF1KE5 EAFRQIKDLFLQGAYDTVRWEFGT---CQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPT
... :. : :. ..: :. :.::... :. .: . .... :::.:::: .
NP_005 RSWDAINRLSNTGS--GLQWLTGALHLCSPLTSQ-DIQHLKDWISETWVNLAMVDYPYAS
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE5 DFLGPLPANPVKVGCDRL----LSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCAD
.:: :::: :.:: :. : .:.. . .. .. :: ::. .: .: . :
NP_005 NFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLG
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE5 PTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRY--CLDTWGVWPRP
: :.::::::. . : .:.: ::: : . .:.. :.. ::: :::
NP_005 TLG---------WSYQACTEVVMPFCTNGVDDMFE--PHSWNLKELSDDCFQQWGVRPRP
360 370 380 390 400
400 410 420 430 440 450
pF1KE5 DWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHP
.:. : . : .. . .::.::::.::::.:::. .... ...::::. ::::::::...
NP_005 SWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNA
410 420 430 440 450 460
460 470 480 490
pF1KE5 EDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL
:: ::. ::.::. . .:..
NP_005 LDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
470 480 490
>>NP_955450 (OMIM: 176785) lysosomal Pro-X carboxypeptid (517 aa)
initn: 1164 init1: 425 opt: 1218 Z-score: 1544.5 bits: 295.3 E(85289): 2.7e-79
Smith-Waterman score: 1245; 43.7% identity (71.7% similar) in 446 aa overlap (40-474:78-507)
10 20 30 40 50 60
pF1KE5 LLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEG
.:::.:. ::: ::.::.:..: .. :
NP_955 YSVLYFQQKALAAGQLHICIIQLNHYKTPLVDHFGFNTV--KTFNQRYLVADKYWKKNGG
50 60 70 80 90 100
70 80 90 100 110 120
pF1KE5 PIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRG-HTEL
:.::::::::. : ::.::. ..: : :.::::::::::.::::: .: . . : ..
NP_955 SILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNF
110 120 130 140 150 160
130 140 150 160 170 180
pF1KE5 LTVEQALADFAELLRALRRDL-GAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASA
:: ::::::::::.. :.: . ::.. :.::.::::::::.:..::::::.:.:::::::
NP_955 LTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASA
170 180 190 200 210 220
190 200 210 220 230 240
pF1KE5 PVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGT--
:. : . :.. ::.::. ..:.:........ :. : :. ..: :.
NP_955 PIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGS--GLQWLTGALH
230 240 250 260 270 280
250 260 270 280 290 300
pF1KE5 -CQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRL----LSEA
:.::... :. .: . .... :::.:::: ..:: :::: :.:: :. : .:..
NP_955 LCSPLTSQ-DIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDS
290 300 310 320 330 340
310 320 330 340 350 360
pF1KE5 QRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFA
. .. .. :: ::. .: .: . : : :.::::::. . :
NP_955 LLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLG---------WSYQACTEVVMPFC
350 360 370 380 390
370 380 390 400 410
pF1KE5 SNNVTDMFPDLPFTDELRQRY--CLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLD
.:.: ::: : . .:.. :.. ::: :::.:. : . : .. . .::.::::.::
NP_955 TNGVDDMFE--PHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELD
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE5 PWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARR
::.:::. .... ...::::. ::::::::... :: ::. ::.::. . .:..
NP_955 PWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYD
460 470 480 490 500 510
480 490
pF1KE5 EQQPALRGGPRLSL
NP_955 SAGKQH
>>XP_005274150 (OMIM: 176785) PREDICTED: lysosomal Pro-X (391 aa)
initn: 978 init1: 425 opt: 1020 Z-score: 1294.5 bits: 248.7 E(85289): 2.3e-65
Smith-Waterman score: 1047; 42.5% identity (71.0% similar) in 393 aa overlap (93-474:3-381)
70 80 90 100 110 120
pF1KE5 FWVRGEGPIFFYTGNEGDVWAFANNSGFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQ
..: : :.::::::::::.::::: .: .
XP_005 MWDVAEELKAMLVFAEHRYYGESLPFGDNSFK
10 20 30
130 140 150 160 170 180
pF1KE5 RG-HTELLTVEQALADFAELLRALRRDL-GAQDAPAIAFGGSYGGMLSAYLRMKYPHLVA
. : ..:: ::::::::::.. :.: . ::.. :.::.::::::::.:..::::::.:.
XP_005 DSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVV
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE5 GALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVR
::::::::. : . :.. ::.::. ..:.:........ :. : :. ..
XP_005 GALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGS--GLQ
100 110 120 130 140 150
250 260 270 280 290
pF1KE5 WEFGT---CQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRL-
: :. :.::... :. .: . .... :::.:::: ..:: :::: :.:: :. :
XP_005 WLTGALHLCSPLTSQ-DIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLK
160 170 180 190 200
300 310 320 330 340 350
pF1KE5 ---LSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACT
.:.. . .. .. :: ::. .: .: . : : :.:::::
XP_005 NPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLG---------WSYQACT
210 220 230 240 250 260
360 370 380 390 400 410
pF1KE5 EINLTFASNNVTDMFPDLPFTDELRQRY--CLDTWGVWPRPDWLLTSFWGGDLRAASNII
:. . : .:.: ::: : . .:.. :.. ::: :::.:. : . : .. . .::.
XP_005 EVVMPFCTNGVDDMFE--PHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIV
270 280 290 300 310
420 430 440 450 460 470
pF1KE5 FSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGE
::::.::::.:::. .... ...::::. ::::::::... :: ::. ::.::. . .
XP_005 FSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKN
320 330 340 350 360 370
480 490
pF1KE5 WVKAARREQQPALRGGPRLSL
:..
XP_005 WIRDFYDSAGKQH
380 390
492 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 05:08:13 2016 done: Tue Nov 8 05:08:15 2016
Total Scan time: 7.920 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]