Result of FASTA (ccds) for
pFN21AE5575
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5575, 462 aa
1>>>pF1KE5575 462 - 462 aa - 462 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6266+/-0.000897; mu= 15.6925+/- 0.054
mean_var=64.1750+/-13.615, 0's: 0 Z-trim(106.2): 30 B-trim: 312 in 1/50
Lambda= 0.160100
statistics sampled from 8837 (8861) to 8837 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.272), width: 16
Scan time: 3.050
The best scores are: opt bits E(32554)
CCDS57974.1 CLCNKB gene_id:1188|Hs108|chr1 ( 517) 1598 377.9 1.3e-104
CCDS168.1 CLCNKB gene_id:1188|Hs108|chr1 ( 687) 1598 378.0 1.7e-104
CCDS57973.1 CLCNKA gene_id:1187|Hs108|chr1 ( 644) 1513 358.3 1.3e-98
CCDS41269.1 CLCNKA gene_id:1187|Hs108|chr1 ( 686) 1513 358.3 1.4e-98
CCDS167.1 CLCNKA gene_id:1187|Hs108|chr1 ( 687) 1513 358.3 1.4e-98
CCDS54690.1 CLCN2 gene_id:1181|Hs108|chr3 ( 854) 794 192.3 1.7e-48
CCDS54692.1 CLCN2 gene_id:1181|Hs108|chr3 ( 869) 794 192.3 1.7e-48
CCDS3263.1 CLCN2 gene_id:1181|Hs108|chr3 ( 898) 794 192.3 1.7e-48
CCDS5881.1 CLCN1 gene_id:1180|Hs108|chr7 ( 988) 740 179.8 1.1e-44
CCDS54691.1 CLCN2 gene_id:1181|Hs108|chr3 ( 881) 528 130.9 5.4e-30
>>CCDS57974.1 CLCNKB gene_id:1188|Hs108|chr1 (517 aa)
initn: 1593 init1: 1593 opt: 1598 Z-score: 1991.4 bits: 377.9 E(32554): 1.3e-104
Smith-Waterman score: 1598; 91.6% identity (95.4% similar) in 262 aa overlap (179-439:137-398)
150 160 170 180 190 200
pF1KE5 VGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPE-NKSKPVYSALATLVL
..: .:.. .. :::::::::::::
CCDS57 PFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVL
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE5 ASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS57 ASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPR
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE5 FTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS57 FTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAG
230 240 250 260 270 280
330 340 350 360 370 380
pF1KE5 GITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS57 GITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSC
290 300 310 320 330 340
390 400 410 420 430 440
pF1KE5 QPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQ
:::::::::::::::::::::::::::::::::::::::::::: . .:.
CCDS57 QPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTD
350 360 370 380 390 400
450 460
pF1KE5 AQMASGVVWFPVRGS
CCDS57 VAKYPLVESTESQILVGIVRRAQLVQALKAEPPSWAPGHQCLQDILAAGCPTEPVTLKLS
410 420 430 440 450 460
>>CCDS168.1 CLCNKB gene_id:1188|Hs108|chr1 (687 aa)
initn: 1593 init1: 1593 opt: 1598 Z-score: 1989.5 bits: 378.0 E(32554): 1.7e-104
Smith-Waterman score: 1958; 71.3% identity (72.0% similar) in 471 aa overlap (97-439:97-567)
70 80 90 100 110 120
pF1KE5 MDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEV
::::::::::::::::::::::::::::::
CCDS16 MDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 KTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS16 KTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTT
130 140 150 160 170 180
190
pF1KE5 TIGEPENKSK--------------------------------------------------
::::::::::
CCDS16 TIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCG
190 200 210 220 230 240
pF1KE5 ------------------------------------------------------------
CCDS16 AFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIF
250 260 270 280 290 300
200 210 220 230
pF1KE5 ------------------PVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHS
::::::::::::::::::::::::::::::::::::::::::
CCDS16 FGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHS
310 320 330 340 350 360
240 250 260 270 280 290
pF1KE5 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS16 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF
370 380 390 400 410 420
300 310 320 330 340 350
pF1KE5 MPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS16 MPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTAL
430 440 450 460 470 480
360 370 380 390 400 410
pF1KE5 LAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS16 LAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVR
490 500 510 520 530 540
420 430 440 450 460
pF1KE5 VEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS
::::::::::::: . .:.
CCDS16 VEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLVQALKAE
550 560 570 580 590 600
>--
initn: 672 init1: 672 opt: 672 Z-score: 833.5 bits: 164.1 E(32554): 4.2e-40
Smith-Waterman score: 672; 100.0% identity (100.0% similar) in 96 aa overlap (1-96:1-96)
10 20 30 40 50 60
pF1KE5 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS16 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
::::::::::::::::::::::::::::::::::::
CCDS16 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL
CCDS16 SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL
130 140 150 160 170 180
>>CCDS57973.1 CLCNKA gene_id:1187|Hs108|chr1 (644 aa)
initn: 1935 init1: 1513 opt: 1513 Z-score: 1883.8 bits: 358.3 E(32554): 1.3e-98
Smith-Waterman score: 1719; 64.9% identity (69.5% similar) in 459 aa overlap (101-431:60-516)
80 90 100 110 120 130
pF1KE5 VESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTML
.::::.. .: .: ::::::.::::
CCDS57 RAIQGGLEWLKQKVFRLGEDWYFLMTLGVLMALVSYAMNF--AIGCVVRGSGIPELKTML
30 40 50 60 70 80
140 150 160 170 180 190
pF1KE5 AGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGE
:::.:::::::::::::::::::::: ::::::::::::::::::.::::::::::::::
CCDS57 AGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGE
90 100 110 120 130 140
pF1KE5 PENKSK------------------------------------------------------
::::::
CCDS57 PENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIF
150 160 170 180 190 200
pF1KE5 ------------------------------------------------------------
CCDS57 RLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFI
210 220 230 240 250 260
200 210 220 230 240
pF1KE5 --------------PVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALM
:::::::::.::::::::..:.::::::::::::::::::::::::
CCDS57 KTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHSWALM
270 280 290 300 310 320
250 260 270 280 290 300
pF1KE5 TQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS57 TQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIF
330 340 350 360 370 380
310 320 330 340 350 360
pF1KE5 VYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLAFE
. :::::::.::.:. ::::::.::.:::::::::::::::::::::::::::::::::
CCDS57 ILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTALLAFE
390 400 410 420 430 440
370 380 390 400 410 420
pF1KE5 VTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHF
.::::::::::::::::::::::::::::::::.:::::::::::::::::::.::::::
CCDS57 LTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHF
450 460 470 480 490 500
430 440 450 460
pF1KE5 MNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS
:::::::::
CCDS57 MNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAEPPSR
510 520 530 540 550 560
>--
initn: 375 init1: 375 opt: 375 Z-score: 463.2 bits: 95.5 E(32554): 1.8e-19
Smith-Waterman score: 375; 88.1% identity (98.3% similar) in 59 aa overlap (1-59:1-59)
10 20 30 40 50 60
pF1KE5 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM
:::.:::::: ::.::::::::::::.:::.:.:::::::::.::::::::::::::::
CCDS57 MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
CCDS57 ALVSYAMNFAIGCVVRGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFL
70 80 90 100 110 120
>>CCDS41269.1 CLCNKA gene_id:1187|Hs108|chr1 (686 aa)
initn: 1513 init1: 1513 opt: 1513 Z-score: 1883.4 bits: 358.3 E(32554): 1.4e-98
Smith-Waterman score: 1850; 68.0% identity (71.5% similar) in 463 aa overlap (97-431:97-559)
70 80 90 100 110 120
pF1KE5 MDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEV
:::::::::::::::::::::::::::::.
CCDS41 MNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 KTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTT
:::::::.:::::::::::::::::::::: ::::::::::::::::::.::::::::::
CCDS41 KTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTT
130 140 150 160 170 180
190
pF1KE5 TIGEPENKSK--------------------------------------------------
::::::::::
CCDS41 TIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCG
190 200 210 220 230 240
pF1KE5 ------------------------------------------------------------
CCDS41 AFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTF
250 260 270 280 290 300
200 210 220 230
pF1KE5 ------------------PVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHS
:::::::::.::::::::..:.::::::::::::::::::::
CCDS41 LSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHS
310 320 330 340 350 360
240 250 260 270 280 290
pF1KE5 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS41 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF
370 380 390 400 410 420
300 310 320 330 340 350
pF1KE5 MPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTAL
::::. :::::::.::.:. ::::::.::.:::::::::::::::::::::::::::::
CCDS41 MPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTAL
430 440 450 460 470 480
360 370 380 390 400 410
pF1KE5 LAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVR
::::.::::::::::::::::::::::::::::::::.:::::::::::::::::::.::
CCDS41 LAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVR
490 500 510 520 530 540
420 430 440 450 460
pF1KE5 VEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS
:::::::::::::
CCDS41 VEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAE
550 560 570 580 590 600
>--
initn: 585 init1: 585 opt: 585 Z-score: 724.9 bits: 144.0 E(32554): 4.7e-34
Smith-Waterman score: 585; 86.5% identity (95.8% similar) in 96 aa overlap (1-96:1-96)
10 20 30 40 50 60
pF1KE5 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM
:::.:::::: ::.::::::::::::.:::.:.:::::::::.:::::::::::::::::
CCDS41 MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
:::: ::..:. :::::::::::::::::::::::
CCDS41 ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL
CCDS41 SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL
130 140 150 160 170 180
>>CCDS167.1 CLCNKA gene_id:1187|Hs108|chr1 (687 aa)
initn: 1513 init1: 1513 opt: 1513 Z-score: 1883.3 bits: 358.3 E(32554): 1.4e-98
Smith-Waterman score: 1850; 68.0% identity (71.5% similar) in 463 aa overlap (97-431:97-559)
70 80 90 100 110 120
pF1KE5 MDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEV
:::::::::::::::::::::::::::::.
CCDS16 MNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 KTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTT
:::::::.:::::::::::::::::::::: ::::::::::::::::::.::::::::::
CCDS16 KTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTT
130 140 150 160 170 180
190
pF1KE5 TIGEPENKSK--------------------------------------------------
::::::::::
CCDS16 TIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCG
190 200 210 220 230 240
pF1KE5 ------------------------------------------------------------
CCDS16 AFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTF
250 260 270 280 290 300
200 210 220 230
pF1KE5 ------------------PVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHS
:::::::::.::::::::..:.::::::::::::::::::::
CCDS16 LSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHS
310 320 330 340 350 360
240 250 260 270 280 290
pF1KE5 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS16 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF
370 380 390 400 410 420
300 310 320 330 340 350
pF1KE5 MPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTAL
::::. :::::::.::.:. ::::::.::.:::::::::::::::::::::::::::::
CCDS16 MPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTAL
430 440 450 460 470 480
360 370 380 390 400 410
pF1KE5 LAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVR
::::.::::::::::::::::::::::::::::::::.:::::::::::::::::::.::
CCDS16 LAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVR
490 500 510 520 530 540
420 430 440 450 460
pF1KE5 VEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS
:::::::::::::
CCDS16 VEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAE
550 560 570 580 590 600
>--
initn: 585 init1: 585 opt: 585 Z-score: 724.9 bits: 144.0 E(32554): 4.7e-34
Smith-Waterman score: 585; 86.5% identity (95.8% similar) in 96 aa overlap (1-96:1-96)
10 20 30 40 50 60
pF1KE5 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM
:::.:::::: ::.::::::::::::.:::.:.:::::::::.:::::::::::::::::
CCDS16 MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
:::: ::..:. :::::::::::::::::::::::
CCDS16 ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL
CCDS16 SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL
130 140 150 160 170 180
>>CCDS54690.1 CLCN2 gene_id:1181|Hs108|chr3 (854 aa)
initn: 1111 init1: 655 opt: 794 Z-score: 984.3 bits: 192.3 E(32554): 1.7e-48
Smith-Waterman score: 894; 36.7% identity (58.2% similar) in 490 aa overlap (90-450:87-567)
60 70 80 90 100 110
pF1KE5 MALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG
::.::.:..:::.:..::.::.: ..:..
CCDS54 AAPELLEYGRSRCARCRAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 GSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAY
::::::.::.: ::::..:: .:.: :::.::.:.: :: . ::: :::::.. : ::
CCDS54 GSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMPLGKEGPFVHIASMCAAL
120 130 140 150 160 170
180 190
pF1KE5 LGRVRTTTIGEPENKSK-------------------PV----------------------
:.. . : ::.:. :.
CCDS54 LSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRG
180 190 200 210 220 230
pF1KE5 ------------------------------------------------------------
CCDS54 FFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALF
240 250 260 270 280 290
200 210 220 230
pF1KE5 ---------------------------YSALATLVLASITYPPSAGRFLASRLSMKQHLD
. ::.::.....:.::. :.:.:..::.:. :
CCDS54 VYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLV
300 310 320 330 340 350
240 250 260 270 280 290
pF1KE5 SLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTI
.::::..: . :. :::.: : :: ..: ::..:..::::: :::::
CCDS54 TLFDNRTW--VRQGLV----EELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTI
360 370 380 390 400
300 310 320 330 340 350
pF1KE5 PMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVT
:.: : :::.:: :::.::: ::... ::.:: . . : :.:::::..::::..::::
CCDS54 PVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVT
410 420 430 440 450 460
360 370 380 390 400 410
pF1KE5 HTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI-LGR
::.:::...::.::::.: :::..::. :::.::: :::.::. . .:::::::.. ::
CCDS54 HTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGR
470 480 490 500 510 520
420 430 440 450 460
pF1KE5 NIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS
. ..::::: .: ... .:.. .. . :. ...:
CCDS54 H-QQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQ
530 540 550 560 570 580
CCDS54 VVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGET
590 600 610 620 630 640
>>CCDS54692.1 CLCN2 gene_id:1181|Hs108|chr3 (869 aa)
initn: 1218 init1: 655 opt: 794 Z-score: 984.2 bits: 192.3 E(32554): 1.7e-48
Smith-Waterman score: 894; 36.7% identity (58.2% similar) in 490 aa overlap (90-450:131-611)
60 70 80 90 100 110
pF1KE5 MALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG
::.::.:..:::.:..::.::.: ..:..
CCDS54 MALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAV
110 120 130 140 150 160
120 130 140 150 160 170
pF1KE5 GSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAY
::::::.::.: ::::..:: .:.: :::.::.:.: :: . ::: :::::.. : ::
CCDS54 GSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMPLGKEGPFVHIASMCAAL
170 180 190 200 210
180 190
pF1KE5 LGRVRTTTIGEPENKSK-------------------PV----------------------
:.. . : ::.:. :.
CCDS54 LSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRG
220 230 240 250 260 270
pF1KE5 ------------------------------------------------------------
CCDS54 FFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALF
280 290 300 310 320 330
200 210 220 230
pF1KE5 ---------------------------YSALATLVLASITYPPSAGRFLASRLSMKQHLD
. ::.::.....:.::. :.:.:..::.:. :
CCDS54 VYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLV
340 350 360 370 380 390
240 250 260 270 280 290
pF1KE5 SLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTI
.::::..: . :. :::.: : :: ..: ::..:..::::: :::::
CCDS54 TLFDNRTW--VRQGLV----EELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTI
400 410 420 430 440 450
300 310 320 330 340 350
pF1KE5 PMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVT
:.: : :::.:: :::.::: ::... ::.:: . . : :.:::::..::::..::::
CCDS54 PVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVT
460 470 480 490 500 510
360 370 380 390 400 410
pF1KE5 HTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI-LGR
::.:::...::.::::.: :::..::. :::.::: :::.::. . .:::::::.. ::
CCDS54 HTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGR
520 530 540 550 560 570
420 430 440 450 460
pF1KE5 NIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS
. ..::::: .: ... .:.. .. . :. ...:
CCDS54 H-QQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQ
580 590 600 610 620 630
CCDS54 VVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGET
640 650 660 670 680 690
>>CCDS3263.1 CLCN2 gene_id:1181|Hs108|chr3 (898 aa)
initn: 1218 init1: 655 opt: 794 Z-score: 983.9 bits: 192.3 E(32554): 1.7e-48
Smith-Waterman score: 894; 36.7% identity (58.2% similar) in 490 aa overlap (90-450:131-611)
60 70 80 90 100 110
pF1KE5 MALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG
::.::.:..:::.:..::.::.: ..:..
CCDS32 MALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAV
110 120 130 140 150 160
120 130 140 150 160 170
pF1KE5 GSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAY
::::::.::.: ::::..:: .:.: :::.::.:.: :: . ::: :::::.. : ::
CCDS32 GSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMPLGKEGPFVHIASMCAAL
170 180 190 200 210
180 190
pF1KE5 LGRVRTTTIGEPENKSK-------------------PV----------------------
:.. . : ::.:. :.
CCDS32 LSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRG
220 230 240 250 260 270
pF1KE5 ------------------------------------------------------------
CCDS32 FFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALF
280 290 300 310 320 330
200 210 220 230
pF1KE5 ---------------------------YSALATLVLASITYPPSAGRFLASRLSMKQHLD
. ::.::.....:.::. :.:.:..::.:. :
CCDS32 VYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLV
340 350 360 370 380 390
240 250 260 270 280 290
pF1KE5 SLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTI
.::::..: . :. :::.: : :: ..: ::..:..::::: :::::
CCDS32 TLFDNRTW--VRQGLV----EELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTI
400 410 420 430 440 450
300 310 320 330 340 350
pF1KE5 PMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVT
:.: : :::.:: :::.::: ::... ::.:: . . : :.:::::..::::..::::
CCDS32 PVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVT
460 470 480 490 500 510
360 370 380 390 400 410
pF1KE5 HTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI-LGR
::.:::...::.::::.: :::..::. :::.::: :::.::. . .:::::::.. ::
CCDS32 HTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGR
520 530 540 550 560 570
420 430 440 450 460
pF1KE5 NIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS
. ..::::: .: ... .:.. .. . :. ...:
CCDS32 H-QQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQ
580 590 600 610 620 630
CCDS32 VVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGET
640 650 660 670 680 690
>>CCDS5881.1 CLCN1 gene_id:1180|Hs108|chr7 (988 aa)
initn: 1122 init1: 600 opt: 740 Z-score: 915.9 bits: 179.8 E(32554): 1.1e-44
Smith-Waterman score: 769; 40.7% identity (70.9% similar) in 302 aa overlap (139-439:343-625)
110 120 130 140 150 160
pF1KE5 GFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGA-KVVGLSCTLACGSTLFLGKVG
.:.:.. : ..:. : :: .:: :
CCDS58 AFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGI-C---CG---LLGAVF
320 330 340 350 360
170 180 190 200 210 220
pF1KE5 PFVHLSVMMAAYLGRVRTTTIGEPENKSKPVYSALATLVLASITYPPSAGRFLASRLSMK
..: .:: :: . .... : . .: ...:.:.::.:.::. :.:.:..: .
CCDS58 VYLHRQVM----LGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMPR
370 380 390 400 410 420
230 240 250 260 270 280
pF1KE5 QHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLIL
. ...::::..:. . . :: : . .: ::: .. . .:.:::::: :.
CCDS58 EAISTLFDNNTWVKHAGD-----PESLGQSAVW---IHPRVNVVIIIFLFFVMKFWMSIV
430 440 450 460 470
290 300 310 320 330 340
pF1KE5 ATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFS
:::.:.: : :::.:: :::.::: :: ....::.::. : :.:::::. ::::..
CCDS58 ATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALT
480 490 500 510 520 530
350 360 370 380 390 400
pF1KE5 GAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI
:::.::.:::.. ::.::::.: ::...::. :: .::: :::.::. . :::::::: .
CCDS58 GAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDL
540 550 560 570 580 590
410 420 430 440 450 460
pF1KE5 LGRNIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS
..... . :: .: ... .. . :.
CCDS58 GWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVE
600 610 620 630 640 650
CCDS58 RSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDE
660 670 680 690 700 710
>--
initn: 414 init1: 338 opt: 406 Z-score: 498.9 bits: 102.7 E(32554): 1.8e-21
Smith-Waterman score: 406; 44.5% identity (71.6% similar) in 155 aa overlap (45-199:113-262)
20 30 40 50 60 70
pF1KE5 PVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESV
.:::: ::. ::.:::::: .:: . .
CCDS58 GSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDGIFLVLLGLLMALVSWSMDYVSAKS
90 100 110 120 130 140
80 90 100 110 120 130
pF1KE5 VRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVV
..:..: : .. : :..: :...:..:. ::. : . :.:.. ::::::.::.: :::
CCDS58 LQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVV
150 160 170 180 190 200
140 150 160 170 180 190
pF1KE5 LEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENK
:..:: .: : ::::.:. : :: . .:: :::::.. . :: :.. .. : :
CCDS58 LKEYLTMKAFVAKVVALTAGL--GSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYE--
210 220 230 240 250
200 210 220 230 240 250
pF1KE5 SKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEEL
.: :
CCDS58 -QPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFR
260 270 280 290 300 310
>>CCDS54691.1 CLCN2 gene_id:1181|Hs108|chr3 (881 aa)
initn: 1134 init1: 439 opt: 528 Z-score: 652.0 bits: 130.9 E(32554): 5.4e-30
Smith-Waterman score: 825; 36.4% identity (55.6% similar) in 475 aa overlap (45-391:86-535)
20 30 40 50 60 70
pF1KE5 PVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESV
:.:::: ::. ::.:::::: .:: :. .
CCDS54 RAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAAC
60 70 80 90 100 110
80 90 100 110 120 130
pF1KE5 VRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVV
..:.::. : .. : ::.::.:..:::.:..::.::.: ..:.. ::::::.::.: :::
CCDS54 LQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVV
120 130 140 150 160 170
140 150 160 170 180 190
pF1KE5 LEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENK
:..:: .:.: :::.::.:.: :: . ::: :::::.. : :: :.. . : ::.
CCDS54 LKEYLTLKTFIAKVIGLTCAL--GSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENE
180 190 200 210 220 230
pF1KE5 SK-------------------PV-------------------------------------
:. :.
CCDS54 SRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLA
240 250 260 270 280 290
pF1KE5 ------------------------------------------------------------
CCDS54 VWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQK
300 310 320 330 340 350
200 210 220 230 240
pF1KE5 ------------YSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNS
. ::.::.....:.::. :.:.:..::.:. : .::::..: . :.
CCDS54 TINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTW--VRQG-
360 370 380 390 400 410
250 260 270 280 290 300
pF1KE5 SPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGA
:::.: : :: ..: ::..:..::::: ::::::.: : :::.::
CCDS54 ---LVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVI--
420 430 440 450 460
310 320 330 340 350 360
pF1KE5 AIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQ
.:: . . : :.:::::..::::..::::::.:::...::.:::
CCDS54 ---------------DGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQ
470 480 490 500 510
370 380 390 400 410 420
pF1KE5 IVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHS
:.: :::..::. :::.::: :::.
CCDS54 IAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRD
520 530 540 550 560 570
462 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 01:59:20 2016 done: Tue Nov 8 01:59:20 2016
Total Scan time: 3.050 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]