Result of FASTA (omim) for
pFN21AE5533
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5533, 467 aa
1>>>pF1KE5533 467 - 467 aa - 467 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6985+/-0.000301; mu= 21.6053+/- 0.019
mean_var=65.5448+/-13.112, 0's: 0 Z-trim(116.6): 12 B-trim: 6 in 1/50
Lambda= 0.158418
statistics sampled from 27929 (27936) to 27929 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.328), width: 16
Scan time: 8.420
The best scores are: opt bits E(85289)
NP_114409 (OMIM: 136820) plasma alpha-L-fucosidase ( 467) 3322 767.9 0
NP_000138 (OMIM: 230000,612280) tissue alpha-L-fuc ( 466) 1866 435.1 1.9e-121
XP_016856394 (OMIM: 230000,612280) PREDICTED: tiss ( 365) 1290 303.4 6.9e-82
XP_005245878 (OMIM: 230000,612280) PREDICTED: tiss ( 341) 1286 302.4 1.2e-81
XP_011539469 (OMIM: 230000,612280) PREDICTED: tiss ( 255) 939 223.0 7.4e-58
>>NP_114409 (OMIM: 136820) plasma alpha-L-fucosidase pre (467 aa)
initn: 3322 init1: 3322 opt: 3322 Z-score: 4099.6 bits: 767.9 E(85289): 0
Smith-Waterman score: 3322; 99.6% identity (100.0% similar) in 467 aa overlap (1-467:1-467)
10 20 30 40 50 60
pF1KE5 MRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 MRPQELPRLAFPLLLLLLLLLPPPPCPAHSATRFDPTWESLDARQLPAWFDQAKFGIFIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 WGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 WGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 FQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 FQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 YSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 YSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 TGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 TGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 SWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQVGSWL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_114 SWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQMGSWL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 KVNGEAIYETYTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGAT
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
NP_114 KVNGEAIYETHTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGAT
370 380 390 400 410 420
430 440 450 460
pF1KE5 EVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI
:::::::::::::::::::::::::::::::::::::::::::::::
NP_114 EVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI
430 440 450 460
>>NP_000138 (OMIM: 230000,612280) tissue alpha-L-fucosid (466 aa)
initn: 1076 init1: 931 opt: 1866 Z-score: 2301.2 bits: 435.1 E(85289): 1.9e-121
Smith-Waterman score: 1866; 54.8% identity (76.8% similar) in 469 aa overlap (1-466:1-465)
10 20 30 40 50
pF1KE5 MR-PQELPRLAFPLLLLLLLLLPPPPCP--AHSATRFDPTWESLDARQLPAWFDQAKFGI
:: : : : : ::::::.: :. :. : : :::.: ::::::.::::.
NP_000 MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 FIHWGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQW
::::::::::..:::::::.:: : :.: .::.:::::.:.: :::: :::.::. ..:
NP_000 FIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEW
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 ADIFQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRF
::.:::.::::.:::.::::::: : : :::::. : ::.::.: :: .:.:.: ..:.
NP_000 ADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKR-NIRY
130 140 150 160 170
180 190 200 210 220 230
pF1KE5 GLYYSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQY
:::.::.::::::.: :....:. ..: .::.::::.:::.:.:...::::. :: :
NP_000 GLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTY
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 WNSTGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTI
::::.::.::::.:::. ::.::::: . :.:::.:.: :...: : :::: : .:
NP_000 WNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSI
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 DKLSWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQVG
::.::::::. ..:: :....::.::: ::: :.::::: :: : .:.::: ::
NP_000 DKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVG
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE5 SWLKVNGEAIYETYTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAIL
.::..:::::: . :: : . : .:::::: . ::::::.:: .: : : :
NP_000 KWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSA--VYAIFLHWPENGVLNLESP-ITT
360 370 380 390 400 410
420 430 440 450 460
pF1KE5 GATEVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI
..:.. .:: :.: . ..:... :::: .: ...:.. ::.:
NP_000 STTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
420 430 440 450 460
>>XP_016856394 (OMIM: 230000,612280) PREDICTED: tissue a (365 aa)
initn: 1076 init1: 931 opt: 1290 Z-score: 1591.2 bits: 303.4 E(85289): 6.9e-82
Smith-Waterman score: 1290; 49.7% identity (74.3% similar) in 362 aa overlap (105-466:7-364)
80 90 100 110 120 130
pF1KE5 WWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWADIFQASGAKYIVLTSK
:: . . .:.. .:.:::.:
XP_016 MTSRLFPLHQGLQTGQRDWSSASFLRPMRYVVLTTK
10 20 30
140 150 160 170 180 190
pF1KE5 HHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFGLYYSLFEWFHPLFLED
:::::: : : :::::. : ::.::.: :: .:.:.: ..:.:::.::.::::::.: :
XP_016 HHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKR-NIRYGLYHSLLEWFHPLYLLD
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE5 ESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWNSTGFLAWLYNESPVR
....:. ..: .::.::::.:::.:.:...::::. :: :::::.::.::::.:::.
XP_016 KKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVK
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE5 GTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDKLSWGYRREAGISDYL
::.::::: . :.:::.:.: :...: : :::: : .:::.::::::. ..::
XP_016 DEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVT
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE5 TIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQVGSWLKVNGEAIYETYTWR
:....::.::: ::: :.::::: :: : .:.::: ::.::..:::::: . ::
XP_016 EESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWR
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE5 SQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGATEVKLLGHGQPLNWI
: . : .:::::: . ::::::.:: .: : : : ..:.. .:: :.:
XP_016 VQWEKNTTSVWYTSKGSA--VYAIFLHWPENGVLNLESP-ITTSTTKITMLGIQGDLKWS
280 290 300 310 320 330
440 450 460
pF1KE5 SLEQNGIMVELPQLTIHQMPCKWGWALALTNVI
. ..:... :::: .: ...:.. ::.:
XP_016 TDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
340 350 360
>>XP_005245878 (OMIM: 230000,612280) PREDICTED: tissue a (341 aa)
initn: 1076 init1: 931 opt: 1286 Z-score: 1586.6 bits: 302.4 E(85289): 1.2e-81
Smith-Waterman score: 1286; 52.1% identity (76.8% similar) in 340 aa overlap (127-466:5-340)
100 110 120 130 140 150
pF1KE5 SFKYEDFGPLFTAKFFNANQWADIFQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEG
.:.:::.::::::: : : :::::. : :
XP_005 MRRRRYVVLTTKHHEGFTNWPSPVSWNWNSKDVG
10 20 30
160 170 180 190 200 210
pF1KE5 PKRDIVKELEVAIRNRTDLRFGLYYSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYEL
:.::.: :: .:.:.: ..:.:::.::.::::::.: :....:. ..: .::.::::.:
XP_005 PHRDLVGELGTALRKR-NIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDL
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE5 VNNYQPEVLWSDGDGGAPDQYWNSTGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYT
::.:.:...::::. :: :::::.::.::::.:::. ::.::::: . :.:::.:.
XP_005 VNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYN
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE5 CSDRYNPGHLLPHKWENCMTIDKLSWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMN
: :...: : :::: : .:::.::::::. ..:: :....::.::: ::: :.:
XP_005 CEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLN
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE5 IGPTLDGTISVVFEERLRQVGSWLKVNGEAIYETYTWRSQNDTVTPDVWYTSKPKEKLVY
:::: :: : .:.::: ::.::..:::::: . :: : . : .:::::: . ::
XP_005 IGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSA--VY
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE5 AIFLKWPTSGQLFLGHPKAILGATEVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCK
::::.:: .: : : : ..:.. .:: :.: . ..:... :::: .: .
XP_005 AIFLHWPENGVLNLESP-ITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAE
280 290 300 310 320 330
460
pF1KE5 WGWALALTNVI
..:.. ::.:
XP_005 FAWTIKLTGVK
340
>>XP_011539469 (OMIM: 230000,612280) PREDICTED: tissue a (255 aa)
initn: 931 init1: 786 opt: 939 Z-score: 1159.7 bits: 223.0 E(85289): 7.4e-58
Smith-Waterman score: 939; 50.6% identity (74.3% similar) in 257 aa overlap (210-466:1-254)
180 190 200 210 220 230
pF1KE5 YYSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYWN
.::::.:::.:.:...::::. :: :::
XP_011 MPELYDLVNSYKPDLIWSDGEWECPDTYWN
10 20 30
240 250 260 270 280 290
pF1KE5 STGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTIDK
::.::.::::.:::. ::.::::: . :.:::.:.: :...: : :::: : .:::
XP_011 STNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDK
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE5 LSWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQVGSW
.::::::. ..:: :....::.::: ::: :.::::: :: : .:.::: ::.:
XP_011 FSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKW
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE5 LKVNGEAIYETYTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILGA
:..:::::: . :: : . : .:::::: . ::::::.:: .: : : : ..
XP_011 LSINGEAIYASKPWRVQWEKNTTSVWYTSKGSA--VYAIFLHWPENGVLNLESP-ITTST
160 170 180 190 200
420 430 440 450 460
pF1KE5 TEVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI
:.. .:: :.: . ..:... :::: .: ...:.. ::.:
XP_011 TKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
210 220 230 240 250
467 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 01:33:41 2016 done: Tue Nov 8 01:33:42 2016
Total Scan time: 8.420 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]