Result of FASTA (omim) for
pFN21AE5519
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5519, 465 aa
1>>>pF1KE5519 465 - 465 aa - 465 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8142+/-0.000471; mu= 20.6770+/- 0.029
mean_var=68.3344+/-13.904, 0's: 0 Z-trim(109.4): 166 B-trim: 253 in 1/51
Lambda= 0.155151
statistics sampled from 17415 (17595) to 17415 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.545), E-opt: 0.2 (0.206), width: 16
Scan time: 6.410
The best scores are: opt bits E(85289)
NP_775807 (OMIM: 137166) gamma-aminobutyric acid r ( 465) 3145 713.5 2.9e-205
NP_000807 (OMIM: 137164,607681,611277) gamma-amino ( 467) 2362 538.3 1.7e-152
NP_944494 (OMIM: 137164,607681,611277) gamma-amino ( 475) 2343 534.0 3.3e-151
XP_016863479 (OMIM: 137166) PREDICTED: gamma-amino ( 336) 2288 521.6 1.3e-147
XP_011519732 (OMIM: 600233) PREDICTED: gamma-amino ( 473) 1744 400.0 7.5e-111
NP_150092 (OMIM: 600233) gamma-aminobutyric acid r ( 467) 1741 399.3 1.2e-110
XP_016877547 (OMIM: 600233) PREDICTED: gamma-amino ( 361) 1323 305.6 1.4e-82
XP_016877548 (OMIM: 600233) PREDICTED: gamma-amino ( 355) 1320 304.9 2.2e-82
XP_005268315 (OMIM: 137142) PREDICTED: gamma-amino ( 462) 1258 291.2 4.1e-78
NP_001158509 (OMIM: 137142) gamma-aminobutyric aci ( 462) 1258 291.2 4.1e-78
XP_006720522 (OMIM: 137142) PREDICTED: gamma-amino ( 462) 1258 291.2 4.1e-78
NP_000801 (OMIM: 137142) gamma-aminobutyric acid r ( 462) 1258 291.2 4.1e-78
NP_001121117 (OMIM: 137160,611136,615744) gamma-am ( 456) 1232 285.3 2.3e-76
NP_001121120 (OMIM: 137160,611136,615744) gamma-am ( 456) 1232 285.3 2.3e-76
NP_001121116 (OMIM: 137160,611136,615744) gamma-am ( 456) 1232 285.3 2.3e-76
NP_001121115 (OMIM: 137160,611136,615744) gamma-am ( 456) 1232 285.3 2.3e-76
NP_000797 (OMIM: 137160,611136,615744) gamma-amino ( 456) 1232 285.3 2.3e-76
NP_004952 (OMIM: 300093) gamma-aminobutyric acid r ( 506) 1229 284.7 3.9e-76
XP_016863472 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 1225 283.8 6.7e-76
NP_000798 (OMIM: 103780,137140) gamma-aminobutyric ( 451) 1225 283.8 6.7e-76
NP_001107647 (OMIM: 103780,137140) gamma-aminobuty ( 451) 1225 283.8 6.7e-76
XP_016863471 (OMIM: 103780,137140) PREDICTED: gamm ( 451) 1225 283.8 6.7e-76
NP_001191195 (OMIM: 137141) gamma-aminobutyric aci ( 535) 1225 283.8 7.7e-76
NP_000800 (OMIM: 137141) gamma-aminobutyric acid r ( 554) 1225 283.8 7.9e-76
NP_000802 (OMIM: 137143) gamma-aminobutyric acid r ( 453) 1219 282.4 1.7e-75
NP_000799 (OMIM: 305660) gamma-aminobutyric acid r ( 492) 1182 274.2 5.7e-73
NP_001317619 (OMIM: 103780,137140) gamma-aminobuty ( 511) 1145 265.9 1.8e-70
XP_011511977 (OMIM: 103780,137140) PREDICTED: gamm ( 511) 1145 265.9 1.8e-70
NP_001257802 (OMIM: 600233) gamma-aminobutyric aci ( 253) 1118 259.6 7.1e-69
XP_005248137 (OMIM: 103780,137140) PREDICTED: gamm ( 396) 1091 253.7 6.5e-67
XP_016884878 (OMIM: 300093) PREDICTED: gamma-amino ( 267) 1077 250.5 4.3e-66
XP_016884875 (OMIM: 300093) PREDICTED: gamma-amino ( 393) 1076 250.4 6.7e-66
NP_944493 (OMIM: 137164,607681,611277) gamma-amino ( 515) 1017 237.3 7.7e-62
NP_001273756 (OMIM: 103780,137140) gamma-aminobuty ( 456) 1011 235.9 1.8e-61
XP_006724874 (OMIM: 305660) PREDICTED: gamma-amino ( 340) 922 215.8 1.4e-55
NP_001139512 (OMIM: 138491,149400) glycine recepto ( 457) 922 216.0 1.8e-55
XP_016877545 (OMIM: 137142) PREDICTED: gamma-amino ( 306) 919 215.1 2.1e-55
XP_016877544 (OMIM: 137142) PREDICTED: gamma-amino ( 306) 919 215.1 2.1e-55
NP_006520 (OMIM: 600421) glycine receptor subunit ( 464) 917 214.8 3.9e-55
XP_016864119 (OMIM: 600421) PREDICTED: glycine rec ( 424) 914 214.1 5.8e-55
NP_000162 (OMIM: 138491,149400) glycine receptor s ( 449) 909 213.0 1.3e-54
XP_016864838 (OMIM: 138491,149400) PREDICTED: glyc ( 465) 909 213.1 1.4e-54
NP_001243632 (OMIM: 137161) gamma-aminobutyric aci ( 462) 904 211.9 2.9e-54
NP_002033 (OMIM: 137161) gamma-aminobutyric acid r ( 479) 904 211.9 3e-54
NP_000804 (OMIM: 600232) gamma-aminobutyric acid r ( 474) 896 210.1 1e-53
NP_068711 (OMIM: 600232) gamma-aminobutyric acid r ( 512) 896 210.2 1.1e-53
NP_001112357 (OMIM: 305990) glycine receptor subun ( 452) 894 209.7 1.4e-53
NP_002054 (OMIM: 305990) glycine receptor subunit ( 452) 894 209.7 1.4e-53
XP_016884916 (OMIM: 305990) PREDICTED: glycine rec ( 452) 892 209.2 1.8e-53
NP_001112358 (OMIM: 305990) glycine receptor subun ( 452) 892 209.2 1.8e-53
>>NP_775807 (OMIM: 137166) gamma-aminobutyric acid recep (465 aa)
initn: 3145 init1: 3145 opt: 3145 Z-score: 3806.1 bits: 713.5 E(85289): 2.9e-205
Smith-Waterman score: 3145; 99.8% identity (99.8% similar) in 465 aa overlap (1-465:1-465)
10 20 30 40 50 60
pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYEYQCLEGKDCASFFCCFE
:::::::::::::::::::::::::::::::::::::::::: :::::::::::::::::
NP_775 QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE
370 380 390 400 410 420
430 440 450 460
pF1KE5 DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
:::::::::::::::::::::::::::::::::::::::::::::
NP_775 DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
430 440 450 460
>>NP_000807 (OMIM: 137164,607681,611277) gamma-aminobuty (467 aa)
initn: 2271 init1: 2271 opt: 2362 Z-score: 2858.8 bits: 538.3 E(85289): 1.7e-152
Smith-Waterman score: 2362; 77.9% identity (90.5% similar) in 444 aa overlap (24-465:27-467)
10 20 30 40 50
pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAP
..:::.:. : .:.:: : :: . ::::::.:
NP_000 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDD-DYEDYASNKTWVLTP
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 KIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQ
:. :::.: :::.::.::::::::::::.::.:.::.::::::::. :::::::::.:::
NP_000 KVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 TWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVL
::.: :::::::.::: :::::::::::::::::::.:.::::::::::.::::::::::
NP_000 TWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 YTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQ
:::::::.::: :::::::::::::::::::::::..:: :.::. ::::.: . :::::
NP_000 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 FAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKD
:.::::::.::...: :::::.:...:::::::::::::::::: : :::::::::::::
NP_000 FSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYF
::::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::
NP_000 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYF
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE5 TSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDD--YEYQCLEGKDCASF
.::.: . ::.: :: : : ..: :. : ::: . :: : : :.::.:::::::
NP_000 VSNRK-PSKDKDKKKKNPAP-TIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASF
360 370 380 390 400 410
420 430 440 450 460
pF1KE5 FCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
::::::::::.::.:::::::::.:::.:::::::: ::::::::.::::
NP_000 FCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
420 430 440 450 460
>>NP_944494 (OMIM: 137164,607681,611277) gamma-aminobuty (475 aa)
initn: 2284 init1: 1870 opt: 2343 Z-score: 2835.7 bits: 534.0 E(85289): 3.3e-151
Smith-Waterman score: 2343; 76.8% identity (89.2% similar) in 452 aa overlap (24-465:27-475)
10 20 30 40 50
pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAP
..:::.:. : .:.:: : :: . ::::::.:
NP_944 MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDD-DYEDYASNKTWVLTP
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 KIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQ
:. :::.: :::.::.::::::::::::.::.:.::.::::::::. :::::::::.:::
NP_944 KVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 TWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVL
::.: :::::::.::: :::::::::::::::::::.:.::::::::::.::::::::::
NP_944 TWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 YTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQ
:::::::.::: :::::::::::::::::::::::..:: :.::. ::::.: . :::::
NP_944 YTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 FAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKD
:.::::::.::...: :::::.:...:::::::::::::::::: : :::::::::::::
NP_944 FSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYF
::::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::
NP_944 AVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYF
300 310 320 330 340 350
360 370 380 390 400
pF1KE5 TSNQKGKTATKDRKLKN--------KASMTPGLHPGSTLIPMNNISVPQEDD--YEYQCL
.::.: . ::.: :: :: : ..: :. : ::: . :: : : :.::
NP_944 VSNRK-PSKDKDKKKKNPLLRMFSFKAP-TIDIRPRSATIQMNNATHLQERDEEYGYECL
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE5 EGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
.:::::::::::::::::.::.:::::::::.:::.:::::::: ::::::::.::::
NP_944 DGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
420 430 440 450 460 470
>>XP_016863479 (OMIM: 137166) PREDICTED: gamma-aminobuty (336 aa)
initn: 2288 init1: 2288 opt: 2288 Z-score: 2771.2 bits: 521.6 E(85289): 1.3e-147
Smith-Waterman score: 2288; 99.7% identity (99.7% similar) in 336 aa overlap (130-465:1-336)
100 110 120 130 140 150
pF1KE5 GPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAH
::::::::::::::::::::::::::::::
XP_016 MKVLMLNSNMVGKIWIPDTFFRNSRKSDAH
10 20 30
160 170 180 190 200 210
pF1KE5 WITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYK
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE5 WKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYI
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE5 PCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSV
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE5 CFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQE
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE5 DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYW
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYW
280 290 300 310 320 330
460
pF1KE5 VGYLYL
::::::
XP_016 VGYLYL
>>XP_011519732 (OMIM: 600233) PREDICTED: gamma-aminobuty (473 aa)
initn: 2103 init1: 1727 opt: 1744 Z-score: 2111.2 bits: 400.0 E(85289): 7.5e-111
Smith-Waterman score: 2095; 67.0% identity (83.8% similar) in 469 aa overlap (24-465:5-473)
10 20 30 40 50
pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLG-NCVDKADDEDD-EDLTVNKTWVLAPK
..::: : : . .. .::. :: . :. ::::::
XP_011 MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPK
10 20 30 40
60 70 80 90 100 110
pF1KE5 IHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQT
.. :.: :::.::. ::.:::::::..::::..:.::::::::. ::::: :::.::::
XP_011 SQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE5 WFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLY
: ::::.::::::.: ::::::: ::::::.::::. ..::::::::.::::::::..::
XP_011 WTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILY
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE5 TLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQF
:::::::::: ::::::::::::::: ::::::::.:. :.:.: :::.:: : ::::::
XP_011 TLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQF
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE5 AFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDA
:.::::.:::. : .::::.:::.:.:::::::::::::::::::::::::::::.:::
XP_011 DFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDA
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE5 VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFT
.::::.:::::::::::::::::::::.:::::::::::.:::.:::::::::.::.:..
XP_011 TPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYS
290 300 310 320 330 340
360 370 380 390
pF1KE5 SNQKGKTATK---------DRKLKNKASM-TPGLH-------------PGSTLIPMNNIS
: .: :. : .: . .. :. .:... : ...: .::
XP_011 SCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSVRIALQNYSLLDMRPPPTAMITLNNSV
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE5 VPQE--DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFAL
:: : :.::.:::: :::::.:.:..::::.::::: : ..:::::.::::.: :
XP_011 YWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLL
410 420 430 440 450 460
460
pF1KE5 FNLVYWVGYLYL
::::::::::::
XP_011 FNLVYWVGYLYL
470
>>NP_150092 (OMIM: 600233) gamma-aminobutyric acid recep (467 aa)
initn: 2103 init1: 1727 opt: 1741 Z-score: 2107.6 bits: 399.3 E(85289): 1.2e-110
Smith-Waterman score: 2104; 67.8% identity (84.7% similar) in 463 aa overlap (24-465:5-467)
10 20 30 40 50
pF1KE5 MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLG-NCVDKADDEDD-EDLTVNKTWVLAPK
..::: : : . .. .::. :: . :. ::::::
NP_150 MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPK
10 20 30 40
60 70 80 90 100 110
pF1KE5 IHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQT
.. :.: :::.::. ::.:::::::..::::..:.::::::::. ::::: :::.::::
NP_150 SQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQT
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE5 WFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLY
: ::::.::::::.: ::::::: ::::::.::::. ..::::::::.::::::::..::
NP_150 WTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILY
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE5 TLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQF
:::::::::: ::::::::::::::: ::::::::.:. :.:.: :::.:: : ::::::
NP_150 TLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQF
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE5 AFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDA
:.::::.:::. : .::::.:::.:.:::::::::::::::::::::::::::::.:::
NP_150 DFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDA
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE5 VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFT
.::::.:::::::::::::::::::::.:::::::::::.:::.:::::::::.::.:..
NP_150 TPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYS
290 300 310 320 330 340
360 370 380 390
pF1KE5 SNQKGKTATK---------DRKLKNKASM-TPGLH-------PGSTLIPMNNISVPQE--
: .: :. : .: . .. :. .:. . : ...: .:: ::
NP_150 SCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFE
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE5 DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYW
: :.::.:::: :::::.:.:..::::.::::: : ..:::::.::::.: :::::::
NP_150 DTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYW
410 420 430 440 450 460
460
pF1KE5 VGYLYL
::::::
NP_150 VGYLYL
>>XP_016877547 (OMIM: 600233) PREDICTED: gamma-aminobuty (361 aa)
initn: 1696 init1: 1320 opt: 1323 Z-score: 1603.4 bits: 305.6 E(85289): 1.4e-82
Smith-Waterman score: 1674; 68.7% identity (84.2% similar) in 361 aa overlap (130-465:1-361)
100 110 120 130 140 150
pF1KE5 GPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAH
::.: ::::::: ::::::.::::. ..::
XP_016 MKILTLNSNMVGLIWIPDTIFRNSKTAEAH
10 20 30
160 170 180 190 200 210
pF1KE5 WITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYK
::::::.::::::::..:::::::::::: ::::::::::::::: ::::::::.:. :.
XP_016 WITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYR
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE5 WKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYI
:.: :::.:: : :::::: :.::::.:::. : .::::.:::.:.::::::::::::::
XP_016 WRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYI
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE5 PCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSV
:::::::::::::::.:::.::::.:::::::::::::::::::::.:::::::::::.:
XP_016 PCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTV
160 170 180 190 200 210
340 350 360 370 380
pF1KE5 CFIFVFAALMEYGTLHYFTSNQKGKTATK---------DRKLKNKASM-TPGLH------
::.:::::::::.::.:..: .: :. : .: . .. :. .:...
XP_016 CFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSVRIALQNY
220 230 240 250 260 270
390 400 410 420 430
pF1KE5 -------PGSTLIPMNNISVPQE--DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHI
: ...: .:: :: : :.::.:::: :::::.:.:..::::.:::::
XP_016 SLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHI
280 290 300 310 320 330
440 450 460
pF1KE5 RIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
: ..:::::.::::.: :::::::::::::
XP_016 DILELDSYSRVFFPTSFLLFNLVYWVGYLYL
340 350 360
>>XP_016877548 (OMIM: 600233) PREDICTED: gamma-aminobuty (355 aa)
initn: 1696 init1: 1320 opt: 1320 Z-score: 1599.9 bits: 304.9 E(85289): 2.2e-82
Smith-Waterman score: 1683; 69.9% identity (85.4% similar) in 355 aa overlap (130-465:1-355)
100 110 120 130 140 150
pF1KE5 GPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAH
::.: ::::::: ::::::.::::. ..::
XP_016 MKILTLNSNMVGLIWIPDTIFRNSKTAEAH
10 20 30
160 170 180 190 200 210
pF1KE5 WITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYK
::::::.::::::::..:::::::::::: ::::::::::::::: ::::::::.:. :.
XP_016 WITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYR
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE5 WKKPSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYI
:.: :::.:: : :::::: :.::::.:::. : .::::.:::.:.::::::::::::::
XP_016 WRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYI
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE5 PCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSV
:::::::::::::::.:::.::::.:::::::::::::::::::::.:::::::::::.:
XP_016 PCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTV
160 170 180 190 200 210
340 350 360 370 380
pF1KE5 CFIFVFAALMEYGTLHYFTSNQKGKTATK---------DRKLKNKASM-TPGLH------
::.:::::::::.::.:..: .: :. : .: . .. :. .:. .
XP_016 CFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQAPSNYSLLDMR
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE5 -PGSTLIPMNNISVPQE--DDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKID
: ...: .:: :: : :.::.:::: :::::.:.:..::::.::::: : ..:
XP_016 PPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHIDILELD
280 290 300 310 320 330
450 460
pF1KE5 SYSRIFFPTAFALFNLVYWVGYLYL
::::.::::.: :::::::::::::
XP_016 SYSRVFFPTSFLLFNLVYWVGYLYL
340 350
>>XP_005268315 (OMIM: 137142) PREDICTED: gamma-aminobuty (462 aa)
initn: 1260 init1: 650 opt: 1258 Z-score: 1523.4 bits: 291.2 E(85289): 4.1e-78
Smith-Waterman score: 1258; 49.1% identity (75.6% similar) in 405 aa overlap (65-463:50-449)
40 50 60 70 80 90
pF1KE5 CVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDV
:.::..::.::::.::: .: : : ..::.
XP_005 ISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDI
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE5 YVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSR
::.:.:::. .::::::..: :.: : ::.:.. :. : ::. ...::: :::::.:..
XP_005 YVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGK
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE5 KSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKN
:: :: .::::.:::. .:: .:::.::::.::: .::..:::: :.:::.:.::.::..
XP_005 KSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNS
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE5 EIEYKWKK---PSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMG
:. : : . :: ::. :: :. ..: .:: : .:.:.::: : :.:..:
XP_005 EVVYVWTNGSTKSVVVAEDGS-RLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIG
200 210 220 230 240 250
280 290 300 310 320 330
pF1KE5 YFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVT
::.::::.:::.::.:: ::::.:...::::: .:.:::::::::: ::.:::::.:.:
XP_005 YFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYAT
260 270 280 290 300 310
340 350 360 370 380
pF1KE5 AMDLFVSVCFIFVFAALMEYGTLHYFTSN---QKGKTATKDRKLKNKASMTPGLHPGSTL
::: :..::. :::.::.:..:..:::. :: : . :.:.: . :. ...
XP_005 AMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVI--LNKSTNA
320 330 340 350 360 370
390 400 410 420 430 440
pF1KE5 IPMNNISVPQEDDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFP
. ...: : . : .. .: . .:. . . . :.:::..::: ::
XP_005 FTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESK--KTYNSISKIDKMSRIVFP
380 390 400 410 420 430
450 460
pF1KE5 TAFALFNLVYWVGYLYL
. :. ::::::. ::
XP_005 VLFGTFNLVYWATYLNREPVIKGAASPK
440 450 460
>>NP_001158509 (OMIM: 137142) gamma-aminobutyric acid re (462 aa)
initn: 1260 init1: 650 opt: 1258 Z-score: 1523.4 bits: 291.2 E(85289): 4.1e-78
Smith-Waterman score: 1258; 49.1% identity (75.6% similar) in 405 aa overlap (65-463:50-449)
40 50 60 70 80 90
pF1KE5 CVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDV
:.::..::.::::.::: .: : : ..::.
NP_001 ISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDI
20 30 40 50 60 70
100 110 120 130 140 150
pF1KE5 YVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSR
::.:.:::. .::::::..: :.: : ::.:.. :. : ::. ...::: :::::.:..
NP_001 YVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGK
80 90 100 110 120 130
160 170 180 190 200 210
pF1KE5 KSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKN
:: :: .::::.:::. .:: .:::.::::.::: .::..:::: :.:::.:.::.::..
NP_001 KSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNS
140 150 160 170 180 190
220 230 240 250 260 270
pF1KE5 EIEYKWKK---PSVEVADPKYWRLYQFAFVGLRNSTEITHTISGDYVIMTIFFDLSRRMG
:. : : . :: ::. :: :. ..: .:: : .:.:.::: : :.:..:
NP_001 EVVYVWTNGSTKSVVVAEDGS-RLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIG
200 210 220 230 240 250
280 290 300 310 320 330
pF1KE5 YFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVT
::.::::.:::.::.:: ::::.:...::::: .:.:::::::::: ::.:::::.:.:
NP_001 YFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYAT
260 270 280 290 300 310
340 350 360 370 380
pF1KE5 AMDLFVSVCFIFVFAALMEYGTLHYFTSN---QKGKTATKDRKLKNKASMTPGLHPGSTL
::: :..::. :::.::.:..:..:::. :: : . :.:.: . :. ...
NP_001 AMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVI--LNKSTNA
320 330 340 350 360 370
390 400 410 420 430 440
pF1KE5 IPMNNISVPQEDDYEYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFP
. ...: : . : .. .: . .:. . . . :.:::..::: ::
NP_001 FTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESK--KTYNSISKIDKMSRIVFP
380 390 400 410 420 430
450 460
pF1KE5 TAFALFNLVYWVGYLYL
. :. ::::::. ::
NP_001 VLFGTFNLVYWATYLNREPVIKGAASPK
440 450 460
465 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 01:25:42 2016 done: Tue Nov 8 01:25:43 2016
Total Scan time: 6.410 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]