Result of FASTA (omim) for
pFN21AE5448
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5448, 334 aa
1>>>pF1KE5448 334 - 334 aa - 334 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9207+/-0.000385; mu= 17.8826+/- 0.024
mean_var=62.3420+/-12.905, 0's: 0 Z-trim(111.7): 61 B-trim: 1111 in 1/53
Lambda= 0.162437
statistics sampled from 20290 (20366) to 20290 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.239), width: 16
Scan time: 6.330
The best scores are: opt bits E(85289)
NP_001188504 (OMIM: 603308) cathepsin L2 prepropro ( 334) 2327 554.1 1.5e-157
NP_001324 (OMIM: 603308) cathepsin L2 preproprotei ( 334) 2327 554.1 1.5e-157
NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 1836 439.0 6.5e-123
NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 1836 439.0 6.5e-123
NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 1836 439.0 6.5e-123
XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L ( 333) 1836 439.0 6.5e-123
NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 1836 439.0 6.5e-123
XP_011516565 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 1413 339.8 3.8e-93
XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 1413 339.8 3.8e-93
NP_000387 (OMIM: 265800,601105) cathepsin K prepro ( 329) 1130 273.6 4.1e-73
NP_004070 (OMIM: 116845) cathepsin S isoform 1 pre ( 331) 1116 270.3 4e-72
NP_001244902 (OMIM: 116880) cathepsin L1 isoform 2 ( 151) 803 196.7 2.6e-50
NP_001186668 (OMIM: 116845) cathepsin S isoform 2 ( 281) 795 195.0 1.6e-49
NP_004381 (OMIM: 116820) pro-cathepsin H isoform a ( 335) 790 193.9 4e-49
XP_016877440 (OMIM: 116820) PREDICTED: pro-catheps ( 317) 784 192.5 1e-48
XP_016877441 (OMIM: 116820) PREDICTED: pro-catheps ( 297) 777 190.8 3e-48
XP_005254238 (OMIM: 116820) PREDICTED: pro-catheps ( 297) 777 190.8 3e-48
XP_011543630 (OMIM: 603539,615362) PREDICTED: cath ( 424) 641 159.1 1.6e-38
NP_003784 (OMIM: 603539,615362) cathepsin F precur ( 484) 641 159.1 1.8e-38
NP_001325 (OMIM: 600550) cathepsin O preproprotein ( 321) 499 125.7 1.3e-28
NP_001306066 (OMIM: 116820) pro-cathepsin H isofor ( 201) 472 119.2 7.3e-27
NP_001805 (OMIM: 170650,245000,245010,602365) dipe ( 463) 452 114.8 3.7e-25
NP_001326 (OMIM: 602364) cathepsin W preproprotein ( 376) 408 104.4 3.9e-22
XP_011519578 (OMIM: 116820) PREDICTED: pro-catheps ( 169) 319 83.3 3.9e-16
NP_001327 (OMIM: 603169) cathepsin Z preproprotein ( 303) 298 78.6 1.9e-14
NP_001304166 (OMIM: 116810) cathepsin B isoform 2 ( 215) 232 63.0 6.6e-10
XP_016868590 (OMIM: 116810) PREDICTED: cathepsin B ( 245) 232 63.1 7.3e-10
NP_680093 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 232 63.1 9.5e-10
XP_016868588 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 232 63.1 9.5e-10
XP_006716307 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 232 63.1 9.5e-10
NP_001899 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 232 63.1 9.5e-10
NP_680090 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 232 63.1 9.5e-10
NP_680092 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 232 63.1 9.5e-10
XP_016868586 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 232 63.1 9.5e-10
XP_011542114 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 232 63.1 9.5e-10
XP_016868589 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 232 63.1 9.5e-10
XP_006716308 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 232 63.1 9.5e-10
XP_016868587 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 232 63.1 9.5e-10
NP_680091 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 232 63.1 9.5e-10
XP_005271164 (OMIM: 616064) PREDICTED: tubulointer ( 362) 208 57.5 4.9e-08
NP_001191344 (OMIM: 616064) tubulointerstitial nep ( 362) 208 57.5 4.9e-08
XP_011540248 (OMIM: 616064) PREDICTED: tubulointer ( 408) 208 57.6 5.4e-08
NP_001191343 (OMIM: 616064) tubulointerstitial nep ( 436) 208 57.6 5.7e-08
NP_071447 (OMIM: 616064) tubulointerstitial nephri ( 467) 208 57.6 6e-08
XP_016866237 (OMIM: 606749) PREDICTED: tubulointer ( 309) 196 54.7 3e-07
XP_016866236 (OMIM: 606749) PREDICTED: tubulointer ( 351) 196 54.7 3.4e-07
XP_016866235 (OMIM: 606749) PREDICTED: tubulointer ( 401) 196 54.8 3.7e-07
XP_011512799 (OMIM: 606749) PREDICTED: tubulointer ( 426) 196 54.8 3.9e-07
XP_006715125 (OMIM: 606749) PREDICTED: tubulointer ( 458) 196 54.8 4.2e-07
NP_055279 (OMIM: 606749) tubulointerstitial nephri ( 476) 196 54.8 4.3e-07
>>NP_001188504 (OMIM: 603308) cathepsin L2 preproprotein (334 aa)
initn: 2327 init1: 2327 opt: 2327 Z-score: 2949.5 bits: 554.1 E(85289): 1.5e-157
Smith-Waterman score: 2327; 100.0% identity (100.0% similar) in 334 aa overlap (1-334:1-334)
10 20 30 40 50 60
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
250 260 270 280 290 300
310 320 330
pF1KE5 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
::::::::::::::::::::::::::::::::::
NP_001 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
310 320 330
>>NP_001324 (OMIM: 603308) cathepsin L2 preproprotein [H (334 aa)
initn: 2327 init1: 2327 opt: 2327 Z-score: 2949.5 bits: 554.1 E(85289): 1.5e-157
Smith-Waterman score: 2327; 100.0% identity (100.0% similar) in 334 aa overlap (1-334:1-334)
10 20 30 40 50 60
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
250 260 270 280 290 300
310 320 330
pF1KE5 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
::::::::::::::::::::::::::::::::::
NP_001 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
310 320 330
>>NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 pre (333 aa)
initn: 1824 init1: 1251 opt: 1836 Z-score: 2327.6 bits: 439.0 E(85289): 6.5e-123
Smith-Waterman score: 1836; 77.5% identity (90.7% similar) in 334 aa overlap (1-334:1-333)
10 20 30 40 50 60
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
:: .:.:::::::::::. ::..:...: .::: : :::: ::::::::::::::::::
NP_001 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
::: :: .:::.::::::::::::.:::::.:. :.:.: ::::::.:::: . :.::::
NP_001 LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
:.:::::::::: :::::::::::::::::::::::.:.::::::::::: ::::.::::
NP_001 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
:.: :::::..:::::::::::: :..: ::: :. :::::::: : : .::::::::
NP_001 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF-VDIPKQEKALMKAV
190 200 210 220 230
250 260 270 280 290 300
pF1KE5 ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
:::::::::.:::: :: ::: ::::::::::...::::::::::::...:.:.::::::
NP_001 ATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVK
240 250 260 270 280 290
310 320 330
pF1KE5 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
:::: ::: .::::.:::. ::::::.:::::.:
NP_001 NSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 prepro (333 aa)
initn: 1824 init1: 1251 opt: 1836 Z-score: 2327.6 bits: 439.0 E(85289): 6.5e-123
Smith-Waterman score: 1836; 77.5% identity (90.7% similar) in 334 aa overlap (1-334:1-333)
10 20 30 40 50 60
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
:: .:.:::::::::::. ::..:...: .::: : :::: ::::::::::::::::::
NP_001 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
::: :: .:::.::::::::::::.:::::.:. :.:.: ::::::.:::: . :.::::
NP_001 LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
:.:::::::::: :::::::::::::::::::::::.:.::::::::::: ::::.::::
NP_001 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
:.: :::::..:::::::::::: :..: ::: :. :::::::: : : .::::::::
NP_001 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF-VDIPKQEKALMKAV
190 200 210 220 230
250 260 270 280 290 300
pF1KE5 ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
:::::::::.:::: :: ::: ::::::::::...::::::::::::...:.:.::::::
NP_001 ATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVK
240 250 260 270 280 290
310 320 330
pF1KE5 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
:::: ::: .::::.:::. ::::::.:::::.:
NP_001 NSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 pre (333 aa)
initn: 1824 init1: 1251 opt: 1836 Z-score: 2327.6 bits: 439.0 E(85289): 6.5e-123
Smith-Waterman score: 1836; 77.5% identity (90.7% similar) in 334 aa overlap (1-334:1-333)
10 20 30 40 50 60
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
:: .:.:::::::::::. ::..:...: .::: : :::: ::::::::::::::::::
NP_001 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
::: :: .:::.::::::::::::.:::::.:. :.:.: ::::::.:::: . :.::::
NP_001 LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
:.:::::::::: :::::::::::::::::::::::.:.::::::::::: ::::.::::
NP_001 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
:.: :::::..:::::::::::: :..: ::: :. :::::::: : : .::::::::
NP_001 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF-VDIPKQEKALMKAV
190 200 210 220 230
250 260 270 280 290 300
pF1KE5 ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
:::::::::.:::: :: ::: ::::::::::...::::::::::::...:.:.::::::
NP_001 ATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVK
240 250 260 270 280 290
310 320 330
pF1KE5 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
:::: ::: .::::.:::. ::::::.:::::.:
NP_001 NSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L1 is (333 aa)
initn: 1824 init1: 1251 opt: 1836 Z-score: 2327.6 bits: 439.0 E(85289): 6.5e-123
Smith-Waterman score: 1836; 77.5% identity (90.7% similar) in 334 aa overlap (1-334:1-333)
10 20 30 40 50 60
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
:: .:.:::::::::::. ::..:...: .::: : :::: ::::::::::::::::::
XP_005 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
::: :: .:::.::::::::::::.:::::.:. :.:.: ::::::.:::: . :.::::
XP_005 LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
:.:::::::::: :::::::::::::::::::::::.:.::::::::::: ::::.::::
XP_005 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
:.: :::::..:::::::::::: :..: ::: :. :::::::: : : .::::::::
XP_005 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF-VDIPKQEKALMKAV
190 200 210 220 230
250 260 270 280 290 300
pF1KE5 ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
:::::::::.:::: :: ::: ::::::::::...::::::::::::...:.:.::::::
XP_005 ATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVK
240 250 260 270 280 290
310 320 330
pF1KE5 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
:::: ::: .::::.:::. ::::::.:::::.:
XP_005 NSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 prepro (333 aa)
initn: 1824 init1: 1251 opt: 1836 Z-score: 2327.6 bits: 439.0 E(85289): 6.5e-123
Smith-Waterman score: 1836; 77.5% identity (90.7% similar) in 334 aa overlap (1-334:1-333)
10 20 30 40 50 60
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
:: .:.:::::::::::. ::..:...: .::: : :::: ::::::::::::::::::
NP_666 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
::: :: .:::.::::::::::::.:::::.:. :.:.: ::::::.:::: . :.::::
NP_666 LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
:.:::::::::: :::::::::::::::::::::::.:.::::::::::: ::::.::::
NP_666 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
:.: :::::..:::::::::::: :..: ::: :. :::::::: : : .::::::::
NP_666 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF-VDIPKQEKALMKAV
190 200 210 220 230
250 260 270 280 290 300
pF1KE5 ATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVK
:::::::::.:::: :: ::: ::::::::::...::::::::::::...:.:.::::::
NP_666 ATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVK
240 250 260 270 280 290
310 320 330
pF1KE5 NSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
:::: ::: .::::.:::. ::::::.:::::.:
NP_666 NSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
300 310 320 330
>>XP_011516565 (OMIM: 116880) PREDICTED: cathepsin L1 is (272 aa)
initn: 1410 init1: 1251 opt: 1413 Z-score: 1793.2 bits: 339.8 E(85289): 3.8e-93
Smith-Waterman score: 1413; 77.0% identity (89.4% similar) in 265 aa overlap (1-264:1-264)
10 20 30 40 50 60
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
:: .:.:::::::::::. ::..:...: .::: : :::: ::::::::::::::::::
XP_011 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
::: :: .:::.::::::::::::.:::::.:. :.:.: ::::::.:::: . :.::::
XP_011 LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
:.:::::::::: :::::::::::::::::::::::.:.::::::::::: ::::.::::
XP_011 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
:.: :::::..:::::::::::: :..: ::: :. :::::::: : : .::::::::
XP_011 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF-VDIPKQEKALMKAV
190 200 210 220 230
250 260 270 280 290
pF1KE5 ATVGPISVAMDAGHSSFQFYK-SGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLV
:::::::::.:::: :: ::: .:.
XP_011 ATVGPISVAIDAGHESFLFYKEAGVKNGAWVAT
240 250 260 270
>>XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L1 is (272 aa)
initn: 1410 init1: 1251 opt: 1413 Z-score: 1793.2 bits: 339.8 E(85289): 3.8e-93
Smith-Waterman score: 1413; 77.0% identity (89.4% similar) in 265 aa overlap (1-264:1-264)
10 20 30 40 50 60
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIE
:: .:.:::::::::::. ::..:...: .::: : :::: ::::::::::::::::::
XP_016 MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLDLPKSVDW
::: :: .:::.::::::::::::.:::::.:. :.:.: ::::::.:::: . :.::::
XP_016 LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNG
:.:::::::::: :::::::::::::::::::::::.:.::::::::::: ::::.::::
XP_016 REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 GFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAV
:.: :::::..:::::::::::: :..: ::: :. :::::::: : : .::::::::
XP_016 GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF-VDIPKQEKALMKAV
190 200 210 220 230
250 260 270 280 290
pF1KE5 ATVGPISVAMDAGHSSFQFYK-SGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLV
:::::::::.:::: :: ::: .:.
XP_016 ATVGPISVAIDAGHESFLFYKEAGVKNGAWVAT
240 250 260 270
>>NP_000387 (OMIM: 265800,601105) cathepsin K preproprot (329 aa)
initn: 1121 init1: 447 opt: 1130 Z-score: 1433.6 bits: 273.6 E(85289): 4.1e-73
Smith-Waterman score: 1130; 50.6% identity (76.5% similar) in 332 aa overlap (7-334:4-329)
10 20 30 40 50
pF1KE5 MNLSLVLAAFCLGIASAVPKFDQNLDTKWYQWKATHRRLYGAN-EEGWRRAVWEKNMKMI
: .. : ..: . .. :::.: :: :::. :. . .: :: .::::.:.:
NP_000 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYI
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 ELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRN--QKFRKGKVFREPLFLD-LPK
.:: : : : : . .::: .::::.:: : : .. .. :.. .. : . :
NP_000 SIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPD
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 SVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQ
:::.:::::::::::: :::::::::..::::::. .:::::..:: :::::: :.
NP_000 SVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--ND
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 GCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKAL
::.::.:. :::::..: :.:::..::::. .: : : : ...:. :. . :.::::
NP_000 GCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE5 MKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKY
.::: :::.:::.::. .:::::..:.:.. .:.: ::.:.::.::::.. .: :.
NP_000 KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGN----KH
240 250 260 270 280 290
300 310 320 330
pF1KE5 WLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV
:..::::: .::..::. .:..::: ::::. ::.:..
NP_000 WIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
300 310 320
334 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 00:52:10 2016 done: Tue Nov 8 00:52:11 2016
Total Scan time: 6.330 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]