Result of FASTA (omim) for
pFN21AE5418
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5418, 318 aa
1>>>pF1KE5418 318 - 318 aa - 318 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6675+/-0.000393; mu= 19.2395+/- 0.024
mean_var=65.8008+/-14.090, 0's: 0 Z-trim(113.1): 45 B-trim: 116 in 1/52
Lambda= 0.158110
statistics sampled from 22213 (22255) to 22213 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.261), width: 16
Scan time: 6.120
The best scores are: opt bits E(85289)
NP_078868 (OMIM: 611715,612379,612713) polyprenol ( 318) 2207 512.3 5.2e-145
XP_016864090 (OMIM: 611715,612379,612713) PREDICTE ( 273) 1701 396.8 2.6e-110
XP_005265823 (OMIM: 611715,612379,612713) PREDICTE ( 273) 1296 304.4 1.7e-82
XP_005265824 (OMIM: 611715,612379,612713) PREDICTE ( 207) 860 204.9 1.2e-52
XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-ox ( 169) 200 54.3 2.1e-07
XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-ox ( 180) 200 54.3 2.2e-07
NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-ster ( 254) 200 54.4 2.9e-07
NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 212) 165 46.4 6.4e-05
NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-d ( 259) 165 46.4 7.4e-05
NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 186) 162 45.6 9.3e-05
>>NP_078868 (OMIM: 611715,612379,612713) polyprenol redu (318 aa)
initn: 2207 init1: 2207 opt: 2207 Z-score: 2724.3 bits: 512.3 E(85289): 5.2e-145
Smith-Waterman score: 2207; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:1-318)
10 20 30 40 50 60
pF1KE5 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK
250 260 270 280 290 300
310
pF1KE5 SKFVSYPKHRKAFLPFLF
::::::::::::::::::
NP_078 SKFVSYPKHRKAFLPFLF
310
>>XP_016864090 (OMIM: 611715,612379,612713) PREDICTED: p (273 aa)
initn: 1701 init1: 1701 opt: 1701 Z-score: 2101.4 bits: 396.8 E(85289): 2.6e-110
Smith-Waterman score: 1701; 100.0% identity (100.0% similar) in 245 aa overlap (74-318:29-273)
50 60 70 80 90 100
pF1KE5 AIFQDLIRYGKTKCGEPSRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAP
::::::::::::::::::::::::::::::
XP_016 MAQYRLTATSTSRVQAILLPKPPSSREHRYFSHFYIISVLWNGFLLWCLTQSLFLGAP
10 20 30 40 50
110 120 130 140 150 160
pF1KE5 FPSWLHGLLRILGAAQFQGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FPSWLHGLLRILGAAQFQGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQY
60 70 80 90 100 110
170 180 190 200 210 220
pF1KE5 CFGLVYYVLVGLTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CFGLVYYVLVGLTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVI
120 130 140 150 160 170
230 240 250 260 270 280
pF1KE5 LGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTN
180 190 200 210 220 230
290 300 310
pF1KE5 VFFNQALSAFLSHQFYKSKFVSYPKHRKAFLPFLF
:::::::::::::::::::::::::::::::::::
XP_016 VFFNQALSAFLSHQFYKSKFVSYPKHRKAFLPFLF
240 250 260 270
>>XP_005265823 (OMIM: 611715,612379,612713) PREDICTED: p (273 aa)
initn: 1319 init1: 1291 opt: 1296 Z-score: 1602.2 bits: 304.4 E(85289): 1.7e-82
Smith-Waterman score: 1792; 85.8% identity (85.8% similar) in 318 aa overlap (1-318:1-273)
10 20 30 40 50 60
pF1KE5 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH
::::::: ::::::::
XP_005 VPMDGRN---------------------------------------------GVVIHCNH
190
250 260 270 280 290 300
pF1KE5 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK
200 210 220 230 240 250
310
pF1KE5 SKFVSYPKHRKAFLPFLF
::::::::::::::::::
XP_005 SKFVSYPKHRKAFLPFLF
260 270
>>XP_005265824 (OMIM: 611715,612379,612713) PREDICTED: p (207 aa)
initn: 879 init1: 860 opt: 860 Z-score: 1066.3 bits: 204.9 E(85289): 1.2e-52
Smith-Waterman score: 1224; 65.1% identity (65.1% similar) in 318 aa overlap (1-318:1-207)
10 20 30 40 50 60
pF1KE5 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ
::
XP_005 QG----------------------------------------------------------
190 200 210 220 230 240
pF1KE5 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH
:::::::
XP_005 -----------------------------------------------------VVIHCNH
250 260 270 280 290 300
pF1KE5 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK
130 140 150 160 170 180
310
pF1KE5 SKFVSYPKHRKAFLPFLF
::::::::::::::::::
XP_005 SKFVSYPKHRKAFLPFLF
190 200
>>XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (169 aa)
initn: 204 init1: 108 opt: 200 Z-score: 253.8 bits: 54.3 E(85289): 2.1e-07
Smith-Waterman score: 200; 36.4% identity (65.3% similar) in 118 aa overlap (205-318:63-169)
180 190 200 210 220 230
pF1KE5 LTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGV
::...:: . . . . :: .:: : :
XP_011 FCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLR--KPGE
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE5 VIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWL-VVTNVFFNQ---AL
. ..::: : : :::. :.:.:.. ....:.. :: : ... .::. .:
XP_011 I---SYRIPQGGLFTYVSGANFLGEIIEWIGYALA------TWSLPALAFAFFSLCFLGL
100 110 120 130 140
300 310
pF1KE5 SAFLSHQFYKSKFVSYPKHRKAFLPFLF
:: :.:: . : .::: :::..::.:
XP_011 RAFHHHRFYLKMFEDYPKSRKALIPFIF
150 160
>>XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (180 aa)
initn: 204 init1: 108 opt: 200 Z-score: 253.4 bits: 54.3 E(85289): 2.2e-07
Smith-Waterman score: 200; 36.4% identity (65.3% similar) in 118 aa overlap (205-318:74-180)
180 190 200 210 220 230
pF1KE5 LTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGV
::...:: . . . . :: .:: : :
XP_011 FCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLR--KPGE
50 60 70 80 90 100
240 250 260 270 280 290
pF1KE5 VIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWL-VVTNVFFNQ---AL
. ..::: : : :::. :.:.:.. ....:.. :: : ... .::. .:
XP_011 I---SYRIPQGGLFTYVSGANFLGEIIEWIGYALA------TWSLPALAFAFFSLCFLGL
110 120 130 140 150
300 310
pF1KE5 SAFLSHQFYKSKFVSYPKHRKAFLPFLF
:: :.:: . : .::: :::..::.:
XP_011 RAFHHHRFYLKMFEDYPKSRKALIPFIF
160 170 180
>>NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-steroid (254 aa)
initn: 204 init1: 108 opt: 200 Z-score: 251.5 bits: 54.4 E(85289): 2.9e-07
Smith-Waterman score: 200; 36.4% identity (65.3% similar) in 118 aa overlap (205-318:148-254)
180 190 200 210 220 230
pF1KE5 LTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGV
::...:: . . . . :: .:: : :
NP_000 FCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLR--KPGE
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE5 VIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWL-VVTNVFFNQ---AL
. ..::: : : :::. :.:.:.. ....:.. :: : ... .::. .:
NP_000 I---SYRIPQGGLFTYVSGANFLGEIIEWIGYALA------TWSLPALAFAFFSLCFLGL
180 190 200 210 220
300 310
pF1KE5 SAFLSHQFYKSKFVSYPKHRKAFLPFLF
:: :.:: . : .::: :::..::.:
NP_000 RAFHHHRFYLKMFEDYPKSRKALIPFIF
230 240 250
>>NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (212 aa)
initn: 218 init1: 95 opt: 165 Z-score: 209.3 bits: 46.4 E(85289): 6.4e-05
Smith-Waterman score: 165; 33.9% identity (55.4% similar) in 121 aa overlap (206-318:105-212)
180 190 200 210 220 230
pF1KE5 TVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHV--ILGNLRKNKAG
:. . .: .. . : :: :::: :
NP_001 CRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRK--PG
80 90 100 110 120 130
240 250 260 270 280 290
pF1KE5 VVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAF
...:: : ::::.. ::..:.: . ..:.. .: : .. : :
NP_001 ---DTGYKIPRGGLFEYVTAANYFGEIMEWCGYALA------SW--SVQGAAFAFFTFCF
140 150 160 170 180
300 310
pF1KE5 LS------HQFYKSKFVSYPKHRKAFLPFLF
:: :..: :: ::: :: ..::::
NP_001 LSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
190 200 210
>>NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-dehyd (259 aa)
initn: 241 init1: 95 opt: 165 Z-score: 208.2 bits: 46.4 E(85289): 7.4e-05
Smith-Waterman score: 165; 27.9% identity (50.7% similar) in 201 aa overlap (141-318:79-259)
120 130 140 150 160
pF1KE5 LLRILGAAQFQGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVY-
:: .:. ...: ..: . : :.:
NP_001 RVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMF---LVHYGHRC--LIYP
50 60 70 80 90 100
170 180 190 200 210
pF1KE5 YVLVG------LTVLSQVPMDGRNAYITGKNLLMQA----RWF----HILGMMMFIWSSA
... : :. . . :.:. .. : : : ..:. . : ..
NP_001 FLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGL--WLTG
110 120 130 140 150 160
220 230 240 250 260 270
pF1KE5 HQYKCHV--ILGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFH
. : :: :::: : ...:: : ::::.. ::..:.: . ..:..
NP_001 MLINIHSDHILRNLRK--PG---DTGYKIPRGGLFEYVTAANYFGEIMEWCGYALA----
170 180 190 200 210
280 290 300 310
pF1KE5 NLTWWLVVTNVFFNQALSAFLS------HQFYKSKFVSYPKHRKAFLPFLF
.: : .. : ::: :..: :: ::: :: ..::::
NP_001 --SW--SVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF
220 230 240 250
>>NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (186 aa)
initn: 234 init1: 95 opt: 162 Z-score: 206.4 bits: 45.6 E(85289): 9.3e-05
Smith-Waterman score: 162; 34.5% identity (55.2% similar) in 116 aa overlap (211-318:84-186)
190 200 210 220 230
pF1KE5 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHV--ILGNLRKNKAGVVIHC
.: .. . : :: ::: : :
NP_001 NGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLR--KPG---DT
60 70 80 90 100
240 250 260 270 280 290
pF1KE5 NHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLS---
...:: : ::::.. ::..:.: . ..:.. .: : .. : :::
NP_001 GYKIPRGGLFEYVTAANYFGEIMEWCGYALA------SW--SVQGAAFAFFTFCFLSGRA
110 120 130 140 150 160
300 310
pF1KE5 ---HQFYKSKFVSYPKHRKAFLPFLF
:..: :: ::: :: ..::::
NP_001 KEHHEWYLRKFEEYPKFRKIIIPFLF
170 180
318 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 00:33:49 2016 done: Tue Nov 8 00:33:50 2016
Total Scan time: 6.120 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]