FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE5370, 288 aa
  1>>>pF1KE5370 288 - 288 aa - 288 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.5980+/-0.000425; mu= 0.3592+/- 0.026
 mean_var=188.6164+/-37.464, 0's: 0 Z-trim(116.9): 27  B-trim: 0 in 0/56
 Lambda= 0.093387
 statistics sampled from 28385 (28411) to 28385 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.333), width:  16
 Scan time:  7.210

The best scores are:                                      opt bits E(85289)
NP_997203 (OMIM: 300714) OTU domain-containing pro ( 288) 1878 265.2 1.1e-70
NP_057107 (OMIM: 612021) OTU domain-containing pro ( 323) 1057 154.6 2.3e-37
NP_001273674 (OMIM: 612021) OTU domain-containing  ( 192)  719 108.9 7.8e-24
XP_011515431 (OMIM: 612021) PREDICTED: OTU domain- ( 192)  719 108.9 7.8e-24


>>NP_997203 (OMIM: 300714) OTU domain-containing protein  (288 aa)
 initn: 1878 init1: 1878 opt: 1878  Z-score: 1390.3  bits: 265.2 E(85289): 1.1e-70
Smith-Waterman score: 1878; 100.0% identity (100.0% similar) in 288 aa overlap (1-288:1-288)

               10        20        30        40        50        60
pF1KE5 MDDPKSEQQRILRRHQRERQELQAQIRSLKNSVPKTDKTKRKQLLQDVARMEAEMAQKHR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 MDDPKSEQQRILRRHQRERQELQAQIRSLKNSVPKTDKTKRKQLLQDVARMEAEMAQKHR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE5 QELEKFQDDSSIESVVEDLAKMNLENRPPRSSKAHRKRERMESEERERQESIFQAEMSEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 QELEKFQDDSSIESVVEDLAKMNLENRPPRSSKAHRKRERMESEERERQESIFQAEMSEH
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE5 LAGFKREEEEKLAAILGARGLEMKAIPADGHCMYRAIQDQLVFSVSVEMLRCRTASYMKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 LAGFKREEEEKLAAILGARGLEMKAIPADGHCMYRAIQDQLVFSVSVEMLRCRTASYMKK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE5 HVDEFLPFFSNPETSDSFGYDDFMIYCDNIVRTTAWGGQLELRALSHVLKTPIEVIQADS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 HVDEFLPFFSNPETSDSFGYDDFMIYCDNIVRTTAWGGQLELRALSHVLKTPIEVIQADS
              190       200       210       220       230       240

              250       260       270       280        
pF1KE5 PTLIIGEEYVKKPIILVYLRYAYSLGEHYNSVTPLEAGAAGGVLPRLL
       ::::::::::::::::::::::::::::::::::::::::::::::::
NP_997 PTLIIGEEYVKKPIILVYLRYAYSLGEHYNSVTPLEAGAAGGVLPRLL
              250       260       270       280        

>>NP_057107 (OMIM: 612021) OTU domain-containing protein  (323 aa)
 initn: 1037 init1: 507 opt: 1057  Z-score: 791.8  bits: 154.6 E(85289): 2.3e-37
Smith-Waterman score: 1057; 56.7% identity (85.5% similar) in 275 aa overlap (7-275:41-314)

                                       10        20        30      
pF1KE5                         MDDPKSEQQRILRRHQRERQELQAQIRSLKNSVPKT
                                     :....::::..:..::::.:...::.:::.
NP_057 KVPTSRCRFLLARVLGYLVVMEAVLTEELDEEEQLLRRHRKEKKELQAKIQGMKNAVPKN
               20        30        40        50        60        70

         40        50        60           70        80        90   
pF1KE5 DKTKRKQLLQDVARMEAEMAQKHRQELEKFQ---DDSSIESVVEDLAKMNLENRPPRSSK
       :: .:::: .:::..: :: ::::.:::...    ...:.::. ..... :::.::: ::
NP_057 DKKRRKQLTEDVAKLEKEMEQKHREELEQLKLTTKENKIDSVAVNISNLVLENQPPRISK
               80        90       100       110       120       130

           100       110       120       130       140       150   
pF1KE5 AHRKRERMESEERERQESIFQAEMSEHLAGFKREEEEKLAAILGARGLEMKAIPADGHCM
       :...::.  . :.::.: : .::. :.:.: .. : :::: ::.:: ::.: ::.:::::
NP_057 AQKRREKKAALEKEREERIAEAEI-ENLTGARHMESEKLAQILAARQLEIKQIPSDGHCM
              140       150        160       170       180         

           160          170       180       190       200       210
pF1KE5 YRAIQDQLV---FSVSVEMLRCRTASYMKKHVDEFLPFFSNPETSDSFGYDDFMIYCDNI
       :.::.:::     ...:  :: .:: ::..::..::::..::.:.: .  ..:. ::..:
NP_057 YKAIEDQLKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDI
     190       200       210       220       230       240         

              220       230       240       250       260       270
pF1KE5 VRTTAWGGQLELRALSHVLKTPIEVIQADSPTLIIGEEYVKKPIILVYLRYAYSLGEHYN
       : :.:::::::::::::.:.::::.:::::: .:.:::: :::.::::.:.::.::::::
NP_057 VNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPLILVYMRHAYGLGEHYN
     250       260       270       280       290       300         

              280        
pF1KE5 SVTPLEAGAAGGVLPRLL
       ::: :             
NP_057 SVTRLVNIVTENCS    
     310       320       

>>NP_001273674 (OMIM: 612021) OTU domain-containing prot  (192 aa)
 initn: 703 init1: 507 opt: 719  Z-score: 548.9  bits: 108.9 E(85289): 7.8e-24
Smith-Waterman score: 719; 59.7% identity (84.0% similar) in 181 aa overlap (98-275:4-183)

        70        80        90       100       110       120       
pF1KE5 DDSSIESVVEDLAKMNLENRPPRSSKAHRKRERMESEERERQESIFQAEMSEHLAGFKRE
                                     .:.  . :.::.: : .::. :.:.: .. 
NP_001                            MISKEKKAALEKEREERIAEAEI-ENLTGARHM
                                          10        20         30  

       130       140       150       160          170       180    
pF1KE5 EEEKLAAILGARGLEMKAIPADGHCMYRAIQDQLV---FSVSVEMLRCRTASYMKKHVDE
       : :::: ::.:: ::.: ::.::::::.::.:::     ...:  :: .:: ::..::..
NP_001 ESEKLAQILAARQLEIKQIPSDGHCMYKAIEDQLKEKDCALTVVALRSQTAEYMQSHVED
             40        50        60        70        80        90  

          190       200       210       220       230       240    
pF1KE5 FLPFFSNPETSDSFGYDDFMIYCDNIVRTTAWGGQLELRALSHVLKTPIEVIQADSPTLI
       ::::..::.:.: .  ..:. ::..:: :.:::::::::::::.:.::::.:::::: .:
NP_001 FLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPII
            100       110       120       130       140       150  

          250       260       270       280        
pF1KE5 IGEEYVKKPIILVYLRYAYSLGEHYNSVTPLEAGAAGGVLPRLL
       .:::: :::.::::.:.::.::::::::: :             
NP_001 VGEEYSKKPLILVYMRHAYGLGEHYNSVTRLVNIVTENCS    
            160       170       180       190      

>>XP_011515431 (OMIM: 612021) PREDICTED: OTU domain-cont  (192 aa)
 initn: 703 init1: 507 opt: 719  Z-score: 548.9  bits: 108.9 E(85289): 7.8e-24
Smith-Waterman score: 719; 59.7% identity (84.0% similar) in 181 aa overlap (98-275:4-183)

        70        80        90       100       110       120       
pF1KE5 DDSSIESVVEDLAKMNLENRPPRSSKAHRKRERMESEERERQESIFQAEMSEHLAGFKRE
                                     .:.  . :.::.: : .::. :.:.: .. 
XP_011                            MISKEKKAALEKEREERIAEAEI-ENLTGARHM
                                          10        20         30  

       130       140       150       160          170       180    
pF1KE5 EEEKLAAILGARGLEMKAIPADGHCMYRAIQDQLV---FSVSVEMLRCRTASYMKKHVDE
       : :::: ::.:: ::.: ::.::::::.::.:::     ...:  :: .:: ::..::..
XP_011 ESEKLAQILAARQLEIKQIPSDGHCMYKAIEDQLKEKDCALTVVALRSQTAEYMQSHVED
             40        50        60        70        80        90  

          190       200       210       220       230       240    
pF1KE5 FLPFFSNPETSDSFGYDDFMIYCDNIVRTTAWGGQLELRALSHVLKTPIEVIQADSPTLI
       ::::..::.:.: .  ..:. ::..:: :.:::::::::::::.:.::::.:::::: .:
XP_011 FLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLELRALSHILQTPIEIIQADSPPII
            100       110       120       130       140       150  

          250       260       270       280        
pF1KE5 IGEEYVKKPIILVYLRYAYSLGEHYNSVTPLEAGAAGGVLPRLL
       .:::: :::.::::.:.::.::::::::: :             
XP_011 VGEEYSKKPLILVYMRHAYGLGEHYNSVTRLVNIVTENCS    
            160       170       180       190      




288 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Nov  8 07:35:26 2016 done: Tue Nov  8 07:35:27 2016
 Total Scan time:  7.210 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]