Result of FASTA (omim) for
pFN21AE5364
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5364, 299 aa
1>>>pF1KE5364 299 - 299 aa - 299 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1681+/-0.00033; mu= 16.8434+/- 0.021
mean_var=71.4870+/-14.596, 0's: 0 Z-trim(115.8): 12 B-trim: 0 in 0/53
Lambda= 0.151691
statistics sampled from 26446 (26456) to 26446 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.675), E-opt: 0.2 (0.31), width: 16
Scan time: 4.870
The best scores are: opt bits E(85289)
NP_076979 (OMIM: 611235) trimeric intracellular ca ( 299) 2042 455.7 5e-128
NP_060582 (OMIM: 611236,615066) trimeric intracell ( 291) 836 191.8 1.4e-48
XP_005252134 (OMIM: 611236,615066) PREDICTED: trim ( 220) 791 181.8 1e-45
XP_005252133 (OMIM: 611236,615066) PREDICTED: trim ( 225) 791 181.9 1e-45
XP_011517131 (OMIM: 611236,615066) PREDICTED: trim ( 215) 662 153.6 3.1e-37
XP_011517133 (OMIM: 611236,615066) PREDICTED: trim ( 215) 662 153.6 3.1e-37
XP_005252132 (OMIM: 611236,615066) PREDICTED: trim ( 237) 655 152.1 9.8e-37
XP_011517135 (OMIM: 611236,615066) PREDICTED: trim ( 175) 430 102.8 5.2e-22
XP_011517134 (OMIM: 611236,615066) PREDICTED: trim ( 200) 312 77.0 3.4e-14
>>NP_076979 (OMIM: 611235) trimeric intracellular cation (299 aa)
initn: 2042 init1: 2042 opt: 2042 Z-score: 2419.5 bits: 455.7 E(85289): 5e-128
Smith-Waterman score: 2042; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299)
10 20 30 40 50 60
pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL
190 200 210 220 230 240
250 260 270 280 290
pF1KE5 EGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_076 EGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD
250 260 270 280 290
>>NP_060582 (OMIM: 611236,615066) trimeric intracellular (291 aa)
initn: 829 init1: 829 opt: 836 Z-score: 993.3 bits: 191.8 E(85289): 1.4e-48
Smith-Waterman score: 836; 41.5% identity (76.2% similar) in 294 aa overlap (11-299:7-291)
10 20 30 40 50 60
pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML
::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. :::
NP_060 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA
::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. .
NP_060 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI
::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .:
NP_060 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL
:.::.:.:..: :...::.:.:. : .:: .:.:..:.:.:. :. . .:.. . : .
NP_060 LKMSYPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYTIFIVATKITMMTTQTSTMTFAPF
180 190 200 210 220 230
250 260 270 280 290
pF1KE5 EGYICPVLFG-----SACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKA
: . .::: :.: .. ... : :.: ... .: . :.. .::..
NP_060 EDTLSWMLFGWQQPFSSC----EKKSEAKSPSNGV-----GSLASKPVDVASDNVKKKHT
240 250 260 270 280
pF1KE5 KKAD
:: .
NP_060 KKNE
290
>>XP_005252134 (OMIM: 611236,615066) PREDICTED: trimeric (220 aa)
initn: 791 init1: 791 opt: 791 Z-score: 941.8 bits: 181.8 E(85289): 1e-45
Smith-Waterman score: 791; 49.1% identity (84.1% similar) in 214 aa overlap (11-224:7-220)
10 20 30 40 50 60
pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML
::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. :::
XP_005 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA
::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. .
XP_005 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI
::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .:
XP_005 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL
:.::.:.:..: :...::.:.:. : .:: .:.:..:.:.:. :
XP_005 LKMSYPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYTIFIVATK
180 190 200 210 220
250 260 270 280 290
pF1KE5 EGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD
>>XP_005252133 (OMIM: 611236,615066) PREDICTED: trimeric (225 aa)
initn: 791 init1: 791 opt: 791 Z-score: 941.6 bits: 181.9 E(85289): 1e-45
Smith-Waterman score: 791; 49.1% identity (84.1% similar) in 214 aa overlap (11-224:7-220)
10 20 30 40 50 60
pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML
::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. :::
XP_005 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA
::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. .
XP_005 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI
::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .:
XP_005 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL
:.::.:.:..: :...::.:.:. : .:: .:.:..:.:.:. :
XP_005 LKMSYPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYTIFIVATKSLNWR
180 190 200 210 220
250 260 270 280 290
pF1KE5 EGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD
>>XP_011517131 (OMIM: 611236,615066) PREDICTED: trimeric (215 aa)
initn: 662 init1: 662 opt: 662 Z-score: 789.3 bits: 153.6 E(85289): 3.1e-37
Smith-Waterman score: 662; 50.3% identity (83.4% similar) in 175 aa overlap (11-185:7-181)
10 20 30 40 50 60
pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML
::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. :::
XP_011 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA
::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. .
XP_011 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI
::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .:
XP_011 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL
:.::.
XP_011 LKMSYFRVHVQNVQPCQGNPAGVSYLHIPAHPASGNIKA
180 190 200 210
>>XP_011517133 (OMIM: 611236,615066) PREDICTED: trimeric (215 aa)
initn: 662 init1: 662 opt: 662 Z-score: 789.3 bits: 153.6 E(85289): 3.1e-37
Smith-Waterman score: 662; 50.3% identity (83.4% similar) in 175 aa overlap (11-185:7-181)
10 20 30 40 50 60
pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML
::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. :::
XP_011 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA
::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. .
XP_011 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI
::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .:
XP_011 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL
:.::.
XP_011 LKMSYFRVHVQNVQPCQGNPAGVSYLHIPAHPASGNIKA
180 190 200 210
>>XP_005252132 (OMIM: 611236,615066) PREDICTED: trimeric (237 aa)
initn: 648 init1: 648 opt: 655 Z-score: 780.5 bits: 152.1 E(85289): 9.8e-37
Smith-Waterman score: 655; 40.2% identity (74.4% similar) in 246 aa overlap (59-299:1-237)
30 40 50 60 70 80
pF1KE5 YFIVSILYLKYEPGAVELSRRHPIASWLCAMLHCFGSYILADLLLGEPLIDYFSNNSSIL
::::::. ::. :::.:: . ...:...::
XP_005 MLHCFGGGILSCLLLAEPPLKFLANHTNIL
10 20 30
90 100 110 120 130 140
pF1KE5 LASAVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFVM
:::..::. :::: :: . .:::.:. .::::.:. ::. :. ::. .:..::.::
XP_005 LASSIWYITFFCPHDLVSQGYSYLPVQLLASGMKEVTRTWKIVGGVTHANSYYKNGWIVM
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE5 IATGWVKGSGVALMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVS
:: ::..:.: ....:::.:..: :::: .: :.::.:.:..: :...::.:.:. : .:
XP_005 IAIGWARGAGGTIITNFERLVKGDWKPEGDEWLKMSYPAKVTLLGSVIFTFQHTQHLAIS
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE5 KASLIFIFTLFMVSCKVFLTATHSHSSPFDALEGYICPVLFG-----SACGGDHHHDNHG
: .:.:..:.:.:. :. . .:.. . : .: . .::: :.: .. ...
XP_005 KHNLMFLYTIFIVATKITMMTTQTSTMTFAPFEDTLSWMLFGWQQPFSSC----EKKSEA
160 170 180 190 200
270 280 290
pF1KE5 GSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD
: :.: ... .: . :.. .::..:: .
XP_005 KSPSNGV-----GSLASKPVDVASDNVKKKHTKKNE
210 220 230
>>XP_011517135 (OMIM: 611236,615066) PREDICTED: trimeric (175 aa)
initn: 423 init1: 423 opt: 430 Z-score: 516.2 bits: 102.8 E(85289): 5.2e-22
Smith-Waterman score: 430; 37.0% identity (72.8% similar) in 184 aa overlap (121-299:1-175)
100 110 120 130 140 150
pF1KE5 SAVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFVMIA
::::.:. ::. :. ::. .:..::.::::
XP_011 MKEVTRTWKIVGGVTHANSYYKNGWIVMIA
10 20 30
160 170 180 190 200 210
pF1KE5 TGWVKGSGVALMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKA
::..:.: ....:::.:..: :::: .: :.::.:.:..: :...::.:.:. : .::
XP_011 IGWARGAGGTIITNFERLVKGDWKPEGDEWLKMSYPAKVTLLGSVIFTFQHTQHLAISKH
40 50 60 70 80 90
220 230 240 250 260
pF1KE5 SLIFIFTLFMVSCKVFLTATHSHSSPFDALEGYICPVLFG-----SACGGDHHHDNHGGS
.:.:..:.:.:. :. . .:.. . : .: . .::: :.: .. ... :
XP_011 NLMFLYTIFIVATKITMMTTQTSTMTFAPFEDTLSWMLFGWQQPFSSC----EKKSEAKS
100 110 120 130 140
270 280 290
pF1KE5 HSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD
:.: ... .: . :.. .::..:: .
XP_011 PSNGV-----GSLASKPVDVASDNVKKKHTKKNE
150 160 170
>>XP_011517134 (OMIM: 611236,615066) PREDICTED: trimeric (200 aa)
initn: 328 init1: 311 opt: 312 Z-score: 375.8 bits: 77.0 E(85289): 3.4e-14
Smith-Waterman score: 312; 48.4% identity (81.3% similar) in 91 aa overlap (11-101:7-91)
10 20 30 40 50 60
pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML
::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. :::
XP_011 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA
::::. ::. :::.:: . ...:...:::::.. ::
XP_011 HCFGGGILSCLLLAEPPLKFLANHTNILLASSI------CPAKVTLLGSVIFTFQHTQHL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI
XP_011 AISKHNLMFLYTIFIVATKITMMTTQTSTMTFAPFEDTLSWMLFGWQQPFSSCEKKSEAK
120 130 140 150 160 170
>--
initn: 168 init1: 157 opt: 164 Z-score: 200.8 bits: 44.6 E(85289): 0.00019
Smith-Waterman score: 164; 27.4% identity (65.0% similar) in 117 aa overlap (188-299:93-200)
160 170 180 190 200 210
pF1KE5 GVALMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFT
:..: :...::.:.:. : .:: .:.:..:
XP_011 ILSCLLLAEPPLKFLANHTNILLASSICPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYT
70 80 90 100 110 120
220 230 240 250 260 270
pF1KE5 LFMVSCKVFLTATHSHSSPFDALEGYICPVLFG-----SACGGDHHHDNHGGSHSGGGPG
.:.:. :. . .:.. . : .: . .::: :.: ... . .. :.. :
XP_011 IFIVATKITMMTTQTSTMTFAPFEDTLSWMLFGWQQPFSSC--EKKSEAKSPSNGVG---
130 140 150 160 170
280 290
pF1KE5 AQHSAMPAKSKEELSEGSRKKKAKKAD
.. .: . :.. .::..:: .
XP_011 ----SLASKPVDVASDNVKKKHTKKNE
180 190 200
299 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 00:08:37 2016 done: Tue Nov 8 00:08:38 2016
Total Scan time: 4.870 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]