Result of FASTA (omim) for
pFN21AE5337
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5337, 259 aa
1>>>pF1KE5337 259 - 259 aa - 259 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.4347+/-0.000432; mu= -1.8993+/- 0.027
mean_var=263.6563+/-53.609, 0's: 0 Z-trim(120.0): 32 B-trim: 644 in 1/53
Lambda= 0.078987
statistics sampled from 34727 (34759) to 34727 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.408), width: 16
Scan time: 4.620
The best scores are: opt bits E(85289)
NP_003832 (OMIM: 603613) tumor necrosis factor rec ( 259) 1760 213.0 4.5e-55
NP_003831 (OMIM: 603614) tumor necrosis factor rec ( 386) 819 105.9 1.1e-22
NP_003835 (OMIM: 603611) tumor necrosis factor rec ( 468) 644 86.0 1.3e-16
NP_003833 (OMIM: 275355,603612) tumor necrosis fac ( 440) 599 80.9 4.4e-15
NP_671716 (OMIM: 275355,603612) tumor necrosis fac ( 411) 523 72.2 1.7e-12
XP_016869433 (OMIM: 275355,603612) PREDICTED: tumo ( 375) 451 63.9 4.7e-10
>>NP_003832 (OMIM: 603613) tumor necrosis factor recepto (259 aa)
initn: 1760 init1: 1760 opt: 1760 Z-score: 1109.8 bits: 213.0 E(85289): 4.5e-55
Smith-Waterman score: 1760; 100.0% identity (100.0% similar) in 259 aa overlap (1-259:1-259)
10 20 30 40 50 60
pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 EHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNEN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 SPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 ETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPASSHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPASSHY
190 200 210 220 230 240
250
pF1KE5 LSCTIVGIIVLIVLLIVFV
:::::::::::::::::::
NP_003 LSCTIVGIIVLIVLLIVFV
250
>>NP_003831 (OMIM: 603614) tumor necrosis factor recepto (386 aa)
initn: 937 init1: 680 opt: 819 Z-score: 528.0 bits: 105.9 E(85289): 1.1e-22
Smith-Waterman score: 819; 71.2% identity (85.3% similar) in 170 aa overlap (5-173:35-204)
10 20 30
pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEV
:: ::::: :::::::: . ::: ::.::
NP_003 GQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEV
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 PQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSD
:::::::::::.:.: :::::::::::.:::::::::::::: :::: :::. ::::::
NP_003 PQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSG
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 QKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC-SRCPSGEVQVSNCTSWDDIQCVEEF
: .::::: ::::::::..:.:...::::::: : . :: : :.::::: .::.: .:
NP_003 QTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNES
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 GANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETM
.:..: .:::::::..: :
NP_003 AASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGIC
190 200 210 220 230 240
>>NP_003835 (OMIM: 603611) tumor necrosis factor recepto (468 aa)
initn: 616 init1: 490 opt: 644 Z-score: 419.1 bits: 86.0 E(85289): 1.3e-16
Smith-Waterman score: 644; 60.0% identity (80.0% similar) in 155 aa overlap (3-156:87-236)
10 20 30
pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQE
:. ::.::::: .::: :. ::.: . .
NP_003 TSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVV--GVLLQVVPSSAATIKLH
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE5 EVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCK
. :... :: .:: :: :: ::::::: :::: ::::: ::::::: .:.:::.::
NP_003 D---QSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACK
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE5 SDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSR-CPSGEVQVSNCTSWDDIQCVE
::....: :: ::.:.:::: :::::.:: :::::::: :: : :.:..:: :.::.::.
NP_003 SDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVH
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE5 EFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEE
. ..:
NP_003 KESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGA
240 250 260 270 280 290
>>NP_003833 (OMIM: 275355,603612) tumor necrosis factor (440 aa)
initn: 685 init1: 403 opt: 599 Z-score: 391.7 bits: 80.9 E(85289): 4.4e-15
Smith-Waterman score: 599; 52.3% identity (72.7% similar) in 176 aa overlap (3-176:33-206)
10 20 30
pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQE
:.:::: :.:..:::: : : :: ..:.
NP_003 QRGQNAPAASGARKRHGPGPREARGARPGPRVPKTL--VLVVAAVLLLVSAESALITQQD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 EVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCK
.::: .::::.: : . :: : : :: : : : ::.. :. :. :: :
NP_003 LAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 SDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC-SRCPSGEVQVSNCTSWDDIQCV-
: . . : :: ::.:::::.:::::.:.:::::::: . :: : :.:..:: :.::.::
NP_003 SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVH
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE5 EEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAE
.: :.. . :.::.:::...::::::
NP_003 KESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKV
190 200 210 220 230 240
>>NP_671716 (OMIM: 275355,603612) tumor necrosis factor (411 aa)
initn: 497 init1: 403 opt: 523 Z-score: 345.3 bits: 72.2 E(85289): 1.7e-12
Smith-Waterman score: 523; 38.2% identity (59.8% similar) in 246 aa overlap (3-242:33-275)
10 20 30
pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQE
:.:::: :.:..:::: : : :: ..:.
NP_671 QRGQNAPAASGARKRHGPGPREARGARPGPRVPKTL--VLVVAAVLLLVSAESALITQQD
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE5 EVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCK
.::: .::::.: : . :: : : :: : : : ::.. :. :. :: :
NP_671 LAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE5 SDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC-SRCPSGEVQVSNCTSWDDIQCVE
: . . : :: ::.:::::.:::::.:.:::::::: . :: : :.:..:: :.::.::.
NP_671 SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVH
130 140 150 160 170 180
160 170 180 190 200
pF1KE5 EFGANATVETPAAEETMNTSPGTPAPAAEETMN-----TSPGTPAPAAEETMTTSPGTPA
. .. : :: . . . .... : : : . . ::.
NP_671 KESGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAED
190 200 210 220 230 240
210 220 230 240 250
pF1KE5 PAAEETMTTSPGTPAPAAEETMTTSPGTPASSHYLSCTIVGIIVLIVLLIVFV
. .: .. : .: .: . :. :.. ..::
NP_671 NVLNEIVSILQPTQVPE-QEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVP
250 260 270 280 290
NP_671 ANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIK
300 310 320 330 340 350
>>XP_016869433 (OMIM: 275355,603612) PREDICTED: tumor ne (375 aa)
initn: 559 init1: 277 opt: 451 Z-score: 301.5 bits: 63.9 E(85289): 4.7e-10
Smith-Waterman score: 451; 52.8% identity (73.2% similar) in 123 aa overlap (56-176:19-141)
30 40 50 60 70 80
pF1KE5 ATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSC
: : :: : : : ::.. :. :
XP_016 MDDVWGMRTIEAPNSTAQGHHISEDGRDCISCKYGQDYSTHWNDLLFC
10 20 30 40
90 100 110 120 130 140
pF1KE5 FPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC-SRCPSGEVQVSNCTSW
. :: : : . . : :: ::.:::::.:::::.:.:::::::: . :: : :.:..:: :
XP_016 LRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPW
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE5 DDIQCV-EEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPG
.::.:: .: :.. . :.::.:::...::::::
XP_016 SDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCK
110 120 130 140 150 160
210 220 230 240 250
pF1KE5 TPAPAAEETMTTSPGTPAPAAEETMTTSPGTPASSHYLSCTIVGIIVLIVLLIVFV
XP_016 SLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQE
170 180 190 200 210 220
259 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 23:54:15 2016 done: Mon Nov 7 23:54:16 2016
Total Scan time: 4.620 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]