Result of FASTA (omim) for
pFN21AE5268
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5268, 201 aa
1>>>pF1KE5268 201 - 201 aa - 201 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9575+/-0.000267; mu= 16.6545+/- 0.017
mean_var=77.6142+/-15.993, 0's: 0 Z-trim(121.9): 26 B-trim: 636 in 1/57
Lambda= 0.145581
statistics sampled from 39154 (39180) to 39154 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.799), E-opt: 0.2 (0.459), width: 16
Scan time: 5.910
The best scores are: opt bits E(85289)
NP_005218 (OMIM: 601380) ephrin-A4 isoform a precu ( 201) 1417 305.8 2.9e-83
NP_872631 (OMIM: 601380) ephrin-A4 isoform b precu ( 207) 1131 245.8 3.6e-65
NP_872632 (OMIM: 601380) ephrin-A4 isoform c precu ( 193) 1128 245.1 5.3e-65
XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 201) 515 116.4 3.1e-26
NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo ( 228) 480 109.1 5.6e-24
NP_004419 (OMIM: 191164) ephrin-A1 isoform a precu ( 205) 435 99.6 3.6e-21
XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 202) 396 91.4 1.1e-18
NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo ( 213) 396 91.4 1.1e-18
XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 298) 396 91.6 1.4e-18
XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 210) 380 88.1 1.1e-17
NP_872626 (OMIM: 191164) ephrin-A1 isoform b precu ( 183) 377 87.4 1.6e-17
NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo ( 238) 333 78.2 1.1e-14
XP_011541553 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 247 60.0 2.2e-09
XP_016864694 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 247 60.0 2.2e-09
NP_004084 (OMIM: 600527) ephrin-B2 precursor [Homo ( 333) 215 53.6 4.2e-07
NP_001397 (OMIM: 602297) ephrin-B3 precursor [Homo ( 340) 215 53.6 4.3e-07
NP_004420 (OMIM: 300035,304110) ephrin-B1 precurso ( 346) 208 52.1 1.2e-06
>>NP_005218 (OMIM: 601380) ephrin-A4 isoform a precursor (201 aa)
initn: 1417 init1: 1417 opt: 1417 Z-score: 1615.7 bits: 305.8 E(85289): 2.9e-83
Smith-Waterman score: 1417; 100.0% identity (100.0% similar) in 201 aa overlap (1-201:1-201)
10 20 30 40 50 60
pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDT
130 140 150 160 170 180
190 200
pF1KE5 PSPLCLLLLLLLLILRLLRIL
:::::::::::::::::::::
NP_005 PSPLCLLLLLLLLILRLLRIL
190 200
>>NP_872631 (OMIM: 601380) ephrin-A4 isoform b precursor (207 aa)
initn: 1143 init1: 1123 opt: 1131 Z-score: 1290.9 bits: 245.8 E(85289): 3.6e-65
Smith-Waterman score: 1131; 94.2% identity (97.1% similar) in 171 aa overlap (1-171:1-169)
10 20 30 40 50 60
pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDT
::::::::::::::::::::::::::::::::::::... . : ::: .:
NP_872 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERRAR-VLPR-SPGGGGIPAACTGGA
130 140 150 160 170
190 200
pF1KE5 PSPLCLLLLLLLLILRLLRIL
NP_872 NSDRQDGALMGEIRGSEVTLAGACPLITG
180 190 200
>>NP_872632 (OMIM: 601380) ephrin-A4 isoform c precursor (193 aa)
initn: 1140 init1: 1120 opt: 1128 Z-score: 1287.9 bits: 245.1 E(85289): 5.3e-65
Smith-Waterman score: 1128; 97.5% identity (98.2% similar) in 163 aa overlap (1-163:1-162)
10 20 30 40 50 60
pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 YEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPFGHVQFSEKIQRFTPFSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWRGGDT
::::::::::::::::::::::::::::::::::::. : ::
NP_872 GFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERNLPS-HPKEPESSQDPLEEEGSLL
130 140 150 160 170
190 200
pF1KE5 PSPLCLLLLLLLLILRLLRIL
NP_872 PALGVPIQTDKMEH
180 190
>>XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (201 aa)
initn: 527 init1: 253 opt: 515 Z-score: 591.9 bits: 116.4 E(85289): 3.1e-26
Smith-Waterman score: 515; 43.6% identity (67.6% similar) in 204 aa overlap (1-198:4-201)
10 20 30 40 50
pF1KE5 MRLLPLLRTVLWA-AFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDI
...: :. ::: .: .: . . :..:::::::::. ::: ... .:::::.
XP_006 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 VCPHYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQ
::::: : . : ..::::.. :: .:. . ...::: :. : : ..::::.:
XP_006 FCPHYEDSVPEDKTERYVLYMVNFDGYSACD-HTSKGFKRWECNRPHSPNGPLKFSEKFQ
70 80 90 100 110
120 130 140 150 160 170
pF1KE5 RFTPFSLGFEFLPGETYYYISVPTPESSGQ-CLRLQVSVC-CKERKSESAHPVGSPGESG
:::::::::: ::. :.::: :... . ::.:.: : .. :::.: : ::..
XP_006 LFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNDTVHESAEP--SRGENA
120 130 140 150 160 170
180 190 200
pF1KE5 TSGWRGGDTPSPLCLLLLLLLLILRLLRIL
.. : :: : .::.:: .: :
XP_006 AQTPR---IPSRLLAILLFLLAMLLTL
180 190 200
>>NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo sap (228 aa)
initn: 516 init1: 244 opt: 480 Z-score: 551.5 bits: 109.1 E(85289): 5.6e-24
Smith-Waterman score: 483; 39.4% identity (63.3% similar) in 226 aa overlap (1-200:4-228)
10 20 30 40 50
pF1KE5 MRLLPLLRTVLWA-AFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDI
...: :. ::: .: .: . . :..:::::::::. ::: ... .:::::.
NP_001 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 VCPHYEGPGPPEGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQ
::::: : . : ..::::.. :: .:. . ...::: :. : : ..::::.:
NP_001 FCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTS-KGFKRWECNRPHSPNGPLKFSEKFQ
70 80 90 100 110
120 130 140 150
pF1KE5 RFTPFSLGFEFLPGETYYYISVPTPESSGQ-CLRLQVSV-----CCK------------E
:::::::::: ::. :.::: :... . ::.:.: : : : .
NP_001 LFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVND
120 130 140 150 160 170
160 170 180 190 200
pF1KE5 RKSESAHPVGSP-GESG--TSGWRGGDTPS-PLCLLLLLLLLILRLLRIL
. .: .:. . ::. . : ...:: : :: .::.:. :: .
NP_001 KVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
180 190 200 210 220
>>NP_004419 (OMIM: 191164) ephrin-A1 isoform a precursor (205 aa)
initn: 427 init1: 196 opt: 435 Z-score: 501.0 bits: 99.6 E(85289): 3.6e-21
Smith-Waterman score: 435; 43.6% identity (67.3% similar) in 156 aa overlap (11-162:4-158)
10 20 30 40 50 60
pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
::: .:: ... ::.:.::::::.. : .... ::::.::.:::
NP_004 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPH
10 20 30 40 50
70 80 90 100 110
pF1KE5 YEGPGPPEGP-ETFALYMVDWPGYESCQAEGPRAYKRWVCSLP---FGHVQFSEKIQRFT
:: . .. : . ::.:. :. :: .. . :: :. : : ..:::.::::
NP_004 YEDHSVADAAMEQYILYLVEHEEYQLCQPQS-KDQVRWQCNRPSAKHGPEKLSEKFQRFT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 PFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWR
::.:: :: :..::::: : . .::::.:.: : .: .::
NP_004 PFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPE
120 130 140 150 160 170
180 190 200
pF1KE5 GGDTPSPLCLLLLLLLLILRLLRIL
NP_004 VRVLHSIGHSAAPRLFPLAWTVLLLPLLLLQTP
180 190 200
>>XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (202 aa)
initn: 340 init1: 172 opt: 396 Z-score: 456.8 bits: 91.4 E(85289): 1.1e-18
Smith-Waterman score: 396; 44.8% identity (65.6% similar) in 163 aa overlap (42-198:46-199)
20 30 40 50 60 70
pF1KE5 WAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPHYEGPGPP-EGP
: .::...:::::: :::: .: :: :
XP_016 ARFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERM
20 30 40 50 60 70
80 90 100 110 120
pF1KE5 ETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQRFTPFSLGFEFLPG
: ..::::. :. ::. . :..::: :. : : ..::::.: :::::::::: ::
XP_016 EHYVLYMVNGEGHASCDHR-QRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPG
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE5 ETYYYISVPTPESSGQ-CLRLQVSVC-CKERKSESAHPVGSPGESGTSGWRGGDTPSPLC
. :::::. :.. . ::::.: : .: :. .:. . ..: .: :: :
XP_016 HEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSP--GG------C
140 150 160 170 180
190 200
pF1KE5 LLLLLLLLILRLLRIL
:.: . .: :
XP_016 RLFLSTIPVLWTLLGS
190 200
>>NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo sap (213 aa)
initn: 440 init1: 172 opt: 396 Z-score: 456.5 bits: 91.4 E(85289): 1.1e-18
Smith-Waterman score: 445; 44.4% identity (65.2% similar) in 187 aa overlap (24-198:33-210)
10 20 30 40
pF1KE5 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDA------VVE
.: :..:::: ::::. : . .::
NP_001 PAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 LGLNDYLDIVCPHYEGPGPP-EGPETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---
...:::::: :::: .: :: : : ..::::. :. ::. . :..::: :. :
NP_001 VSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHR-QRGFKRWECNRPAAPG
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 GHVQFSEKIQRFTPFSLGFEFLPGETYYYISVPTPESSGQ-CLRLQVSVC-CKERKSESA
: ..::::.: :::::::::: ::. :::::. :.. . ::::.: : .: :.
NP_001 GPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAP
130 140 150 160 170 180
170 180 190 200
pF1KE5 HPVGSPGESGTSGWRGGDTPSPLCLLLLLLLLILRLLRIL
.:. . ..: .: :: : :.: . .: :
NP_001 EPIFTSNNSCSSP--GG------CRLFLSTIPVLWTLLGS
190 200 210
>>XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 isofo (298 aa)
initn: 340 init1: 172 opt: 396 Z-score: 454.6 bits: 91.6 E(85289): 1.4e-18
Smith-Waterman score: 396; 44.8% identity (65.6% similar) in 163 aa overlap (42-198:142-295)
20 30 40 50 60 70
pF1KE5 WAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPHYEGPGPP-EGP
: .::...:::::: :::: .: :: :
XP_016 ARFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERM
120 130 140 150 160 170
80 90 100 110 120
pF1KE5 ETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQRFTPFSLGFEFLPG
: ..::::. :. ::. . :..::: :. : : ..::::.: :::::::::: ::
XP_016 EHYVLYMVNGEGHASCDHR-QRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPG
180 190 200 210 220 230
130 140 150 160 170 180
pF1KE5 ETYYYISVPTPESSGQ-CLRLQVSVC-CKERKSESAHPVGSPGESGTSGWRGGDTPSPLC
. :::::. :.. . ::::.: : .: :. .:. . ..: .: :: :
XP_016 HEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSP--GG------C
240 250 260 270 280
190 200
pF1KE5 LLLLLLLLILRLLRIL
:.: . .: :
XP_016 RLFLSTIPVLWTLLGS
290
>>XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (210 aa)
initn: 421 init1: 176 opt: 380 Z-score: 438.4 bits: 88.1 E(85289): 1.1e-17
Smith-Waterman score: 383; 38.9% identity (62.2% similar) in 185 aa overlap (41-200:27-210)
20 30 40 50 60 70
pF1KE5 LWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPHYEGPGPPEGP
::: ... .:::::. ::::: : .
XP_011 MQTLEPACFRFSLHTNTNKQCTLGFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKT
10 20 30 40 50
80 90 100 110 120
pF1KE5 ETFALYMVDWPGYESCQAEGPRAYKRWVCSLPF---GHVQFSEKIQRFTPFSLGFEFLPG
: ..::::.. :: .:. . ...::: :. : : ..::::.: :::::::::: ::
XP_011 ERYVLYMVNFDGYSACDHTS-KGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPG
60 70 80 90 100 110
130 140 150 160
pF1KE5 ETYYYISVPTPESSGQ-CLRLQVSV-----CCK------------ERKSESAHPVGSP-G
. :.::: :... . ::.:.: : : : .. .: .:. .
XP_011 REYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVH
120 130 140 150 160 170
170 180 190 200
pF1KE5 ESG--TSGWRGGDTPS-PLCLLLLLLLLILRLLRIL
::. . : ...:: : :: .::.:. :: .
XP_011 ESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
180 190 200 210
201 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 23:17:31 2016 done: Mon Nov 7 23:17:32 2016
Total Scan time: 5.910 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]