Result of FASTA (omim) for
pFN21AE5253
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5253, 199 aa
1>>>pF1KE5253 199 - 199 aa - 199 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1872+/-0.000434; mu= 10.4504+/- 0.027
mean_var=102.9204+/-20.218, 0's: 0 Z-trim(112.9): 22 B-trim: 665 in 1/54
Lambda= 0.126422
statistics sampled from 21959 (21971) to 21959 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.258), width: 16
Scan time: 5.000
The best scores are: opt bits E(85289)
NP_065145 (OMIM: 606486) charged multivesicular bo ( 199) 1228 234.2 1.1e-61
NP_002759 (OMIM: 164010,614961) charged multivesic ( 196) 682 134.6 1e-31
NP_055268 (OMIM: 610893) charged multivesicular bo ( 222) 296 64.2 1.8e-10
NP_940818 (OMIM: 610893) charged multivesicular bo ( 222) 296 64.2 1.8e-10
XP_005258803 (OMIM: 610893) PREDICTED: charged mul ( 265) 291 63.3 3.8e-10
XP_005258804 (OMIM: 610893) PREDICTED: charged mul ( 265) 291 63.3 3.8e-10
NP_054762 (OMIM: 600795,609512,614696) charged mul ( 213) 195 45.8 6e-05
XP_011531878 (OMIM: 600795,609512,614696) PREDICTE ( 229) 195 45.8 6.4e-05
NP_001231573 (OMIM: 600795,609512,614696) charged ( 172) 173 41.7 0.00082
>>NP_065145 (OMIM: 606486) charged multivesicular body p (199 aa)
initn: 1228 init1: 1228 opt: 1228 Z-score: 1228.4 bits: 234.2 E(85289): 1.1e-61
Smith-Waterman score: 1228; 100.0% identity (100.0% similar) in 199 aa overlap (1-199:1-199)
10 20 30 40 50 60
pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 QFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 QFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSV
130 140 150 160 170 180
190
pF1KE5 ASAEQDELSQRLARLRDQV
:::::::::::::::::::
NP_065 ASAEQDELSQRLARLRDQV
190
>>NP_002759 (OMIM: 164010,614961) charged multivesicular (196 aa)
initn: 723 init1: 609 opt: 682 Z-score: 690.3 bits: 134.6 E(85289): 1e-31
Smith-Waterman score: 682; 55.8% identity (85.3% similar) in 197 aa overlap (4-197:1-196)
10 20 30 40 50 60
pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKN
:. ::.:::.::.: . ::: .:. :::.::.:::. . :.: ::..::::::.::
NP_002 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECARVYAENAIRKKN
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 QAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEH
..::.:::..::::::..::::::: :::.:: :.:..: .:.::.:.:.:..::.::.
NP_002 EGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQKVSSVMDRFEQ
60 70 80 90 100 110
130 140 150 160 170
pF1KE5 QFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGL---DLNMELPQGQTGSVG
: ..:::.:. :::.:::.:::::::.::: :....:.: :: : .::.: . .::
NP_002 QVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLSQLPEGAS-AVG
120 130 140 150 160 170
180 190
pF1KE5 TSVASAEQDELSQRLARLRDQV
: . ...:.::.::: ::.
NP_002 ESSVRSQEDQLSRRLAALRN
180 190
>>NP_055268 (OMIM: 610893) charged multivesicular body p (222 aa)
initn: 342 init1: 287 opt: 296 Z-score: 309.1 bits: 64.2 E(85289): 1.8e-10
Smith-Waterman score: 299; 30.7% identity (66.3% similar) in 199 aa overlap (11-196:22-220)
10 20 30 40
pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR
:. : .::.: .: . .:: : ::: ..:.:...:
NP_055 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE
: :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..:
NP_055 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMEL-
.:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. ::
NP_055 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
170 180 190
pF1KE5 --PQ-GQTGSVGT------SVASAEQD---ELSQRLARLRDQV
:. : . ::.. ..::: : .: .:: ::
NP_055 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
190 200 210 220
>>NP_940818 (OMIM: 610893) charged multivesicular body p (222 aa)
initn: 342 init1: 287 opt: 296 Z-score: 309.1 bits: 64.2 E(85289): 1.8e-10
Smith-Waterman score: 299; 30.7% identity (66.3% similar) in 199 aa overlap (11-196:22-220)
10 20 30 40
pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR
:. : .::.: .: . .:: : ::: ..:.:...:
NP_940 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE
: :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..:
NP_940 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMEL-
.:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. ::
NP_940 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
170 180 190
pF1KE5 --PQ-GQTGSVGT------SVASAEQD---ELSQRLARLRDQV
:. : . ::.. ..::: : .: .:: ::
NP_940 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
190 200 210 220
>>XP_005258803 (OMIM: 610893) PREDICTED: charged multive (265 aa)
initn: 307 init1: 291 opt: 291 Z-score: 303.1 bits: 63.3 E(85289): 3.8e-10
Smith-Waterman score: 291; 30.4% identity (70.3% similar) in 158 aa overlap (11-168:22-179)
10 20 30 40
pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR
:. : .::.: .: . .:: : ::: ..:.:...:
XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE
: :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..:
XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELP
.:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. ::
XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
170 180 190
pF1KE5 QGQTGSVGTSVASAEQDELSQRLARLRDQV
XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK
190 200 210 220 230 240
>>XP_005258804 (OMIM: 610893) PREDICTED: charged multive (265 aa)
initn: 307 init1: 291 opt: 291 Z-score: 303.1 bits: 63.3 E(85289): 3.8e-10
Smith-Waterman score: 291; 30.4% identity (70.3% similar) in 158 aa overlap (11-168:22-179)
10 20 30 40
pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR
:. : .::.: .: . .:: : ::: ..:.:...:
XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE
: :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..:
XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELP
.:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. ::
XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
170 180 190
pF1KE5 QGQTGSVGTSVASAEQDELSQRLARLRDQV
XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK
190 200 210 220 230 240
>>NP_054762 (OMIM: 600795,609512,614696) charged multive (213 aa)
initn: 131 init1: 64 opt: 195 Z-score: 209.8 bits: 45.8 E(85289): 6e-05
Smith-Waterman score: 201; 19.5% identity (65.8% similar) in 190 aa overlap (11-195:21-210)
10 20 30 40 50
pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARI
:. . . . :. .:.:: . .::: . :: :. ..
NP_054 MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACKV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 HAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEK
:.. .. ..: . . .:..: ........ .. :.. .:. ..:.:.:. : :. .:
NP_054 LAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQK
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 ISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQ
:..:... ... ....::... . ... . ..... :: :.... .. .
NP_054 TLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAK
130 140 150 160 170 180
180 190
pF1KE5 GQTG-----SVGTSVASAEQDELSQRLARLRDQV
. .. :..:: :. ..:. ..: :
NP_054 APSAARSLPSASTSKATISDEEIERQLKALGVD
190 200 210
>>XP_011531878 (OMIM: 600795,609512,614696) PREDICTED: c (229 aa)
initn: 131 init1: 64 opt: 195 Z-score: 209.3 bits: 45.8 E(85289): 6.4e-05
Smith-Waterman score: 201; 19.5% identity (65.8% similar) in 190 aa overlap (11-195:37-226)
10 20 30 40
pF1KE5 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAI
:. . . . :. .:.:: . .:::
XP_011 NHHLPDSSDSSTSAYRVARITDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 QKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMD
. :: :. .. :.. .. ..: . . .:..: ........ .. :.. .:. ..:.:.
XP_011 KIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQ
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 ATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEA
:. : :. .: :..:... ... ....::... . ... . ..... ::
XP_011 AVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEI
130 140 150 160 170 180
170 180 190
pF1KE5 GLDLNMELPQGQTG-----SVGTSVASAEQDELSQRLARLRDQV
:.... .. .. .. :..:: :. ..:. ..: :
XP_011 GIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD
190 200 210 220
>>NP_001231573 (OMIM: 600795,609512,614696) charged mult (172 aa)
initn: 137 init1: 64 opt: 173 Z-score: 189.4 bits: 41.7 E(85289): 0.00082
Smith-Waterman score: 179; 19.3% identity (67.5% similar) in 166 aa overlap (35-195:4-169)
10 20 30 40 50 60
pF1KE5 EKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVN
.::: . :: :. .. :.. .. ..: .
NP_001 MELEIKKMAKIGNKEACKVLAKQLVHLRKQKTR
10 20 30
70 80 90 100 110 120
pF1KE5 FLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFET
. .:..: ........ .. :.. .:. ..:.:.:. : :. .: :..:...
NP_001 TFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMK
40 50 60 70 80 90
130 140 150 160 170
pF1KE5 LDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTG-----SVGTS
... ....::... . ... . ..... :: :.... .. .. .. :..::
NP_001 MEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTS
100 110 120 130 140 150
180 190
pF1KE5 VASAEQDELSQRLARLRDQV
:. ..:. ..: :
NP_001 KATISDEEIERQLKALGVD
160 170
199 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:54:12 2016 done: Mon Nov 7 22:54:12 2016
Total Scan time: 5.000 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]