Result of FASTA (omim) for
pFN21AE5249
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5249, 182 aa
1>>>pF1KE5249 182 - 182 aa - 182 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.1511+/-0.000382; mu= 19.3103+/- 0.024
mean_var=62.8775+/-12.970, 0's: 0 Z-trim(112.6): 62 B-trim: 0 in 0/56
Lambda= 0.161743
statistics sampled from 21497 (21559) to 21497 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.253), width: 16
Scan time: 5.570
The best scores are: opt bits E(85289)
NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens ( 182) 1190 286.0 2.3e-77
NP_849199 (OMIM: 607891) CKLF-like MARVEL transmem ( 173) 419 106.0 3.2e-23
XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like M ( 196) 374 95.6 5.1e-20
XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like M ( 130) 366 93.5 1.4e-19
XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like M ( 100) 250 66.3 1.7e-11
NP_005425 (OMIM: 602022) MAL-like protein [Homo sa ( 153) 201 55.1 6.1e-08
NP_002362 (OMIM: 188860) myelin and lymphocyte pro ( 153) 198 54.4 1e-07
XP_011510111 (OMIM: 602022) PREDICTED: MAL-like pr ( 149) 192 53.0 2.6e-07
NP_852662 (OMIM: 607887) CKLF-like MARVEL transmem ( 208) 184 51.3 1.2e-06
XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like M ( 221) 184 51.3 1.2e-06
NP_848933 (OMIM: 607887) CKLF-like MARVEL transmem ( 234) 184 51.3 1.3e-06
NP_113672 (OMIM: 616970) MARVEL domain-containing ( 173) 179 50.0 2.3e-06
NP_443118 (OMIM: 609684) protein MAL2 [Homo sapien ( 176) 177 49.6 3.3e-06
NP_001277121 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_001018656 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_001277123 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_001018655 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_001018654 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_001018657 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_001277118 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_001277120 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_612382 (OMIM: 609959) myeloid-associated differ ( 322) 164 46.8 4e-05
NP_001277122 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_001277119 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_001277117 (OMIM: 609959) myeloid-associated dif ( 322) 164 46.8 4e-05
NP_071883 (OMIM: 188860) myelin and lymphocyte pro ( 111) 159 45.2 4.4e-05
NP_001307237 (OMIM: 607891) CKLF-like MARVEL trans ( 115) 148 42.6 0.00027
NP_612419 (OMIM: 607890) CKLF-like MARVEL transmem ( 175) 144 41.9 0.00068
XP_011531621 (OMIM: 607890) PREDICTED: CKLF-like M ( 151) 138 40.4 0.0016
XP_016861135 (OMIM: 607890) PREDICTED: CKLF-like M ( 179) 138 40.5 0.0018
XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like M ( 179) 135 39.8 0.0029
XP_016876442 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 127 37.8 0.0098
XP_016876443 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 127 37.8 0.0098
NP_612469 (OMIM: 607888) CKLF-like MARVEL transmem ( 156) 127 37.8 0.0098
>>NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens] (182 aa)
initn: 1190 init1: 1190 opt: 1190 Z-score: 1509.8 bits: 286.0 E(85289): 2.3e-77
Smith-Waterman score: 1190; 100.0% identity (100.0% similar) in 182 aa overlap (1-182:1-182)
10 20 30 40 50 60
pF1KE5 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 HLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 HLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 ACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 ACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGG
130 140 150 160 170 180
pF1KE5 YA
::
NP_057 YA
>>NP_849199 (OMIM: 607891) CKLF-like MARVEL transmembran (173 aa)
initn: 270 init1: 270 opt: 419 Z-score: 537.8 bits: 106.0 E(85289): 3.2e-23
Smith-Waterman score: 419; 42.8% identity (71.7% similar) in 159 aa overlap (8-166:12-168)
10 20 30 40 50
pF1KE5 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIA
:.: .:: :.. .: :.. : :.:. : :.. ..:::::::.:::
NP_849 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 DTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYI
: : ::.::::::::: :..:. .. .:. . . .. .::: : . :: :: :::.
NP_849 GTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 TAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQ
.: .. ...: . : .. .:. ::.:::: :: : :. ...::. :::
NP_849 SAAVVDASSV--SPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
130 140 150 160 170
180
pF1KE5 MAGGYA
>>XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like MARVE (196 aa)
initn: 278 init1: 278 opt: 374 Z-score: 480.4 bits: 95.6 E(85289): 5.1e-20
Smith-Waterman score: 374; 45.1% identity (71.4% similar) in 133 aa overlap (34-166:61-191)
10 20 30 40 50 60
pF1KE5 FPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLY
:: :.. ::::::::.::: : :
XP_011 AYDREFLRTLPGFLIVAEILISLPITDPLHRSALSTTARDILVLGLLVWTLIAGTEYFRV
40 50 60 70 80 90
70 80 90 100 110 120
pF1KE5 PAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFIACS
::.::::::::: :..:. .. .:. . . .. .::: : . :: :: :::..: .. .
XP_011 PAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDA
100 110 120 130 140 150
130 140 150 160 170 180
pF1KE5 AAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA
..: . : .. .:. ::.:::: :: : :. ...::. :::
XP_011 SSV--SPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
160 170 180 190
>>XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like MARVE (130 aa)
initn: 282 init1: 270 opt: 366 Z-score: 472.5 bits: 93.5 E(85289): 1.4e-19
Smith-Waterman score: 366; 46.3% identity (73.6% similar) in 121 aa overlap (46-166:7-125)
20 30 40 50 60 70
pF1KE5 AQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVF
:::::::.::: : : ::.:::::::::
XP_016 MFRRIQVLGLLVWTLIAGTEYFRVPAFGWVMFVAVF
10 20 30
80 90 100 110 120 130
pF1KE5 LWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFIACSAAVDLTSLRGTR
:..:. .. .:. . . .. .::: : . :: :: :::..: .. ...: . : ..
XP_016 YWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSV--SPERDSH
40 50 60 70 80 90
140 150 160 170 180
pF1KE5 PYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA
.:. ::.:::: :: : :. ...::. :::
XP_016 NFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ
100 110 120 130
>>XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like MARVE (100 aa)
initn: 166 init1: 154 opt: 250 Z-score: 327.5 bits: 66.3 E(85289): 1.7e-11
Smith-Waterman score: 250; 40.2% identity (72.2% similar) in 97 aa overlap (70-166:1-95)
40 50 60 70 80 90
pF1KE5 LMLLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVP
:::::: :..:. .. .:. . . .. .::
XP_016 MFVAVFYWVLTVFFLIIYITMTYTRIPQVP
10 20 30
100 110 120 130 140 150
pF1KE5 WPLVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAF
: : . :: :: :::..: .. ...: . : .. .:. ::.:::: :: : :. ...
XP_016 WTTVGLCFNGSAFVLYLSAAVVDASSV--SPERDSHNFNSWAASSFFAFLVTICYAGNTY
40 50 60 70 80
160 170 180
pF1KE5 FSYQAWRGVGSNAATSQMAGGYA
::. :::
XP_016 FSFIAWRSRTIQ
90 100
>>NP_005425 (OMIM: 602022) MAL-like protein [Homo sapien (153 aa)
initn: 164 init1: 125 opt: 201 Z-score: 263.5 bits: 55.1 E(85289): 6.1e-08
Smith-Waterman score: 201; 30.2% identity (65.1% similar) in 126 aa overlap (39-162:29-151)
10 20 30 40 50 60
pF1KE5 STRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLYPAY-G
:..: .:..:.:::...: : . .:: :
NP_005 MASPDPPATSYAPSDVPSGVALFLTIPFAFFLPELIFGFLVWTMVAAT-HIVYPLLQG
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 WVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFI-ACSAAV
:::.:.. .:...... ::: .. .. : .. ... .. .::..: . :..
NP_005 WVMYVSLTSFLISLMFLLSYLFGFYKRFE--SWRVLDSLYHGTTGILYMSAAVLQVHATI
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE5 DLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA
.: : : .:::::: .. . : . :: :
NP_005 VSEKLLDPRIYYINSAASFFAFIATLLYILHAFSIYYH
120 130 140 150
>>NP_002362 (OMIM: 188860) myelin and lymphocyte protein (153 aa)
initn: 146 init1: 132 opt: 198 Z-score: 259.7 bits: 54.4 E(85289): 1e-07
Smith-Waterman score: 198; 29.4% identity (60.8% similar) in 153 aa overlap (19-166:4-151)
10 20 30 40 50
pF1KE5 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGF-VRSRLGALMLL-QLVLGLLVWALIADT
: :. .. :. :: : . : :... ....: ::: :.:..
NP_002 MAPAAATGGSTLPS-GFSVFTTLPDLLFIFEFIFGGLVWILVASS
10 20 30 40
60 70 80 90 100 110
pF1KE5 --PYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYI
:. : . ::::::.:: ...: .:. ::.. : . : . .. .:...:.
NP_002 LVPWPL--VQGWVMFVSVFCFVATTTLIILYIIGAHGG--ETSWVTLDAAYHCTAALFYL
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE5 TAFIACS-AAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATS
.: . . :.. . . : :.. :: :. .. . : : : :: :.
NP_002 SASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS
110 120 130 140 150
180
pF1KE5 QMAGGYA
>>XP_011510111 (OMIM: 602022) PREDICTED: MAL-like protei (149 aa)
initn: 155 init1: 116 opt: 192 Z-score: 252.3 bits: 53.0 E(85289): 2.6e-07
Smith-Waterman score: 192; 30.0% identity (64.2% similar) in 120 aa overlap (45-162:31-147)
20 30 40 50 60 70
pF1KE5 PAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIADTPYHLYPAY-GWVMFVA
:..:.:::...: : . .:: ::::.:.
XP_011 MEKLTEDSRKKKKGAGIFGKETRIQNTTKLLIFGFLVWTMVAAT-HIVYPLLQGWVMYVS
10 20 30 40 50
80 90 100 110 120 130
pF1KE5 VFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYITAFI-ACSAAVDLTSLR
. .:...... ::: .. .. : .. ... .. .::..: . :.. .:
XP_011 LTSFLISLMFLLSYLFGFYKRFE--SWRVLDSLYHGTTGILYMSAAVLQVHATIVSEKLL
60 70 80 90 100 110
140 150 160 170 180
pF1KE5 GTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQMAGGYA
: : .:::::: .. . : . :: :
XP_011 DPRIYYINSAASFFAFIATLLYILHAFSIYYH
120 130 140
>>NP_852662 (OMIM: 607887) CKLF-like MARVEL transmembran (208 aa)
initn: 154 init1: 76 opt: 184 Z-score: 240.5 bits: 51.3 E(85289): 1.2e-06
Smith-Waterman score: 185; 30.7% identity (59.0% similar) in 166 aa overlap (13-166:24-176)
10 20 30 40
pF1KE5 MAEFPSKVSTRTSSPAQGAEASVS------ALRPDLGFVRSRLGALMLL
::: : . :: .:: : ..:. :: : .
NP_852 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 QLVLGLLVWALIADTPYHLYPAYG--WVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWP
:..:.:... : .: . : : . ::. ..:: ::. .. ..:::.. .. :
NP_852 QVILALIAFICI-ETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWN
70 80 90 100 110
110 120 130 140 150
pF1KE5 LVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRA----AASFFACLVMIAYGVS
:. .. : . ..::. :.. :..: :.:: :: .:. :. ::.:.
NP_852 LTDLV-NTG-----LSAFLFFIASIVLAAL------NHRAGAEIAAVIFGFLATAAYAVN
120 130 140 150 160
160 170 180
pF1KE5 AFFSYQAWRGVGSNAATSQMAGGYA
.:.. : ::
NP_852 TFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDT
170 180 190 200
>>XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like MARVE (221 aa)
initn: 154 init1: 76 opt: 184 Z-score: 240.2 bits: 51.3 E(85289): 1.2e-06
Smith-Waterman score: 185; 30.7% identity (59.0% similar) in 166 aa overlap (13-166:24-176)
10 20 30 40
pF1KE5 MAEFPSKVSTRTSSPAQGAEASVS------ALRPDLGFVRSRLGALMLL
::: : . :: .:: : ..:. :: : .
XP_016 MRSGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE5 QLVLGLLVWALIADTPYHLYPAYG--WVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWP
:..:.:... : .: . : : . ::. ..:: ::. .. ..:::.. .. :
XP_016 QVILALIAFICI-ETIMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWN
70 80 90 100 110
110 120 130 140 150
pF1KE5 LVLMIFNISATVLYITAFIACSAAVDLTSLRGTRPYNQRA----AASFFACLVMIAYGVS
:. .. : . ..::. :.. :..: :.:: :: .:. :. ::.:.
XP_016 LTDLV-NTG-----LSAFLFFIASIVLAAL------NHRAGAEIAAVIFGFLATAAYAVN
120 130 140 150 160
160 170 180
pF1KE5 AFFSYQAWRGVGSNAATSQMAGGYA
.:.. : ::
XP_016 TFLAVQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDTLNWKPNGHQQVKG
170 180 190 200 210 220
182 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:52:23 2016 done: Mon Nov 7 22:52:24 2016
Total Scan time: 5.570 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]