Result of FASTA (omim) for
pFN21AE5245
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5245, 187 aa
1>>>pF1KE5245 187 - 187 aa - 187 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7517+/-0.000307; mu= 15.7315+/- 0.019
mean_var=56.9140+/-11.371, 0's: 0 Z-trim(115.6): 11 B-trim: 0 in 0/52
Lambda= 0.170006
statistics sampled from 26154 (26165) to 26154 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.307), width: 16
Scan time: 5.910
The best scores are: opt bits E(85289)
NP_789785 (OMIM: 616588) dihydrofolate reductase, ( 187) 1249 314.0 8.8e-86
XP_011510839 (OMIM: 616588) PREDICTED: dihydrofola ( 187) 1249 314.0 8.8e-86
NP_001182572 (OMIM: 616588) dihydrofolate reductas ( 187) 1249 314.0 8.8e-86
NP_000782 (OMIM: 126060,613839) dihydrofolate redu ( 187) 1130 284.8 5.4e-77
NP_001277283 (OMIM: 126060,613839) dihydrofolate r ( 135) 821 209.0 2.7e-54
NP_001277286 (OMIM: 126060,613839) dihydrofolate r ( 129) 759 193.7 9.9e-50
>>NP_789785 (OMIM: 616588) dihydrofolate reductase, mito (187 aa)
initn: 1249 init1: 1249 opt: 1249 Z-score: 1661.0 bits: 314.0 E(85289): 8.8e-86
Smith-Waterman score: 1249; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187)
10 20 30 40 50 60
pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_789 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
130 140 150 160 170 180
pF1KE5 EVCEKDD
:::::::
NP_789 EVCEKDD
>>XP_011510839 (OMIM: 616588) PREDICTED: dihydrofolate r (187 aa)
initn: 1249 init1: 1249 opt: 1249 Z-score: 1661.0 bits: 314.0 E(85289): 8.8e-86
Smith-Waterman score: 1249; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187)
10 20 30 40 50 60
pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
130 140 150 160 170 180
pF1KE5 EVCEKDD
:::::::
XP_011 EVCEKDD
>>NP_001182572 (OMIM: 616588) dihydrofolate reductase, m (187 aa)
initn: 1249 init1: 1249 opt: 1249 Z-score: 1661.0 bits: 314.0 E(85289): 8.8e-86
Smith-Waterman score: 1249; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187)
10 20 30 40 50 60
pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
130 140 150 160 170 180
pF1KE5 EVCEKDD
:::::::
NP_001 EVCEKDD
>>NP_000782 (OMIM: 126060,613839) dihydrofolate reductas (187 aa)
initn: 1130 init1: 1130 opt: 1130 Z-score: 1503.3 bits: 284.8 E(85289): 5.4e-77
Smith-Waterman score: 1130; 93.4% identity (96.2% similar) in 183 aa overlap (5-187:5-187)
10 20 30 40 50 60
pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
:::::::::::::::::::: :::::::::::::::::::::::::::::.:::::
NP_000 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.:::::::
NP_000 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
:::::::: :::::::::::::::::::: :::::::::::::::::::::: : :::::
NP_000 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
130 140 150 160 170 180
pF1KE5 EVCEKDD
:: ::.:
NP_000 EVYEKND
>>NP_001277283 (OMIM: 126060,613839) dihydrofolate reduc (135 aa)
initn: 836 init1: 821 opt: 821 Z-score: 1095.7 bits: 209.0 E(85289): 2.7e-54
Smith-Waterman score: 821; 91.9% identity (95.6% similar) in 135 aa overlap (53-187:1-135)
30 40 50 60 70 80
pF1KE5 LPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINLVLSRELKE
::.:::::::::::::: ::::::::::::
NP_001 MGKKTWFSIPEKNRPLKGRINLVLSRELKE
10 20 30
90 100 110 120 130 140
pF1KE5 PPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSSVYKEAMNHLGHLKLFVTRIMQD
::::::::.:::::::::::.:::::::::.::::::::::::::: :::::::::::::
NP_001 PPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQD
40 50 60 70 80 90
150 160 170 180
pF1KE5 FESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKFEVCEKDD
::::::: :::::::::::::::::::::: : ::::::: ::.:
NP_001 FESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
100 110 120 130
>>NP_001277286 (OMIM: 126060,613839) dihydrofolate reduc (129 aa)
initn: 759 init1: 759 opt: 759 Z-score: 1013.8 bits: 193.7 E(85289): 9.9e-50
Smith-Waterman score: 759; 95.0% identity (98.3% similar) in 119 aa overlap (5-123:5-123)
10 20 30 40 50 60
pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS
:::::::::::::::::::: :::::::::::::::::::::::::::::.:::::
NP_001 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS
::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.:::::::
NP_001 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF
:::
NP_001 VYKIPRCSL
187 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:50:04 2016 done: Mon Nov 7 22:50:05 2016
Total Scan time: 5.910 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]