Result of FASTA (omim) for
pFN21AE5229
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5229, 186 aa
1>>>pF1KE5229 186 - 186 aa - 186 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6680+/-0.000312; mu= 12.9283+/- 0.020
mean_var=107.8411+/-21.016, 0's: 0 Z-trim(118.7): 183 B-trim: 160 in 1/52
Lambda= 0.123504
statistics sampled from 31759 (31982) to 31759 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.74), E-opt: 0.2 (0.375), width: 16
Scan time: 4.820
The best scores are: opt bits E(85289)
NP_954582 (OMIM: 604294,614402) ventral anterior h ( 186) 1240 230.7 1.1e-60
NP_001106175 (OMIM: 604294,614402) ventral anterio ( 334) 960 181.1 1.7e-45
NP_036608 (OMIM: 604295) ventral anterior homeobox ( 290) 488 96.9 3.1e-20
XP_006712045 (OMIM: 604295) PREDICTED: ventral ant ( 150) 468 93.0 2.3e-19
XP_011531052 (OMIM: 604295) PREDICTED: ventral ant ( 150) 468 93.0 2.3e-19
XP_011531053 (OMIM: 604295) PREDICTED: ventral ant ( 150) 468 93.0 2.3e-19
XP_011530999 (OMIM: 600034) PREDICTED: homeobox pr ( 119) 200 45.2 4.7e-05
NP_004088 (OMIM: 600034) homeobox protein EMX1 [Ho ( 290) 200 45.6 8.8e-05
NP_064448 (OMIM: 605211) barH-like 1 homeobox prot ( 327) 193 44.4 0.00023
NP_004089 (OMIM: 269160,600035) homeobox protein E ( 252) 186 43.0 0.00045
NP_001417 (OMIM: 131290) homeobox protein engraile ( 392) 186 43.2 0.00061
NP_076920 (OMIM: 142965) homeobox protein Hox-B4 [ ( 251) 180 41.9 0.00094
NP_001418 (OMIM: 131310) homeobox protein engraile ( 333) 179 41.9 0.0013
NP_001158727 (OMIM: 142994,176450) motor neuron an ( 189) 171 40.2 0.0023
NP_001073927 (OMIM: 142991) homeobox even-skipped ( 476) 175 41.3 0.0027
NP_005506 (OMIM: 142994,176450) motor neuron and p ( 401) 171 40.5 0.004
XP_016868632 (OMIM: 610772) PREDICTED: homeobox pr ( 265) 166 39.5 0.0055
XP_005264260 (OMIM: 600034) PREDICTED: homeobox pr ( 280) 163 39.0 0.0083
>>NP_954582 (OMIM: 604294,614402) ventral anterior homeo (186 aa)
initn: 1240 init1: 1240 opt: 1240 Z-score: 1210.7 bits: 230.7 E(85289): 1.1e-60
Smith-Waterman score: 1240; 100.0% identity (100.0% similar) in 186 aa overlap (1-186:1-186)
10 20 30 40 50 60
pF1KE5 MFGKPDKMDVRCHSDAEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 MFGKPDKMDVRCHSDAEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 NKSKSNSAADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 NKSKSNSAADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RCQYVVGRERTELARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_954 RCQYVVGRERTELARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGG
130 140 150 160 170 180
pF1KE5 RGWQPL
::::::
NP_954 RGWQPL
>>NP_001106175 (OMIM: 604294,614402) ventral anterior ho (334 aa)
initn: 961 init1: 944 opt: 960 Z-score: 937.9 bits: 181.1 E(85289): 1.7e-45
Smith-Waterman score: 960; 89.8% identity (93.4% similar) in 167 aa overlap (1-167:1-162)
10 20 30 40 50 60
pF1KE5 MFGKPDKMDVRCHSDAEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFGKPDKMDVRCHSDAEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 NKSKSNSAADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKSKSNSAADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RCQYVVGRERTELARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGG
:::::::::::::::::::::::.. .:.: :::: . :.
NP_001 RCQYVVGRERTELARQLNLSETQVKVWFQNRR-----TKQKKDQGKDSELRSVVSETAAT
130 140 150 160 170
pF1KE5 RGWQPL
NP_001 CSVLRLLEQGRLLSPPGLPALLPPCATGALGSALRGPSLPALGAGAAAGSAAAAAAAAPG
180 190 200 210 220 230
>>NP_036608 (OMIM: 604295) ventral anterior homeobox 2 [ (290 aa)
initn: 508 init1: 461 opt: 488 Z-score: 484.2 bits: 96.9 E(85289): 3.1e-20
Smith-Waterman score: 488; 62.6% identity (80.2% similar) in 131 aa overlap (46-173:45-174)
20 30 40 50 60 70
pF1KE5 AEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDCNKSKSNSAADP---D
: :. ..: :. . . :.. : :
NP_036 RAESGGGGGRCGDRSGAGDLRADGGGHSPTEVAGTSASSPAGSRESGADSDGQPGPGEAD
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE5 YCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTE
.:::::::::::.::::.::::::::::::::::::::::::::::::::::::::::::
NP_036 HCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTE
80 90 100 110 120 130
140 150 160 170 180
pF1KE5 LARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGGRGWQPL
:::::::::::.. .:.: :. : :.. .:. ... :
NP_036 LARQLNLSETQVKVWFQNRRTKQK-KDQSRDLEKRASSSASEAFATSNILRLLEQGRLLS
140 150 160 170 180 190
NP_036 VPRAPSLLALTPSLPGLPASHRGTSLGDPRNSSPRLNPLSSASASPPLPPPLPAVCFSSA
200 210 220 230 240 250
>>XP_006712045 (OMIM: 604295) PREDICTED: ventral anterio (150 aa)
initn: 492 init1: 461 opt: 468 Z-score: 468.5 bits: 93.0 E(85289): 2.3e-19
Smith-Waterman score: 468; 74.3% identity (85.1% similar) in 101 aa overlap (46-143:45-145)
20 30 40 50 60 70
pF1KE5 AEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDCNKSKSNSAADP---D
: :. ..: :. . . :.. : :
XP_006 RAESGGGGGRCGDRSGAGDLRADGGGHSPTEVAGTSASSPAGSRESGADSDGQPGPGEAD
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE5 YCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTE
.:::::::::::.::::.::::::::::::::::::::::::::::::::::::::::::
XP_006 HCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTE
80 90 100 110 120 130
140 150 160 170 180
pF1KE5 LARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGGRGWQPL
:::::::::::
XP_006 LARQLNLSETQNQPQS
140 150
>>XP_011531052 (OMIM: 604295) PREDICTED: ventral anterio (150 aa)
initn: 492 init1: 461 opt: 468 Z-score: 468.5 bits: 93.0 E(85289): 2.3e-19
Smith-Waterman score: 468; 74.3% identity (85.1% similar) in 101 aa overlap (46-143:45-145)
20 30 40 50 60 70
pF1KE5 AEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDCNKSKSNSAADP---D
: :. ..: :. . . :.. : :
XP_011 RAESGGGGGRCGDRSGAGDLRADGGGHSPTEVAGTSASSPAGSRESGADSDGQPGPGEAD
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE5 YCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTE
.:::::::::::.::::.::::::::::::::::::::::::::::::::::::::::::
XP_011 HCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTE
80 90 100 110 120 130
140 150 160 170 180
pF1KE5 LARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGGRGWQPL
:::::::::::
XP_011 LARQLNLSETQNQPQS
140 150
>>XP_011531053 (OMIM: 604295) PREDICTED: ventral anterio (150 aa)
initn: 492 init1: 461 opt: 468 Z-score: 468.5 bits: 93.0 E(85289): 2.3e-19
Smith-Waterman score: 468; 74.3% identity (85.1% similar) in 101 aa overlap (46-143:45-145)
20 30 40 50 60 70
pF1KE5 AEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDCNKSKSNSAADP---D
: :. ..: :. . . :.. : :
XP_011 RAESGGGGGRCGDRSGAGDLRADGGGHSPTEVAGTSASSPAGSRESGADSDGQPGPGEAD
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE5 YCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTE
.:::::::::::.::::.::::::::::::::::::::::::::::::::::::::::::
XP_011 HCRRILVRDAKGTIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTE
80 90 100 110 120 130
140 150 160 170 180
pF1KE5 LARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGGRGWQPL
:::::::::::
XP_011 LARQLNLSETQNQPQS
140 150
>>XP_011530999 (OMIM: 600034) PREDICTED: homeobox protei (119 aa)
initn: 176 init1: 163 opt: 200 Z-score: 211.7 bits: 45.2 E(85289): 4.7e-05
Smith-Waterman score: 200; 39.5% identity (69.8% similar) in 86 aa overlap (99-184:20-102)
70 80 90 100 110 120
pF1KE5 ADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGR
.::: ::.:. :: ::: :.. .::::
XP_011 MVASDVPQDGLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGA
10 20 30 40
130 140 150 160 170 180
pF1KE5 ERTELARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGGRGWQPL
:: .:: .:.:::::.. .:.: : :..: ... : ......:. :.
XP_011 ERKQLAGSLSLSETQVKVWFQNRRTKY---KRQKLEEEGPESEQKKKGSHHINRWRIATK
50 60 70 80 90 100
XP_011 QANGEDIDVTSND
110
>>NP_004088 (OMIM: 600034) homeobox protein EMX1 [Homo s (290 aa)
initn: 180 init1: 163 opt: 200 Z-score: 206.8 bits: 45.6 E(85289): 8.8e-05
Smith-Waterman score: 200; 39.5% identity (69.8% similar) in 86 aa overlap (99-184:191-273)
70 80 90 100 110 120
pF1KE5 ADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGR
.::: ::.:. :: ::: :.. .::::
NP_004 WVLRNRFFGHRFQASDVPQDGLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGA
170 180 190 200 210 220
130 140 150 160 170 180
pF1KE5 ERTELARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGGRGWQPL
:: .:: .:.:::::.. .:.: : :..: ... : ......:. :.
NP_004 ERKQLAGSLSLSETQVKVWFQNRRTKY---KRQKLEEEGPESEQKKKGSHHINRWRIATK
230 240 250 260 270
NP_004 QANGEDIDVTSND
280 290
>>NP_064448 (OMIM: 605211) barH-like 1 homeobox protein (327 aa)
initn: 120 init1: 120 opt: 193 Z-score: 199.4 bits: 44.4 E(85289): 0.00023
Smith-Waterman score: 193; 38.5% identity (66.4% similar) in 122 aa overlap (40-154:120-232)
10 20 30 40 50 60
pF1KE5 VRCHSDAEAARVSKNAHKESRESKGAEGNLPAAFLKEPQGAFSASGAAEDC----NKSKS
::: :: : ..:. :::: .:: :
NP_064 RTVTSSFLIRDILADCKPLAACAPYSSSGQPAA--PEPGGRLAAK-AAEDFRDKLDKSGS
90 100 110 120 130 140
70 80 90 100 110 120
pF1KE5 NSAADPDYCRRILVRDAKGSIREIILPKG---LDLDRPKRTRTSFTAEQLYRLEMEFQRC
:...: .: :.. .:. ::: . . : .:...::.:: .:: .:: :.:
NP_064 NASSDSEYK----VKE-EGD-REISSSRDSPPVRLKKPRKARTAFTDHQLAQLERSFERQ
150 160 170 180 190 200
130 140 150 160 170 180
pF1KE5 QYVVGRERTELARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGGRG
.:. ..: ::: .:::..::... .:.: :
NP_064 KYLSVQDRMELAASLNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSP
210 220 230 240 250 260
pF1KE5 WQPL
NP_064 YFYPQSLVSNLDPGAALYLYRGPSAPPPALQRPLVPRILIHGLQGASEPPPPLPPLAGVL
270 280 290 300 310 320
>>NP_004089 (OMIM: 269160,600035) homeobox protein EMX2 (252 aa)
initn: 164 init1: 164 opt: 186 Z-score: 194.1 bits: 43.0 E(85289): 0.00045
Smith-Waterman score: 186; 38.4% identity (69.8% similar) in 86 aa overlap (99-184:153-235)
70 80 90 100 110 120
pF1KE5 ADPDYCRRILVRDAKGSIREIILPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGR
.::: ::.:. :: ::: :.. .::::
NP_004 LIHRYRYLGHRFQGNDTSPESFLLHNALARKPKRIRTAFSPSQLLRLEHAFEKNHYVVGA
130 140 150 160 170 180
130 140 150 160 170 180
pF1KE5 ERTELARQLNLSETQANSEENNERFKRGIKKQKKKRKKEPANDESRRGDSGGRGWQPL
:: .::..:.:.:::.. .:.: : .:.:: ... .. ....: :.
NP_004 ERKQLAHSLSLTETQVKVWFQNRRTK--FKRQKLEEEGSDSQ-QKKKGTHHINRWRIATK
190 200 210 220 230
NP_004 QASPEEIDVTSDD
240 250
186 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:42:17 2016 done: Mon Nov 7 22:42:18 2016
Total Scan time: 4.820 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]