FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE5218, 190 aa
  1>>>pF1KE5218 190 - 190 aa - 190 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8908+/-0.000341; mu= 15.0161+/- 0.021
 mean_var=57.3160+/-11.710, 0's: 0 Z-trim(113.9): 28  B-trim: 11 in 1/52
 Lambda= 0.169409
 statistics sampled from 23524 (23529) to 23524 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.664), E-opt: 0.2 (0.276), width:  16
 Scan time:  5.080

The best scores are:                                      opt bits E(85289)
NP_001850 (OMIM: 603085) high affinity copper upta ( 190) 1272 318.8 3.4e-87
NP_001851 (OMIM: 603088) probable low affinity cop ( 143)  223 62.3   4e-10
XP_016869756 (OMIM: 603088) PREDICTED: probable lo ( 199)  222 62.2 6.3e-10
XP_011516518 (OMIM: 603088) PREDICTED: probable lo ( 141)  217 60.9 1.1e-09


>>NP_001850 (OMIM: 603085) high affinity copper uptake p  (190 aa)
 initn: 1272 init1: 1272 opt: 1272  Z-score: 1686.5  bits: 318.8 E(85289): 3.4e-87
Smith-Waterman score: 1272; 100.0% identity (100.0% similar) in 190 aa overlap (1-190:1-190)

               10        20        30        40        50        60
pF1KE5 MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDHSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE5 LVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETH
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE5 KTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKA
              130       140       150       160       170       180

              190
pF1KE5 VVVDITEHCH
       ::::::::::
NP_001 VVVDITEHCH
              190

>>NP_001851 (OMIM: 603088) probable low affinity copper   (143 aa)
 initn: 210 init1: 118 opt: 223  Z-score: 302.7  bits: 62.3 E(85289): 4e-10
Smith-Waterman score: 228; 33.6% identity (65.0% similar) in 143 aa overlap (43-174:1-135)

             20        30        40        50        60        70  
pF1KE5 DSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGA
                                     : : : :.   : :::.   ... . :: .
NP_001                               MAMHFIFSDTAV-LLFDFWSVHSPAGMALS
                                             10         20         

             80        90       100       110       120       130  
pF1KE5 FVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFP-
        ....:::..:::.:... .::  .:: .   ..:.   . ::      ..:..  ::: 
NP_001 VLVLLLLAVLYEGIKVGKAKLL--NQVLV---NLPTSISQQTIAETDGDSAGSD--SFPV
      30        40        50             60        70          80  

                       140       150       160       170       180 
pF1KE5 ----------HLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAV
                 :. :...:.:::::.::.::  :.:: .. ..:. :...::.:       
NP_001 GRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLST
             90       100       110       120       130       140  

             190
pF1KE5 VVDITEHCH
                
NP_001 A        
                

>>XP_016869756 (OMIM: 603088) PREDICTED: probable low af  (199 aa)
 initn: 196 init1: 118 opt: 222  Z-score: 299.2  bits: 62.2 E(85289): 6.3e-10
Smith-Waterman score: 227; 30.5% identity (64.3% similar) in 154 aa overlap (33-174:45-191)

             10        20        30        40        50         60 
pF1KE5 HSHHMGMSYMDSNSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVE-LLFSGL
                                     :   :  .    ....: :...  :::.  
XP_016 FVALVSRRLQDTHMAQLPDKMAANQICLPFHPHTDVCLHRNSFSMHFIFSDTAVLLFDFW
           20        30        40        50        60        70    

              70        80        90       100       110       120 
pF1KE5 VINTAGEMAGAFVAVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHK
        ... . :: . ....:::..:::.:... .::  .:: .   ..:.   . ::      
XP_016 SVHSPAGMALSVLVLLLLAVLYEGIKVGKAKLL--NQVLV---NLPTSISQQTIAETDGD
           80        90       100         110          120         

             130                  140       150       160       170
pF1KE5 TVGQQMLSFP-----------HLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGT
       ..:..  :::           :. :...:.:::::.::.::  :.:: .. ..:. :...
XP_016 SAGSD--SFPVGRTHHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAV
     130         140       150       160       170       180       

              180       190
pF1KE5 GYFLFSWKKAVVVDITEHCH
       ::.:                
XP_016 GYYLAYPLLSTA        
       190                 

>>XP_011516518 (OMIM: 603088) PREDICTED: probable low af  (141 aa)
 initn: 210 init1: 118 opt: 217  Z-score: 294.9  bits: 60.9 E(85289): 1.1e-09
Smith-Waterman score: 222; 33.3% identity (65.2% similar) in 141 aa overlap (45-174:1-133)

           20        30        40        50        60        70    
pF1KE5 NSTMQPSHHHPTTSASHSHGGGDSSMMMMPMTFYFGFKNVELLFSGLVINTAGEMAGAFV
                                     : : :.   : :::.   ... . :: . .
XP_011                               MHFIFSDTAV-LLFDFWSVHSPAGMALSVL
                                             10         20         

           80        90       100       110       120       130    
pF1KE5 AVFLLAMFYEGLKIARESLLRKSQVSIRYNSMPVPGPNGTILMETHKTVGQQMLSFP---
       ...:::..:::.:... .::  .:: .   ..:.   . ::      ..:..  :::   
XP_011 VLLLLAVLYEGIKVGKAKLL--NQVLV---NLPTSISQQTIAETDGDSAGSD--SFPVGR
      30        40          50           60        70          80  

                     140       150       160       170       180   
pF1KE5 --------HLLQTVLHIIQVVISYFLMLIFMTYNGYLCIAVAAGAGTGYFLFSWKKAVVV
               :. :...:.:::::.::.::  :.:: .. ..:. :...::.:         
XP_011 THHRWYLCHFGQSLIHVIQVVIGYFIMLAVMSYNTWIFLGVVLGSAVGYYLAYPLLSTA 
             90       100       110       120       130       140  

           190
pF1KE5 DITEHCH




190 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 22:36:41 2016 done: Mon Nov  7 22:36:42 2016
 Total Scan time:  5.080 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]