Result of FASTA (omim) for
pFN21AE5213
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5213, 244 aa
1>>>pF1KE5213 244 - 244 aa - 244 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2581+/-0.000338; mu= 14.3444+/- 0.021
mean_var=62.6481+/-13.127, 0's: 0 Z-trim(113.6): 28 B-trim: 0 in 0/55
Lambda= 0.162039
statistics sampled from 23011 (23039) to 23011 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.27), width: 16
Scan time: 6.710
The best scores are: opt bits E(85289)
NP_056158 (OMIM: 610684) CTD nuclear envelope phos ( 244) 1623 387.9 8.7e-108
NP_001137247 (OMIM: 610684) CTD nuclear envelope p ( 244) 1623 387.9 8.7e-108
NP_001008393 (OMIM: 608592) CTD small phosphatase- ( 276) 462 116.5 4.9e-26
XP_016861009 (OMIM: 608592) PREDICTED: CTD small p ( 282) 462 116.5 5e-26
XP_016861008 (OMIM: 608592) PREDICTED: CTD small p ( 297) 462 116.5 5.2e-26
NP_005799 (OMIM: 608592) CTD small phosphatase-lik ( 265) 457 115.3 1.1e-25
NP_001193807 (OMIM: 605323) carboxy-terminal domai ( 260) 436 110.4 3.1e-24
NP_872580 (OMIM: 605323) carboxy-terminal domain R ( 260) 436 110.4 3.1e-24
XP_011509872 (OMIM: 605323) PREDICTED: carboxy-ter ( 393) 436 110.5 4.5e-24
NP_067021 (OMIM: 605323) carboxy-terminal domain R ( 261) 432 109.5 6e-24
XP_011509871 (OMIM: 605323) PREDICTED: carboxy-ter ( 394) 432 109.6 8.5e-24
NP_005721 (OMIM: 608711) carboxy-terminal domain R ( 271) 415 105.5 9.8e-23
XP_005268613 (OMIM: 608711) PREDICTED: carboxy-ter ( 277) 415 105.5 9.9e-23
XP_016860107 (OMIM: 605323) PREDICTED: carboxy-ter ( 275) 370 95.0 1.5e-19
XP_016860105 (OMIM: 605323) PREDICTED: carboxy-ter ( 408) 370 95.1 2e-19
XP_016860106 (OMIM: 605323) PREDICTED: carboxy-ter ( 276) 366 94.1 2.8e-19
XP_016860104 (OMIM: 605323) PREDICTED: carboxy-ter ( 409) 366 94.1 3.9e-19
NP_001316488 (OMIM: 607381) mitochondrial import i ( 240) 218 59.4 6.4e-09
XP_011525793 (OMIM: 607381) PREDICTED: mitochondri ( 341) 218 59.5 8.7e-09
NP_001001563 (OMIM: 607381) mitochondrial import i ( 456) 218 59.6 1.1e-08
NP_001189433 (OMIM: 604168,604927) RNA polymerase ( 842) 162 46.6 0.00016
XP_011524563 (OMIM: 604168,604927) PREDICTED: RNA ( 851) 162 46.6 0.00016
NP_430255 (OMIM: 604168,604927) RNA polymerase II ( 867) 162 46.6 0.00017
NP_001305440 (OMIM: 604168,604927) RNA polymerase ( 867) 162 46.6 0.00017
NP_004706 (OMIM: 604168,604927) RNA polymerase II ( 961) 162 46.6 0.00018
XP_016881567 (OMIM: 604168,604927) PREDICTED: RNA ( 776) 141 41.7 0.0046
>>NP_056158 (OMIM: 610684) CTD nuclear envelope phosphat (244 aa)
initn: 1623 init1: 1623 opt: 1623 Z-score: 2056.1 bits: 387.9 E(85289): 8.7e-108
Smith-Waterman score: 1623; 100.0% identity (100.0% similar) in 244 aa overlap (1-244:1-244)
10 20 30 40 50 60
pF1KE5 MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 RKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 RKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQ
190 200 210 220 230 240
pF1KE5 HRLW
::::
NP_056 HRLW
>>NP_001137247 (OMIM: 610684) CTD nuclear envelope phosp (244 aa)
initn: 1623 init1: 1623 opt: 1623 Z-score: 2056.1 bits: 387.9 E(85289): 8.7e-108
Smith-Waterman score: 1623; 100.0% identity (100.0% similar) in 244 aa overlap (1-244:1-244)
10 20 30 40 50 60
pF1KE5 MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 RKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 SIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQ
190 200 210 220 230 240
pF1KE5 HRLW
::::
NP_001 HRLW
>>NP_001008393 (OMIM: 608592) CTD small phosphatase-like (276 aa)
initn: 443 init1: 237 opt: 462 Z-score: 588.4 bits: 116.5 E(85289): 4.9e-26
Smith-Waterman score: 501; 41.4% identity (69.7% similar) in 198 aa overlap (45-236:84-272)
20 30 40 50 60
pF1KE5 AFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPL-SPVSRNRLAQVK-----RKILVLDL
..:. :: .. : .: .: .:.::
NP_001 NVEAPPPSSPSVLPPLVEENGGLQKGDQRQVIPIPSPPAKYLLPEVTVLDYGKKCVVIDL
60 70 80 90 100 110
70 80 90 100 110 120
pF1KE5 DETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELV
::::.:: . .: . :::. : :: . .: :::::: ::. ..: .: :
NP_001 DETLVHS--------SFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECV
120 130 140 150 160
130 140 150 160 170 180
pF1KE5 VFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNS
.::::. :.. ::: :: .... : .:. :... :.:.:::: . .::...:.:::
NP_001 LFTASLAKYADPVADLLDR-WGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNS
170 180 190 200 210 220
190 200 210 220 230 240
pF1KE5 PGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
:..: ::.::.:..:::.: .:: ::.:.:....: :: :.: :
NP_001 PASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCNR
230 240 250 260 270
>>XP_016861009 (OMIM: 608592) PREDICTED: CTD small phosp (282 aa)
initn: 443 init1: 237 opt: 462 Z-score: 588.3 bits: 116.5 E(85289): 5e-26
Smith-Waterman score: 501; 41.4% identity (69.7% similar) in 198 aa overlap (45-236:69-257)
20 30 40 50 60
pF1KE5 AFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPL-SPVSRNRLAQVK-----RKILVLDL
..:. :: .. : .: .: .:.::
XP_016 NVEAPPPSSPSVLPPLVEENGGLQKGDQRQVIPIPSPPAKYLLPEVTVLDYGKKCVVIDL
40 50 60 70 80 90
70 80 90 100 110 120
pF1KE5 DETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELV
::::.:: . .: . :::. : :: . .: :::::: ::. ..: .: :
XP_016 DETLVHS--------SFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECV
100 110 120 130 140 150
130 140 150 160 170 180
pF1KE5 VFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNS
.::::. :.. ::: :: .... : .:. :... :.:.:::: . .::...:.:::
XP_016 LFTASLAKYADPVADLLDR-WGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNS
160 170 180 190 200
190 200 210 220 230 240
pF1KE5 PGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
:..: ::.::.:..:::.: .:: ::.:.:....: :: :.: :
XP_016 PASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCNSWIHMELFG
210 220 230 240 250 260
XP_016 NFPCCYRAATKWN
270 280
>>XP_016861008 (OMIM: 608592) PREDICTED: CTD small phosp (297 aa)
initn: 443 init1: 237 opt: 462 Z-score: 588.0 bits: 116.5 E(85289): 5.2e-26
Smith-Waterman score: 501; 41.4% identity (69.7% similar) in 198 aa overlap (45-236:84-272)
20 30 40 50 60
pF1KE5 AFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPL-SPVSRNRLAQVK-----RKILVLDL
..:. :: .. : .: .: .:.::
XP_016 NVEAPPPSSPSVLPPLVEENGGLQKGDQRQVIPIPSPPAKYLLPEVTVLDYGKKCVVIDL
60 70 80 90 100 110
70 80 90 100 110 120
pF1KE5 DETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELV
::::.:: . .: . :::. : :: . .: :::::: ::. ..: .: :
XP_016 DETLVHS--------SFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECV
120 130 140 150 160
130 140 150 160 170 180
pF1KE5 VFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNS
.::::. :.. ::: :: .... : .:. :... :.:.:::: . .::...:.:::
XP_016 LFTASLAKYADPVADLLDR-WGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNS
170 180 190 200 210 220
190 200 210 220 230 240
pF1KE5 PGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
:..: ::.::.:..:::.: .:: ::.:.:....: :: :.: :
XP_016 PASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCNSWIHMELFG
230 240 250 260 270 280
XP_016 NFPCCYRAATKWN
290
>>NP_005799 (OMIM: 608592) CTD small phosphatase-like pr (265 aa)
initn: 443 init1: 237 opt: 457 Z-score: 582.4 bits: 115.3 E(85289): 1.1e-25
Smith-Waterman score: 494; 43.8% identity (72.2% similar) in 176 aa overlap (61-236:95-261)
40 50 60 70 80 90
pF1KE5 QIRTVIQYQTVRYDILPLSPVSRNRLAQVKRKILVLDLDETLIHSHHDGVLRPTVRPGTP
.: .:.::::::.:: . .: .
NP_005 VLPPLVEENGGLQKPPAKYLLPEVTVLDYGKKCVVIDLDETLVHS--------SFKPISN
70 80 90 100 110
100 110 120 130 140 150
pF1KE5 PDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRS
:::. : :: . .: :::::: ::. ..: .: :.::::. :.. ::: :: .
NP_005 ADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDR-WG
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE5 ILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPS
... : .:. :... :.:.:::: . .::...:.::::..: ::.::.:..:::.: .
NP_005 VFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMT
180 190 200 210 220 230
220 230 240
pF1KE5 DTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
:: ::.:.:....: :: :.: :
NP_005 DTELLDLIPFFEGLSREDDVYSMLHRLCNR
240 250 260
>>NP_001193807 (OMIM: 605323) carboxy-terminal domain RN (260 aa)
initn: 476 init1: 283 opt: 436 Z-score: 556.0 bits: 110.4 E(85289): 3.1e-24
Smith-Waterman score: 478; 43.5% identity (68.4% similar) in 193 aa overlap (46-234:70-253)
20 30 40 50 60 70
pF1KE5 FAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSR---NRLAQVKRKI-LVLDLDET
.: .::. . :: . :: .:.:::::
NP_001 HSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKTPVQYLLPEAKAQDSDKICVVIDLDET
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE5 LIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFT
:.:: . .: . :::. : :: . .: :::::: ::. ... .: :.::
NP_001 LVHS--------SFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFT
100 110 120 130 140 150
140 150 160 170 180 190
pF1KE5 ASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGA
::. :.. ::: ::. . .. : .:. :... :.:.:::: . :: ..::::::..
NP_001 ASLAKYADPVADLLDK-WGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPAS
160 170 180 190 200 210
200 210 220 230 240
pF1KE5 YRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
: :::::.:. :::.. ::: : .:::... : . :: :::
NP_001 YVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
220 230 240 250 260
>>NP_872580 (OMIM: 605323) carboxy-terminal domain RNA p (260 aa)
initn: 476 init1: 283 opt: 436 Z-score: 556.0 bits: 110.4 E(85289): 3.1e-24
Smith-Waterman score: 478; 43.5% identity (68.4% similar) in 193 aa overlap (46-234:70-253)
20 30 40 50 60 70
pF1KE5 FAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSR---NRLAQVKRKI-LVLDLDET
.: .::. . :: . :: .:.:::::
NP_872 HSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKTPVQYLLPEAKAQDSDKICVVIDLDET
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE5 LIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFT
:.:: . .: . :::. : :: . .: :::::: ::. ... .: :.::
NP_872 LVHS--------SFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFT
100 110 120 130 140 150
140 150 160 170 180 190
pF1KE5 ASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGA
::. :.. ::: ::. . .. : .:. :... :.:.:::: . :: ..::::::..
NP_872 ASLAKYADPVADLLDK-WGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPAS
160 170 180 190 200 210
200 210 220 230 240
pF1KE5 YRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
: :::::.:. :::.. ::: : .:::... : . :: :::
NP_872 YVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
220 230 240 250 260
>>XP_011509872 (OMIM: 605323) PREDICTED: carboxy-termina (393 aa)
initn: 476 init1: 283 opt: 436 Z-score: 553.2 bits: 110.5 E(85289): 4.5e-24
Smith-Waterman score: 478; 43.5% identity (68.4% similar) in 193 aa overlap (46-234:203-386)
20 30 40 50 60 70
pF1KE5 FAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSR---NRLAQVKRKI-LVLDLDET
.: .::. . :: . :: .:.:::::
XP_011 HSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKTPVQYLLPEAKAQDSDKICVVIDLDET
180 190 200 210 220 230
80 90 100 110 120 130
pF1KE5 LIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFT
:.:: . .: . :::. : :: . .: :::::: ::. ... .: :.::
XP_011 LVHS--------SFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFT
240 250 260 270 280
140 150 160 170 180 190
pF1KE5 ASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGA
::. :.. ::: ::. . .. : .:. :... :.:.:::: . :: ..::::::..
XP_011 ASLAKYADPVADLLDK-WGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPAS
290 300 310 320 330 340
200 210 220 230 240
pF1KE5 YRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
: :::::.:. :::.. ::: : .:::... : . :: :::
XP_011 YVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
350 360 370 380 390
>>NP_067021 (OMIM: 605323) carboxy-terminal domain RNA p (261 aa)
initn: 476 init1: 283 opt: 432 Z-score: 550.9 bits: 109.5 E(85289): 6e-24
Smith-Waterman score: 474; 45.3% identity (69.8% similar) in 179 aa overlap (57-234:85-254)
30 40 50 60 70 80
pF1KE5 LLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVKRKI-LVLDLDETLIHSHHDGVLRPTV
:: . :: .:.::::::.:: .
NP_067 PAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHS--------SF
60 70 80 90 100
90 100 110 120 130 140
pF1KE5 RPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKL
.: . :::. : :: . .: :::::: ::. ... .: :.::::. :.. ::: :
NP_067 KPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLL
110 120 130 140 150 160
150 160 170 180 190 200
pF1KE5 DNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSW
:. . .. : .:. :... :.:.:::: . :: ..::::::..: :::::.:. ::
NP_067 DK-WGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASW
170 180 190 200 210 220
210 220 230 240
pF1KE5 FSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
:.. ::: : .:::... : . :: :::
NP_067 FDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
230 240 250 260
244 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:33:53 2016 done: Mon Nov 7 22:33:54 2016
Total Scan time: 6.710 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]