Result of FASTA (omim) for
pFN21AE5172
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5172, 162 aa
1>>>pF1KE5172 162 - 162 aa - 162 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8305+/-0.000295; mu= 14.4870+/- 0.018
mean_var=60.4752+/-12.779, 0's: 0 Z-trim(117.7): 73 B-trim: 999 in 1/56
Lambda= 0.164925
statistics sampled from 29869 (29942) to 29869 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.751), E-opt: 0.2 (0.351), width: 16
Scan time: 5.550
The best scores are: opt bits E(85289)
NP_003786 (OMIM: 605930) sorting nexin-3 isoform a ( 162) 1084 265.7 2.4e-71
NP_001243114 (OMIM: 300883) sorting nexin-12 isofo ( 162) 910 224.2 7e-59
NP_037478 (OMIM: 300883) sorting nexin-12 isoform ( 162) 910 224.2 7e-59
NP_001243117 (OMIM: 300883) sorting nexin-12 isofo ( 158) 877 216.4 1.6e-56
NP_001287858 (OMIM: 605930) sorting nexin-3 isofor ( 140) 751 186.4 1.5e-47
NP_001287857 (OMIM: 605930) sorting nexin-3 isofor ( 105) 559 140.6 6.8e-34
NP_690040 (OMIM: 605930) sorting nexin-3 isoform b ( 130) 531 134.0 8.2e-32
NP_001243116 (OMIM: 300883) sorting nexin-12 isofo ( 96) 475 120.6 6.6e-28
NP_001243115 (OMIM: 300883) sorting nexin-12 isofo ( 92) 442 112.7 1.5e-25
XP_016856917 (OMIM: 614904) PREDICTED: sorting nex ( 336) 245 66.2 5.3e-11
XP_006710741 (OMIM: 614904) PREDICTED: sorting nex ( 387) 245 66.3 6e-11
XP_016856914 (OMIM: 614904) PREDICTED: sorting nex ( 387) 245 66.3 6e-11
XP_016856916 (OMIM: 614904) PREDICTED: sorting nex ( 387) 245 66.3 6e-11
XP_011539866 (OMIM: 614904) PREDICTED: sorting nex ( 387) 245 66.3 6e-11
XP_016856915 (OMIM: 614904) PREDICTED: sorting nex ( 387) 245 66.3 6e-11
XP_006710740 (OMIM: 614904) PREDICTED: sorting nex ( 422) 245 66.3 6.4e-11
NP_057060 (OMIM: 614904) sorting nexin-7 isoform a ( 451) 245 66.3 6.8e-11
NP_003090 (OMIM: 601272) sorting nexin-1 isoform a ( 522) 240 65.2 1.7e-10
NP_001229862 (OMIM: 601272) sorting nexin-1 isofor ( 557) 240 65.2 1.8e-10
XP_005257319 (OMIM: 614906) PREDICTED: sorting nex ( 262) 232 63.1 3.7e-10
NP_001317249 (OMIM: 614906) sorting nexin-11 isofo ( 262) 232 63.1 3.7e-10
NP_037455 (OMIM: 614906) sorting nexin-11 isoform ( 270) 232 63.1 3.8e-10
NP_689450 (OMIM: 614906) sorting nexin-11 isoform ( 270) 232 63.1 3.8e-10
XP_011522999 (OMIM: 614906) PREDICTED: sorting nex ( 270) 232 63.1 3.8e-10
XP_005257317 (OMIM: 614906) PREDICTED: sorting nex ( 270) 232 63.1 3.8e-10
NP_001265128 (OMIM: 605929) sorting nexin-2 isofor ( 402) 231 63.0 6.2e-10
NP_003091 (OMIM: 605929) sorting nexin-2 isoform 1 ( 519) 231 63.0 7.6e-10
XP_016867575 (OMIM: 614780,615085) PREDICTED: sort ( 227) 226 61.6 9e-10
XP_016867574 (OMIM: 614780,615085) PREDICTED: sort ( 227) 226 61.6 9e-10
XP_016867576 (OMIM: 614780,615085) PREDICTED: sort ( 227) 226 61.6 9e-10
NP_001305127 (OMIM: 614780,615085) sorting nexin-1 ( 227) 226 61.6 9e-10
NP_001186766 (OMIM: 614780,615085) sorting nexin-1 ( 198) 219 59.9 2.6e-09
NP_001186764 (OMIM: 614780,615085) sorting nexin-1 ( 201) 217 59.4 3.6e-09
NP_037454 (OMIM: 614780,615085) sorting nexin-10 i ( 201) 217 59.4 3.6e-09
XP_006715775 (OMIM: 614780,615085) PREDICTED: sort ( 201) 217 59.4 3.6e-09
NP_001305128 (OMIM: 614780,615085) sorting nexin-1 ( 201) 217 59.4 3.6e-09
NP_683758 (OMIM: 601272) sorting nexin-1 isoform b ( 457) 213 58.7 1.3e-08
XP_005254668 (OMIM: 601272) PREDICTED: sorting nex ( 399) 202 56.1 7.4e-08
XP_016867577 (OMIM: 614780,615085) PREDICTED: sort ( 161) 192 53.4 1.9e-07
NP_003785 (OMIM: 605931) sorting nexin-4 [Homo sap ( 450) 187 52.5 9.6e-07
XP_016862903 (OMIM: 605931) PREDICTED: sorting nex ( 482) 187 52.5 1e-06
NP_733827 (OMIM: 607591) serine/threonine-protein ( 464) 138 40.9 0.0032
NP_037389 (OMIM: 607591) serine/threonine-protein ( 496) 138 40.9 0.0034
NP_001028750 (OMIM: 607591) serine/threonine-prote ( 496) 138 40.9 0.0034
>>NP_003786 (OMIM: 605930) sorting nexin-3 isoform a [Ho (162 aa)
initn: 1084 init1: 1084 opt: 1084 Z-score: 1401.9 bits: 265.7 E(85289): 2.4e-71
Smith-Waterman score: 1084; 100.0% identity (100.0% similar) in 162 aa overlap (1-162:1-162)
10 20 30 40 50 60
pF1KE5 MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 KLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQ
70 80 90 100 110 120
130 140 150 160
pF1KE5 GLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
::::::::::::::::::::::::::::::::::::::::::
NP_003 GLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
130 140 150 160
>>NP_001243114 (OMIM: 300883) sorting nexin-12 isoform 1 (162 aa)
initn: 907 init1: 907 opt: 910 Z-score: 1178.1 bits: 224.2 E(85289): 7e-59
Smith-Waterman score: 910; 79.0% identity (96.3% similar) in 162 aa overlap (1-161:1-162)
10 20 30 40 50
pF1KE5 MAET-VADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPI
:..: ::::::: .:::.:.:::::::::::::. :::::::::.::::::.:..:::::
NP_001 MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 FKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERK
:::::: :::::::::::..::::.::.:::::::::. ::::::::.:::...:::::.
NP_001 FKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERR
70 80 90 100 110 120
120 130 140 150 160
pF1KE5 QGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
:::::::::.:::::::::::::::::.: ::..:.:.:.:.
NP_001 QGLEQFINKIAGHPLAQNERCLHMFLQEEAIDRNYVPGKVRQ
130 140 150 160
>>NP_037478 (OMIM: 300883) sorting nexin-12 isoform 1 [H (162 aa)
initn: 907 init1: 907 opt: 910 Z-score: 1178.1 bits: 224.2 E(85289): 7e-59
Smith-Waterman score: 910; 79.0% identity (96.3% similar) in 162 aa overlap (1-161:1-162)
10 20 30 40 50
pF1KE5 MAET-VADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPI
:..: ::::::: .:::.:.:::::::::::::. :::::::::.::::::.:..:::::
NP_037 MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 FKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERK
:::::: :::::::::::..::::.::.:::::::::. ::::::::.:::...:::::.
NP_037 FKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERR
70 80 90 100 110 120
120 130 140 150 160
pF1KE5 QGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
:::::::::.:::::::::::::::::.: ::..:.:.:.:.
NP_037 QGLEQFINKIAGHPLAQNERCLHMFLQEEAIDRNYVPGKVRQ
130 140 150 160
>>NP_001243117 (OMIM: 300883) sorting nexin-12 isoform 4 (158 aa)
initn: 878 init1: 626 opt: 877 Z-score: 1135.8 bits: 216.4 E(85289): 1.6e-56
Smith-Waterman score: 877; 78.4% identity (93.8% similar) in 162 aa overlap (1-161:1-158)
10 20 30 40 50
pF1KE5 MAET-VADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPI
:..: ::::::: .:::.:.:::::::::::::. :::::::::.:::::: :::::
NP_001 MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYE----TNLPI
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 FKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERK
:::::: :::::::::::..::::.::.:::::::::. ::::::::.:::...:::::.
NP_001 FKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERR
60 70 80 90 100 110
120 130 140 150 160
pF1KE5 QGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
:::::::::.:::::::::::::::::.: ::..:.:.:.:.
NP_001 QGLEQFINKIAGHPLAQNERCLHMFLQEEAIDRNYVPGKVRQ
120 130 140 150
>>NP_001287858 (OMIM: 605930) sorting nexin-3 isoform d (140 aa)
initn: 750 init1: 737 opt: 751 Z-score: 974.6 bits: 186.4 E(85289): 1.5e-47
Smith-Waterman score: 888; 86.4% identity (86.4% similar) in 162 aa overlap (1-162:1-140)
10 20 30 40 50 60
pF1KE5 MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIF
:::::::::::::::::::::::::::::::: ::::::
NP_001 MAETVADTRRLITKPQNLNDAYGPPSNFLEID----------------------TNLPIF
10 20 30
70 80 90 100 110 120
pF1KE5 KLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQ
40 50 60 70 80 90
130 140 150 160
pF1KE5 GLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
::::::::::::::::::::::::::::::::::::::::::
NP_001 GLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
100 110 120 130 140
>>NP_001287857 (OMIM: 605930) sorting nexin-3 isoform c (105 aa)
initn: 559 init1: 559 opt: 559 Z-score: 729.4 bits: 140.6 E(85289): 6.8e-34
Smith-Waterman score: 559; 100.0% identity (100.0% similar) in 86 aa overlap (1-86:1-86)
10 20 30 40 50 60
pF1KE5 MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 KLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQ
::::::::::::::::::::::::::
NP_001 KLKESTVRRRYSDFEWLRSELERESKGRWSSSGTERTLSSHVFTR
70 80 90 100
>>NP_690040 (OMIM: 605930) sorting nexin-3 isoform b [Ho (130 aa)
initn: 531 init1: 531 opt: 531 Z-score: 692.1 bits: 134.0 E(85289): 8.2e-32
Smith-Waterman score: 803; 80.2% identity (80.2% similar) in 162 aa overlap (1-162:1-130)
10 20 30 40 50 60
pF1KE5 MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVK------
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 KLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQ
::::::::::::::::::::::::::::::::::
NP_690 --------------------------VVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQ
60 70 80
130 140 150 160
pF1KE5 GLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
::::::::::::::::::::::::::::::::::::::::::
NP_690 GLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
90 100 110 120 130
>>NP_001243116 (OMIM: 300883) sorting nexin-12 isoform 3 (96 aa)
initn: 470 init1: 470 opt: 475 Z-score: 622.0 bits: 120.6 E(85289): 6.6e-28
Smith-Waterman score: 475; 77.2% identity (91.3% similar) in 92 aa overlap (1-91:1-92)
10 20 30 40 50
pF1KE5 MAET-VADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPI
:..: ::::::: .:::.:.:::::::::::::. :::::::::.::::::.:..:::::
NP_001 MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 FKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERK
:::::: :::::::::::..::::.:: :
NP_001 FKLKESCVRRRYSDFEWLKNELERDSKNCWAPTGSE
70 80 90
120 130 140 150 160
pF1KE5 QGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
>>NP_001243115 (OMIM: 300883) sorting nexin-12 isoform 2 (92 aa)
initn: 266 init1: 266 opt: 442 Z-score: 579.8 bits: 112.7 E(85289): 1.5e-25
Smith-Waterman score: 442; 76.1% identity (87.0% similar) in 92 aa overlap (1-91:1-88)
10 20 30 40 50
pF1KE5 MAET-VADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPI
:..: ::::::: .:::.:.:::::::::::::. :::::::::.:::::: :::::
NP_001 MSDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYE----TNLPI
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 FKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERK
:::::: :::::::::::..::::.:: :
NP_001 FKLKESCVRRRYSDFEWLKNELERDSKNCWAPTGSE
60 70 80 90
120 130 140 150 160
pF1KE5 QGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
>>XP_016856917 (OMIM: 614904) PREDICTED: sorting nexin-7 (336 aa)
initn: 246 init1: 114 opt: 245 Z-score: 318.4 bits: 66.2 E(85289): 5.3e-11
Smith-Waterman score: 245; 35.8% identity (66.7% similar) in 123 aa overlap (24-145:27-144)
10 20 30 40 50
pF1KE5 MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNL
: . : : :..:.. . : ::.: .::.
XP_016 MDMNSFSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSR
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 PIFKLKESTVRRRYSDFEWLRSELER-ESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIE
: .: :::::.:: ::...::. . ...:::: : ... . : :.:.:::
XP_016 GEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVER-----FNDDFIE
70 80 90 100 110
120 130 140 150 160
pF1KE5 ERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA
:...:..:.:..: :: .. ...::
XP_016 TRRKALHKFLNRIADHPTLTFNEDFKIFLTAQAWELSSHKKQGPGLLSRMGQTVRAVASS
120 130 140 150 160 170
162 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:16:28 2016 done: Mon Nov 7 22:16:29 2016
Total Scan time: 5.550 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]