Result of FASTA (omim) for
pFN21AE5154
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5154, 100 aa
1>>>pF1KE5154 100 - 100 aa - 100 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8833+/-0.000252; mu= 8.3896+/- 0.016
mean_var=104.2172+/-20.918, 0's: 0 Z-trim(123.2): 172 B-trim: 2100 in 1/59
Lambda= 0.125633
statistics sampled from 42456 (42701) to 42456 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.844), E-opt: 0.2 (0.501), width: 16
Scan time: 4.150
The best scores are: opt bits E(85289)
NP_067545 (OMIM: 603260) homeobox protein BarH-lik ( 254) 667 129.9 1.7e-30
XP_011541346 (OMIM: 604823) PREDICTED: homeobox pr ( 134) 447 89.8 1e-18
XP_011541345 (OMIM: 604823) PREDICTED: homeobox pr ( 233) 447 90.0 1.6e-18
NP_003649 (OMIM: 604823) homeobox protein BarH-lik ( 279) 447 90.1 1.8e-18
NP_001091639 (OMIM: 611074) brain-specific homeobo ( 233) 237 52.0 4.5e-07
NP_068777 (OMIM: 142995) H2.0-like homeobox protei ( 488) 232 51.3 1.5e-06
NP_835221 (OMIM: 600029) homeobox protein DLX-1 is ( 255) 212 47.5 1.1e-05
NP_064447 (OMIM: 605212) barH-like 2 homeobox prot ( 387) 209 47.1 2.2e-05
NP_002720 (OMIM: 604420) hematopoietically-express ( 270) 206 46.4 2.5e-05
NP_064448 (OMIM: 605211) barH-like 1 homeobox prot ( 327) 207 46.7 2.5e-05
NP_004396 (OMIM: 126255) homeobox protein DLX-2 [H ( 328) 204 46.1 3.7e-05
XP_016867292 (OMIM: 220600,600028) PREDICTED: home ( 161) 198 44.8 4.6e-05
XP_005250242 (OMIM: 220600,600028) PREDICTED: home ( 161) 198 44.8 4.6e-05
NP_005213 (OMIM: 600030) homeobox protein DLX-6 [H ( 293) 201 45.5 4.9e-05
XP_016868632 (OMIM: 610772) PREDICTED: homeobox pr ( 265) 198 44.9 6.7e-05
NP_005212 (OMIM: 220600,600028) homeobox protein D ( 289) 198 45.0 7.1e-05
NP_005211 (OMIM: 104510,190320,600525) homeobox pr ( 287) 194 44.2 0.00012
NP_001925 (OMIM: 601911,616788) homeobox protein D ( 168) 189 43.1 0.00015
XP_016879780 (OMIM: 601911,616788) PREDICTED: home ( 168) 189 43.1 0.00015
NP_149416 (OMIM: 607808) homeobox protein Nkx-2.4 ( 354) 193 44.1 0.00016
NP_612138 (OMIM: 601911,616788) homeobox protein D ( 240) 189 43.3 0.00019
NP_001476 (OMIM: 601135) homeobox protein GBX-2 is ( 348) 191 43.8 0.0002
NP_076920 (OMIM: 142965) homeobox protein Hox-B4 [ ( 251) 189 43.3 0.0002
NP_796374 (OMIM: 605955) homeobox protein Nkx-6.2 ( 277) 189 43.3 0.00021
XP_016872278 (OMIM: 605955) PREDICTED: homeobox pr ( 277) 189 43.3 0.00021
NP_002135 (OMIM: 142968,614744) homeobox protein H ( 301) 189 43.4 0.00023
NP_006159 (OMIM: 602563) homeobox protein Nkx-6.1 ( 367) 190 43.6 0.00023
NP_001180 (OMIM: 602183,613330) homeobox protein N ( 333) 189 43.4 0.00025
XP_016867454 (OMIM: 603354) PREDICTED: homeobox pr ( 203) 185 42.5 0.00028
XP_016867453 (OMIM: 603354) PREDICTED: homeobox pr ( 204) 185 42.5 0.00028
NP_066305 (OMIM: 604640) T-cell leukemia homeobox ( 291) 187 43.0 0.00029
XP_011530999 (OMIM: 600034) PREDICTED: homeobox pr ( 119) 179 41.2 0.0004
NP_001129743 (OMIM: 217095,611770) homeobox protei ( 301) 184 42.5 0.00043
NP_001092304 (OMIM: 603354) homeobox protein GBX-1 ( 363) 185 42.7 0.00043
NP_055435 (OMIM: 142974) homeobox protein Hox-C4 [ ( 264) 183 42.2 0.00044
NP_705897 (OMIM: 142974) homeobox protein Hox-C4 [ ( 264) 183 42.2 0.00044
NP_001035091 (OMIM: 214300,600147) homeobox protei ( 139) 179 41.3 0.00045
NP_660328 (OMIM: 606727) homeobox protein Nkx-2.3 ( 364) 184 42.5 0.00049
NP_001158727 (OMIM: 142994,176450) motor neuron an ( 189) 180 41.6 0.0005
NP_005512 (OMIM: 186770) T-cell leukemia homeobox ( 330) 183 42.3 0.00052
XP_011538046 (OMIM: 186770) PREDICTED: T-cell leuk ( 342) 183 42.3 0.00053
NP_001182446 (OMIM: 186770) T-cell leukemia homeob ( 257) 180 41.7 0.00063
XP_011538047 (OMIM: 186770) PREDICTED: T-cell leuk ( 269) 180 41.7 0.00065
NP_008827 (OMIM: 142950) homeobox protein Hox-A7 [ ( 230) 179 41.4 0.00066
NP_000200 (OMIM: 125853,260370,600733,606176,60639 ( 283) 180 41.7 0.00067
NP_004518 (OMIM: 214300,600147) homeobox protein M ( 254) 179 41.5 0.00071
NP_005513 (OMIM: 142955,601536) homeobox protein H ( 335) 180 41.8 0.00076
NP_004088 (OMIM: 600034) homeobox protein EMX1 [Ho ( 290) 179 41.5 0.00078
NP_710160 (OMIM: 142972) homeobox protein Hox-C6 i ( 153) 175 40.6 0.0008
NP_004378 (OMIM: 108900,187500,217095,225250,60058 ( 324) 179 41.6 0.00084
>>NP_067545 (OMIM: 603260) homeobox protein BarH-like 1 (254 aa)
initn: 667 init1: 667 opt: 667 Z-score: 668.6 bits: 129.9 E(85289): 1.7e-30
Smith-Waterman score: 667; 100.0% identity (100.0% similar) in 100 aa overlap (1-100:155-254)
10 20 30
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQL
::::::::::::::::::::::::::::::
NP_067 GKLEAAGPGEPGTKAKKGRRSRTVFTELQLMGLEKRFEKQKYLSTPDRIDLAESLGLSQL
130 140 150 160 170 180
40 50 60 70 80 90
pF1KE5 QVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 QVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVP
190 200 210 220 230 240
100
pF1KE5 GEPSDRSRED
::::::::::
NP_067 GEPSDRSRED
250
>>XP_011541346 (OMIM: 604823) PREDICTED: homeobox protei (134 aa)
initn: 464 init1: 315 opt: 447 Z-score: 456.8 bits: 89.8 E(85289): 1e-18
Smith-Waterman score: 447; 68.7% identity (86.9% similar) in 99 aa overlap (1-99:1-97)
10 20 30 40 50 60
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKKIVLQGGGLESPTKPK
:::::.:.::::::::::.:::.::::.:::::::::::::::::.::.:: :.:::::
XP_011 MGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTWYQNRRMKWKKMVLKGGQ-EAPTKPK
10 20 30 40 50
70 80 90 100
pF1KE5 GRPKKNSIPTSEQLTEQERAKDAEKPAEVPGEPSDRSRED
::::::::::::.. .:. .. . : :::. ..:
XP_011 GRPKKNSIPTSEEIEAEEKMNSQAQGQE-QLEPSQGQEELCEAQEPKARDVPLEMAEPPD
60 70 80 90 100 110
XP_011 PPQELPIPSSEPPPLS
120 130
>>XP_011541345 (OMIM: 604823) PREDICTED: homeobox protei (233 aa)
initn: 454 init1: 315 opt: 447 Z-score: 453.6 bits: 90.0 E(85289): 1.6e-18
Smith-Waterman score: 447; 68.7% identity (86.9% similar) in 99 aa overlap (1-99:100-196)
10 20 30
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQL
:::::.:.::::::::::.:::.::::.::
XP_011 LASSESETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQL
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE5 QVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVP
:::::::::::::::.::.:: :.:::::::::::::::::.. .:. .. . :
XP_011 QVKTWYQNRRMKWKKMVLKGGQ-EAPTKPKGRPKKNSIPTSEEIEAEEKMNSQAQGQE-Q
130 140 150 160 170 180
100
pF1KE5 GEPSDRSRED
:::. ..:
XP_011 LEPSQGQEELCEAQEPKARDVPLEMAEPPDPPQELPIPSSEPPPLS
190 200 210 220 230
>>NP_003649 (OMIM: 604823) homeobox protein BarH-like 2 (279 aa)
initn: 454 init1: 315 opt: 447 Z-score: 452.6 bits: 90.1 E(85289): 1.8e-18
Smith-Waterman score: 447; 68.7% identity (86.9% similar) in 99 aa overlap (1-99:146-242)
10 20 30
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQL
:::::.:.::::::::::.:::.::::.::
NP_003 LASSESETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQL
120 130 140 150 160 170
40 50 60 70 80 90
pF1KE5 QVKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVP
:::::::::::::::.::.:: :.:::::::::::::::::.. .:. .. . :
NP_003 QVKTWYQNRRMKWKKMVLKGGQ-EAPTKPKGRPKKNSIPTSEEIEAEEKMNSQAQGQE-Q
180 190 200 210 220 230
100
pF1KE5 GEPSDRSRED
:::. ..:
NP_003 LEPSQGQEELCEAQEPKARDVPLEMAEPPDPPQELPIPSSEPPPLS
240 250 260 270
>>NP_001091639 (OMIM: 611074) brain-specific homeobox pr (233 aa)
initn: 219 init1: 219 opt: 237 Z-score: 247.9 bits: 52.0 E(85289): 4.5e-07
Smith-Waterman score: 237; 48.7% identity (73.7% similar) in 76 aa overlap (2-73:124-199)
10 20 30
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQLQ
::::::: :.:::::.:..:: .:.::. :
NP_001 LFPHPQHAELPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQ
100 110 120 130 140 150
40 50 60 70 80
pF1KE5 VKTWYQNRRMKWKKIVLQGGGL----ESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPA
::::.:::::: :: . .. ..: .:.: :. . :. .
NP_001 VKTWFQNRRMKHKKQLRKSQDEPKAPDGPESPEGSPRGSEAATAAEARLSLPAGPFVLTE
160 170 180 190 200 210
90 100
pF1KE5 EVPGEPSDRSRED
NP_001 PEDEVDIGDEGELGSGPHVL
220 230
>>NP_068777 (OMIM: 142995) H2.0-like homeobox protein [H (488 aa)
initn: 209 init1: 209 opt: 232 Z-score: 238.8 bits: 51.3 E(85289): 1.5e-06
Smith-Waterman score: 232; 39.4% identity (69.7% similar) in 99 aa overlap (2-100:290-385)
10 20 30
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQLQ
::::::: :::.. ::: .:: :::.. :
NP_068 YAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQ
260 270 280 290 300 310
40 50 60 70 80 90
pF1KE5 VKTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVPG
::.:.:::::::.. .. . .. : :. ... :... ::.. . ... .:. .
NP_068 VKVWFQNRRMKWRH-SKEAQAQKDKDKEAGEKPSGGAPAADG--EQDERSPSRSEGEAES
320 330 340 350 360 370
100
pF1KE5 EPSDRSRED
: :: :
NP_068 ESSDSESLDMAPSDTERTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGGGNSFSF
380 390 400 410 420 430
>>NP_835221 (OMIM: 600029) homeobox protein DLX-1 isofor (255 aa)
initn: 219 init1: 201 opt: 212 Z-score: 222.9 bits: 47.5 E(85289): 1.1e-05
Smith-Waterman score: 212; 47.1% identity (76.5% similar) in 68 aa overlap (3-69:143-210)
10 20 30
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQLQV
:..::.. .::. :.: .:: ::::.: ::
NP_835 VVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQV
120 130 140 150 160 170
40 50 60 70 80 90
pF1KE5 KTWYQNRRMKWKKIVLQGGG-LESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVPG
: :.::.: :.::.. :::. ::. . .:: . . :
NP_835 KIWFQNKRSKFKKLMKQGGAALEGSALANGRALSAGSPPVPPGWNPNSSSGKGSGGNAGS
180 190 200 210 220 230
100
pF1KE5 EPSDRSRED
NP_835 YIPSYTSWYPSAHQEAMQQPQLM
240 250
>>NP_064447 (OMIM: 605212) barH-like 2 homeobox protein (387 aa)
initn: 209 init1: 209 opt: 209 Z-score: 217.6 bits: 47.1 E(85289): 2.2e-05
Smith-Waterman score: 209; 67.4% identity (88.4% similar) in 43 aa overlap (3-45:247-289)
10 20 30
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQLQV
::. ::.:::::. ::.::: .:.:.. ::
NP_064 EITSSRESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQV
220 230 240 250 260 270
40 50 60 70 80 90
pF1KE5 KTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVPGE
:::::::: :::.
NP_064 KTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAA
280 290 300 310 320 330
>>NP_002720 (OMIM: 604420) hematopoietically-expressed h (270 aa)
initn: 214 init1: 196 opt: 206 Z-score: 216.7 bits: 46.4 E(85289): 2.5e-05
Smith-Waterman score: 206; 40.6% identity (64.4% similar) in 101 aa overlap (3-100:152-245)
10 20 30
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQLQV
:::.:: ::::: :.: ::. : ::. ::
NP_002 KPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQV
130 140 150 160 170 180
40 50 60 70 80 90
pF1KE5 KTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVPGE
:::.:::: ::... :.: . : . . .:. .: . .:. .. .: : . .
NP_002 KTWFQNRRAKWRRL-----KQENPQSNK-KEELESLDSSCD-QRQDLPSEQNKGASLDSS
190 200 210 220 230
100
pF1KE5 ---PSDRSRED
:: :.::
NP_002 QCSPSPASQEDLESEISEDSDQEVDIEGDKSYFNAG
240 250 260 270
>>NP_064448 (OMIM: 605211) barH-like 1 homeobox protein (327 aa)
initn: 207 init1: 207 opt: 207 Z-score: 216.6 bits: 46.7 E(85289): 2.5e-05
Smith-Waterman score: 207; 67.4% identity (88.4% similar) in 43 aa overlap (3-45:193-235)
10 20 30
pF1KE5 MGLEKRFEKQKYLSTPDRIDLAESLGLSQLQV
::. ::.:::::. ::..:: ::.:.. ::
NP_064 EISSSRDSPPVRLKKPRKARTAFTDHQLAQLERSFERQKYLSVQDRMELAASLNLTDTQV
170 180 190 200 210 220
40 50 60 70 80 90
pF1KE5 KTWYQNRRMKWKKIVLQGGGLESPTKPKGRPKKNSIPTSEQLTEQERAKDAEKPAEVPGE
:::::::: :::.
NP_064 KTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYPQSLVSNLDPGAALYLYRG
230 240 250 260 270 280
100 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 22:01:57 2016 done: Mon Nov 7 22:01:58 2016
Total Scan time: 4.150 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]