Result of FASTA (omim) for
pFN21AE5055
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5055, 197 aa
1>>>pF1KE5055 197 - 197 aa - 197 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3901+/-0.000276; mu= 14.6976+/- 0.017
mean_var=89.1047+/-17.894, 0's: 0 Z-trim(121.0): 24 B-trim: 316 in 2/48
Lambda= 0.135870
statistics sampled from 36937 (36962) to 36937 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.779), E-opt: 0.2 (0.433), width: 16
Scan time: 5.870
The best scores are: opt bits E(85289)
NP_004549 (OMIM: 602018) neurturin preproprotein [ ( 197) 1354 274.2 9.3e-74
XP_011526343 (OMIM: 602018) PREDICTED: neurturin i ( 197) 1354 274.2 9.3e-74
XP_011512332 (OMIM: 171300,209880,600837,613711) P ( 159) 336 74.6 9.3e-14
NP_001265027 (OMIM: 171300,209880,600837,613711) g ( 159) 336 74.6 9.3e-14
XP_016864826 (OMIM: 171300,209880,600837,613711) P ( 185) 336 74.7 1e-13
NP_954701 (OMIM: 171300,209880,600837,613711) glia ( 185) 336 74.7 1e-13
NP_001177398 (OMIM: 171300,209880,600837,613711) g ( 202) 336 74.7 1.1e-13
NP_000505 (OMIM: 171300,209880,600837,613711) glia ( 211) 336 74.7 1.1e-13
NP_001177397 (OMIM: 171300,209880,600837,613711) g ( 228) 336 74.7 1.2e-13
NP_476432 (OMIM: 603886) artemin isoform 1 preprop ( 220) 330 73.5 2.7e-13
NP_001129687 (OMIM: 603886) artemin isoform 3 [Hom ( 228) 330 73.6 2.7e-13
NP_476431 (OMIM: 603886) artemin isoform 3 [Homo s ( 228) 330 73.6 2.7e-13
NP_004149 (OMIM: 602921) persephin preproprotein [ ( 156) 298 67.1 1.6e-11
NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 173 42.9 0.00063
>>NP_004549 (OMIM: 602018) neurturin preproprotein [Homo (197 aa)
initn: 1354 init1: 1354 opt: 1354 Z-score: 1445.2 bits: 274.2 E(85289): 9.3e-74
Smith-Waterman score: 1354; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197)
10 20 30 40 50 60
pF1KE5 MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLPRTLDARIARLAQYRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLPRTLDARIARLAQYRAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARPCGLRELEVRVSELGLGYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARPCGLRELEVRVSELGLGYA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 SDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAH
130 140 150 160 170 180
190
pF1KE5 SRYHTVHELSARECACV
:::::::::::::::::
NP_004 SRYHTVHELSARECACV
190
>>XP_011526343 (OMIM: 602018) PREDICTED: neurturin isofo (197 aa)
initn: 1354 init1: 1354 opt: 1354 Z-score: 1445.2 bits: 274.2 E(85289): 9.3e-74
Smith-Waterman score: 1354; 100.0% identity (100.0% similar) in 197 aa overlap (1-197:1-197)
10 20 30 40 50 60
pF1KE5 MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLPRTLDARIARLAQYRAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MQRWKAAALASVLCSSVLSIWMCREGLLLSHRLGPALVPLHRLPRTLDARIARLAQYRAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 LQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARPCGLRELEVRVSELGLGYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARPCGLRELEVRVSELGLGYA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 SDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAH
130 140 150 160 170 180
190
pF1KE5 SRYHTVHELSARECACV
:::::::::::::::::
XP_011 SRYHTVHELSARECACV
190
>>XP_011512332 (OMIM: 171300,209880,600837,613711) PREDI (159 aa)
initn: 322 init1: 156 opt: 336 Z-score: 368.0 bits: 74.6 E(85289): 9.3e-14
Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:46-159)
60 70 80 90 100 110
pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV
:.:. :...: : : : : ... :
XP_011 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV
20 30 40 50 60 70
120 130 140 150 160 170
pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED
..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..:
XP_011 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD
80 90 100 110 120 130
180 190
pF1KE5 EVSFLDAHSRYHTVHELSARECACV
..:::: . :: ... ::..:.:.
XP_011 DLSFLDDNLVYHILRKHSAKRCGCI
140 150
>>NP_001265027 (OMIM: 171300,209880,600837,613711) glial (159 aa)
initn: 322 init1: 156 opt: 336 Z-score: 368.0 bits: 74.6 E(85289): 9.3e-14
Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:46-159)
60 70 80 90 100 110
pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV
:.:. :...: : : : : ... :
NP_001 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV
20 30 40 50 60 70
120 130 140 150 160 170
pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED
..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..:
NP_001 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD
80 90 100 110 120 130
180 190
pF1KE5 EVSFLDAHSRYHTVHELSARECACV
..:::: . :: ... ::..:.:.
NP_001 DLSFLDDNLVYHILRKHSAKRCGCI
140 150
>>XP_016864826 (OMIM: 171300,209880,600837,613711) PREDI (185 aa)
initn: 322 init1: 156 opt: 336 Z-score: 367.1 bits: 74.7 E(85289): 1e-13
Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:72-185)
60 70 80 90 100 110
pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV
:.:. :...: : : : : ... :
XP_016 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED
..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..:
XP_016 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD
110 120 130 140 150 160
180 190
pF1KE5 EVSFLDAHSRYHTVHELSARECACV
..:::: . :: ... ::..:.:.
XP_016 DLSFLDDNLVYHILRKHSAKRCGCI
170 180
>>NP_954701 (OMIM: 171300,209880,600837,613711) glial ce (185 aa)
initn: 322 init1: 156 opt: 336 Z-score: 367.1 bits: 74.7 E(85289): 1e-13
Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:72-185)
60 70 80 90 100 110
pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV
:.:. :...: : : : : ... :
NP_954 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED
..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..:
NP_954 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD
110 120 130 140 150 160
180 190
pF1KE5 EVSFLDAHSRYHTVHELSARECACV
..:::: . :: ... ::..:.:.
NP_954 DLSFLDDNLVYHILRKHSAKRCGCI
170 180
>>NP_001177398 (OMIM: 171300,209880,600837,613711) glial (202 aa)
initn: 324 init1: 156 opt: 336 Z-score: 366.6 bits: 74.7 E(85289): 1.1e-13
Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:89-202)
60 70 80 90 100 110
pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV
:.:. :...: : : : : ... :
NP_001 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED
..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..:
NP_001 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD
120 130 140 150 160 170
180 190
pF1KE5 EVSFLDAHSRYHTVHELSARECACV
..:::: . :: ... ::..:.:.
NP_001 DLSFLDDNLVYHILRKHSAKRCGCI
180 190 200
>>NP_000505 (OMIM: 171300,209880,600837,613711) glial ce (211 aa)
initn: 321 init1: 156 opt: 336 Z-score: 366.3 bits: 74.7 E(85289): 1.1e-13
Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:98-211)
60 70 80 90 100 110
pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV
:.:. :...: : : : : ... :
NP_000 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED
..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..:
NP_000 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD
130 140 150 160 170 180
180 190
pF1KE5 EVSFLDAHSRYHTVHELSARECACV
..:::: . :: ... ::..:.:.
NP_000 DLSFLDDNLVYHILRKHSAKRCGCI
190 200 210
>>NP_001177397 (OMIM: 171300,209880,600837,613711) glial (228 aa)
initn: 321 init1: 156 opt: 336 Z-score: 365.9 bits: 74.7 E(85289): 1.2e-13
Smith-Waterman score: 336; 41.7% identity (71.3% similar) in 115 aa overlap (87-197:115-228)
60 70 80 90 100 110
pF1KE5 YRALLQGAPDAMELRELTPWAGRPPGPRRRAGPRRRRARARLGARP----CGLRELEVRV
:.:. :...: : : : : ... :
NP_001 IQATIKRLKRSPDKQMAVLPRRERNRQAAAANPENSRGKGRRGQRGKNRGCVLTAIHLNV
90 100 110 120 130 140
120 130 140 150 160 170
pF1KE5 SELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYED
..::::: . : ..::::.:.:.:: .:: :. : . ::: ..: .: :::: :..:
NP_001 TDLGLGYETKEELIFRYCSGSCDAAETTYDKILKNLSRNRRLVSDKV-GQACCRPIAFDD
150 160 170 180 190 200
180 190
pF1KE5 EVSFLDAHSRYHTVHELSARECACV
..:::: . :: ... ::..:.:.
NP_001 DLSFLDDNLVYHILRKHSAKRCGCI
210 220
>>NP_476432 (OMIM: 603886) artemin isoform 1 preproprote (220 aa)
initn: 353 init1: 159 opt: 330 Z-score: 359.7 bits: 73.5 E(85289): 2.7e-13
Smith-Waterman score: 330; 41.1% identity (53.1% similar) in 207 aa overlap (4-197:24-219)
10 20 30
pF1KE5 MQRWKA-AALASVLCSSVLSIWMCREGLLLSHRLGPALV-
: . :::: : ::: . . : :: :
NP_476 MELGLGGLSTLSHCPWPRQQPALWPTLAALA--LLSSVAEASLGSAPRSPAPREGPPPVL
10 20 30 40 50
40 50 60 70 80 90
pF1KE5 --PLHRLPRTLDARIARLAQYRALLQGAPDAMELRELTPWAGRPPG--PR----RRAGPR
: .:: .: :: . :: : . : : . ::. :: :::
NP_476 ASPAGHLP---GGRTARWCSGRAR---RPPPQPSRPAPPPPA-PPSALPRGGRAARAGGP
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE5 RRRARARLGARPCGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQ
:::: ::: : :: : : ::::. ::: : ::.:.:.:. : .::.: :
NP_476 GSRARAA-GARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLG
120 130 140 150 160 170
160 170 180 190
pF1KE5 RRRLRRE---RVRAQPCCRPTAYEDEVSFLDAHSRYHTVHELSARECACV
:: : .::::::: :: :::.:..: ..:: .::: :.:.
NP_476 AGALRPPPGSRPVSQPCCRPTRYE-AVSFMDVNSTWRTVDRLSATACGCLG
180 190 200 210 220
197 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:35:27 2016 done: Tue Nov 8 04:35:27 2016
Total Scan time: 5.870 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]