Result of FASTA (omim) for
pFN21AE4591
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4591, 1107 aa
1>>>pF1KE4591 1107 - 1107 aa - 1107 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2378+/-0.000377; mu= 13.3274+/- 0.024
mean_var=138.1361+/-28.385, 0's: 0 Z-trim(117.1): 37 B-trim: 555 in 1/55
Lambda= 0.109124
statistics sampled from 28784 (28823) to 28784 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.682), E-opt: 0.2 (0.338), width: 16
Scan time: 13.460
The best scores are: opt bits E(85289)
NP_001243778 (OMIM: 174761,612591,615381) DNA poly (1107) 7467 1188.1 0
NP_002682 (OMIM: 174761,612591,615381) DNA polymer (1107) 7467 1188.1 0
XP_011525340 (OMIM: 174761,612591,615381) PREDICTE (1107) 7467 1188.1 0
XP_016882370 (OMIM: 174761,612591,615381) PREDICTE (1107) 7467 1188.1 0
XP_016882371 (OMIM: 174761,612591,615381) PREDICTE (1083) 4703 752.9 2.3e-216
XP_005259065 (OMIM: 174761,612591,615381) PREDICTE (1083) 4703 752.9 2.3e-216
NP_001295561 (OMIM: 174761,612591,615381) DNA poly (1133) 4043 649.0 4.4e-185
NP_001273361 (OMIM: 602776) DNA polymerase zeta ca (3052) 779 135.5 4.7e-30
NP_001273360 (OMIM: 602776) DNA polymerase zeta ca (3052) 779 135.5 4.7e-30
XP_016866643 (OMIM: 602776) PREDICTED: DNA polymer (3078) 779 135.5 4.8e-30
XP_016866642 (OMIM: 602776) PREDICTED: DNA polymer (3078) 779 135.5 4.8e-30
XP_016866641 (OMIM: 602776) PREDICTED: DNA polymer (3078) 779 135.5 4.8e-30
XP_011534333 (OMIM: 602776) PREDICTED: DNA polymer (3079) 779 135.5 4.8e-30
XP_011534334 (OMIM: 602776) PREDICTED: DNA polymer (3079) 779 135.5 4.8e-30
NP_002903 (OMIM: 602776) DNA polymerase zeta catal (3130) 779 135.5 4.8e-30
XP_011534332 (OMIM: 602776) PREDICTED: DNA polymer (3131) 779 135.5 4.8e-30
XP_011534331 (OMIM: 602776) PREDICTED: DNA polymer (3156) 779 135.5 4.9e-30
XP_011534330 (OMIM: 602776) PREDICTED: DNA polymer (3157) 779 135.5 4.9e-30
XP_006724562 (OMIM: 301220,310465,312040) PREDICTE (1326) 448 83.1 1.2e-14
XP_011543842 (OMIM: 301220,310465,312040) PREDICTE (1350) 448 83.1 1.2e-14
XP_016885085 (OMIM: 301220,310465,312040) PREDICTE (1353) 448 83.1 1.2e-14
XP_016885084 (OMIM: 301220,310465,312040) PREDICTE (1432) 448 83.1 1.3e-14
XP_016885083 (OMIM: 301220,310465,312040) PREDICTE (1443) 448 83.1 1.3e-14
NP_058633 (OMIM: 301220,310465,312040) DNA polymer (1462) 448 83.2 1.3e-14
NP_001317289 (OMIM: 301220,310465,312040) DNA poly (1468) 448 83.2 1.3e-14
XP_016866644 (OMIM: 602776) PREDICTED: DNA polymer (2254) 240 50.5 0.00013
XP_011534338 (OMIM: 602776) PREDICTED: DNA polymer (2328) 240 50.5 0.00013
>>NP_001243778 (OMIM: 174761,612591,615381) DNA polymera (1107 aa)
initn: 7467 init1: 7467 opt: 7467 Z-score: 6357.2 bits: 1188.1 E(85289): 0
Smith-Waterman score: 7467; 99.9% identity (100.0% similar) in 1107 aa overlap (1-1107:1-1107)
10 20 30 40 50 60
pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_001 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
1030 1040 1050 1060 1070 1080
1090 1100
pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW
:::::::::::::::::::::::::::
NP_001 MRKKVRKDLEDQEQLLRRFGPPGPEAW
1090 1100
>>NP_002682 (OMIM: 174761,612591,615381) DNA polymerase (1107 aa)
initn: 7467 init1: 7467 opt: 7467 Z-score: 6357.2 bits: 1188.1 E(85289): 0
Smith-Waterman score: 7467; 99.9% identity (100.0% similar) in 1107 aa overlap (1-1107:1-1107)
10 20 30 40 50 60
pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_002 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
1030 1040 1050 1060 1070 1080
1090 1100
pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW
:::::::::::::::::::::::::::
NP_002 MRKKVRKDLEDQEQLLRRFGPPGPEAW
1090 1100
>>XP_011525340 (OMIM: 174761,612591,615381) PREDICTED: D (1107 aa)
initn: 7467 init1: 7467 opt: 7467 Z-score: 6357.2 bits: 1188.1 E(85289): 0
Smith-Waterman score: 7467; 99.9% identity (100.0% similar) in 1107 aa overlap (1-1107:1-1107)
10 20 30 40 50 60
pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_011 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
1030 1040 1050 1060 1070 1080
1090 1100
pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW
:::::::::::::::::::::::::::
XP_011 MRKKVRKDLEDQEQLLRRFGPPGPEAW
1090 1100
>>XP_016882370 (OMIM: 174761,612591,615381) PREDICTED: D (1107 aa)
initn: 7467 init1: 7467 opt: 7467 Z-score: 6357.2 bits: 1188.1 E(85289): 0
Smith-Waterman score: 7467; 99.9% identity (100.0% similar) in 1107 aa overlap (1-1107:1-1107)
10 20 30 40 50 60
pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_016 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
1030 1040 1050 1060 1070 1080
1090 1100
pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW
:::::::::::::::::::::::::::
XP_016 MRKKVRKDLEDQEQLLRRFGPPGPEAW
1090 1100
>>XP_016882371 (OMIM: 174761,612591,615381) PREDICTED: D (1083 aa)
initn: 4695 init1: 4695 opt: 4703 Z-score: 4005.6 bits: 752.9 E(85289): 2.3e-216
Smith-Waterman score: 7253; 97.7% identity (97.8% similar) in 1107 aa overlap (1-1107:1-1083)
10 20 30 40 50 60
pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_016 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
:::::::::::::::::::::::::::::::::: ::
XP_016 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALK------------------------SV
670 680 690
730 740 750 760 770 780
pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
1000 1010 1020 1030 1040 1050
1090 1100
pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW
:::::::::::::::::::::::::::
XP_016 MRKKVRKDLEDQEQLLRRFGPPGPEAW
1060 1070 1080
>>XP_005259065 (OMIM: 174761,612591,615381) PREDICTED: D (1083 aa)
initn: 4695 init1: 4695 opt: 4703 Z-score: 4005.6 bits: 752.9 E(85289): 2.3e-216
Smith-Waterman score: 7253; 97.7% identity (97.8% similar) in 1107 aa overlap (1-1107:1-1083)
10 20 30 40 50 60
pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_005 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGYYDVPIAT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQFIRTPTGDEFVKTSVRKGLLPQIL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSV
:::::::::::::::::::::::::::::::::: ::
XP_005 ENLLSARKRAKAELAKETDPLRRQVLDGRQLALK------------------------SV
670 680 690
730 740 750 760 770 780
pF1KE4 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAAD
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE4 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLV
760 770 780 790 800 810
850 860 870 880 890 900
pF1KE4 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH
820 830 840 850 860 870
910 920 930 940 950 960
pF1KE4 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQ
880 890 900 910 920 930
970 980 990 1000 1010 1020
pF1KE4 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLS
940 950 960 970 980 990
1030 1040 1050 1060 1070 1080
pF1KE4 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFY
1000 1010 1020 1030 1040 1050
1090 1100
pF1KE4 MRKKVRKDLEDQEQLLRRFGPPGPEAW
:::::::::::::::::::::::::::
XP_005 MRKKVRKDLEDQEQLLRRFGPPGPEAW
1060 1070 1080
>>NP_001295561 (OMIM: 174761,612591,615381) DNA polymera (1133 aa)
initn: 7453 init1: 4042 opt: 4043 Z-score: 3443.7 bits: 649.0 E(85289): 4.4e-185
Smith-Waterman score: 7405; 97.6% identity (97.7% similar) in 1133 aa overlap (1-1107:1-1133)
10 20 30 40 50 60
pF1KE4 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
NP_001 VLEGVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVPVLRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELTGPAVLAVELCSRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAPYEANVDFEIRFMVDTDIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDVVSHPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGPWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPF
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLGEQKEDVQHSIITDLQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEMARVTG
490 500 510 520 530 540
550 560 570 580 590
pF1KE4 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKG--------
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEGGEDYTGATVIEPLKGVRPQDRAG
550 560 570 580 590 600
600 610 620 630
pF1KE4 ------------------YYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTE
::::::::::::::::::::::::::::::::::::::::::
NP_001 AAWELLALTPGRGCSPPRYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTE
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE4 DQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAKETDPLRRQVLDGRQLALK
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE4 VSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTSAKVVYG
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE4 DTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKRYAGLLF
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE4 SSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDLLCN
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE4 RIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVA
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE4 AYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTV
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE4 LTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFCQPRESELYQKEVSHLNALEERFSRL
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100
pF1KE4 WTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQEQLLRRFGPPGPEAW
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQEQLLRRFGPPGPEAW
1090 1100 1110 1120 1130
>>NP_001273361 (OMIM: 602776) DNA polymerase zeta cataly (3052 aa)
initn: 889 init1: 312 opt: 779 Z-score: 660.5 bits: 135.5 E(85289): 4.7e-30
Smith-Waterman score: 1161; 26.5% identity (56.6% similar) in 1121 aa overlap (52-1099:1989-3052)
30 40 50 60 70 80
pF1KE4 LWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLR
... .. : .:.. . : .: . . :
NP_001 FSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTG-CSQTASESQMLP
1960 1970 1980 1990 2000 2010
90 100 110 120 130 140
pF1KE4 PTPPALDPQTEPLIFQQLEIDHYVGPAQP-VPGGPPPSHGSVPVLRAFGVTDEGFSVCCH
:. : ::. . .. . ..:.. ..: : :: .. : .:.. :. : .
NP_001 PVASASDPEKD----EDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEE
2020 2030 2040 2050 2060 2070
150 160 170 180 190
pF1KE4 IHGFA-PYFYTPAPPGFGPEHMGDLQRELNLA-ISRDSRGGRELTGPAVLAVELCSRESM
. ..: : : :. .. :. : .. :. .: :. : ::.
NP_001 LPSLAFENFLKPIKDGIQKSPCSEPQEPLVISPINTRARTGK------------C--ESL
2080 2090 2100 2110
200 210 220 230 240 250
pF1KE4 FGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDT
.:. .:... :.:::. .. ::. : : ... . .:
NP_001 C-FHS---TPIIQ------------RKLLERLPEAPGLSPLSTEPKTQKLS--NKKGSNT
2120 2130 2140 2150 2160
260 270 280 290 300 310
pF1KE4 DIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDV-----VSHPPEGP-WQRIAPLRV
: . : ...: . :... : . ... :. ..: : .
NP_001 DTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTL
2170 2180 2190 2200 2210 2220
320 330 340 350
pF1KE4 LSFDIECAGRKGIFPEPERDPVIQICSL--GLRWGEPEP-FLRLALT-------------
.: ... :. . :.:: :: ::.: . : : . ::
NP_001 ISVELHARTRRDLEPDPEFDP---ICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVFS
2230 2240 2250 2260 2270
360 370 380 390 400
pF1KE4 --LRPCAPIL------GAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLIS
.: .:.: : .: :. :.. ...:. .:::.. ::.:: . ::..
NP_001 QDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQ
2280 2290 2300 2310 2320 2330
410 420 430 440 450 460
pF1KE4 RAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYK
:: .:... ...:: . : .. . . : . ...:::. ... ... :
NP_001 RAAALSIDLCRMISRVPDDKIENRFAA-ERDEYGSYTMSEINIVGRITLNLWRIMRNEVA
2340 2350 2360 2370 2380 2390
470 480 490 500 510 520
pF1KE4 LRSYTLNAVSFHFLGEQKEDVQHSIITD-LQNGNDQTRRRLAVYCLKDAYLPLRLLERLM
: .::.. :::: : .. ...: ..: .: : ... . .. . :..::.:
NP_001 LTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLD
2400 2410 2420 2430 2440 2450
530 540 550 560 570 580
pF1KE4 VLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA--MHEGLLMPVV--KSEGGEDYTG
.. .. ::::. :. . ..:.::.: .: :..:: : :. . : : .:.
NP_001 LIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCV
2460 2470 2480 2490 2500 2510
590 600 610 620 630
pF1KE4 ATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQF------
..:: . .:. . .:::.::::::..:.: :..: : : ...:: :.:
NP_001 PLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCL--GHVENLG-KYDEFKFGCTS
2520 2530 2540 2550 2560 2570
640 650 660 670 680
pF1KE4 ----------IR-----TPTGDEFVKTSVRKGLLPQILENLLSARKRAKAEL-AKETDPL
.: .:.: ::: :::::.::..::..:..: .: . : . :
NP_001 LRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRA
2580 2590 2600 2610 2620 2630
690 700 710 720 730 740
pF1KE4 RRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYT
..::.:::.::. :: ..:.:.:. :..::.:...:.. .:. .:.. .::.. :
NP_001 LSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVND--T
2640 2650 2660 2670 2680 2690
750 760 770 780 790 800
pF1KE4 VENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFP
. : :.::::::::.. . .. ... .:.: :. :.. :.:..:.:::::.:
NP_001 KKWG----ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLP
2700 2710 2720 2730 2740
810 820 830 840 850 860
pF1KE4 YLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGA
.: .::::.: .. . . .: ::.:.::::.:: :.... ::. :. ::
NP_001 CVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLI
2750 2760 2770 2780 2790 2800
870 880 890 900 910
pF1KE4 VAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH-VELAERMRKRDPGSAPSLG
..: :: .. .:......:: . : : . .::...: : : :..:
NP_001 KQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVG
2810 2820 2830 2840 2850 2860
920 930 940 950 960 970
pF1KE4 DRVPYVIISAAKGVAAYMKSEDPLFVLEH-SLPIDTQYYLEQQLAKPLLRIFEPILG---
.::::::: .. :: . . :. ::. .: ... ::. .:. :: ::: ..:
NP_001 ERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFS-LIGIDV
2870 2880 2890 2900 2910 2920
980 990 1000 1010 1020 1030
pF1KE4 -EGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFC--QPR
: .. . .. :. : . . .: . : . .: ..: : ::.
NP_001 FSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPV-CDDLTQH--GICSKCRSQPQ
2930 2940 2950 2960 2970 2980
1040 1050 1060 1070 1080 1090
pF1KE4 E-SELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLED
. . . ..:. .:. .:.. .. :. : : . . . :.: .::... ..: ..:
NP_001 HVAVILNQEIRELERQQEQLVKI---CKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSK
2990 3000 3010 3020 3030 3040
1100
pF1KE4 Q---EQLLRRFGPPGPEAW
.::: .:
NP_001 APYLRQLLDQF
3050
>>NP_001273360 (OMIM: 602776) DNA polymerase zeta cataly (3052 aa)
initn: 889 init1: 312 opt: 779 Z-score: 660.5 bits: 135.5 E(85289): 4.7e-30
Smith-Waterman score: 1161; 26.5% identity (56.6% similar) in 1121 aa overlap (52-1099:1989-3052)
30 40 50 60 70 80
pF1KE4 LWDDDDAPRPSQFEEDLALMEEMEAEHRLQEQEEEELQSVLEGVADGQVPPSAIDPRWLR
... .. : .:.. . : .: . . :
NP_001 FSSSVNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTG-CSQTASESQMLP
1960 1970 1980 1990 2000 2010
90 100 110 120 130 140
pF1KE4 PTPPALDPQTEPLIFQQLEIDHYVGPAQP-VPGGPPPSHGSVPVLRAFGVTDEGFSVCCH
:. : ::. . .. . ..:.. ..: : :: .. : .:.. :. : .
NP_001 PVASASDPEKD----EDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEE
2020 2030 2040 2050 2060 2070
150 160 170 180 190
pF1KE4 IHGFA-PYFYTPAPPGFGPEHMGDLQRELNLA-ISRDSRGGRELTGPAVLAVELCSRESM
. ..: : : :. .. :. : .. :. .: :. : ::.
NP_001 LPSLAFENFLKPIKDGIQKSPCSEPQEPLVISPINTRARTGK------------C--ESL
2080 2090 2100 2110
200 210 220 230 240 250
pF1KE4 FGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDT
.:. .:... :.:::. .. ::. : : ... . .:
NP_001 C-FHS---TPIIQ------------RKLLERLPEAPGLSPLSTEPKTQKLS--NKKGSNT
2120 2130 2140 2150 2160
260 270 280 290 300 310
pF1KE4 DIVGCNWLELPAGKYALRLKEKATQCQLEADVLWSDV-----VSHPPEGP-WQRIAPLRV
: . : ...: . :... : . ... :. ..: : .
NP_001 DTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTL
2170 2180 2190 2200 2210 2220
320 330 340 350
pF1KE4 LSFDIECAGRKGIFPEPERDPVIQICSL--GLRWGEPEP-FLRLALT-------------
.: ... :. . :.:: :: ::.: . : : . ::
NP_001 ISVELHARTRRDLEPDPEFDP---ICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVFS
2230 2240 2250 2260 2270
360 370 380 390 400
pF1KE4 --LRPCAPIL------GAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLIS
.: .:.: : .: :. :.. ...:. .:::.. ::.:: . ::..
NP_001 QDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDILLGYEIQMHSWGYLLQ
2280 2290 2300 2310 2320 2330
410 420 430 440 450 460
pF1KE4 RAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYK
:: .:... ...:: . : .. . . : . ...:::. ... ... :
NP_001 RAAALSIDLCRMISRVPDDKIENRFAA-ERDEYGSYTMSEINIVGRITLNLWRIMRNEVA
2340 2350 2360 2370 2380 2390
470 480 490 500 510 520
pF1KE4 LRSYTLNAVSFHFLGEQKEDVQHSIITD-LQNGNDQTRRRLAVYCLKDAYLPLRLLERLM
: .::.. :::: : .. ...: ..: .: : ... . .. . :..::.:
NP_001 LTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLD
2400 2410 2420 2430 2440 2450
530 540 550 560 570 580
pF1KE4 VLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQA--MHEGLLMPVV--KSEGGEDYTG
.. .. ::::. :. . ..:.::.: .: :..:: : :. . : : .:.
NP_001 LIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCV
2460 2470 2480 2490 2500 2510
590 600 610 620 630
pF1KE4 ATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQF------
..:: . .:. . .:::.::::::..:.: :..: : : ...:: :.:
NP_001 PLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCL--GHVENLG-KYDEFKFGCTS
2520 2530 2540 2550 2560 2570
640 650 660 670 680
pF1KE4 ----------IR-----TPTGDEFVKTSVRKGLLPQILENLLSARKRAKAEL-AKETDPL
.: .:.: ::: :::::.::..::..:..: .: . : . :
NP_001 LRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRA
2580 2590 2600 2610 2620 2630
690 700 710 720 730 740
pF1KE4 RRQVLDGRQLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYT
..::.:::.::. :: ..:.:.:. :..::.:...:.. .:. .:.. .::.. :
NP_001 LSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVND--T
2640 2650 2660 2670 2680 2690
750 760 770 780 790 800
pF1KE4 VENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFP
. : :.::::::::.. . .. ... .:.: :. :.. :.:..:.:::::.:
NP_001 KKWG----ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLP
2700 2710 2720 2730 2740
810 820 830 840 850 860
pF1KE4 YLLISKKRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGA
.: .::::.: .. . . .: ::.:.::::.:: :.... ::. :. ::
NP_001 CVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLI
2750 2760 2770 2780 2790 2800
870 880 890 900 910
pF1KE4 VAHAQDVISDLLCNRIDISQLVITKELTRAASDYAGKQAH-VELAERMRKRDPGSAPSLG
..: :: .. .:......:: . : : . .::...: : : :..:
NP_001 KQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVG
2810 2820 2830 2840 2850 2860
920 930 940 950 960 970
pF1KE4 DRVPYVIISAAKGVAAYMKSEDPLFVLEH-SLPIDTQYYLEQQLAKPLLRIFEPILG---
.::::::: .. :: . . :. ::. .: ... ::. .:. :: ::: ..:
NP_001 ERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFS-LIGIDV
2870 2880 2890 2900 2910 2920
980 990 1000 1010 1020 1030
pF1KE4 -EGRAEAVLLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFC--QPR
: .. . .. :. : . . .: . : . .: ..: : ::.
NP_001 FSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPV-CDDLTQH--GICSKCRSQPQ
2930 2940 2950 2960 2970 2980
1040 1050 1060 1070 1080 1090
pF1KE4 E-SELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLED
. . . ..:. .:. .:.. .. :. : : . . . :.: .::... ..: ..:
NP_001 HVAVILNQEIRELERQQEQLVKI---CKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSK
2990 3000 3010 3020 3030 3040
1100
pF1KE4 Q---EQLLRRFGPPGPEAW
.::: .:
NP_001 APYLRQLLDQF
3050
>>XP_016866643 (OMIM: 602776) PREDICTED: DNA polymerase (3078 aa)
initn: 889 init1: 312 opt: 779 Z-score: 660.5 bits: 135.5 E(85289): 4.8e-30
Smith-Waterman score: 1121; 30.0% identity (62.0% similar) in 753 aa overlap (387-1099:2343-3078)
360 370 380 390 400 410
pF1KE4 LRPCAPILGAKVQSYEKEEDLLQAWSTFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQ
..:::.. ::.:: . ::..:: .:...
XP_016 NIIKRGCHQHVRCFQYPHFFYFCKQLRERNMYDPDILLGYEIQMHSWGYLLQRAAALSID
2320 2330 2340 2350 2360 2370
420 430 440 450 460 470
pF1KE4 TFPFLGRVAGLCSNIRDSSFQSKQTGRRDTKVVSMVGRVQMDMLQVLLREYKLRSYTLNA
...:: . : .. . . : . ...:::. ... ... : : .::..
XP_016 LCRMISRVPDDKIENRFAA-ERDEYGSYTMSEINIVGRITLNLWRIMRNEVALTNYTFEN
2380 2390 2400 2410 2420 2430
480 490 500 510 520 530
pF1KE4 VSFHFLGEQKEDVQHSIITD-LQNGNDQTRRRLAVYCLKDAYLPLRLLERLMVLVNAVEM
:::: : .. ...: ..: .: : ... . .. . :..::.: .. .. ::
XP_016 VSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEM
2440 2450 2460 2470 2480 2490
540 550 560 570 580 590
pF1KE4 ARVTGVPLSYLLSRGQQVKVVSQLLRQA--MHEGLLMPVV--KSEGGEDYTGATVIEPLK
::. :. . ..:.::.: .: :..:: : :. . : : .:. ..:: .
XP_016 ARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSVQQRSQMRAPQCVPLIMEPES
2500 2510 2520 2530 2540 2550
600 610 620 630
pF1KE4 GYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGTAQKLGLTEDQF--------------
.:. . .:::.::::::..:.: :..: : : ...:: :.:
XP_016 RFYSNSVLVLDFQSLYPSIVIAYNYCFSTCL--GHVENLG-KYDEFKFGCTSLRVPPDLL
2560 2570 2580 2590 2600
640 650 660 670 680
pF1KE4 --IR-----TPTGDEFVKTSVRKGLLPQILENLLSARKRAKAEL-AKETDPLRRQVLDGR
.: .:.: ::: :::::.::..::..:..: .: . : . : ..::.:
XP_016 YQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQDRALSRMLDAR
2610 2620 2630 2640 2650 2660
690 700 710 720 730 740
pF1KE4 QLALKVSANSVYGFTGAQV-GKLPCLEISQSVTGFGRQMIEKTKQLVESKYTVENGYSTS
::.::. :: ..:.:.:. :..::.:...:.. .:. .:.. .::.. : . :
XP_016 QLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVND--TKKWG----
2670 2680 2690 2700 2710 2720
750 760 770 780 790 800
pF1KE4 AKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISKKR
:.::::::::.. . .. ... .:.: :. :.. :.:..:.:::::.: .: .:::
XP_016 ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKKR
2730 2740 2750 2760 2770 2780
810 820 830 840 850 860
pF1KE4 YAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVI
:.: .. . . .: ::.:.::::.:: :.... ::. :. :: ..:
XP_016 YVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQC
2790 2800 2810 2820 2830 2840
870 880 890 900 910 920
pF1KE4 SDLLCNRIDISQLVITKELTRAASDYAGKQAH-VELAERMRKRDPGSAPSLGDRVPYVII
:: .. .:......:: . : : . .::...: : : :..:.:::::::
XP_016 MKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVII
2850 2860 2870 2880 2890 2900
930 940 950 960 970 980
pF1KE4 SAAKGVAAYMKSEDPLFVLEH-SLPIDTQYYLEQQLAKPLLRIFEPILG----EGRAEAV
.. :: . . :. ::. .: ... ::. .:. :: ::: ..: :
XP_016 YGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFS-LIGIDVFSWYHELP
2910 2920 2930 2940 2950 2960
990 1000 1010 1020 1030
pF1KE4 LLRGDHTRCKTVLTGKVGGLLAFAKRRNCCIGCRTVLSHQGAVCEFC--QPRE-SELYQK
.. . .. :. : . . .: . : . .: ..: : ::.. . . ..
XP_016 RIHKATSSSRSEPEGRKGTISQYFTTLHCPV-CDDLTQH--GICSKCRSQPQHVAVILNQ
2970 2980 2990 3000 3010
1040 1050 1060 1070 1080 1090
pF1KE4 EVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQ---EQLL
:. .:. .:.. .. :. : : . . . :.: .::... ..: ..: .:::
XP_016 EIRELERQQEQLVKI---CKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSKAPYLRQLL
3020 3030 3040 3050 3060 3070
1100
pF1KE4 RRFGPPGPEAW
.:
XP_016 DQF
1107 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:44:36 2016 done: Sat Nov 5 23:44:38 2016
Total Scan time: 13.460 Total Display time: 0.450
Function used was FASTA [36.3.4 Apr, 2011]