Result of FASTA (omim) for
pFN21AE4588
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4588, 913 aa
1>>>pF1KE4588 913 - 913 aa - 913 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.4682+/-0.000433; mu= 1.1909+/- 0.027
mean_var=172.5482+/-35.958, 0's: 0 Z-trim(116.5): 52 B-trim: 1718 in 2/55
Lambda= 0.097638
statistics sampled from 27586 (27638) to 27586 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.324), width: 16
Scan time: 13.040
The best scores are: opt bits E(85289)
NP_003579 (OMIM: 300304,300354) cullin-4B isoform ( 913) 5859 838.2 0
XP_005262538 (OMIM: 300304,300354) PREDICTED: cull ( 915) 5845 836.2 0
NP_001073341 (OMIM: 300304,300354) cullin-4B isofo ( 895) 5715 817.9 0
NP_001317553 (OMIM: 300304,300354) cullin-4B isofo ( 900) 5715 817.9 0
XP_006724847 (OMIM: 300304,300354) PREDICTED: cull ( 902) 5701 815.9 0
XP_011529702 (OMIM: 300304,300354) PREDICTED: cull ( 717) 4620 663.6 9.5e-190
XP_011529701 (OMIM: 300304,300354) PREDICTED: cull ( 719) 4606 661.7 3.7e-189
XP_011529703 (OMIM: 300304,300354) PREDICTED: cull ( 701) 4346 625.0 3.9e-178
NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [H ( 759) 4103 590.8 8.4e-168
NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo ( 659) 3755 541.8 4.2e-153
NP_001265442 (OMIM: 603137) cullin-4A isoform 2 [H ( 659) 3755 541.8 4.2e-153
XP_011535825 (OMIM: 603137) PREDICTED: cullin-4A i ( 659) 3755 541.8 4.2e-153
NP_001265443 (OMIM: 603137) cullin-4A isoform 3 [H ( 667) 3711 535.6 3.1e-151
NP_001311305 (OMIM: 603135) cullin-2 isoform e [Ho ( 614) 979 150.7 2e-35
NP_001311304 (OMIM: 603135) cullin-2 isoform d [Ho ( 682) 979 150.7 2.2e-35
XP_011518049 (OMIM: 603135) PREDICTED: cullin-2 is ( 745) 979 150.7 2.4e-35
NP_003582 (OMIM: 603135) cullin-2 isoform c [Homo ( 745) 979 150.7 2.4e-35
NP_001185706 (OMIM: 603135) cullin-2 isoform c [Ho ( 745) 979 150.7 2.4e-35
NP_001185708 (OMIM: 603135) cullin-2 isoform b [Ho ( 758) 979 150.8 2.5e-35
NP_001185707 (OMIM: 603135) cullin-2 isoform a [Ho ( 764) 979 150.8 2.5e-35
XP_011518046 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 979 150.8 2.6e-35
XP_011518045 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 979 150.8 2.6e-35
XP_011518047 (OMIM: 603135) PREDICTED: cullin-2 is ( 808) 979 150.8 2.6e-35
NP_003581 (OMIM: 603136,614496) cullin-3 isoform 1 ( 768) 977 150.5 3e-35
XP_011510297 (OMIM: 603136,614496) PREDICTED: cull ( 754) 972 149.8 4.8e-35
XP_006712863 (OMIM: 603136,614496) PREDICTED: cull ( 757) 972 149.8 4.9e-35
NP_001244127 (OMIM: 603136,614496) cullin-3 isofor ( 774) 972 149.8 5e-35
NP_001244126 (OMIM: 603136,614496) cullin-3 isofor ( 702) 888 137.9 1.7e-31
XP_011510298 (OMIM: 603136,614496) PREDICTED: cull ( 704) 888 137.9 1.7e-31
XP_011510296 (OMIM: 603136,614496) PREDICTED: cull ( 719) 888 137.9 1.7e-31
XP_011514933 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31
XP_005250117 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31
XP_011514934 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31
XP_011514931 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31
XP_011514932 (OMIM: 603134) PREDICTED: cullin-1 is ( 776) 872 135.7 8.6e-31
NP_003583 (OMIM: 603134) cullin-1 [Homo sapiens] ( 776) 872 135.7 8.6e-31
XP_016868212 (OMIM: 603134) PREDICTED: cullin-1 is ( 455) 839 131.0 1.3e-29
XP_016873854 (OMIM: 601741) PREDICTED: cullin-5 is ( 519) 440 74.8 1.2e-12
XP_016873853 (OMIM: 601741) PREDICTED: cullin-5 is ( 519) 440 74.8 1.2e-12
XP_005271739 (OMIM: 601741) PREDICTED: cullin-5 is ( 721) 288 53.4 4.7e-06
XP_016873852 (OMIM: 601741) PREDICTED: cullin-5 is ( 742) 288 53.4 4.8e-06
NP_003469 (OMIM: 601741) cullin-5 [Homo sapiens] ( 780) 288 53.4 5e-06
XP_011541315 (OMIM: 601741) PREDICTED: cullin-5 is ( 396) 260 49.4 4.1e-05
NP_037498 (OMIM: 606946) anaphase-promoting comple ( 822) 226 44.7 0.0023
>>NP_003579 (OMIM: 300304,300354) cullin-4B isoform 1 [H (913 aa)
initn: 5859 init1: 5859 opt: 5859 Z-score: 4469.1 bits: 838.2 E(85289): 0
Smith-Waterman score: 5859; 99.9% identity (100.0% similar) in 913 aa overlap (1-913:1-913)
10 20 30 40 50 60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 LQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
850 860 870 880 890 900
910
pF1KE4 RDKENPNQYNYIA
:::::::::::::
NP_003 RDKENPNQYNYIA
910
>>XP_005262538 (OMIM: 300304,300354) PREDICTED: cullin-4 (915 aa)
initn: 4229 init1: 4229 opt: 5845 Z-score: 4458.4 bits: 836.2 E(85289): 0
Smith-Waterman score: 5845; 99.7% identity (99.8% similar) in 915 aa overlap (1-913:1-915)
10 20 30 40 50 60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
610 620 630 640 650 660
670 680 690 700 710
pF1KE4 QFKQ--YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG
:::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE4 RKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE4 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE4 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY
850 860 870 880 890 900
900 910
pF1KE4 MERDKENPNQYNYIA
:::::::::::::::
XP_005 MERDKENPNQYNYIA
910
>>NP_001073341 (OMIM: 300304,300354) cullin-4B isoform 2 (895 aa)
initn: 5715 init1: 5715 opt: 5715 Z-score: 4359.6 bits: 817.9 E(85289): 0
Smith-Waterman score: 5715; 99.9% identity (100.0% similar) in 891 aa overlap (23-913:5-895)
10 20 30 40 50 60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
::::::::::::::::::::::::::::::::::::::
NP_001 MFPTGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
10 20 30 40
70 80 90 100 110 120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE4 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE4 LQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE4 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
770 780 790 800 810 820
850 860 870 880 890 900
pF1KE4 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
830 840 850 860 870 880
910
pF1KE4 RDKENPNQYNYIA
:::::::::::::
NP_001 RDKENPNQYNYIA
890
>>NP_001317553 (OMIM: 300304,300354) cullin-4B isoform 3 (900 aa)
initn: 5715 init1: 5715 opt: 5715 Z-score: 4359.6 bits: 817.9 E(85289): 0
Smith-Waterman score: 5715; 99.9% identity (100.0% similar) in 891 aa overlap (23-913:10-900)
10 20 30 40 50 60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
::::::::::::::::::::::::::::::::::::::
NP_001 MKSVCPVTSGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
10 20 30 40
70 80 90 100 110 120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE4 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRK
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE4 LQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRR
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE4 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTE
770 780 790 800 810 820
850 860 870 880 890 900
pF1KE4 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYME
830 840 850 860 870 880
910
pF1KE4 RDKENPNQYNYIA
:::::::::::::
NP_001 RDKENPNQYNYIA
890 900
>>XP_006724847 (OMIM: 300304,300354) PREDICTED: cullin-4 (902 aa)
initn: 4085 init1: 4085 opt: 5701 Z-score: 4348.9 bits: 815.9 E(85289): 0
Smith-Waterman score: 5701; 99.7% identity (99.8% similar) in 893 aa overlap (23-913:10-902)
10 20 30 40 50 60
pF1KE4 MMSQSSGSGDGNDDEATTSKDGGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
::::::::::::::::::::::::::::::::::::::
XP_006 MKSVCPVTSGFSSPSPSAAAAAQEVRSATDGNTSTTPPTSAKKRKLN
10 20 30 40
70 80 90 100 110 120
pF1KE4 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSSSSSSNSSNEREDFDSTSSSSSTPPLQPRDSASPSTSSFCLGVSVAASSHVPIQKKLR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FEDTLEFVGFDAKMAEESSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEEL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQM
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKR
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLF
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE4 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKF
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE4 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 INAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGK
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE4 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMI
590 600 610 620 630 640
670 680 690 700 710
pF1KE4 QFKQ--YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG
:::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSG
650 660 670 680 690 700
720 730 740 750 760 770
pF1KE4 RKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGEL
710 720 730 740 750 760
780 790 800 810 820 830
pF1KE4 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQAST
770 780 790 800 810 820
840 850 860 870 880 890
pF1KE4 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDY
830 840 850 860 870 880
900 910
pF1KE4 MERDKENPNQYNYIA
:::::::::::::::
XP_006 MERDKENPNQYNYIA
890 900
>>XP_011529702 (OMIM: 300304,300354) PREDICTED: cullin-4 (717 aa)
initn: 4618 init1: 4618 opt: 4620 Z-score: 3527.6 bits: 663.6 E(85289): 9.5e-190
Smith-Waterman score: 4620; 99.0% identity (99.6% similar) in 717 aa overlap (197-913:1-717)
170 180 190 200 210 220
pF1KE4 VASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEA
.. .: :::::::::::::::::::::::
XP_011 MIDPDFADKPKLPENYTDETWQKLKEAVEA
10 20 30
230 240 250 260 270 280
pF1KE4 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE4 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE4 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE4 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE4 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE4 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE4 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE4 GMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQE
460 470 480 490 500 510
710 720 730 740 750 760
pF1KE4 IFKTFYLGKHSGRKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEE
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_011 IFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEE
520 530 540 550 560 570
770 780 790 800 810 820
pF1KE4 IKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQI
580 590 600 610 620 630
830 840 850 860 870 880
pF1KE4 QMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADL
640 650 660 670 680 690
890 900 910
pF1KE4 KKRIESLIDRDYMERDKENPNQYNYIA
:::::::::::::::::::::::::::
XP_011 KKRIESLIDRDYMERDKENPNQYNYIA
700 710
>>XP_011529701 (OMIM: 300304,300354) PREDICTED: cullin-4 (719 aa)
initn: 2988 init1: 2988 opt: 4606 Z-score: 3516.9 bits: 661.7 E(85289): 3.7e-189
Smith-Waterman score: 4606; 98.7% identity (99.3% similar) in 719 aa overlap (197-913:1-719)
170 180 190 200 210 220
pF1KE4 VASVHHANGLAKSSTTVSSFANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEA
.. .: :::::::::::::::::::::::
XP_011 MIDPDFADKPKLPENYTDETWQKLKEAVEA
10 20 30
230 240 250 260 270 280
pF1KE4 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFL
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE4 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKT
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE4 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQ
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE4 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE4 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKV
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE4 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKM
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE4 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLE
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE4 GMFKDMELSKDIMIQFKQ--YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKL
:::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_011 GMFKDMELSKDIMIQFKQVKYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKL
460 470 480 490 500 510
710 720 730 740 750 760
pF1KE4 QEIFKTFYLGKHSGRKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSL
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_011 QEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSL
520 530 540 550 560 570
770 780 790 800 810 820
pF1KE4 EEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKIN
580 590 600 610 620 630
830 840 850 860 870 880
pF1KE4 QIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPA
640 650 660 670 680 690
890 900 910
pF1KE4 DLKKRIESLIDRDYMERDKENPNQYNYIA
:::::::::::::::::::::::::::::
XP_011 DLKKRIESLIDRDYMERDKENPNQYNYIA
700 710
>>XP_011529703 (OMIM: 300304,300354) PREDICTED: cullin-4 (701 aa)
initn: 2728 init1: 2728 opt: 4346 Z-score: 3319.2 bits: 625.0 E(85289): 3.9e-178
Smith-Waterman score: 4346; 96.4% identity (98.0% similar) in 699 aa overlap (217-913:9-701)
190 200 210 220 230 240
pF1KE4 ANSKPGSAKKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVEN
: :.. . .. :.: . .. .::::
XP_011 MQILFMFLWIVLRKII--LRCSSSNR----RIKEAVEN
10 20 30
250 260 270 280 290 300
pF1KE4 LCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSI
40 50 60 70 80 90
310 320 330 340 350 360
pF1KE4 FLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRS
100 110 120 130 140 150
370 380 390 400 410 420
pF1KE4 LLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEAD
160 170 180 190 200 210
430 440 450 460 470 480
pF1KE4 RLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGG
220 230 240 250 260 270
490 500 510 520 530 540
pF1KE4 VQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKE
280 290 300 310 320 330
550 560 570 580 590 600
pF1KE4 AFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF
340 350 360 370 380 390
610 620 630 640 650 660
pF1KE4 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQ--
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQVK
400 410 420 430 440 450
670 680 690 700 710 720
pF1KE4 YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQ
460 470 480 490 500 510
730 740 750 760 770 780
pF1KE4 STIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS
::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQS
520 530 540 550 560 570
790 800 810 820 830 840
pF1KE4 LACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQ
580 590 600 610 620 630
850 860 870 880 890 900
pF1KE4 DRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKE
640 650 660 670 680 690
910
pF1KE4 NPNQYNYIA
:::::::::
XP_011 NPNQYNYIA
700
>>NP_001008895 (OMIM: 603137) cullin-4A isoform 1 [Homo (759 aa)
initn: 4069 init1: 4069 opt: 4103 Z-score: 3133.6 bits: 590.8 E(85289): 8.4e-168
Smith-Waterman score: 4103; 82.6% identity (94.8% similar) in 749 aa overlap (168-913:13-759)
140 150 160 170 180 190
pF1KE4 SSSSSSSSSPTAATSQQQQLKNKSILISSVASVHHANGLAKSSTTVSSFANSKPGSA---
: : ..:::.: .. .. : .:::.:
NP_001 MADEAPRKGSFSALVGRTNGLTKPAALAA--APAKPGGAGGS
10 20 30 40
200 210 220 230 240 250
pF1KE4 KKLVIKNFKDKPKLPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISA
::::::::.:.:.::.:::..::.::.:::.:.:.::::.:::::::::::::::.:.:
NP_001 KKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSP
50 60 70 80 90 100
260 270 280 290 300 310
pF1KE4 NLYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTY
::::::: ::::..::: :::::::::::::::. :::.:::::::::::::::::::
NP_001 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY
110 120 130 140 150 160
320 330 340 350 360 370
pF1KE4 VLQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSM
::::: :::::::::::::.:::::. ::.::::::::::::::.:::.:::::::::.:
NP_001 VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM
170 180 190 200 210 220
380 390 400 410 420 430
pF1KE4 LSDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQ
:::::.:.:::: .:::::: :::::::.:::::::::::.::.::::::.::.:::::.
NP_001 LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
230 240 250 260 270 280
440 450 460 470 480 490
pF1KE4 TTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQW
.::: ::: ::::::::::::::::::..::::::. ::. .:::::::::: :.:::.:
NP_001 STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW
290 300 310 320 330 340
500 510 520 530 540 550
pF1KE4 IEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINK
::::.::..::::::::: :::.::::::::::.:..:: :::.:.: :::.:::::::
NP_001 SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK
350 360 370 380 390 400
560 570 580 590 600 610
pF1KE4 RPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKR
:::::::::::.::::::::::::::::::. ::::::.::::.::::::::::::::::
NP_001 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
410 420 430 440 450 460
620 630 640 650 660 670
pF1KE4 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGN
:::::::::::::::::::::::::::::::::::::::::::::..:::.::::. :
NP_001 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP
470 480 490 500 510 520
680 690 700 710 720 730
pF1KE4 IELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTIGHCVLKA
:.::::::::::::::.:::::: :::.::::.::.::::::::::::::.:.:: ::::
NP_001 IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA
530 540 550 560 570 580
740 750 760 770 780 790
pF1KE4 EFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLA
::::::::.::::::::::::::::. ::.::::.::::::.:::::::::::::::::
NP_001 EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI
590 600 610 620 630 640
800 810 820 830 840 850
pF1KE4 KNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAI
:.::::..::::::: : .::::::::::::::::::::::.::::::::::::::::::
NP_001 KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI
650 660 670 680 690 700
860 870 880 890 900 910
pF1KE4 VRIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA
::::::::::.:::::::.::::::::::.:::::::::::::::::::.:::::.:.:
NP_001 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA
710 720 730 740 750
>>NP_003580 (OMIM: 603137) cullin-4A isoform 2 [Homo sap (659 aa)
initn: 3755 init1: 3755 opt: 3755 Z-score: 2869.7 bits: 541.8 E(85289): 4.2e-153
Smith-Waterman score: 3755; 85.6% identity (95.9% similar) in 658 aa overlap (256-913:2-659)
230 240 250 260 270 280
pF1KE4 AIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDHIKAQIHQFREDSLDSVLF
::::::: ::::..::: :::::::::::
NP_003 MLYKQLRQACEDHVQAQILPFREDSLDSVLF
10 20 30
290 300 310 320 330 340
pF1KE4 LKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIWDMGLELFRAHIISDQKVQNK
::::. :::.:::::::::::::::::::::::: :::::::::::::.:::::. ::.:
NP_003 LKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSK
40 50 60 70 80 90
350 360 370 380 390 400
pF1KE4 TIDGILLLIERERNGEAIDRSLLRSLLSMLSDLQIYQDSFEQRFLEETNRLYAAEGQKLM
:::::::::::::.:::.:::::::::.::::::.:.:::: .:::::: :::::::.::
NP_003 TIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLM
100 110 120 130 140 150
410 420 430 440 450 460
pF1KE4 QEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLL
:::::::::.::.::::::.::.:::::..::: ::: ::::::::::::::::::..::
NP_003 QEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLL
160 170 180 190 200 210
470 480 490 500 510 520
pF1KE4 DENRIQDLSLLYQLFSRVRGGVQVLLQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDK
::::. ::. .:::::::::: :.:::.: ::::.::..::::::::: :::.:::::::
NP_003 DENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDK
220 230 240 250 260 270
530 540 550 560 570 580
pF1KE4 VDHIIDICFLKNEKFINAMKEAFETFINKRPNKPAELIAKYVDSKLRAGNKEATDEELEK
:::.:..:: :::.:.: :::.::::::::::::::::::.::::::::::::::::::.
NP_003 VDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELER
280 290 300 310 320 330
590 600 610 620 630 640
pF1KE4 MLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKL
::::::.::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKL
340 350 360 370 380 390
650 660 670 680 690 700
pF1KE4 EGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQ
::::::::::::::..:::.::::. : :.::::::::::::::.:::::: :::.:::
NP_003 EGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQ
400 410 420 430 440 450
710 720 730 740 750 760
pF1KE4 EIFKTFYLGKHSGRKLQWQSTIGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLE
:.::.::::::::::::::.:.:: ::::::::::::.::::::::::::::::. ::.:
NP_003 EVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFE
460 470 480 490 500 510
770 780 790 800 810 820
pF1KE4 EIKQATGIEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQ
:::.::::::.::::::::::::::::: :.::::..::::::: : .::::::::::::
NP_003 EIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQ
520 530 540 550 560 570
830 840 850 860 870 880
pF1KE4 IQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKPAD
::::::::::.::::::::::::::::::::::::::::.:::::::.::::::::::.:
NP_003 IQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGD
580 590 600 610 620 630
890 900 910
pF1KE4 LKKRIESLIDRDYMERDKENPNQYNYIA
::::::::::::::::::.:::::.:.:
NP_003 LKKRIESLIDRDYMERDKDNPNQYHYVA
640 650
913 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:57:56 2016 done: Mon Nov 7 16:57:58 2016
Total Scan time: 13.040 Total Display time: 0.230
Function used was FASTA [36.3.4 Apr, 2011]