Result of FASTA (omim) for
pFN21AE4531
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4531, 594 aa
1>>>pF1KE4531 594 - 594 aa - 594 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.7434+/-0.00039; mu= 4.9300+/- 0.024
mean_var=231.0322+/-48.365, 0's: 0 Z-trim(120.3): 137 B-trim: 2048 in 1/54
Lambda= 0.084380
statistics sampled from 35154 (35328) to 35154 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.414), width: 16
Scan time: 12.210
The best scores are: opt bits E(85289)
NP_058544 (OMIM: 605263) SHC-transforming protein ( 594) 3976 497.1 6.6e-140
XP_011517087 (OMIM: 605263) PREDICTED: SHC-transfo ( 598) 3958 495.0 3e-139
XP_011517088 (OMIM: 605263) PREDICTED: SHC-transfo ( 452) 2778 351.2 4.3e-96
XP_016870299 (OMIM: 605263) PREDICTED: SHC-transfo ( 307) 1798 231.8 2.7e-60
XP_011508194 (OMIM: 600560) PREDICTED: SHC-transfo ( 593) 1398 183.3 2e-45
XP_016870298 (OMIM: 605263) PREDICTED: SHC-transfo ( 359) 1193 158.2 4.4e-38
NP_001123512 (OMIM: 600560) SHC-transforming prote ( 584) 1197 158.8 4.5e-38
NP_892113 (OMIM: 600560) SHC-transforming protein ( 583) 1190 158.0 8.1e-38
XP_005245506 (OMIM: 600560) PREDICTED: SHC-transfo ( 598) 1190 158.0 8.3e-38
NP_003020 (OMIM: 600560) SHC-transforming protein ( 474) 1181 156.8 1.5e-37
NP_001123513 (OMIM: 600560) SHC-transforming prote ( 473) 1174 156.0 2.7e-37
XP_005245508 (OMIM: 600560) PREDICTED: SHC-transfo ( 488) 1174 156.0 2.8e-37
NP_001189788 (OMIM: 600560) SHC-transforming prote ( 428) 1129 150.4 1.1e-35
XP_011508200 (OMIM: 600560) PREDICTED: SHC-transfo ( 432) 1068 143.0 1.9e-33
NP_036567 (OMIM: 605217) SHC-transforming protein ( 582) 1027 138.1 7.6e-32
XP_011526195 (OMIM: 605217) PREDICTED: SHC-transfo ( 594) 1027 138.2 7.8e-32
XP_011526197 (OMIM: 605217) PREDICTED: SHC-transfo ( 537) 1019 137.1 1.4e-31
XP_011526196 (OMIM: 605217) PREDICTED: SHC-transfo ( 549) 1019 137.2 1.4e-31
XP_011508195 (OMIM: 600560) PREDICTED: SHC-transfo ( 592) 943 127.9 9.3e-29
XP_011526198 (OMIM: 605217) PREDICTED: SHC-transfo ( 437) 912 124.0 1e-27
XP_016882056 (OMIM: 605217) PREDICTED: SHC-transfo ( 437) 912 124.0 1e-27
XP_011508196 (OMIM: 600560) PREDICTED: SHC-transfo ( 575) 671 94.8 8.4e-19
XP_011508199 (OMIM: 600560) PREDICTED: SHC-transfo ( 465) 655 92.8 2.8e-18
XP_016857571 (OMIM: 600560) PREDICTED: SHC-transfo ( 565) 526 77.1 1.7e-13
XP_016857570 (OMIM: 600560) PREDICTED: SHC-transfo ( 566) 526 77.1 1.7e-13
XP_016857572 (OMIM: 600560) PREDICTED: SHC-transfo ( 455) 510 75.1 5.6e-13
>>NP_058544 (OMIM: 605263) SHC-transforming protein 3 [H (594 aa)
initn: 3976 init1: 3976 opt: 3976 Z-score: 2632.7 bits: 497.1 E(85289): 6.6e-140
Smith-Waterman score: 3976; 99.5% identity (99.8% similar) in 594 aa overlap (1-594:1-594)
10 20 30 40 50 60
pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
NP_058 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIGSIGQA
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
NP_058 SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_058 VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
490 500 510 520 530 540
550 560 570 580 590
pF1KE4 AKHLLLVDPEGTIQTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
:::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_058 AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
550 560 570 580 590
>>XP_011517087 (OMIM: 605263) PREDICTED: SHC-transformin (598 aa)
initn: 2699 init1: 2699 opt: 3958 Z-score: 2620.8 bits: 495.0 E(85289): 3e-139
Smith-Waterman score: 3958; 98.8% identity (99.2% similar) in 598 aa overlap (1-594:1-598)
10 20 30 40 50 60
pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_011 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIGSIGQA
::::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::
XP_011 SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
310 320 330 340 350 360
370 380 390 400 410
pF1KE4 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQG----SSDIYSTPEGKLHVA
::::::::::::::::::::::::::::::::::::::::: :::::::::::::::
XP_011 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGERQGSSDIYSTPEGKLHVA
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 PTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVE
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE4 CISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGM
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE4 HNGQAKHLLLVDPEGTIQTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
XP_011 HNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
550 560 570 580 590
>>XP_011517088 (OMIM: 605263) PREDICTED: SHC-transformin (452 aa)
initn: 1519 init1: 1519 opt: 2778 Z-score: 1846.1 bits: 351.2 E(85289): 4.3e-96
Smith-Waterman score: 2778; 98.6% identity (99.0% similar) in 417 aa overlap (182-594:36-452)
160 170 180 190 200 210
pF1KE4 GVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSS
::::::::::::::::::::::::::::::
XP_011 KSPRGFPIPRTWPRLREAVWSGRWTLRKKGREAISRVCEAVPGAKGAFKKRKPPSKMLSS
10 20 30 40 50 60
220 230 240 250 260 270
pF1KE4 ILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVT
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_011 ILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVA
70 80 90 100 110 120
280 290 300 310 320 330
pF1KE4 KDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTE
130 140 150 160 170 180
340 350 360 370 380 390
pF1KE4 EEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGE
190 200 210 220 230 240
400 410 420 430 440
pF1KE4 DWQQTPLRQG----SSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPR
:::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DWQQTPLRQGERQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPR
250 260 270 280 290 300
450 460 470 480 490 500
pF1KE4 KDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRK
310 320 330 340 350 360
510 520 530 540 550 560
pF1KE4 EAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLI
::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_011 EAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLI
370 380 390 400 410 420
570 580 590
pF1KE4 NHHLESSLPIVSAGSELCLQQPVERKQ
:::::::::::::::::::::::::::
XP_011 NHHLESSLPIVSAGSELCLQQPVERKQ
430 440 450
>>XP_016870299 (OMIM: 605263) PREDICTED: SHC-transformin (307 aa)
initn: 1798 init1: 1798 opt: 1798 Z-score: 1203.6 bits: 231.8 E(85289): 2.7e-60
Smith-Waterman score: 1798; 99.3% identity (99.6% similar) in 278 aa overlap (1-278:1-278)
10 20 30 40 50 60
pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIGSIGQA
::::::::::::::::::::::::::::::.:::::::
XP_016 SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRGSRWSGGMTFAGRRAPFNPLQS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
XP_016 LSHFGML
>>XP_011508194 (OMIM: 600560) PREDICTED: SHC-transformin (593 aa)
initn: 1613 init1: 927 opt: 1398 Z-score: 936.7 bits: 183.3 E(85289): 2e-45
Smith-Waterman score: 1666; 48.1% identity (67.8% similar) in 628 aa overlap (3-593:6-592)
10 20 30 40 50
pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP
:. ::: .::.:..:... :..:.. . .: : : : :
XP_011 MDLLPPKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLP
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 VD-GPGSLGHLLHKVSHLKLSS-SGLRGLSSAARERAGARLSGSCSAPSLAAPD-GSAPS
: .: .: .. ..:.:.:.. .: : :.. ::. : .: : :: : :
XP_011 GDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGA---AMPDSGPLPL
60 70 80 90 100
120 130 140 150 160
pF1KE4 APRAPAMSAA--RK-----GRPGDEPLPR-------PPRGAPHASDQVLGPGVTYVVKYL
.:.. :. :. : : : : :: : .:.:.::::.:.:.:.
XP_011 LQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYM
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE4 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF
::.:::.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.:
XP_011 GCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKF
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE4 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRAC
::: :.::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.:::
XP_011 AGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRAC
230 240 250 260 270 280
290 300 310 320 330
pF1KE4 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHD---------RMQSLD-EPWT
::::: .:::::::..:::::::::::::. : :. . :: :: ..: :
XP_011 HILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDSHSFTVLSLRMAGFDGSAWD
290 300 310 320 330 340
340 350 360 370 380
pF1KE4 EEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF
::: . :: :::..:.: :: :: .: ::. . :: .:. : . :: ::: :.
XP_011 EEEEEPPDHQYYNDFPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATL
350 360 370 380 390 400
390 400 410 420 430 440
pF1KE4 --GEDWQQTP-LRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVS
:. : .:. : :. . :.:::.:.. : : .
XP_011 PVGQPVGGDPEVRKQMPPPPPCPAGR----ELFDDPSYVNVQNLDKARQAVGGAGPPNPA
410 420 430 440 450
450 460 470 480 490 500
pF1KE4 SAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWY
:.:: ::::::::::::. : : ...: :.:..: :.
XP_011 INGSAPR-DLFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWF
460 470 480 490
510 520 530 540 550 560
pF1KE4 QGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVF
.:..::.:::.::. .::::::.:::.::..::::...:: ::::::::::...:::. :
XP_011 HGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRF
500 510 520 530 540 550
570 580 590
pF1KE4 DSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
.:.::::..:... :::.:::::::::::::::
XP_011 ESVSHLISYHMDNHLPIISAGSELCLQQPVERKL
560 570 580 590
>>XP_016870298 (OMIM: 605263) PREDICTED: SHC-transformin (359 aa)
initn: 1211 init1: 1187 opt: 1193 Z-score: 804.7 bits: 158.2 E(85289): 4.4e-38
Smith-Waterman score: 1193; 87.9% identity (92.6% similar) in 215 aa overlap (1-210:1-215)
10 20 30 40 50 60
pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::
XP_016 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
130 140 150 160 170 180
190 200 210 220 230
pF1KE4 TR---EAISRVCEAVP-GAKGAFKK-RKPPSKMLSSILGKSNLQFAGMSISLTISTASLN
:: :..... : : . ... :: :: .:
XP_016 TRVHLEGLAKLSSQVTSGFQHSINALRKQKSKRISYPQDLAQAERSCVEWKMDIEEEGQV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 LRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILECCDGLAQDVIG
XP_016 WSHPEWFLLLPRCPGFSHGLCWVLPWVLWMHPACWKFCALCFHPFVVVMTVYLSPVPSSA
250 260 270 280 290 300
>>NP_001123512 (OMIM: 600560) SHC-transforming protein 1 (584 aa)
initn: 1524 init1: 960 opt: 1197 Z-score: 804.5 bits: 158.8 E(85289): 4.5e-38
Smith-Waterman score: 1694; 48.8% identity (68.8% similar) in 619 aa overlap (3-593:6-583)
10 20 30 40 50
pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP
:. ::: .::.:..:... :..:.. . .: : : : :
NP_001 MDLLPPKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLP
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 VD-GPGSLGHLLHKVSHLKLSS-SGLRGLSSAARERAGARLSGSCSAPSLAAPD-GSAPS
: .: .: .. ..:.:.:.. .: : :.. ::. : .: : :: : :
NP_001 GDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGA---AMPDSGPLPL
60 70 80 90 100
120 130 140 150 160
pF1KE4 APRAPAMSAA--RK-----GRPGDEPLPR-------PPRGAPHASDQVLGPGVTYVVKYL
.:.. :. :. : : : : :: : .:.:.::::.:.:.:.
NP_001 LQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYM
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE4 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF
::.:::.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.:
NP_001 GCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKF
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE4 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRAC
::: :.::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.:::
NP_001 AGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRAC
230 240 250 260 270 280
290 300 310 320 330
pF1KE4 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEGDGSDH
::::: .:::::::..:::::::::::::. : :. . :::: ..: : ::: . ::
NP_001 HILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDH
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE4 PYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF--GEDWQQT
:::..:.: :: :: .: ::. . :: .:. : . :: ::: :. :.
NP_001 QYYNDFPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATLPVGQPVGGD
350 360 370 380 390 400
400 410 420 430 440
pF1KE4 P-LRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVSSAESSPRKD
: .:. : :. . :.:::.:.. : : . :.:: :
NP_001 PEVRKQMPPPPPCPAGR----ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR-D
410 420 430 440 450
450 460 470 480 490 500
pF1KE4 LFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEA
:::::::::::. : : ...: :.:..: :..:..::.::
NP_001 LFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWFHGKLSRREA
460 470 480 490
510 520 530 540 550 560
pF1KE4 EGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINH
:.::. .::::::.:::.::..::::...:: ::::::::::...:::. :.:.::::..
NP_001 EALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISY
500 510 520 530 540 550
570 580 590
pF1KE4 HLESSLPIVSAGSELCLQQPVERKQ
:... :::.:::::::::::::::
NP_001 HMDNHLPIISAGSELCLQQPVERKL
560 570 580
>>NP_892113 (OMIM: 600560) SHC-transforming protein 1 is (583 aa)
initn: 1441 init1: 960 opt: 1190 Z-score: 799.9 bits: 158.0 E(85289): 8.1e-38
Smith-Waterman score: 1687; 48.8% identity (68.8% similar) in 619 aa overlap (3-593:6-582)
10 20 30 40 50
pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP
:. ::: .::.:..:... :..:.. . .: : : : :
NP_892 MDLLPPKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLP
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 VD-GPGSLGHLLHKVSHLKLSS-SGLRGLSSAARERAGARLSGSCSAPSLAAPD-GSAPS
: .: .: .. ..:.:.:.. .: : :.. ::. : .: : :: : :
NP_892 GDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGA---AMPDSGPLPL
60 70 80 90 100
120 130 140 150 160
pF1KE4 APRAPAMSAA--RK-----GRPGDEPLPR-------PPRGAPHASDQVLGPGVTYVVKYL
.:.. :. :. : : : : :: : .:.:.::::.:.:.:.
NP_892 LQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYM
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE4 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF
::.:::.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.:
NP_892 GCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKF
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE4 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRAC
::: :.::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.:::
NP_892 AGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRAC
230 240 250 260 270 280
290 300 310 320 330
pF1KE4 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEGDGSDH
::::: .:::::::..:::::::::::::. : :. . :::: ..: : ::: . ::
NP_892 HILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDH
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE4 PYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF--GEDWQQT
:::..:.: :: :: .: ::. . :: .:. : . :: ::: :. :.
NP_892 QYYNDFPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATLPVGQPVGGD
350 360 370 380 390 400
400 410 420 430 440
pF1KE4 P-LRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVSSAESSPRKD
: .:. : .: . :.:::.:.. : : . :.:: :
NP_892 PEVRKQMPPPPPCPGRELF-----DDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR-D
410 420 430 440 450
450 460 470 480 490 500
pF1KE4 LFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEA
:::::::::::. : : ...: :.:..: :..:..::.::
NP_892 LFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWFHGKLSRREA
460 470 480 490
510 520 530 540 550 560
pF1KE4 EGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINH
:.::. .::::::.:::.::..::::...:: ::::::::::...:::. :.:.::::..
NP_892 EALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISY
500 510 520 530 540 550
570 580 590
pF1KE4 HLESSLPIVSAGSELCLQQPVERKQ
:... :::.:::::::::::::::
NP_892 HMDNHLPIISAGSELCLQQPVERKL
560 570 580
>>XP_005245506 (OMIM: 600560) PREDICTED: SHC-transformin (598 aa)
initn: 1239 init1: 960 opt: 1190 Z-score: 799.8 bits: 158.0 E(85289): 8.3e-38
Smith-Waterman score: 1485; 47.0% identity (67.1% similar) in 583 aa overlap (3-557:6-546)
10 20 30 40 50
pF1KE4 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP
:. ::: .::.:..:... :..:.. . .: : : : :
XP_005 MDLLPPKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLP
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 VD-GPGSLGHLLHKVSHLKLSS-SGLRGLSSAARERAGARLSGSCSAPSLAAPD-GSAPS
: .: .: .. ..:.:.:.. .: : :.. ::. : .: : :: : :
XP_005 GDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGA---AMPDSGPLPL
60 70 80 90 100
120 130 140 150 160
pF1KE4 APRAPAMSAA--RK-----GRPGDEPLPR-------PPRGAPHASDQVLGPGVTYVVKYL
.:.. :. :. : : : : :: : .:.:.::::.:.:.:.
XP_005 LQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYM
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE4 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF
::.:::.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.:
XP_005 GCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKF
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE4 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRAC
::: :.::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.:::
XP_005 AGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRAC
230 240 250 260 270 280
290 300 310 320 330
pF1KE4 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEGDGSDH
::::: .:::::::..:::::::::::::. : :. . :::: ..: : ::: . ::
XP_005 HILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDH
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE4 PYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF--GEDWQQT
:::..:.: :: :: .: ::. . :: .:. : . :: ::: :. :.
XP_005 QYYNDFPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATLPVGQPVGGD
350 360 370 380 390 400
400 410 420 430 440
pF1KE4 P-LRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVSSAESSPRKD
: .:. : .: . :.:::.:.. : : . :.:: :
XP_005 PEVRKQMPPPPPCPGRELF-----DDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR-D
410 420 430 440 450
450 460 470 480 490 500
pF1KE4 LFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEA
:::::::::::. : : ...: :.:..: :..:..::.::
XP_005 LFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWFHGKLSRREA
460 470 480 490
510 520 530 540 550 560
pF1KE4 EGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINH
:.::. .::::::.:::.::..::::...:: ::::::::::.... .
XP_005 EALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVSVAEVWVRGGKKEGTV
500 510 520 530 540 550
570 580 590
pF1KE4 HLESSLPIVSAGSELCLQQPVERKQ
XP_005 PYSVSLFLPSLLCRHSRWAAVYGPLLLFKVSGIFLQRLIP
560 570 580 590
>>NP_003020 (OMIM: 600560) SHC-transforming protein 1 is (474 aa)
initn: 1550 init1: 960 opt: 1181 Z-score: 795.2 bits: 156.8 E(85289): 1.5e-37
Smith-Waterman score: 1631; 56.1% identity (75.5% similar) in 469 aa overlap (136-593:33-473)
110 120 130 140 150 160
pF1KE4 AAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEV
.: :: : .:.:.::::.:.:.:.::.::
NP_003 KLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEV
10 20 30 40 50 60
170 180 190 200 210 220
pF1KE4 LRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSI
:.:::.:::.::::.:::::: ::::::::::: ..::: :. ::::::.:::.:::: :
NP_003 LQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPI
70 80 90 100 110 120
230 240 250 260 270 280
pF1KE4 SLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVTKDPVNRRACHILEC
.::.::.:::: . : :::::::::.::::::::::::..:::::.:::::.::::::::
NP_003 TLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILEC
130 140 150 160 170 180
290 300 310 320 330 340
pF1KE4 CDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEGDGSDHPYYNS
.:::::::..:::::::::::::. : :. . :::: ..: : ::: . :: :::.
NP_003 PEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYND
190 200 210 220 230 240
350 360 370 380 390 400
pF1KE4 IPSKMPPPGGFLDTRLKPRPHAPDTAQ-FAGKEQTYYQGRHLGDTF--GEDWQQTP-LRQ
.:.: :: :: .: ::. . :: .:. : . :: ::: :. :. : .:.
NP_003 FPGKEPPLGGVVDMRLR-EGAAPGAARPTAPNAQT---PSHLGATLPVGQPVGGDPEVRK
250 260 270 280 290
410 420 430 440 450
pF1KE4 GSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQ------AWPAAVSSAESSPRKDLFDMK
: :. . :.:::.:.. : : . :.:: ::::::
NP_003 QMPPPPPCPAGR----ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPR-DLFDMK
300 310 320 330 340 350
460 470 480 490 500 510
pF1KE4 PFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLE
::::::. : : ...: :.:..: :..:..::.:::.::.
NP_003 PFEDALR-------------------VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQ
360 370 380 390
520 530 540 550 560 570
pF1KE4 KDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIQTKDRVFDSISHLINHHLESS
.::::::.:::.::..::::...:: ::::::::::...:::. :.:.::::..:...
NP_003 LNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNH
400 410 420 430 440 450
580 590
pF1KE4 LPIVSAGSELCLQQPVERKQ
:::.:::::::::::::::
NP_003 LPIISAGSELCLQQPVERKL
460 470
594 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:12:20 2016 done: Sun Nov 6 00:12:22 2016
Total Scan time: 12.210 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]