Result of FASTA (omim) for
pFN21AE4530
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4530, 592 aa
1>>>pF1KE4530 592 - 592 aa - 592 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.1216+/-0.000595; mu= -9.0783+/- 0.036
mean_var=337.6986+/-70.139, 0's: 0 Z-trim(114.2): 36 B-trim: 178 in 1/52
Lambda= 0.069793
statistics sampled from 23971 (23994) to 23971 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.281), width: 16
Scan time: 11.430
The best scores are: opt bits E(85289)
NP_002044 (OMIM: 600411) guanylate-binding protein ( 592) 3832 400.7 7.2e-111
NP_060754 (OMIM: 600413) guanylate-binding protein ( 595) 3359 353.1 1.6e-96
NP_004111 (OMIM: 600412) guanylate-binding protein ( 591) 3018 318.7 3.4e-86
XP_011539535 (OMIM: 600413) PREDICTED: guanylate-b ( 516) 2886 305.4 3e-82
XP_005270800 (OMIM: 600413) PREDICTED: guanylate-b ( 516) 2886 305.4 3e-82
NP_001306108 (OMIM: 600413) guanylate-binding prot ( 516) 2886 305.4 3e-82
NP_001127958 (OMIM: 611467) guanylate-binding prot ( 586) 2567 273.3 1.6e-72
NP_443174 (OMIM: 611467) guanylate-binding protein ( 586) 2567 273.3 1.6e-72
XP_016856502 (OMIM: 600413) PREDICTED: guanylate-b ( 461) 2483 264.8 4.6e-70
NP_001306109 (OMIM: 600413) guanylate-binding prot ( 461) 2483 264.8 4.6e-70
XP_006710637 (OMIM: 600413) PREDICTED: guanylate-b ( 568) 2269 243.3 1.7e-63
NP_001306110 (OMIM: 600413) guanylate-binding prot ( 544) 2244 240.8 9.1e-63
NP_443173 (OMIM: 612466) guanylate-binding protein ( 640) 2151 231.5 6.8e-60
NP_997281 (OMIM: 612468) guanylate-binding protein ( 638) 2149 231.3 7.8e-60
XP_011539137 (OMIM: 612467) PREDICTED: guanylate-b ( 633) 2097 226.0 2.9e-58
NP_940862 (OMIM: 612467) guanylate-binding protein ( 633) 2097 226.0 2.9e-58
XP_016856503 (OMIM: 600413) PREDICTED: guanylate-b ( 380) 1553 171.1 6.1e-42
XP_011539536 (OMIM: 600413) PREDICTED: guanylate-b ( 514) 1553 171.2 7.7e-42
NP_001307186 (OMIM: 612467) guanylate-binding prot ( 503) 1438 159.6 2.3e-38
>>NP_002044 (OMIM: 600411) guanylate-binding protein 1 [ (592 aa)
initn: 3832 init1: 3832 opt: 3832 Z-score: 2111.5 bits: 400.7 E(85289): 7.2e-111
Smith-Waterman score: 3832; 99.7% identity (100.0% similar) in 592 aa overlap (1-592:1-592)
10 20 30 40 50 60
pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_002 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE
::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_002 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV
490 500 510 520 530 540
550 560 570 580 590
pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
550 560 570 580 590
>>NP_060754 (OMIM: 600413) guanylate-binding protein 3 i (595 aa)
initn: 3508 init1: 2385 opt: 3359 Z-score: 1854.0 bits: 353.1 E(85289): 1.6e-96
Smith-Waterman score: 3359; 87.4% identity (95.4% similar) in 586 aa overlap (1-586:1-584)
10 20 30 40 50 60
pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG
:: ::::::::::::::::.:.:::::::::::::::.::::::::::::::::::::::
NP_060 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV
:.:::::::::.::::::::::::::::: : ::::::::::::.:::::::::::.:::
NP_060 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW
:::::.::::.::::::::::::::::::::::::::::::::: ::::::::::::::
NP_060 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENE--DSADFVSFFPDFVW
130 140 150 160 170
190 200 210 220 230 240
pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR
:::::::::::::::::::::: ::::: .::::::..:::::::::::::::::::::
NP_060 TLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY
:.::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
NP_060 PIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTY
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS
.:::: :::::::::::::::::::::::::::::.::::::::::.:.::::::::: :
NP_060 INAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE
:::: ::....:::::::::::.:::::.:::::::::::::::::::.:::::::::::
NP_060 EREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEE
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ
::::::::::::: ::.::::::.::::::::::::::::::::::::::.:::::::::
NP_060 EVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV
::::::::::: ::::::::::::..::: : .::::.::.:::::.:::::::: .:.
NP_060 ILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERA
480 490 500 510 520 530
550 560 570 580 590
pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
:::.:::.::. ::::: ..::: : :: ..:::: :: ....
NP_060 QLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI
540 550 560 570 580 590
>>NP_004111 (OMIM: 600412) guanylate-binding protein 2 [ (591 aa)
initn: 3071 init1: 2115 opt: 3018 Z-score: 1668.5 bits: 318.7 E(85289): 3.4e-86
Smith-Waterman score: 3018; 75.7% identity (93.6% similar) in 592 aa overlap (1-591:1-590)
10 20 30 40 50 60
pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG
:: ::.. ::: ::.::.:.:..::::::::::::::.::::::::::::::::::::::
NP_004 MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV
::.::::::::.::::::::::::::::: : :::::::::::.:::::.:::::::::.
NP_004 KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW
::::::::::.:::::::::::.:::::: ::...::: ..: :.:::::::::: :::
NP_004 LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSP--GNNSVDDSADFVSFFPAFVW
130 140 150 160 170
190 200 210 220 230 240
pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR
:::::.:.::.::.:.: :.:: ::::.:::..:...:: :::::::::::.::::::
NP_004 TLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDW
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY
:. .. ::.::.:..:::.:.:..:::.:::::.:.:..::::::: :::::::::::::
NP_004 PAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTY
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS
::::::::::::::::::::::::::::.:::::::::::::::::::.:::::::::::
NP_004 VNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE
::::::::...::::::..::..:.:::: .::::::::..:::: : .::: ::.::::
NP_004 EREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEE
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ
.:: : .:::::::::.::::.::.:::. :::::::.:.:. ::.:::...::.:::::
NP_004 DVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV
.:.:::: :::::.:::::.:. :::.:.:.:::.::::::.:::::.:::::::: ::.
NP_004 SLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRA
480 490 500 510 520 530
550 560 570 580 590
pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRR-RKACTIS
::. :::.::::::::::.::::::..::. ....: :.: . . . :.:
NP_004 QLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL
540 550 560 570 580 590
>>XP_011539535 (OMIM: 600413) PREDICTED: guanylate-bindi (516 aa)
initn: 3035 init1: 2385 opt: 2886 Z-score: 1597.5 bits: 305.4 E(85289): 3e-82
Smith-Waterman score: 2886; 86.6% identity (94.9% similar) in 507 aa overlap (80-586:1-505)
50 60 70 80 90 100
pF1KE4 GKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDN
:::::::::: : ::::::::::::.::::
XP_011 MWCVPHPKKPEHTLVLLDTEGLGDVKKGDN
10 20 30
110 120 130 140 150 160
pF1KE4 QNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSA
:::::::.::::::::.::::.:::::::::::::::::::::::::::::::: ::::
XP_011 QNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENEN--EDSA
40 50 60 70 80
170 180 190 200 210 220
pF1KE4 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKF
::::::::::::::::::::::::::::::::: ::::: .::::::..:::::::::::
XP_011 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKF
90 100 110 120 130 140
230 240 250 260 270 280
pF1KE4 FPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVN
:::::::::: :.::::::::::::::::::::::::::::::::::::::::::::.::
XP_011 FPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVN
150 160 170 180 190 200
290 300 310 320 330 340
pF1KE4 GPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTES
:::::::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:.
XP_011 GPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAET
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE4 LQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSG
::::::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::.
XP_011 LQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSA
270 280 290 300 310 320
410 420 430 440 450 460
pF1KE4 LLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKE
:::::::::::::::::::::::: ::.::::::.:::::::::::::::::::::::::
XP_011 LLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKE
330 340 350 360 370 380
470 480 490 500 510 520
pF1KE4 SMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLK
:.::::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.:
XP_011 SVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVK
390 400 410 420 430 440
530 540 550 560 570 580
pF1KE4 QLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKAC
::::::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: ....
XP_011 QLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKR
450 460 470 480 490 500
590
pF1KE4 TIS
XP_011 YMSHKLKI
510
>>XP_005270800 (OMIM: 600413) PREDICTED: guanylate-bindi (516 aa)
initn: 3035 init1: 2385 opt: 2886 Z-score: 1597.5 bits: 305.4 E(85289): 3e-82
Smith-Waterman score: 2886; 86.6% identity (94.9% similar) in 507 aa overlap (80-586:1-505)
50 60 70 80 90 100
pF1KE4 GKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDN
:::::::::: : ::::::::::::.::::
XP_005 MWCVPHPKKPEHTLVLLDTEGLGDVKKGDN
10 20 30
110 120 130 140 150 160
pF1KE4 QNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSA
:::::::.::::::::.::::.:::::::::::::::::::::::::::::::: ::::
XP_005 QNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENEN--EDSA
40 50 60 70 80
170 180 190 200 210 220
pF1KE4 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKF
::::::::::::::::::::::::::::::::: ::::: .::::::..:::::::::::
XP_005 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKF
90 100 110 120 130 140
230 240 250 260 270 280
pF1KE4 FPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVN
:::::::::: :.::::::::::::::::::::::::::::::::::::::::::::.::
XP_005 FPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVN
150 160 170 180 190 200
290 300 310 320 330 340
pF1KE4 GPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTES
:::::::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:.
XP_005 GPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAET
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE4 LQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSG
::::::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::.
XP_005 LQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSA
270 280 290 300 310 320
410 420 430 440 450 460
pF1KE4 LLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKE
:::::::::::::::::::::::: ::.::::::.:::::::::::::::::::::::::
XP_005 LLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKE
330 340 350 360 370 380
470 480 490 500 510 520
pF1KE4 SMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLK
:.::::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.:
XP_005 SVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVK
390 400 410 420 430 440
530 540 550 560 570 580
pF1KE4 QLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKAC
::::::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: ....
XP_005 QLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKR
450 460 470 480 490 500
590
pF1KE4 TIS
XP_005 YMSHKLKI
510
>>NP_001306108 (OMIM: 600413) guanylate-binding protein (516 aa)
initn: 3035 init1: 2385 opt: 2886 Z-score: 1597.5 bits: 305.4 E(85289): 3e-82
Smith-Waterman score: 2886; 86.6% identity (94.9% similar) in 507 aa overlap (80-586:1-505)
50 60 70 80 90 100
pF1KE4 GKSYLMNKLAGKKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDN
:::::::::: : ::::::::::::.::::
NP_001 MWCVPHPKKPEHTLVLLDTEGLGDVKKGDN
10 20 30
110 120 130 140 150 160
pF1KE4 QNDSWIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSA
:::::::.::::::::.::::.:::::::::::::::::::::::::::::::: ::::
NP_001 QNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENEN--EDSA
40 50 60 70 80
170 180 190 200 210 220
pF1KE4 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKF
::::::::::::::::::::::::::::::::: ::::: .::::::..:::::::::::
NP_001 DFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKF
90 100 110 120 130 140
230 240 250 260 270 280
pF1KE4 FPKKKCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVN
:::::::::: :.::::::::::::::::::::::::::::::::::::::::::::.::
NP_001 FPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVN
150 160 170 180 190 200
290 300 310 320 330 340
pF1KE4 GPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTES
:::::::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:.
NP_001 GPRLESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAET
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE4 LQELLDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSG
::::::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::.
NP_001 LQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSA
270 280 290 300 310 320
410 420 430 440 450 460
pF1KE4 LLQVIFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKE
:::::::::::::::::::::::: ::.::::::.:::::::::::::::::::::::::
NP_001 LLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKE
330 340 350 360 370 380
470 480 490 500 510 520
pF1KE4 SMTDAILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLK
:.::::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.:
NP_001 SVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVK
390 400 410 420 430 440
530 540 550 560 570 580
pF1KE4 QLTEKMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKAC
::::::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: ....
NP_001 QLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKR
450 460 470 480 490 500
590
pF1KE4 TIS
NP_001 YMSHKLKI
510
>>NP_001127958 (OMIM: 611467) guanylate-binding protein (586 aa)
initn: 2588 init1: 1743 opt: 2567 Z-score: 1423.1 bits: 273.3 E(85289): 1.6e-72
Smith-Waterman score: 2567; 66.7% identity (84.4% similar) in 591 aa overlap (1-591:1-585)
10 20 30 40 50 60
pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG
:: ::::. ::::::: : .: .: :::.::::::::.::::::::::::::::::::::
NP_001 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV
:.::::..:::::::::::.::::::. :.: ::::::::::::::.::.:: :::::.
NP_001 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW
:::::::::... :.: :.: :. ::::: .....::: .. ::: :: .:::::.::
NP_001 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDR--VEDPADSASFFPDLVW
130 140 150 160 170
190 200 210 220 230 240
pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR
::::: : :: ::: .:::::: ::. :.:..:. ..::::::::.:::::::::.::
NP_001 TLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY
:.:..:::::: : :.::.:::::::..:::::::.: :::: :::.::: ::..:::::
NP_001 PAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTY
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS
:::::::::::.::::::::: :::::::::::::.:::::::::: :.::::::::: :
NP_001 VNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE
::::::::...::::::. ::::: . :. :..:.::.: ::::: ::.::. ::.::::
NP_001 EREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEE
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ
:: ::::::::. ::.:: ..:: :::.::::::::::.:: :::::::.. :::::::
NP_001 AVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV
.::: ::. . .::::. .: :. : .::.:::::...:: .::...: :: .
NP_001 ALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQ
480 490 500 510 520 530
550 560 570 580 590
pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
. : ::.. ..::: :. :: ..: . .:.: : . :..
NP_001 NWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL
540 550 560 570 580
>>NP_443174 (OMIM: 611467) guanylate-binding protein 5 [ (586 aa)
initn: 2588 init1: 1743 opt: 2567 Z-score: 1423.1 bits: 273.3 E(85289): 1.6e-72
Smith-Waterman score: 2567; 66.7% identity (84.4% similar) in 591 aa overlap (1-591:1-585)
10 20 30 40 50 60
pF1KE4 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG
:: ::::. ::::::: : .: .: :::.::::::::.::::::::::::::::::::::
NP_443 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV
:.::::..:::::::::::.::::::. :.: ::::::::::::::.::.:: :::::.
NP_443 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW
:::::::::... :.: :.: :. ::::: .....::: .. ::: :: .:::::.::
NP_443 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDR--VEDPADSASFFPDLVW
130 140 150 160 170
190 200 210 220 230 240
pF1KE4 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR
::::: : :: ::: .:::::: ::. :.:..:. ..::::::::.:::::::::.::
NP_443 TLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY
:.:..:::::: : :.::.:::::::..:::::::.: :::: :::.::: ::..:::::
NP_443 PAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTY
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQELLDLHRDS
:::::::::::.::::::::: :::::::::::::.:::::::::: :.::::::::: :
NP_443 VNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSPLEE
::::::::...::::::. ::::: . :. :..:.::.: ::::: ::.::. ::.::::
NP_443 EREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEE
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ
:: ::::::::. ::.:: ..:: :::.::::::::::.:: :::::::.. :::::::
NP_443 AVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQ
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE4 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV
.::: ::. . .::::. .: :. : .::.:::::...:: .::...: :: .
NP_443 ALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQ
480 490 500 510 520 530
550 560 570 580 590
pF1KE4 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
. : ::.. ..::: :. :: ..: . .:.: : . :..
NP_443 NWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL
540 550 560 570 580
>>XP_016856502 (OMIM: 600413) PREDICTED: guanylate-bindi (461 aa)
initn: 2632 init1: 2385 opt: 2483 Z-score: 1378.9 bits: 264.8 E(85289): 4.6e-70
Smith-Waterman score: 2483; 86.0% identity (94.6% similar) in 443 aa overlap (144-586:10-450)
120 130 140 150 160 170
pF1KE4 WIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVS
::::::::::::::::::::: :::::::
XP_016 MQVQRRDPIYVTELTHRIRSKSSPDENENE--DSADFVS
10 20 30
180 190 200 210 220 230
pF1KE4 FFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKK
::::::::::::::::::::::::::::: ::::: .::::::..:::::::::::::::
XP_016 FFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKK
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 KCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRL
:::::: :.::::::::::::::::::::::::::::::::::::::::::::.::::::
XP_016 KCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 ESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQEL
:::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:.::::
XP_016 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE4 LDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQV
::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::.::::
XP_016 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV
220 230 240 250 260 270
420 430 440 450 460 470
pF1KE4 IFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTD
:::::::::::::::::::: ::.::::::.::::::::::::::::::::::::::.::
XP_016 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTD
280 290 300 310 320 330
480 490 500 510 520 530
pF1KE4 AILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTE
::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.:::::
XP_016 AILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTE
340 350 360 370 380 390
540 550 560 570 580 590
pF1KE4 KMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: ....
XP_016 KMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSH
400 410 420 430 440 450
XP_016 KLKI
460
>>NP_001306109 (OMIM: 600413) guanylate-binding protein (461 aa)
initn: 2632 init1: 2385 opt: 2483 Z-score: 1378.9 bits: 264.8 E(85289): 4.6e-70
Smith-Waterman score: 2483; 86.0% identity (94.6% similar) in 443 aa overlap (144-586:10-450)
120 130 140 150 160 170
pF1KE4 WIFALAVLLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVS
::::::::::::::::::::: :::::::
NP_001 MQVQRRDPIYVTELTHRIRSKSSPDENENE--DSADFVS
10 20 30
180 190 200 210 220 230
pF1KE4 FFPDFVWTLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKK
::::::::::::::::::::::::::::: ::::: .::::::..:::::::::::::::
NP_001 FFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKK
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE4 KCFVFDRPVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRL
:::::: :.::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_001 KCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRL
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE4 ESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTESLQEL
:::::::.:::: :::::::::::::::::::::::::::::.::::::::::.:.::::
NP_001 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE4 LDLHRDSEREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQV
::::: ::::: ::....:::::::::::.:::::.:::::::::::::::::::.::::
NP_001 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV
220 230 240 250 260 270
420 430 440 450 460 470
pF1KE4 IFSPLEEEVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTD
:::::::::::::::::::: ::.::::::.::::::::::::::::::::::::::.::
NP_001 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTD
280 290 300 310 320 330
480 490 500 510 520 530
pF1KE4 AILQTDQTLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTE
::::::: ::::::::::: ::::::::::::..::: : .::::.::.:::::.:::::
NP_001 AILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTE
340 350 360 370 380 390
540 550 560 570 580 590
pF1KE4 KMENDRVQLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRRKACTIS
::: .:.:::.:::.::. ::::: ..::: : :: ..:::: :: ....
NP_001 KMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSH
400 410 420 430 440 450
NP_001 KLKI
460
592 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:13:03 2016 done: Sun Nov 6 00:13:04 2016
Total Scan time: 11.430 Total Display time: 0.140
Function used was FASTA [36.3.4 Apr, 2011]