FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4515, 547 aa
  1>>>pF1KE4515 547 - 547 aa - 547 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.3004+/-0.000461; mu= 18.7506+/- 0.029
 mean_var=70.8342+/-14.578, 0's: 0 Z-trim(109.6): 50  B-trim: 159 in 1/49
 Lambda= 0.152389
 statistics sampled from 17824 (17837) to 17824 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.209), width:  16
 Scan time:  8.570

The best scores are:                                      opt bits E(85289)
NP_060882 (OMIM: 600833) suppressor of tumorigenic ( 554) 3622 806.1       0
NP_068708 (OMIM: 600833) suppressor of tumorigenic ( 585) 2049 460.3 7.4e-129


>>NP_060882 (OMIM: 600833) suppressor of tumorigenicity   (554 aa)
 initn: 2897 init1: 2897 opt: 3622  Z-score: 4303.7  bits: 806.1 E(85289):    0
Smith-Waterman score: 3622; 98.7% identity (98.7% similar) in 554 aa overlap (1-547:1-554)

               10        20        30        40        50        60
pF1KE4 MAEAATGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MAEAATGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTP
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KE4 KFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNS----
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::    
NP_060 KFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSN
               70        80        90       100       110       120

           120       130       140       150       160       170   
pF1KE4 ---DSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDS
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDS
              130       140       150       160       170       180

           180       190       200       210       220       230   
pF1KE4 DHLRPADAIMQKAWRERNPQARISAAHEALEINECATAYILLAEEEATTIAEAEKLFKQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DHLRPADAIMQKAWRERNPQARISAAHEALEINECATAYILLAEEEATTIAEAEKLFKQA
              190       200       210       220       230       240

           240       250       260       270       280       290   
pF1KE4 LKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLM
              250       260       270       280       290       300

           300       310       320       330       340       350   
pF1KE4 KEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSD
              310       320       330       340       350       360

           360       370       380       390       400       410   
pF1KE4 KFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIA
              370       380       390       400       410       420

           420       430       440       450       460       470   
pF1KE4 YAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 YAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHE
              430       440       450       460       470       480

           480       490       500       510       520       530   
pF1KE4 VSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVE
              490       500       510       520       530       540

           540       
pF1KE4 SILPSSLWHQLTRI
       ::::::::::::::
NP_060 SILPSSLWHQLTRI
              550    

>>NP_068708 (OMIM: 600833) suppressor of tumorigenicity   (585 aa)
 initn: 2806 init1: 2042 opt: 2049  Z-score: 2434.4  bits: 460.3 E(85289): 7.4e-129
Smith-Waterman score: 3371; 91.9% identity (93.3% similar) in 566 aa overlap (1-536:1-565)

               10        20        30        40        50        60
pF1KE4 MAEAATGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 MAEAATGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTP
               10        20        30        40        50        60

               70        80        90       100       110          
pF1KE4 KFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNS----
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::    
NP_068 KFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSN
               70        80        90       100       110       120

           120       130       140       150       160       170   
pF1KE4 ---DSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDS
          :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 GDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDS
              130       140       150       160       170       180

           180       190       200                              210
pF1KE4 DHLRPADAIMQKAWRERNPQARISAAHEALEINE-----------------------CAT
       ::::::::::::::::::::::::::::::::::                       :::
NP_068 DHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCAT
              190       200       210       220       230       240

              220       230       240       250       260       270
pF1KE4 AYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 AYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKR
              250       260       270       280       290       300

              280       290       300       310       320       330
pF1KE4 RLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 RLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDD
              310       320       330       340       350       360

              340       350       360       370       380       390
pF1KE4 ISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 ISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYL
              370       380       390       400       410       420

              400       410       420       430       440       450
pF1KE4 LEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 LEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKG
              430       440       450       460       470       480

              460       470       480       490       500       510
pF1KE4 HLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_068 HLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELM
              490       500       510       520       530       540

              520       530       540                
pF1KE4 GVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTRI         
       ::::::... .:   .:   . .::.                    
NP_068 GVFAKAMID-IFCSAEFRDWNCKSIFMRVEDELEIPPAPQSQHFQN
               550       560       570       580     




547 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 00:19:21 2016 done: Sun Nov  6 00:19:22 2016
 Total Scan time:  8.570 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]