Result of FASTA (omim) for
pFN21AE4505
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4505, 529 aa
1>>>pF1KE4505 529 - 529 aa - 529 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6749+/-0.000389; mu= 16.3919+/- 0.024
mean_var=73.6485+/-15.169, 0's: 0 Z-trim(112.8): 13 B-trim: 714 in 1/57
Lambda= 0.149449
statistics sampled from 21800 (21804) to 21800 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.256), width: 16
Scan time: 8.420
The best scores are: opt bits E(85289)
NP_000511 (OMIM: 272800,606869) beta-hexosaminidas ( 529) 3650 796.7 0
NP_001305754 (OMIM: 272800,606869) beta-hexosamini ( 540) 3075 672.7 7.7e-193
NP_000512 (OMIM: 268800,606873) beta-hexosaminidas ( 556) 2043 450.2 7.6e-126
NP_001278933 (OMIM: 268800,606873) beta-hexosamini ( 331) 1552 344.2 3.6e-94
>>NP_000511 (OMIM: 272800,606869) beta-hexosaminidase su (529 aa)
initn: 3650 init1: 3650 opt: 3650 Z-score: 4253.2 bits: 796.7 E(85289): 0
Smith-Waterman score: 3650; 99.8% identity (100.0% similar) in 529 aa overlap (1-529:1-529)
10 20 30 40 50 60
pF1KE4 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 YLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV
:::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::
NP_000 YLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV
430 440 450 460 470 480
490 500 510 520
pF1KE4 AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
490 500 510 520
>>NP_001305754 (OMIM: 272800,606869) beta-hexosaminidase (540 aa)
initn: 3066 init1: 3066 opt: 3075 Z-score: 3583.1 bits: 672.7 E(85289): 7.7e-193
Smith-Waterman score: 3618; 97.8% identity (98.0% similar) in 540 aa overlap (1-529:1-540)
10 20 30 40 50 60
pF1KE4 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
10 20 30 40 50 60
70 80 90 100
pF1KE4 LDEAFQRYRDLLFGSGSWPRPYLTG-----------KRHTLEKNVLVVSVVTPGCNQLPT
::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_001 LDEAFQRYRDLLFGSGSWPRPYLTGWPHQAYPVFLGKRHTLEKNVLVVSVVTPGCNQLPT
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 LESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPH
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 RGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNP
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 VTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGP
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 VNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFK
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 QLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTK
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE4 AGFRALLSAPWYLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNL
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_001 AGFRALLSAPWYLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNL
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE4 VPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
490 500 510 520 530 540
>>NP_000512 (OMIM: 268800,606873) beta-hexosaminidase su (556 aa)
initn: 2021 init1: 805 opt: 2043 Z-score: 2380.3 bits: 450.2 E(85289): 7.6e-126
Smith-Waterman score: 2043; 56.9% identity (80.4% similar) in 504 aa overlap (22-525:55-554)
10 20 30 40 50
pF1KE4 MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVS
:::: : . . . . : :.:: .... .
NP_000 AMLALLTQVALVVQVAEAARAPSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPN
30 40 50 60 70 80
60 70 80 90 100 110
pF1KE4 SAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLE
:.: :.:..:.:::.::. .:: .: . . .: ...:: .. :. .:..
NP_000 STAGPSCTLLEEAFRRYHGYIFGFYKWHHEPAEFQAKTQVQQLLVSITLQSECDAFPNIS
90 100 110 120 130 140
120 130 140 150 160 170
pF1KE4 SVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRG
: :.::: ... .: .. :::::::::::::::.... ::: ::.. : : ::: :::
NP_000 SDESYTLLVKEPVAVLKANRVWGALRGLETFSQLVYQDSYGTFTINESTIIDSPRFSHRG
150 160 170 180 190 200
180 190 200 210 220 230
pF1KE4 LLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVT
.:.::::::::.. :: :::.::.::.::.:::.::: ::::.:.::::: ::::. ..
NP_000 ILIDTSRHYLPVKIILKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYS-LS
210 220 230 240 250 260
240 250 260 270 280 290
pF1KE4 HIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVN
:.:: .::. ::::::::::::: :::::::::::: : ::::::: .. .:::.:
NP_000 HVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQNKLDSFGPIN
270 280 290 300 310 320
300 310 320 330 340 350
pF1KE4 PSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQL
:.::.:: :..::: :.: :::: ..:::::::.: ::.:::.::::::.:::: :::.:
NP_000 PTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQKGFGTDFKKL
330 340 350 360 370 380
360 370 380 390 400 410
pF1KE4 ESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAG
:::::: .:::... .:: .:::::::.:.:. : ::..::... : .:: :: .:
NP_000 ESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSA---YPEELSRVTASG
390 400 410 420 430 440
420 430 440 450 460 470
pF1KE4 FRALLSAPWYLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVP
: ..:::::::. :::: ::. .: :::: : :: .:: : ::::::.:::::: :::.:
NP_000 FPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGEYVDATNLTP
450 460 470 480 490 500
480 490 500 510 520
pF1KE4 RLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
::::::.::.:::::.: . :. ::.::.. ::....::. :::: .:.:..:
NP_000 RLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYCNHENM
510 520 530 540 550
>>NP_001278933 (OMIM: 268800,606873) beta-hexosaminidase (331 aa)
initn: 1530 init1: 805 opt: 1552 Z-score: 1811.6 bits: 344.2 E(85289): 3.6e-94
Smith-Waterman score: 1552; 63.7% identity (84.4% similar) in 333 aa overlap (193-525:1-329)
170 180 190 200 210 220
pF1KE4 DFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELM
::.::.::.:::.::: ::::.:.:::::
NP_001 MAFNKFNVLHWHIVDDQSFPYQSITFPELS
10 20 30
230 240 250 260 270 280
pF1KE4 RKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSE
::::. ..:.:: .::. ::::::::::::: :::::::::::: : ::::::: ..
NP_001 NKGSYS-LSHVYTPNDVRMVIEYARLRGIRVLPEFDTPGHTLSWGKGQKDLLTPCYSRQN
40 50 60 70 80
290 300 310 320 330 340
pF1KE4 PSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKK
.:::.::.::.:: :..::: :.: :::: ..:::::::.: ::.:::.::::::.:
NP_001 KLDSFGPINPTLNTTYSFLTTFFKEISEVFPDQFIHLGGDEVEFKCWESNPKIQDFMRQK
90 100 110 120 130 140
350 360 370 380 390 400
pF1KE4 GFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMK
::: :::.::::::: .:::... .:: .:::::::.:.:. : ::..::... : .
NP_001 GFGTDFKKLESFYIQKVLDIIATINKGSIVWQEVFDDKAKLAPGTIVEVWKDSA---YPE
150 160 170 180 190 200
410 420 430 440 450 460
pF1KE4 ELELVTKAGFRALLSAPWYLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGE
:: :: .:: ..:::::::. :::: ::. .: :::: : :: .:: : ::::::.:::
NP_001 ELSRVTASGFPVILSAPWYLDLISYGQDWRKYYKVEPLDFGGTQKQKQLFIGGEACLWGE
210 220 230 240 250 260
470 480 490 500 510 520
pF1KE4 YVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFC
::: :::.:::::::.::.:::::.: . :. ::.::.. ::....::. :::: .:.:
NP_001 YVDATNLTPRLWPRASAVGERLWSSKDVRDMDDAYDRLTRHRCRMVERGIAAQPLYAGYC
270 280 290 300 310 320
pF1KE4 EQEFEQT
..:
NP_001 NHENM
330
529 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 15:15:29 2016 done: Mon Nov 7 15:15:30 2016
Total Scan time: 8.420 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]