Result of FASTA (omim) for
pFN21AE4492
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4492, 512 aa
1>>>pF1KE4492 512 - 512 aa - 512 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1666+/-0.000379; mu= 18.5505+/- 0.023
mean_var=66.4618+/-14.135, 0's: 0 Z-trim(112.7): 176 B-trim: 50 in 1/51
Lambda= 0.157322
statistics sampled from 21562 (21752) to 21562 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.255), width: 16
Scan time: 8.750
The best scores are: opt bits E(85289)
NP_001093242 (OMIM: 124075) cytochrome P450 4B1 is ( 512) 3554 815.9 0
NP_000770 (OMIM: 124075) cytochrome P450 4B1 isofo ( 511) 3537 812.1 0
NP_001306090 (OMIM: 124075) cytochrome P450 4B1 is ( 497) 2702 622.5 8.6e-178
XP_016855955 (OMIM: 124075) PREDICTED: cytochrome ( 496) 2685 618.7 1.2e-176
NP_001306091 (OMIM: 124075) cytochrome P450 4B1 is ( 349) 2420 558.4 1.2e-158
NP_001306092 (OMIM: 124075) cytochrome P450 4B1 is ( 348) 2403 554.6 1.7e-157
XP_011539134 (OMIM: 124075) PREDICTED: cytochrome ( 296) 2033 470.6 2.9e-132
NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519) 1804 418.7 2e-116
NP_001010969 (OMIM: 615341) cytochrome P450 4A22 i ( 519) 1686 391.9 2.3e-108
NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 1657 385.4 2.2e-106
XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 1543 359.5 1.3e-98
XP_016855954 (OMIM: 601310) PREDICTED: cytochrome ( 415) 1536 357.8 3.4e-98
XP_011539135 (OMIM: 124075) PREDICTED: cytochrome ( 278) 1513 352.5 9.3e-97
NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 1516 353.4 9.4e-97
NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 1512 352.4 1.6e-96
NP_001073 (OMIM: 604426) phylloquinone omega-hydro ( 520) 1425 332.7 1.6e-90
NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 1413 330.0 1e-89
NP_067010 (OMIM: 611517) phylloquinone omega-hydro ( 524) 1412 329.8 1.2e-89
NP_001122404 (OMIM: 611517) phylloquinone omega-hy ( 524) 1412 329.8 1.2e-89
NP_001186137 (OMIM: 601270) docosahexaenoic acid o ( 520) 1396 326.1 1.5e-88
XP_016882303 (OMIM: 601270) PREDICTED: docosahexae ( 520) 1396 326.1 1.5e-88
NP_001186138 (OMIM: 601270) docosahexaenoic acid o ( 520) 1396 326.1 1.5e-88
NP_000887 (OMIM: 601270) docosahexaenoic acid omeg ( 520) 1391 325.0 3.3e-88
XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 1388 324.3 5.4e-88
XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 1388 324.3 5.4e-88
NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 1388 324.3 5.4e-88
NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 1373 320.9 5.7e-87
XP_005259968 (OMIM: 601270) PREDICTED: docosahexae ( 371) 1237 289.9 8.4e-78
XP_011526316 (OMIM: 601270) PREDICTED: docosahexae ( 371) 1237 289.9 8.4e-78
XP_011526504 (OMIM: 611485) PREDICTED: cytochrome ( 375) 1214 284.7 3.2e-76
XP_006722913 (OMIM: 611485) PREDICTED: cytochrome ( 375) 1214 284.7 3.2e-76
XP_011526510 (OMIM: 611485) PREDICTED: cytochrome ( 375) 1214 284.7 3.2e-76
NP_001306084 (OMIM: 601310) cytochrome P450 4A11 i ( 487) 1137 267.3 7.2e-71
XP_011526505 (OMIM: 611485) PREDICTED: cytochrome ( 352) 1107 260.4 6.2e-69
XP_011526507 (OMIM: 611485) PREDICTED: cytochrome ( 352) 1107 260.4 6.2e-69
XP_011526506 (OMIM: 611485) PREDICTED: cytochrome ( 352) 1107 260.4 6.2e-69
XP_011526509 (OMIM: 611485) PREDICTED: cytochrome ( 334) 1059 249.5 1.1e-65
XP_016881721 (OMIM: 611545) PREDICTED: cytochrome ( 418) 999 236.0 1.7e-61
NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 877 208.3 4.4e-53
XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 874 207.7 7.1e-53
XP_016882661 (OMIM: 611485) PREDICTED: cytochrome ( 411) 861 204.6 4.5e-52
XP_016882304 (OMIM: 601270) PREDICTED: docosahexae ( 391) 859 204.2 5.9e-52
XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 784 187.1 7.9e-47
XP_005270596 (OMIM: 601310) PREDICTED: cytochrome ( 357) 644 155.3 2.7e-37
XP_016855953 (OMIM: 601310) PREDICTED: cytochrome ( 421) 644 155.4 3.1e-37
XP_005270827 (OMIM: 615341) PREDICTED: cytochrome ( 261) 563 136.9 7.1e-32
NP_001295031 (OMIM: 615341) cytochrome P450 4A22 i ( 357) 563 137.0 9.2e-32
XP_005270824 (OMIM: 615341) PREDICTED: cytochrome ( 421) 563 137.0 1e-31
NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 540 131.8 4.5e-30
NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 538 131.4 6.2e-30
>>NP_001093242 (OMIM: 124075) cytochrome P450 4B1 isofor (512 aa)
initn: 3554 init1: 3554 opt: 3554 Z-score: 4357.8 bits: 815.9 E(85289): 0
Smith-Waterman score: 3554; 100.0% identity (100.0% similar) in 512 aa overlap (1-512:1-512)
10 20 30 40 50 60
pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
430 440 450 460 470 480
490 500 510
pF1KE4 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
::::::::::::::::::::::::::::::::
NP_001 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
490 500 510
>>NP_000770 (OMIM: 124075) cytochrome P450 4B1 isoform b (511 aa)
initn: 2106 init1: 2106 opt: 3537 Z-score: 4337.0 bits: 812.1 E(85289): 0
Smith-Waterman score: 3537; 99.8% identity (99.8% similar) in 512 aa overlap (1-512:1-511)
10 20 30 40 50 60
pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_000 FCDVGHMALNTLMKCTFGRGDTGLGH-RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
190 200 210 220 230
250 260 270 280 290 300
pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
420 430 440 450 460 470
490 500 510
pF1KE4 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
::::::::::::::::::::::::::::::::
NP_000 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
480 490 500 510
>>NP_001306090 (OMIM: 124075) cytochrome P450 4B1 isofor (497 aa)
initn: 2702 init1: 2702 opt: 2702 Z-score: 3312.9 bits: 622.5 E(85289): 8.6e-178
Smith-Waterman score: 3398; 97.1% identity (97.1% similar) in 512 aa overlap (1-512:1-497)
10 20 30 40 50 60
pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRG-------------
70 80 90 100
130 140 150 160 170 180
pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
410 420 430 440 450 460
490 500 510
pF1KE4 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
::::::::::::::::::::::::::::::::
NP_001 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
470 480 490
>>XP_016855955 (OMIM: 124075) PREDICTED: cytochrome P450 (496 aa)
initn: 2830 init1: 2106 opt: 2685 Z-score: 3292.1 bits: 618.7 E(85289): 1.2e-176
Smith-Waterman score: 3381; 96.9% identity (96.9% similar) in 512 aa overlap (1-512:1-496)
10 20 30 40 50 60
pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRG-------------
70 80 90 100
130 140 150 160 170 180
pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 --GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
XP_016 FCDVGHMALNTLMKCTFGRGDTGLGH-RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD
410 420 430 440 450 460
490 500 510
pF1KE4 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
::::::::::::::::::::::::::::::::
XP_016 PSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
470 480 490
>>NP_001306091 (OMIM: 124075) cytochrome P450 4B1 isofor (349 aa)
initn: 2420 init1: 2420 opt: 2420 Z-score: 2969.2 bits: 558.4 E(85289): 1.2e-158
Smith-Waterman score: 2420; 100.0% identity (100.0% similar) in 349 aa overlap (164-512:1-349)
140 150 160 170 180 190
pF1KE4 WLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLM
::::::::::::::::::::::::::::::
NP_001 MLDKWEEKAREGKSFDIFCDVGHMALNTLM
10 20 30
200 210 220 230 240 250
pF1KE4 KCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV
40 50 60 70 80 90
260 270 280 290 300 310
pF1KE4 AHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTF
100 110 120 130 140 150
320 330 340 350 360 370
pF1KE4 MFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKE
160 170 180 190 200 210
380 390 400 410 420 430
pF1KE4 SFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFST
220 230 240 250 260 270
440 450 460 470 480 490
pF1KE4 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL
280 290 300 310 320 330
500 510
pF1KE4 RSKNGFHLHLKPLGPGSGK
:::::::::::::::::::
NP_001 RSKNGFHLHLKPLGPGSGK
340
>>NP_001306092 (OMIM: 124075) cytochrome P450 4B1 isofor (348 aa)
initn: 2106 init1: 2106 opt: 2403 Z-score: 2948.4 bits: 554.6 E(85289): 1.7e-157
Smith-Waterman score: 2403; 99.7% identity (99.7% similar) in 349 aa overlap (164-512:1-348)
140 150 160 170 180 190
pF1KE4 WLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLM
::::::::::::::::::::::::::::::
NP_001 MLDKWEEKAREGKSFDIFCDVGHMALNTLM
10 20 30
200 210 220 230 240 250
pF1KE4 KCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KCTFGRGDTGLGH-RDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQV
40 50 60 70 80
260 270 280 290 300 310
pF1KE4 AHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTF
90 100 110 120 130 140
320 330 340 350 360 370
pF1KE4 MFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKE
150 160 170 180 190 200
380 390 400 410 420 430
pF1KE4 SFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFST
210 220 230 240 250 260
440 450 460 470 480 490
pF1KE4 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL
270 280 290 300 310 320
500 510
pF1KE4 RSKNGFHLHLKPLGPGSGK
:::::::::::::::::::
NP_001 RSKNGFHLHLKPLGPGSGK
330 340
>>XP_011539134 (OMIM: 124075) PREDICTED: cytochrome P450 (296 aa)
initn: 2033 init1: 2033 opt: 2033 Z-score: 2495.6 bits: 470.6 E(85289): 2.9e-132
Smith-Waterman score: 2033; 100.0% identity (100.0% similar) in 294 aa overlap (1-294:1-294)
10 20 30 40 50 60
pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARGR
250 260 270 280 290
310 320 330 340 350 360
pF1KE4 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD
>>NP_000769 (OMIM: 601310) cytochrome P450 4A11 isoform (519 aa)
initn: 1810 init1: 1537 opt: 1804 Z-score: 2211.1 bits: 418.7 E(85289): 2e-116
Smith-Waterman score: 1804; 52.6% identity (76.3% similar) in 506 aa overlap (1-506:6-509)
10 20 30 40 50
pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLF
. :: : . :.. :: :::.: ..: ..: :.:: : ::...:: ::.::::
NP_000 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 GHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVY
:: :.:. :... .:.. :: : : :. ...:.::: :.. .:.:::. :
NP_000 GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 DFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREG
:. ::: :::.:.: :.:::..:::.::::.:::::.....:.:.::::::: .
NP_000 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 KSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHND
. ...: :. :.:.:.:::.:.. . ..:: :.:::. :. .:. . ..::
NP_000 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARD
:: :: :: ::::.::.::::::. ::: :: : .::. .:::::::::: :.
NP_000 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 EDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF
:. ::: :::::::::::::::::.:::::.:: .: .:.::.:::::.. .:::
NP_000 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHR
. :. : .: : ::::::..::::::: . :.:: :::: :::::: : .. . ::.::.
NP_000 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 NSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF
: :::.::::: .::. .: .: ::.:::.: :::::.::::.:.::.::. ::::
NP_000 NPKVWPNPEVFDPFRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRF
430 440 450 460 470
480 490 500 510
pF1KE4 EFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
:. ::.:.:: . .:::.::::.::.:. :
NP_000 ELLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL
480 490 500 510
>>NP_001010969 (OMIM: 615341) cytochrome P450 4A22 isofo (519 aa)
initn: 1692 init1: 1424 opt: 1686 Z-score: 2066.4 bits: 391.9 E(85289): 2.3e-108
Smith-Waterman score: 1686; 51.9% identity (74.8% similar) in 489 aa overlap (18-506:23-509)
10 20 30 40 50
pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLF
: :::.: ..: .: :.:: : ::...:: ::.::::
NP_001 MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 GHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVY
:: :.:. :... .. :: : : :. ...:.::: :.. .:.:::. :
NP_001 GHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 DFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREG
:. :: :::.:.: :.:::..:::.:: :.:::::.....:.:.::::::: .
NP_001 KFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 KSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHND
. ...: :. :.:.:.:: .:.. . ..:: :.:::. :. . . ..::
NP_001 SPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEND
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 FIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARD
:: :: :: ::::.::.::::::. ::: :: : .::. .:::::::::: :.
NP_001 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 EDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDF
:. ::: :::::::::::::::::.:::::.:: .: .:.::.:::::.. .:::
NP_001 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHR
. :. : .: : ::::::..::::::: . :.:: :::: :::::: : .. . ::.::.
NP_001 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 NSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRF
: :::. :::: ::. .: .: ::.:::.: :::::.::::...::. :. ::::
NP_001 NPKVWPNLEVFDPSRFAP--GSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRF
430 440 450 460 470
480 490 500 510
pF1KE4 EFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
:. ::.:.:: : .:::.::::.::.:. :
NP_001 ELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL
480 490 500 510
>>NP_828847 (OMIM: 614999) cytochrome P450 4X1 isoform 1 (509 aa)
initn: 1494 init1: 1121 opt: 1657 Z-score: 2030.9 bits: 385.4 E(85289): 2.2e-106
Smith-Waterman score: 1657; 48.0% identity (77.2% similar) in 487 aa overlap (22-506:22-506)
10 20 30 40 50 60
pF1KE4 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE
:.::.:. :.: :::: : . . ::.:::::..::
NP_828 MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ
::. ...:. ...: : :.:.: : .:. ::.:::::.. :: :::. . :
NP_828 IQDD-NMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPP
70 80 90 100 110
130 140 150 160 170
pF1KE4 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEK-AREGKSFD
.:.:: .:.::::.:::.:::::::...:: :. :...:...::::::. . . : .
NP_828 LLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 IFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYW
.. .. :.:. .:::.:.. . .: . : :. .:. .. .:: :. ::.:.:.
NP_828 VYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 LTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDI
:.:.: :: . .: ...:: .:.::: .:: . . .:.. :::::.:.:.::.
NP_828 LSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGS
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 KLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWD
..:: :...::.::.. :::: ...:::.:::.:: ::::.::::::: :::: . . ::
NP_828 SFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWD
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 DLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAV
.::.:.: ::::::. :: : ::.. :.::::.:: :: .:::: . . :..::.: ::
NP_828 QLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAV
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE4 WPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSL
: .:.::: :::: ::...:::.:..::::: ::::::.::: :.::. :. ::.:. .
NP_828 WKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP
420 430 440 450 460 470
480 490 500 510
pF1KE4 DPSRLPIKMP-QLVLRSKNGFHLHLKPLGPGSGK
::.: :. .: ...:. :::..:::: :
NP_828 DPTR-PLTFPNHFILKPKNGMYLHLKKLSEC
480 490 500
512 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:46:40 2016 done: Sun Nov 6 00:46:42 2016
Total Scan time: 8.750 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]