Result of FASTA (omim) for
pFN21AE4491
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4491, 512 aa
1>>>pF1KE4491 512 - 512 aa - 512 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8718+/-0.000416; mu= 15.5621+/- 0.026
mean_var=78.3348+/-16.029, 0's: 0 Z-trim(112.6): 177 B-trim: 775 in 2/50
Lambda= 0.144909
statistics sampled from 21342 (21523) to 21342 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.252), width: 16
Scan time: 8.360
The best scores are: opt bits E(85289)
NP_001306146 (OMIM: 108330) cytochrome P450 1A1 is ( 512) 3459 733.0 4.8e-211
NP_000490 (OMIM: 108330) cytochrome P450 1A1 isofo ( 512) 3459 733.0 4.8e-211
NP_001306145 (OMIM: 108330) cytochrome P450 1A1 is ( 483) 2604 554.3 2.9e-157
NP_000752 (OMIM: 124060) cytochrome P450 1A2 [Homo ( 516) 2549 542.8 9e-154
XP_016877442 (OMIM: 108330) PREDICTED: cytochrome ( 484) 1787 383.5 7.7e-106
NP_000095 (OMIM: 231300,600975,601771,604229) cyto ( 543) 1277 276.9 1.1e-73
NP_000093 (OMIM: 202110,609300) steroid 17-alpha-h ( 508) 910 200.2 1.2e-50
XP_011528270 (OMIM: 124030,608902) PREDICTED: cyto ( 491) 852 188.0 5.4e-47
NP_000097 (OMIM: 124030,608902) cytochrome P450 2D ( 497) 850 187.6 7.3e-47
XP_011528268 (OMIM: 124030,608902) PREDICTED: cyto ( 502) 850 187.6 7.3e-47
NP_898898 (OMIM: 610670,615030) cytochrome P450 2U ( 544) 820 181.4 6.1e-45
XP_005262774 (OMIM: 610670,615030) PREDICTED: cyto ( 562) 820 181.4 6.3e-45
NP_000757 (OMIM: 608055) cytochrome P450 2A13 [Hom ( 494) 690 154.2 8.5e-37
NP_000766 (OMIM: 601258) cytochrome P450 2J2 [Homo ( 502) 677 151.4 5.7e-36
NP_000753 (OMIM: 122700,122720,188890,211980) cyto ( 494) 664 148.7 3.7e-35
NP_000765 (OMIM: 124070) cytochrome P450 2F1 precu ( 491) 660 147.9 6.5e-35
XP_016881874 (OMIM: 124070) PREDICTED: cytochrome ( 566) 660 147.9 7.4e-35
NP_085079 (OMIM: 608054) cytochrome P450 2A7 isofo ( 443) 656 147.0 1.1e-34
NP_000755 (OMIM: 608054) cytochrome P450 2A7 isofo ( 494) 656 147.0 1.2e-34
NP_000760 (OMIM: 124020,609535) cytochrome P450 2C ( 490) 655 146.8 1.3e-34
XP_016871247 (OMIM: 122700,601130) PREDICTED: cyto ( 490) 654 146.6 1.6e-34
NP_000762 (OMIM: 122700,601130) cytochrome P450 2C ( 490) 654 146.6 1.6e-34
NP_000491 (OMIM: 201910,613815) steroid 21-hydroxy ( 495) 654 146.6 1.6e-34
NP_000763 (OMIM: 601131) cytochrome P450 2C18 isof ( 490) 652 146.2 2.1e-34
NP_001185784 (OMIM: 601129) cytochrome P450 2C8 is ( 420) 647 145.1 3.8e-34
NP_001185782 (OMIM: 601129) cytochrome P450 2C8 is ( 420) 647 145.1 3.8e-34
NP_000761 (OMIM: 601129) cytochrome P450 2C8 isofo ( 490) 647 145.2 4.3e-34
NP_001020332 (OMIM: 124030,608902) cytochrome P450 ( 446) 646 144.9 4.6e-34
XP_011528272 (OMIM: 124030,608902) PREDICTED: cyto ( 451) 646 144.9 4.6e-34
NP_001185783 (OMIM: 601129) cytochrome P450 2C8 is ( 388) 644 144.5 5.4e-34
NP_000758 (OMIM: 123930,614546) cytochrome P450 2B ( 491) 641 143.9 1e-33
NP_085125 (OMIM: 611529) cytochrome P450 2S1 precu ( 504) 612 137.8 7e-32
NP_000764 (OMIM: 124040) cytochrome P450 2E1 precu ( 493) 609 137.2 1.1e-31
NP_078790 (OMIM: 600081,608713) vitamin D 25-hydro ( 501) 604 136.2 2.2e-31
XP_016872681 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29
XP_016872680 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29
XP_011518197 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29
XP_016872682 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29
XP_011518200 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29
XP_016872683 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29
XP_016872684 (OMIM: 600081,608713) PREDICTED: vita ( 386) 572 129.4 1.8e-29
XP_016872679 (OMIM: 600081,608713) PREDICTED: vita ( 446) 572 129.5 2.1e-29
XP_005252846 (OMIM: 600081,608713) PREDICTED: vita ( 447) 572 129.5 2.1e-29
XP_005252845 (OMIM: 600081,608713) PREDICTED: vita ( 453) 572 129.5 2.1e-29
XP_011524856 (OMIM: 124070) PREDICTED: cytochrome ( 434) 541 123.0 1.8e-27
XP_011524854 (OMIM: 124070) PREDICTED: cytochrome ( 498) 541 123.0 2e-27
XP_011524853 (OMIM: 124070) PREDICTED: cytochrome ( 498) 541 123.0 2e-27
NP_001122062 (OMIM: 201910,613815) steroid 21-hydr ( 465) 540 122.8 2.2e-27
XP_016881873 (OMIM: 124070) PREDICTED: cytochrome ( 573) 541 123.0 2.3e-27
XP_011524851 (OMIM: 123930,614546) PREDICTED: cyto ( 294) 532 121.0 4.8e-27
>>NP_001306146 (OMIM: 108330) cytochrome P450 1A1 isofor (512 aa)
initn: 3459 init1: 3459 opt: 3459 Z-score: 3909.9 bits: 733.0 E(85289): 4.8e-211
Smith-Waterman score: 3459; 100.0% identity (100.0% similar) in 512 aa overlap (1-512:1-512)
10 20 30 40 50 60
pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
430 440 450 460 470 480
490 500 510
pF1KE4 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
::::::::::::::::::::::::::::::::
NP_001 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
490 500 510
>>NP_000490 (OMIM: 108330) cytochrome P450 1A1 isoform 1 (512 aa)
initn: 3459 init1: 3459 opt: 3459 Z-score: 3909.9 bits: 733.0 E(85289): 4.8e-211
Smith-Waterman score: 3459; 100.0% identity (100.0% similar) in 512 aa overlap (1-512:1-512)
10 20 30 40 50 60
pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
430 440 450 460 470 480
490 500 510
pF1KE4 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
::::::::::::::::::::::::::::::::
NP_000 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
490 500 510
>>NP_001306145 (OMIM: 108330) cytochrome P450 1A1 isofor (483 aa)
initn: 3231 init1: 2604 opt: 2604 Z-score: 2944.3 bits: 554.3 E(85289): 2.9e-157
Smith-Waterman score: 3177; 94.1% identity (94.3% similar) in 512 aa overlap (1-512:1-483)
10 20 30 40 50 60
pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
:::::::::::::::::::::::::::: .::
NP_001 DRSHLPYMEAFILETFRHSSFVPFTIPH-----------------------------RKL
370 380 390
430 440 450 460 470 480
pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
400 410 420 430 440 450
490 500 510
pF1KE4 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
::::::::::::::::::::::::::::::::
NP_001 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
460 470 480
>>NP_000752 (OMIM: 124060) cytochrome P450 1A2 [Homo sap (516 aa)
initn: 2549 init1: 1426 opt: 2549 Z-score: 2881.7 bits: 542.8 E(85289): 9e-154
Smith-Waterman score: 2549; 73.0% identity (90.6% similar) in 508 aa overlap (5-511:7-512)
10 20 30 40 50
pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKN
. .::::.::::.::::::::... ::.::::::.:: ::::::.::.::::::
NP_000 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 PHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNG
::::::::::.::::::::::::::.::: ::::::::::::::::::::::: :::..:
NP_000 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 QSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELM
::..:: :::::::::::::::.:..::::::::::.::::::::::::..::: :::::
NP_000 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 AGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIP
::::::.:: :::::.::: :.:::... .. .:.::::. ...: :...:::: ::.:
NP_000 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 ILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENA
::::::::.:. :: .:..: :.:: :.:::. :.:. .:::: .:..: :. . .
NP_000 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKH--SKKGPRAS
250 260 270 280 290
300 310 320 330 340 350
pF1KE4 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPR
. . .:::.:.: :.:::::::::::::::::::: .:..:::::.:::::::: ::::
NP_000 GNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPR
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 LSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQ
:::: .:::.:::::::::::::.::::::::::::.:.:::::: ::::::::.:::
NP_000 LSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDP
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE4 KLWVNPSEFLPERFLTPDG-AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR
.:: .:::: :::::: :: ::.: ::::...::::::.::::..:.::.:::::::::.
NP_000 ELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQ
420 430 440 450 460 470
480 490 500 510
pF1KE4 VEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
.::::: :::::.::::::::::: ::: : .::
NP_000 LEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
480 490 500 510
>>XP_016877442 (OMIM: 108330) PREDICTED: cytochrome P450 (484 aa)
initn: 1787 init1: 1787 opt: 1787 Z-score: 2021.2 bits: 383.5 E(85289): 7.7e-106
Smith-Waterman score: 3199; 94.5% identity (94.5% similar) in 512 aa overlap (1-512:1-484)
10 20 30 40 50 60
pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
:::::::::::::::::::::::::::::::::::::::::
XP_016 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLN-------------------
190 200 210 220
250 260 270 280 290 300
pF1KE4 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ---------AFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
230 240 250 260 270
310 320 330 340 350 360
pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
400 410 420 430 440 450
490 500 510
pF1KE4 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
::::::::::::::::::::::::::::::::
XP_016 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
460 470 480
>>NP_000095 (OMIM: 231300,600975,601771,604229) cytochro (543 aa)
initn: 1175 init1: 626 opt: 1277 Z-score: 1444.2 bits: 276.9 E(85289): 1.1e-73
Smith-Waterman score: 1277; 40.1% identity (70.8% similar) in 504 aa overlap (2-499:13-512)
10 20 30 40
pF1KE4 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLI
: :.:.. : .:: .. : : : . . . ::::..::::
NP_000 MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 GHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDL
:. ..:. ::...:....::::.:::.:: :.:::.: .:.::::.::. : :: .
NP_000 GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 YTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEV
.: ..:.:.::.:. : : ..:: :.. ...: .. .: : :: :: .::.
NP_000 ASFRVVSGGRSMAFGHYS-EHWKVQRRAAHSMMRNF-FTRQPRSRQ--VLEGHVLSEARE
130 140 150 160 170
170 180 190 200 210 220
pF1KE4 LISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVG
:.. : . : . ..: .::.:.::. :.::: ::.:. :. :.. :..::..::
NP_000 LVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVG
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 SGNPADFIPILRYLPNPSLNAFKD---LNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSL
.:. .: .: :.:.::: ..:.. ::..: .:. .: .... : ::. :..
NP_000 AGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAF
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 IEHCQEKQLDEN--ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI
: ..: .. ....:. :.. . :.:::. ::..::..: :. .. : :: ..
NP_000 ILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRV
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 QEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPK
: ::: :.::.: : ..:. .:::. ::. :..: ::::: ::::.:: .::. :..:::
NP_000 QAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPK
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 GRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIA
::::::..::: : :: .: : ::: :: :.: :. .:.::..:::.:::: ..
NP_000 DTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELS
420 430 440 450 460 470
470 480 490 500 510
pF1KE4 RWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
. ..:::..:: .. .: . . . :. ::::.:
NP_000 KMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNL
480 490 500 510 520 530
NP_000 QAKETCQ
540
>>NP_000093 (OMIM: 202110,609300) steroid 17-alpha-hydro (508 aa)
initn: 825 init1: 555 opt: 910 Z-score: 1030.0 bits: 200.2 E(85289): 1.2e-50
Smith-Waterman score: 910; 33.1% identity (66.9% similar) in 487 aa overlap (13-483:4-468)
10 20 30 40 50
pF1KE4 MLFPISMSATEFLLASVIFCL--VFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKN
:.: ... : .:: : . : : : : . . ::.: . : ..
NP_000 MWELVALLLLTLAYLFWPKR----RCP-GAKYPKSLLSLPLVGSLPFLPRH
10 20 30 40
60 70 80 90 100 110
pF1KE4 PHL--ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLIS
:. . .....:: . ..:.:. .:... . ...:...: ::.:::.. :. . :
NP_000 GHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE4 NG-QSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQ
:. ....:. ::: : .:::: . .:.. .: .. ::. . .: ::::
NP_000 NNRKGIAFA-DSGAHWQLHRRLA---MATFALFKDGDQK----LEKIICQE----ISTLC
110 120 130 140 150
180 190 200 210 220 230
pF1KE4 ELMAGP-GHFNPYRY-VVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNP
...: :. . : :.::::: :::. : .. :: . : :... . ... .
NP_000 DMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSL
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE4 ADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQ
.:..: :. .:: .:. .:. . ....:..... . :.. : .. :.:. : :.
NP_000 VDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLM---QAKM
220 230 240 250 260 270
300 310 320 330 340
pF1KE4 LDENANVQ-------LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEE
..:.:. :::..:.. . :.:::: .:.:....:.: .:. ::.:..:. ::
NP_000 NSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEE
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE4 LDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRC
.: .: :: : .:::..: .:: : :..: .:. :::... :.:. : . ::
NP_000 IDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTE
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE4 VFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV--IIFGMGKRKCIGETIAR
:..: : ..:..: : .:..:.:::::.: :. ...: .: . :: : :.:::: .::
NP_000 VIINLWALHHNEKEWHQPDQFMPERFLNPAGT--QLISPSVSYLPFGAGPRSCIGEILAR
400 410 420 430 440
470 480 490 500 510
pF1KE4 WEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
:.::..: :::: .. ::
NP_000 QELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
450 460 470 480 490 500
>>XP_011528270 (OMIM: 124030,608902) PREDICTED: cytochro (491 aa)
initn: 699 init1: 410 opt: 852 Z-score: 964.7 bits: 188.0 E(85289): 5.4e-47
Smith-Waterman score: 865; 31.4% identity (66.0% similar) in 474 aa overlap (38-503:32-487)
10 20 30 40 50 60
pF1KE4 SATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRM
. :::: : .:..: . .: ....
XP_011 GLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMS--FS
...:::...... ::::::.:: ..:.::: .:.: :: . ... : . :
XP_011 RRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF
::.: .::.. . :....... ::. :..:: : ... . . : :
XP_011 ARYGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAFANHSGRP--F
130 140 150 160 170
190 200 210 220 230 240
pF1KE4 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG---NPADFIPILR
: . .:.::: .. :::.... ..: :..: .. : :: . . .:.:
XP_011 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE-GLKEESGFLREVLNAVPVLL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 YLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLDENANV
..: . .... ... : . ..... :: :.. .. ::.:.... . .. . : .
XP_011 HIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK--GNPES
240 250 260 270 280
310 320 330 340 350 360
pF1KE4 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
...::.. .: :::.::. :..:...:.:. ....: :::..:.:.: :::. :::...
XP_011 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMG
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
:..:.:: : : :. : ...::. . : :.:: ..:: :::: ...: .. .:. .
XP_011 DQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAV
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
: .: .: ::.:: .: . : : . :. :.: :.:: .:: :.:::.. :::. :
XP_011 WEKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF
410 420 430 440 450 460
490 500 510
pF1KE4 SVPLGVKVDMTPIY-GLTMKHACCEHFQMQLRS
::: : . : . :. .::
XP_011 SVPTG---QPRPSHHGVFAFLGCCCTDP
470 480 490
>>NP_000097 (OMIM: 124030,608902) cytochrome P450 2D6 is (497 aa)
initn: 699 init1: 410 opt: 850 Z-score: 962.3 bits: 187.6 E(85289): 7.3e-47
Smith-Waterman score: 863; 31.7% identity (67.4% similar) in 454 aa overlap (38-485:32-471)
10 20 30 40 50 60
pF1KE4 SATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRM
. :::: : .:..: . .: ....
NP_000 GLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMS--FS
...:::...... ::::::.:: ..:.::: .:.: :: . ... : . :
NP_000 RRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF
::.: .::.. . :....... ::. :..:: : ... . . : :
NP_000 ARYGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAFANHSGRP--F
130 140 150 160 170
190 200 210 220 230 240
pF1KE4 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNL-NNNFGEVVGSGNPA-DFIPILRY
: . .:.::: .. :::.... ..: :..: .... : : . . .:.: .
NP_000 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLDENANVQ
.: . .... ... : . ..... :: :.. .. ::.:.... . .. . : . .
NP_000 IPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK--GNPESS
240 250 260 270 280
310 320 330 340 350 360
pF1KE4 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD
..::.. .: :::.::. :..:...:.:. ....: :::..:.:.: :::. :::...:
NP_000 FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGD
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW
..:.:: : : :. : ...::. . : :.:: ..:: :::: ...: .. .:. .:
NP_000 QAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS
.: .: ::.:: .: . : : . :. :.: :.:: .:: :.:::.. :::. ::
NP_000 EKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS
410 420 430 440 450 460
490 500 510
pF1KE4 VPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
:: :
NP_000 VPTGQPRPSHHGVFAFLVSPSPYELCAVPR
470 480 490
>>XP_011528268 (OMIM: 124030,608902) PREDICTED: cytochro (502 aa)
initn: 699 init1: 410 opt: 850 Z-score: 962.3 bits: 187.6 E(85289): 7.3e-47
Smith-Waterman score: 863; 31.7% identity (67.4% similar) in 454 aa overlap (38-485:32-471)
10 20 30 40 50 60
pF1KE4 SATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRM
. :::: : .:..: . .: ....
XP_011 GLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMS--FS
...:::...... ::::::.:: ..:.::: .:.: :: . ... : . :
XP_011 RRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF
::.: .::.. . :....... ::. :..:: : ... . . : :
XP_011 ARYGPAWREQRRFSVSTLRNLGLGKKS-------LEQWVTEEAACLCAAFANHSGRP--F
130 140 150 160 170
190 200 210 220 230 240
pF1KE4 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNL-NNNFGEVVGSGNPA-DFIPILRY
: . .:.::: .. :::.... ..: :..: .... : : . . .:.: .
XP_011 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLH
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLDENANVQ
.: . .... ... : . ..... :: :.. .. ::.:.... . .. . : . .
XP_011 IPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK--GNPESS
240 250 260 270 280
310 320 330 340 350 360
pF1KE4 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD
..::.. .: :::.::. :..:...:.:. ....: :::..:.:.: :::. :::...:
XP_011 FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGD
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW
..:.:: : : :. : ...::. . : :.:: ..:: :::: ...: .. .:. .:
XP_011 QAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS
.: .: ::.:: .: . : : . :. :.: :.:: .:: :.:::.. :::. ::
XP_011 EKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS
410 420 430 440 450 460
490 500 510
pF1KE4 VPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
:: :
XP_011 VPTGQPRPSHHGVFAFLDWLPLWALRDAAVQTPDQ
470 480 490 500
512 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:47:13 2016 done: Sun Nov 6 00:47:14 2016
Total Scan time: 8.360 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]