Result of FASTA (omim) for
pFN21AE4486
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4486, 502 aa
1>>>pF1KE4486 502 - 502 aa - 502 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8967+/-0.000388; mu= 20.1204+/- 0.024
mean_var=64.3087+/-13.295, 0's: 0 Z-trim(112.0): 190 B-trim: 1850 in 2/49
Lambda= 0.159933
statistics sampled from 20522 (20743) to 20522 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.611), E-opt: 0.2 (0.243), width: 16
Scan time: 9.520
The best scores are: opt bits E(85289)
NP_000768 (OMIM: 145500,605325) cytochrome P450 3A ( 502) 3312 773.3 0
NP_001278759 (OMIM: 145500,605325) cytochrome P450 ( 492) 3185 744.0 2.2e-214
NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 2878 673.2 4.8e-193
NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502) 2871 671.6 1.5e-192
NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 2800 655.2 1.2e-187
NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 2595 607.9 2.2e-173
NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504) 2583 605.1 1.5e-172
XP_011514145 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 2542 595.6 8.5e-170
XP_016867270 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 2542 595.6 8.5e-170
NP_001278758 (OMIM: 145500,605325) cytochrome P450 ( 389) 2542 595.6 8.5e-170
XP_016867269 (OMIM: 124010) PREDICTED: cytochrome ( 449) 2392 561.0 2.5e-159
XP_006715922 (OMIM: 145500,605325) PREDICTED: cyto ( 381) 2226 522.7 7.4e-148
NP_476437 (OMIM: 606534) cytochrome P450 3A43 isof ( 420) 2160 507.5 3.1e-143
XP_016867271 (OMIM: 145500,605325) PREDICTED: cyto ( 322) 2115 497.0 3.3e-140
XP_016868032 (OMIM: 606534) PREDICTED: cytochrome ( 394) 2007 472.2 1.2e-132
XP_016868031 (OMIM: 606534) PREDICTED: cytochrome ( 394) 2007 472.2 1.2e-132
XP_016868033 (OMIM: 606534) PREDICTED: cytochrome ( 360) 1832 431.7 1.7e-120
XP_016868034 (OMIM: 606534) PREDICTED: cytochrome ( 360) 1832 431.7 1.7e-120
NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393) 1481 350.8 4.2e-96
NP_001177413 (OMIM: 145500,605325) cytochrome P450 ( 140) 721 175.1 1.2e-43
NP_001159725 (OMIM: 231095,274180,614158) thrombox ( 580) 633 155.2 4.6e-37
NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 588 144.8 5.6e-34
NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 582 143.4 1.4e-33
NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 576 142.1 3.8e-33
NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 573 141.3 5.5e-33
NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 573 141.4 6.1e-33
NP_001186138 (OMIM: 601270) docosahexaenoic acid o ( 520) 567 140.0 1.6e-32
XP_016882303 (OMIM: 601270) PREDICTED: docosahexae ( 520) 567 140.0 1.6e-32
NP_001186137 (OMIM: 601270) docosahexaenoic acid o ( 520) 567 140.0 1.6e-32
NP_997235 (OMIM: 210370,608614) cytochrome P450 4V ( 525) 561 138.6 4.2e-32
NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519) 555 137.2 1.1e-31
XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 550 136.1 2.5e-31
NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 547 135.4 4e-31
XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 547 135.4 4e-31
XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 547 135.4 4e-31
XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 545 134.9 5e-31
XP_016863526 (OMIM: 210370,608614) PREDICTED: cyto ( 393) 543 134.4 6e-31
NP_001122404 (OMIM: 611517) phylloquinone omega-hy ( 524) 543 134.4 7.5e-31
NP_067010 (OMIM: 611517) phylloquinone omega-hydro ( 524) 543 134.4 7.5e-31
NP_000887 (OMIM: 601270) docosahexaenoic acid omeg ( 520) 539 133.5 1.4e-30
NP_001093242 (OMIM: 124075) cytochrome P450 4B1 is ( 512) 536 132.8 2.3e-30
NP_000770 (OMIM: 124075) cytochrome P450 4B1 isofo ( 511) 534 132.4 3.1e-30
NP_001010969 (OMIM: 615341) cytochrome P450 4A22 i ( 519) 534 132.4 3.2e-30
NP_001073 (OMIM: 604426) phylloquinone omega-hydro ( 520) 531 131.7 5.1e-30
XP_016868061 (OMIM: 231095,274180,614158) PREDICTE ( 411) 529 131.1 5.9e-30
XP_016868060 (OMIM: 231095,274180,614158) PREDICTE ( 418) 529 131.1 5.9e-30
XP_016868059 (OMIM: 231095,274180,614158) PREDICTE ( 451) 529 131.2 6.3e-30
NP_112246 (OMIM: 231095,274180,614158) thromboxane ( 460) 529 131.2 6.4e-30
XP_011514846 (OMIM: 231095,274180,614158) PREDICTE ( 463) 529 131.2 6.4e-30
NP_001124438 (OMIM: 231095,274180,614158) thrombox ( 534) 529 131.2 7.2e-30
>>NP_000768 (OMIM: 145500,605325) cytochrome P450 3A5 is (502 aa)
initn: 3312 init1: 3312 opt: 3312 Z-score: 4128.0 bits: 773.3 E(85289): 0
Smith-Waterman score: 3312; 100.0% identity (100.0% similar) in 502 aa overlap (1-502:1-502)
10 20 30 40 50 60
pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
430 440 450 460 470 480
490 500
pF1KE4 LLQPEKPIVLKVDSRDGTLSGE
::::::::::::::::::::::
NP_000 LLQPEKPIVLKVDSRDGTLSGE
490 500
>>NP_001278759 (OMIM: 145500,605325) cytochrome P450 3A5 (492 aa)
initn: 3183 init1: 3183 opt: 3185 Z-score: 3969.8 bits: 744.0 E(85289): 2.2e-214
Smith-Waterman score: 3185; 98.6% identity (99.4% similar) in 490 aa overlap (14-502:3-492)
10 20 30 40 50
pF1KE4 MDLIPNLAVETWLLLAVSLVLLYL-YGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWK
:: . :.::.. :::::::::::::::::::::::::::::::::::
NP_001 MQLLMLELLLLFIVYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWK
10 20 30 40
60 70 80 90 100 110
pF1KE4 FDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAIS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE4 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAY
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE4 SMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVS
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE4 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE4 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE4 VNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE4 SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ
410 420 430 440 450 460
480 490 500
pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE
:::::::::::::::::::::::
NP_001 GLLQPEKPIVLKVDSRDGTLSGE
470 480 490
>>NP_059488 (OMIM: 124010) cytochrome P450 3A4 isoform 1 (503 aa)
initn: 2397 init1: 2397 opt: 2878 Z-score: 3586.8 bits: 673.2 E(85289): 4.8e-193
Smith-Waterman score: 2878; 84.3% identity (95.6% similar) in 502 aa overlap (1-501:1-502)
10 20 30 40 50 60
pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
: :::.::.::::::::::::::::::..:::::.::::::::::.:::.:::..:. :
NP_059 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
: ::.:::::.:: :.:: :::::::::.:.::::::::::::::: .:::::::::::.
NP_059 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
::::::::.:::::::::::::::: ::::::::::::::::::: ::::::::.:::::
NP_059 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
:::::.:::::::::::::::::::.:::.:.: ::::.:::: .:::: :..:.::. .
NP_059 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
::... ::: :::.:::.:::.: ::::.::::::::::::::::::::::::::.::::
NP_059 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
:::::::::::::::: .::::::::::::::.:::::::::::::::.:.:::::::::
NP_059 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
::::::::.:.::::.:::::::::.::::: .:.::.::::.:::::::::.: :::::
NP_059 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ
:: ::.::::::::::.::::::::::::::::::::::::::::::::::::::::.
NP_059 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
430 440 450 460 470 480
480 490 500
pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE
::::::::.::::.:::::.::
NP_059 GLLQPEKPVVLKVESRDGTVSGA
490 500
>>NP_001189784 (OMIM: 124010) cytochrome P450 3A4 isofor (502 aa)
initn: 1588 init1: 1588 opt: 2871 Z-score: 3578.1 bits: 671.6 E(85289): 1.5e-192
Smith-Waterman score: 2871; 84.5% identity (95.6% similar) in 502 aa overlap (1-501:1-501)
10 20 30 40 50 60
pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
: :::.::.::::::::::::::::::..:::::.::::::::::.:::.:::..:. :
NP_001 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
: ::.:::::.:: :.:: :::::::::.:.::::::::::::::: .:::::::::::.
NP_001 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
::::::::.:::::::::::::::: ::::::::::::::::::: ::::::::.:::::
NP_001 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
:::::.:::::::::::::::::::.:::.:.: ::::.::::: :::: :..:.::. .
NP_001 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSII-FPFLIPILEVLNICV
190 200 210 220 230
250 260 270 280 290 300
pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
::... ::: :::.:::.:::.: ::::.::::::::::::::::::::::::::.::::
NP_001 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
:::::::::::::::: .::::::::::::::.:::::::::::::::.:.:::::::::
NP_001 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
::::::::.:.::::.:::::::::.::::: .:.::.::::.:::::::::.: :::::
NP_001 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
360 370 380 390 400 410
430 440 450 460 470
pF1KE4 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ
:: ::.::::::::::.::::::::::::::::::::::::::::::::::::::::.
NP_001 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
420 430 440 450 460 470
480 490 500
pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE
::::::::.::::.:::::.::
NP_001 GLLQPEKPVVLKVESRDGTVSGA
480 490 500
>>NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo sap (503 aa)
initn: 2364 init1: 2364 opt: 2800 Z-score: 3489.5 bits: 655.2 E(85289): 1.2e-187
Smith-Waterman score: 2800; 81.9% identity (94.6% similar) in 502 aa overlap (1-501:1-502)
10 20 30 40 50 60
pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
:::::::::::::::::::.::::::::::::::.::::::::::.:::.::.:.: : :
NP_000 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
: :::::: :.:: :. : :.:::::::.:.::::::::::::::: .:::::::.:::.
NP_000 DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
::::::::::::::::::::::::: ::::::::::::::::::: ::::::: .:::::
NP_000 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
:::::.:::::.:::::::::::::.:::.:.:. :::. ::: .::::::..::::...
NP_000 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
::. .:.::.:::...:..::.. ::::.:::::::::::::..:.::::::::: ::::
NP_000 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
:::::::::::::::: .::::::::::::.:::::.:::::::::::.:.:.:::::::
NP_000 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
::::::::::.::::.:::::::::.::::: .:.::.:.::::::::::::.: :::::
NP_000 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ
:: ::.::::::::::.::::::::::::.::::::.::::::::::::::::::::
NP_000 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG
430 440 450 460 470 480
480 490 500
pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE
::: :::::::..::: :.::
NP_000 GLLLTEKPIVLKAESRDETVSGA
490 500
>>NP_476436 (OMIM: 606534) cytochrome P450 3A43 isoform (503 aa)
initn: 2185 init1: 2185 opt: 2595 Z-score: 3233.9 bits: 607.9 E(85289): 2.2e-173
Smith-Waterman score: 2595; 75.7% identity (91.8% similar) in 502 aa overlap (1-501:1-502)
10 20 30 40 50 60
pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
::::::.:.:::.:.:.::::::.:::..: :::.::::::::::.::..: : .:::.:
NP_476 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
: :: .:::.::: :::: :.:.: :::.:.:::::::::::::. :::.::.:::.:.
NP_476 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
::::::::::.::::.::: :.::: :::.: ::.:::.::.:::..: ..:::.::::.
NP_476 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
::::::: ::::.::::::::::... ::.::. ::::..: : :::::::::::::..:
NP_476 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
::::. .::..:..:::.:::.::::::.::.: ::::::::::.::::::::::.::::
NP_476 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
:.:::.:.:::..: : .::::::::::::::.::::::::::: ::::.::::::::::
NP_476 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
:::::::::. :. :.::::.:::::::::: :..: ::::::::::::::.: :::::
NP_476 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ
:: ::::: : : :::.:::::::::::: :.:::.::.:::::::::::::::::::.
NP_476 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL
430 440 450 460 470 480
480 490 500
pF1KE4 GLLQPEKPIVLKVDSRDGTLSGE
.::::::::::: ::: ::
NP_476 PILQPEKPIVLKVHLRDGITSGP
490 500
>>NP_073731 (OMIM: 606534) cytochrome P450 3A43 isoform (504 aa)
initn: 2160 init1: 2160 opt: 2583 Z-score: 3218.9 bits: 605.1 E(85289): 1.5e-172
Smith-Waterman score: 2583; 75.5% identity (91.7% similar) in 503 aa overlap (1-501:1-503)
10 20 30 40 50 60
pF1KE4 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
::::::.:.:::.:.:.::::::.:::..: :::.::::::::::.::..: : .:::.:
NP_073 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
: :: .:::.::: :::: :.:.: :::.:.:::::::::::::. :::.::.:::.:.
NP_073 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
::::::::::.::::.::: :.::: :::.: ::.:::.::.:::..: ..:::.::::.
NP_073 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
::::::: ::::.::::::::::... ::.::. ::::..: : :::::::::::::..:
NP_073 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
::::. .::..:..:::.:::.::::::.::.: ::::::::::.::::::::::.::::
NP_073 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
:.:::.:.:::..: : .::::::::::::::.::::::::::: ::::.::::::::::
NP_073 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
310 320 330 340 350 360
370 380 390 400 410
pF1KE4 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPE-RF
:::::::::. :. :.::::.:::::::::: :..: ::::::::::::::.: :: ::
NP_073 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 SKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT
::: ::::: : : :::.:::::::::::: :.:::.::.:::::::::::::::::::.
NP_073 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN
430 440 450 460 470 480
480 490 500
pF1KE4 QGLLQPEKPIVLKVDSRDGTLSGE
.::::::::::: ::: ::
NP_073 LPILQPEKPIVLKVHLRDGITSGP
490 500
>>XP_011514145 (OMIM: 145500,605325) PREDICTED: cytochro (389 aa)
initn: 2542 init1: 2542 opt: 2542 Z-score: 3169.4 bits: 595.6 E(85289): 8.5e-170
Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 389 aa overlap (114-502:1-389)
90 100 110 120 130 140
pF1KE4 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK
::::::::::::::::::::::::::::::
XP_011 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK
10 20 30
150 160 170 180 190 200
pF1KE4 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE4 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE4 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE4 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE4 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE4 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
340 350 360 370 380
>>XP_016867270 (OMIM: 145500,605325) PREDICTED: cytochro (389 aa)
initn: 2542 init1: 2542 opt: 2542 Z-score: 3169.4 bits: 595.6 E(85289): 8.5e-170
Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 389 aa overlap (114-502:1-389)
90 100 110 120 130 140
pF1KE4 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK
::::::::::::::::::::::::::::::
XP_016 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK
10 20 30
150 160 170 180 190 200
pF1KE4 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE4 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE4 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE4 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE4 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE4 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
340 350 360 370 380
>>NP_001278758 (OMIM: 145500,605325) cytochrome P450 3A5 (389 aa)
initn: 2542 init1: 2542 opt: 2542 Z-score: 3169.4 bits: 595.6 E(85289): 8.5e-170
Smith-Waterman score: 2542; 100.0% identity (100.0% similar) in 389 aa overlap (114-502:1-389)
90 100 110 120 130 140
pF1KE4 ITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLK
::::::::::::::::::::::::::::::
NP_001 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK
10 20 30
150 160 170 180 190 200
pF1KE4 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE4 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE4 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE4 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE4 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIG
280 290 300 310 320 330
450 460 470 480 490 500
pF1KE4 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
340 350 360 370 380
502 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:49:39 2016 done: Sun Nov 6 00:49:41 2016
Total Scan time: 9.520 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]