Result of FASTA (omim) for
pFN21AE4470
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4470, 492 aa
1>>>pF1KE4470 492 - 492 aa - 492 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0879+/-0.000398; mu= 10.0275+/- 0.025
mean_var=133.4515+/-26.936, 0's: 0 Z-trim(116.4): 317 B-trim: 36 in 1/54
Lambda= 0.111023
statistics sampled from 27283 (27608) to 27283 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.324), width: 16
Scan time: 8.700
The best scores are: opt bits E(85289)
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 3494 571.3 2.1e-162
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 3494 571.3 2.1e-162
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 3494 571.4 2.2e-162
XP_011528034 (OMIM: 602060) PREDICTED: transmembra ( 410) 2781 457.1 4.4e-128
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 2747 451.6 1.8e-126
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 2431 401.1 3.5e-111
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 1191 202.4 2.2e-51
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 1180 200.7 7.4e-51
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 1000 171.9 4e-42
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 995 171.1 7.3e-42
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 993 170.8 9.1e-42
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 989 170.0 9.3e-42
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 907 157.0 1.1e-37
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 905 156.6 1.3e-37
NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 900 156.1 4.4e-37
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 893 154.7 4.7e-37
XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 899 155.9 5e-37
XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 899 155.9 5e-37
XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 899 155.9 5.1e-37
XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 899 155.9 5.1e-37
XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 899 155.9 5.1e-37
XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 899 155.9 5.1e-37
NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 822 143.3 1.2e-33
NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 822 143.3 1.3e-33
NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 822 143.3 1.3e-33
NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 822 143.3 1.3e-33
NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 821 143.2 1.5e-33
NP_001265514 (OMIM: 605236,614595) atrial natriure ( 938) 824 143.9 1.9e-33
NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 824 143.9 2.1e-33
XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 805 140.6 8.9e-33
XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 805 140.6 9e-33
XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 805 140.6 9.5e-33
XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 805 140.6 9.5e-33
XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 801 140.0 1.5e-32
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 767 134.5 5.9e-31
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 767 134.5 5.9e-31
NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 764 133.9 5.9e-31
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 767 134.6 7.9e-31
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 767 134.6 8e-31
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 767 134.6 8e-31
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 747 131.3 5e-30
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 747 131.3 5.2e-30
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 747 131.3 5.2e-30
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 747 131.3 5.2e-30
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 747 131.3 5.2e-30
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 747 131.3 5.2e-30
XP_005265767 (OMIM: 605369) PREDICTED: transmembra ( 301) 711 125.4 2.2e-28
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 717 126.7 2.6e-28
NP_004253 (OMIM: 605369) transmembrane protease se ( 418) 711 125.5 2.8e-28
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 712 125.8 3.5e-28
>>XP_011528033 (OMIM: 602060) PREDICTED: transmembrane p (492 aa)
initn: 3494 init1: 3494 opt: 3494 Z-score: 3036.6 bits: 571.3 E(85289): 2.1e-162
Smith-Waterman score: 3494; 100.0% identity (100.0% similar) in 492 aa overlap (1-492:1-492)
10 20 30 40 50 60
pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
430 440 450 460 470 480
490
pF1KE4 TDWIYRQMRADG
::::::::::::
XP_011 TDWIYRQMRADG
490
>>NP_005647 (OMIM: 602060) transmembrane protease serine (492 aa)
initn: 3494 init1: 3494 opt: 3494 Z-score: 3036.6 bits: 571.3 E(85289): 2.1e-162
Smith-Waterman score: 3494; 100.0% identity (100.0% similar) in 492 aa overlap (1-492:1-492)
10 20 30 40 50 60
pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
430 440 450 460 470 480
490
pF1KE4 TDWIYRQMRADG
::::::::::::
NP_005 TDWIYRQMRADG
490
>>NP_001128571 (OMIM: 602060) transmembrane protease ser (529 aa)
initn: 3494 init1: 3494 opt: 3494 Z-score: 3036.2 bits: 571.4 E(85289): 2.2e-162
Smith-Waterman score: 3494; 100.0% identity (100.0% similar) in 492 aa overlap (1-492:38-529)
10 20 30
pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQP
::::::::::::::::::::::::::::::
NP_001 GESGCEERGAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQP
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE4 TVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE4 LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVR
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE4 LYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFM
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE4 KLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQ
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE4 VSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE4 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE4 GKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKN
430 440 450 460 470 480
460 470 480 490
pF1KE4 NIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
::::::::::::::::::::::::::::::::::::::::::
NP_001 NIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
490 500 510 520
>>XP_011528034 (OMIM: 602060) PREDICTED: transmembrane p (410 aa)
initn: 2781 init1: 2781 opt: 2781 Z-score: 2420.6 bits: 457.1 E(85289): 4.4e-128
Smith-Waterman score: 2781; 99.5% identity (99.5% similar) in 393 aa overlap (1-393:1-393)
10 20 30 40 50 60
pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
:::::::::::::::::::::::::::::: :
XP_011 VKPVCLPNPGMMLQPEQLCWISGWGATEEKDPTEPPMRERAFLGSAEPPQ
370 380 390 400 410
430 440 450 460 470 480
pF1KE4 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
>>XP_011528035 (OMIM: 602060) PREDICTED: transmembrane p (384 aa)
initn: 2747 init1: 2747 opt: 2747 Z-score: 2391.5 bits: 451.6 E(85289): 1.8e-126
Smith-Waterman score: 2747; 100.0% identity (100.0% similar) in 384 aa overlap (109-492:1-384)
80 90 100 110 120 130
pF1KE4 SKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSH
::::::::::::::::::::::::::::::
XP_011 MGSKCSNSGIECDSSGTCINPSNWCDGVSH
10 20 30
140 150 160 170 180 190
pF1KE4 CPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQ
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE4 GIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVG
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE4 GESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQS
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE4 FMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE4 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQ
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE4 GDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
340 350 360 370 380
>>XP_005261100 (OMIM: 602060) PREDICTED: transmembrane p (452 aa)
initn: 2431 init1: 2431 opt: 2431 Z-score: 2117.0 bits: 401.1 E(85289): 3.5e-111
Smith-Waterman score: 3087; 91.7% identity (91.9% similar) in 492 aa overlap (1-492:1-452)
10 20 30 40 50 60
pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIEC
::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKF------------
70 80 90 100
130 140 150 160 170 180
pF1KE4 DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
.:::::::::::::::::::::::::::::::
XP_005 ----------------------------IRLYGPNFILQVYSSQRKSWHPVCQDDWNENY
110 120 130 140
190 200 210 220 230 240
pF1KE4 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLR
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE4 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE4 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDL
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE4 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLI
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE4 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVF
390 400 410 420 430 440
490
pF1KE4 TDWIYRQMRADG
::::::::::::
XP_005 TDWIYRQMRADG
450
>>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa)
initn: 1037 init1: 648 opt: 1191 Z-score: 1043.6 bits: 202.4 E(85289): 2.2e-51
Smith-Waterman score: 1191; 46.0% identity (68.4% similar) in 411 aa overlap (89-491:52-450)
60 70 80 90 100 110
pF1KE4 QASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGI
...: . . ::: :: .: ::..
NP_001 DDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHF---DCSGK-Y
30 40 50 60 70
120 130 140 150 160 170
pF1KE4 ECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNE
.: :: ::. ::::: : :::: ::::. : : .:::... ::. .:.:::.
NP_001 RCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAA--SWKTMCSDDWKG
80 90 100 110 120 130
180 190 200 210 220 230
pF1KE4 NYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNV---DIYKKLYHS----DAC
.:. .:: ..:. . . ::... .: .: . .: .. : :.:: ..:
NP_001 HYANVACAQLGFPS-YVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGC
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE4 SSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWI
.: ::.:.: ::: . : ::::::. .: . ::::.::. :. :.::::.::: ::
NP_001 ASGHVVTLQCTACGHRRGYS--SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWI
200 210 220 230 240 250
300 310 320 330 340 350
pF1KE4 VTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGA-GYQVEKVISHPNYDSKTKNNDIALMK
.:::::: : : :: .:.. :.. : .. :::.. : .: : .:::::::
NP_001 ITAAHCVYD-LYLPKSWTIQVGLV--SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMK
260 270 280 290 300
360 370 380 390 400 410
pF1KE4 LQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC
: :::::....:::::: . ..:: :::::::. : .: ::: : : :: .. :
NP_001 LAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGDASPVLNHAAVPLISNKIC
310 320 330 340 350 360
420 430 440 450 460 470
pF1KE4 NSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYR
: : :: ..:.:.:.:::.: :.::::::::::::: .. .: :.: ::.: :::.. .
NP_001 NHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNK
370 380 390 400 410 420
480 490
pF1KE4 PGVYGNVMVFTDWIYRQMRADG
:::: : : :::..::. :
NP_001 PGVYTRVTSFLDWIHEQMERDLKT
430 440 450
>>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa)
initn: 1014 init1: 386 opt: 1180 Z-score: 1034.0 bits: 200.7 E(85289): 7.4e-51
Smith-Waterman score: 1180; 45.9% identity (68.2% similar) in 412 aa overlap (89-491:52-451)
60 70 80 90 100 110
pF1KE4 QASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGI
...: . . ::: :: .: ::..
NP_076 DDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHF---DCSGK-Y
30 40 50 60 70
120 130 140 150 160 170
pF1KE4 ECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNE
.: :: ::. ::::: : :::: ::::. : : .:::... ::. .:.:::.
NP_076 RCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAA--SWKTMCSDDWKG
80 90 100 110 120 130
180 190 200 210 220 230
pF1KE4 NYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNV---DIYKKLYHS----DAC
.:. .:: ..:. . . ::... .: .: . .: .. : :.:: ..:
NP_076 HYANVACAQLGFPS-YVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGC
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE4 SSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWI
.: ::.:.: ::: . : ::::::. .: . ::::.::. :. :.::::.::: ::
NP_076 ASGHVVTLQCTACGHRRGYS--SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWI
200 210 220 230 240 250
300 310 320 330 340 350
pF1KE4 VTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGA-GYQVEKVISHPNYDSKTKNNDIALMK
.:::::: : : :: .:.. :.. : .. :::.. : .: : .:::::::
NP_076 ITAAHCVYD-LYLPKSWTIQVGLV--SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMK
260 270 280 290 300
360 370 380 390 400
pF1KE4 LQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE-KGKTSEVLNAAKVLLIETQR
: :::::....:::::: . ..:: :::::::. : .: ::: : : :: ..
NP_076 LAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKI
310 320 330 340 350 360
410 420 430 440 450 460
pF1KE4 CNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAY
:: : :: ..:.:.:.:::.: :.::::::::::::: .. .: :.: ::.: :::..
NP_076 CNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVN
370 380 390 400 410 420
470 480 490
pF1KE4 RPGVYGNVMVFTDWIYRQMRADG
.:::: : : :::..::. :
NP_076 KPGVYTRVTSFLDWIHEQMERDLKT
430 440 450
>>NP_001193718 (OMIM: 610050) transmembrane protease ser (532 aa)
initn: 866 init1: 497 opt: 1000 Z-score: 877.2 bits: 171.9 E(85289): 4e-42
Smith-Waterman score: 1006; 34.4% identity (62.1% similar) in 506 aa overlap (7-491:35-526)
10 20 30
pF1KE4 MALNSGSPPAIGPYYENH-GYQPENPYPAQ--PTVV
:: .: . : : ::: :. .
NP_001 SHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQASPAGT
10 20 30 40 50 60
40 50 60 70 80
pF1KE4 P----TVYEVHPAQYYPSPV-PQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCIT
: . .. ::: :. . : : .:.. : . .. :..: :: :. : .
NP_001 PPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVYLVRA
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 LTLGTFLV--GAALAAGLLWKFMGSKCS----NSGIEC-DSSGTCINPSNWCDGVSHCPG
.:. . . : .: : . ..::. .. .: . . :::: :
NP_001 TPVGAVPIRSSPARSAPATRATRESPVQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKL
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 GEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIV
:: :::. . .:..::.. ..: :.:...::..:.. .:...:... ...
NP_001 KSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAH
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 DD-SGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGE
: ..: :... :.. : ..:..:. : :. .::.: ::. ..: ::::
NP_001 RDFANSFSILRYNST-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGA
250 260 270 280 290
270 280 290 300 310
pF1KE4 SALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILR
: . :::::::: ..:.:::..: .:..::::: :: :.. : ..::
NP_001 LASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAG--T
300 310 320 330 340 350
320 330 340 350 360 370
pF1KE4 QSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPE
... . .. ..: . :: .. . :::::.:.::::.. ..:.::: :. .. .
NP_001 SNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLN
360 370 380 390 400 410
380 390 400 410 420 430
pF1KE4 QLCWISGWGATEEKG-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVD
. :::.:.: :.: ::: : ..: ::. ..::. :::. .:: :.::: :.:. :
NP_001 ETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRD
420 430 440 450 460 470
440 450 460 470 480 490
pF1KE4 SCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
::::::::::: .:: :.: : ::::.::.. .:::: .: ::: .:...
NP_001 SCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFR
480 490 500 510 520 530
NP_001 KS
>>NP_001070731 (OMIM: 610050) transmembrane protease ser (567 aa)
initn: 882 init1: 497 opt: 995 Z-score: 872.5 bits: 171.1 E(85289): 7.3e-42
Smith-Waterman score: 1009; 35.4% identity (63.4% similar) in 492 aa overlap (9-491:91-561)
10 20 30
pF1KE4 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPT-VY
::.. .. . . . :. :. :: ::
NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY
70 80 90 100 110 120
40 50 60 70 80 90
pF1KE4 EVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTL-GTFLV
:. .:: : : :.. . .:: :: . : . : : : :.
NP_001 LVR-----ATPVGAVPIRSSPARSAPATRATRESP-GTSLPKFTWREGQKQLPLIGCVLL
130 140 150 160 170
100 110 120 130 140 150
pF1KE4 GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN
::...:. :. . ...::. .. .: . . :::: : :: :::. .
NP_001 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE4 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT
.:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... :.
NP_001 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE4 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH
. : ..:..:. : :. .::.: ::. . .::::: : . ::::::::
NP_001 T-----IQESLHRSE-CPSQRYISLQCSHCGL---RAMTGRIVGGALASDSKWPWQVSLH
300 310 320 330 340
280 290 300 310 320 330
pF1KE4 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK
..:.:::..: .:..::::: :: :.. : ..:: . .:. . .
NP_001 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE
350 360 370 380 390
340 350 360 370 380 390
pF1KE4 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK
.: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.:
NP_001 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET
400 410 420 430 440 450
400 410 420 430 440
pF1KE4 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK
::: : ..: ::. ..::. :::. .:: :.::: :.:. :::::::::::: .
NP_001 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ
460 470 480 490 500 510
450 460 470 480 490
pF1KE4 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
:: :.: : ::::.::.. .:::: .: ::: .:...
NP_001 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS
520 530 540 550 560
492 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:54:41 2016 done: Sun Nov 6 00:54:43 2016
Total Scan time: 8.700 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]