Result of FASTA (omim) for
pFN21AE4460
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4460, 477 aa
1>>>pF1KE4460 477 - 477 aa - 477 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.6319+/-0.000323; mu= 7.8444+/- 0.020
mean_var=134.1893+/-26.583, 0's: 0 Z-trim(119.4): 75 B-trim: 0 in 0/58
Lambda= 0.110717
statistics sampled from 33280 (33355) to 33280 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.725), E-opt: 0.2 (0.391), width: 16
Scan time: 9.230
The best scores are: opt bits E(85289)
NP_002413 (OMIM: 185250,614466) stromelysin-1 prep ( 477) 3274 534.2 3.1e-151
NP_002416 (OMIM: 185260) stromelysin-2 preproprote ( 476) 2656 435.5 1.6e-121
NP_002417 (OMIM: 601046) macrophage metalloelastas ( 470) 1695 282.0 2.5e-75
NP_004762 (OMIM: 604629,612529) matrix metalloprot ( 483) 1464 245.1 3.3e-64
NP_002412 (OMIM: 120353,226600,606963) interstitia ( 469) 1029 175.6 2.7e-43
NP_002418 (OMIM: 250400,600108,602111) collagenase ( 471) 1023 174.6 5.2e-43
NP_002415 (OMIM: 120355) neutrophil collagenase is ( 467) 973 166.6 1.3e-40
NP_005931 (OMIM: 185261) stromelysin-3 preproprote ( 488) 916 157.5 7.5e-38
NP_001291371 (OMIM: 120355) neutrophil collagenase ( 444) 909 156.4 1.5e-37
XP_011541137 (OMIM: 120355) PREDICTED: neutrophil ( 444) 909 156.4 1.5e-37
XP_016873260 (OMIM: 120355) PREDICTED: neutrophil ( 444) 909 156.4 1.5e-37
NP_001291370 (OMIM: 120355) neutrophil collagenase ( 444) 909 156.4 1.5e-37
XP_011541138 (OMIM: 120355) PREDICTED: neutrophil ( 377) 906 155.9 1.8e-37
XP_011541136 (OMIM: 120355) PREDICTED: neutrophil ( 476) 906 155.9 2.2e-37
NP_001139410 (OMIM: 120353,226600,606963) intersti ( 403) 860 148.5 3.2e-35
NP_002414 (OMIM: 178990) matrilysin preproprotein ( 267) 847 146.4 9.4e-35
NP_002420 (OMIM: 601807,611543) matrix metalloprot ( 508) 805 139.8 1.7e-32
XP_016874798 (OMIM: 601807,611543) PREDICTED: matr ( 366) 676 119.1 2e-26
NP_004521 (OMIM: 120360,259600) 72 kDa type IV col ( 660) 658 116.4 2.5e-25
NP_001121363 (OMIM: 120360,259600) 72 kDa type IV ( 610) 653 115.6 4e-25
NP_001289439 (OMIM: 120360,259600) 72 kDa type IV ( 584) 633 112.4 3.5e-24
NP_001289437 (OMIM: 120360,259600) 72 kDa type IV ( 584) 633 112.4 3.5e-24
NP_001289438 (OMIM: 120360,259600) 72 kDa type IV ( 584) 633 112.4 3.5e-24
NP_068573 (OMIM: 605470) matrix metalloproteinase- ( 261) 626 111.1 3.9e-24
XP_016874796 (OMIM: 602285) PREDICTED: matrix meta ( 434) 615 109.4 2e-23
NP_057239 (OMIM: 602285) matrix metalloproteinase- ( 603) 615 109.5 2.7e-23
XP_011518521 (OMIM: 605470) PREDICTED: matrix meta ( 191) 604 107.5 3.4e-23
XP_011526802 (OMIM: 604871) PREDICTED: matrix meta ( 556) 611 108.8 3.9e-23
XP_016883087 (OMIM: 604871) PREDICTED: matrix meta ( 614) 611 108.9 4.2e-23
NP_006681 (OMIM: 604871) matrix metalloproteinase- ( 645) 611 108.9 4.4e-23
NP_004985 (OMIM: 120361,613073) matrix metalloprot ( 707) 611 108.9 4.8e-23
XP_016874797 (OMIM: 601807,611543) PREDICTED: matr ( 387) 592 105.7 2.3e-22
XP_011536657 (OMIM: 602285) PREDICTED: matrix meta ( 519) 578 103.6 1.4e-21
XP_011536659 (OMIM: 602285) PREDICTED: matrix meta ( 519) 578 103.6 1.4e-21
XP_011536658 (OMIM: 602285) PREDICTED: matrix meta ( 519) 578 103.6 1.4e-21
NP_004986 (OMIM: 277950,600754) matrix metalloprot ( 582) 549 98.9 3.9e-20
XP_011520906 (OMIM: 608482) PREDICTED: matrix meta ( 478) 481 88.0 6.1e-17
XP_011520904 (OMIM: 608482) PREDICTED: matrix meta ( 528) 481 88.1 6.6e-17
NP_071913 (OMIM: 608482) matrix metalloproteinase- ( 562) 481 88.1 7e-17
NP_005932 (OMIM: 602262) matrix metalloproteinase- ( 607) 463 85.2 5.5e-16
XP_016880552 (OMIM: 608417) PREDICTED: matrix meta ( 378) 452 83.4 1.2e-15
XP_016880551 (OMIM: 608417) PREDICTED: matrix meta ( 378) 452 83.4 1.2e-15
XP_016880553 (OMIM: 608417) PREDICTED: matrix meta ( 378) 452 83.4 1.2e-15
XP_011523533 (OMIM: 608417) PREDICTED: matrix meta ( 390) 452 83.4 1.3e-15
NP_116568 (OMIM: 608417) matrix metalloproteinase- ( 393) 452 83.4 1.3e-15
XP_011523532 (OMIM: 608417) PREDICTED: matrix meta ( 418) 452 83.4 1.4e-15
XP_011523530 (OMIM: 608417) PREDICTED: matrix meta ( 435) 452 83.4 1.4e-15
XP_011523531 (OMIM: 608417) PREDICTED: matrix meta ( 435) 452 83.4 1.4e-15
XP_011523528 (OMIM: 608417) PREDICTED: matrix meta ( 435) 452 83.4 1.4e-15
XP_011523529 (OMIM: 608417) PREDICTED: matrix meta ( 435) 452 83.4 1.4e-15
>>NP_002413 (OMIM: 185250,614466) stromelysin-1 prepropr (477 aa)
initn: 3274 init1: 3274 opt: 3274 Z-score: 2836.2 bits: 534.2 E(85289): 3.1e-151
Smith-Waterman score: 3274; 99.8% identity (100.0% similar) in 477 aa overlap (1-477:1-477)
10 20 30 40 50 60
pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPV
::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::
NP_002 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
430 440 450 460 470
>>NP_002416 (OMIM: 185260) stromelysin-2 preproprotein [ (476 aa)
initn: 2731 init1: 2443 opt: 2656 Z-score: 2302.7 bits: 435.5 E(85289): 1.6e-121
Smith-Waterman score: 2656; 78.4% identity (92.0% similar) in 477 aa overlap (1-477:1-476)
10 20 30 40 50 60
pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPV
: : .:.:::. :::::::.:::. ::.. .:.:.:::.::.:::::::: :::::. .
NP_002 MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLI
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
::::. ::::::::::::::.::::::::::::::::::: .:::.::::::::::::::
NP_002 VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
::::::.::::::.:::::::::::::::::::::::::::::::.:::::: :::::.
NP_002 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
::::: ::::. :: ::::::.::.:..:::::::::::.::::::::::::::::::::
NP_002 LAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLY
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
.:.:.:..:::::::.::::::::::: : : :::::. :: ::.:::::::::.:
NP_002 NSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIS
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
::::: :.::::.:::.: . :::.::::.::::::: .::::::.:.: :::::::.:
NP_002 TLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEF
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
::::::::.:::::::::::::::.::::::.:::::.:::::. ::::::::. .:::
NP_002 WAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQ
360 370 380 390 400 410
430 440 450 460 470
pF1KE4 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
:::. ::.::::.. :.:::.. :::::::.::::.::::::. ::: :::::::.:
NP_002 GFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC
420 430 440 450 460 470
>>NP_002417 (OMIM: 601046) macrophage metalloelastase pr (470 aa)
initn: 1514 init1: 807 opt: 1695 Z-score: 1473.2 bits: 282.0 E(85289): 2.5e-75
Smith-Waterman score: 1695; 51.6% identity (77.7% similar) in 479 aa overlap (1-477:1-470)
10 20 30 40 50 60
pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPV
:: : :::: .: .: ::.... : ... . ..:::..: :: . .. : :: .
NP_002 MKFLLILLLQATA-SGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNL
10 20 30 40 50
70 80 90 100 110
pF1KE4 VK-KIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIV
.: ::.:::.::::.:::.::..:::.:. :::::::: ::: .:: : ::: ..::::
NP_002 MKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRIN
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 NYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGN
:::::. .. :: :..::..:: .:::: ::.. : :::.. :: ::::. ::: :.
NP_002 NYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 VLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPL
.::::..:: ::.::::::.:: :: . ::::::.:.::::::::: ::.. .:.:.:
NP_002 ILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPT
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 YHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAV
:. . :.. :::: ::: ::::::: : .. . : :. . :: ::: ::::::
NP_002 YKYV-DINTFRLSADDIRGIQSLYGDPKENQRLP-------NPDNSEPALCDPNLSFDAV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 STLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQ
.:. ..:..:::: :: : .. . ..::::.::.::::..::::. ... ::.:: ..
NP_002 TTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDK
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 FWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSME
.: : . . . .::..::..::: :.:::::. . . .:::::...:::.::.:. :.
NP_002 YWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMD
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE4 PGFPKQIAEDFPGIDSKIDAVF-EEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
::.:: :...: :: :::::: . ..::: ::.:.:.: ...:.:::::::..:
NP_002 PGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
420 430 440 450 460 470
>>NP_004762 (OMIM: 604629,612529) matrix metalloproteina (483 aa)
initn: 1316 init1: 797 opt: 1464 Z-score: 1273.6 bits: 245.1 E(85289): 3.3e-64
Smith-Waterman score: 1464; 46.4% identity (72.6% similar) in 489 aa overlap (1-477:1-483)
10 20 30 40 50
pF1KE4 MKSLP-----ILLLLCVAVCSAYPLDGAA--RGEDTSMNLVQKYLENYYDLEK--DVKQF
:: :: ..:.. . .: : :: : ... :.: ::..:: .. .. ..
NP_004 MKVLPASGLAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 VRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRK
: : :. ...::.:.: :.::.::::::. :..:..:::::::::...: ::: :::.:
NP_004 VAR-GSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKK
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 THLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDF
. ::::: .:::.. . ::.::: ::..: ..::.: :. ::::::::: .:::
NP_004 NTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 YPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSAN
:::::: ..::::.::: :..::.:::. :.:: :.: ::: :::::.::.::: ::..
NP_004 YPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTD
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 TEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCD
::::: :. . :.: .::..:::.:::: : .: : .:. : ::
NP_004 PSALMYPTYK-YKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAP-HHKPSIPDLCD
240 250 260 270 280 290
300 310 320 330 340
pF1KE4 PALSFDAVSTLRGEILIFKDRHFWRKS--LRK-LEPELHLISSFWPSLPSGVDAAYEVTS
. :::::. : :.:.:::: :::.. :: ..: :.: .:.: :.:::::::.
NP_004 SSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPS--TITSSFPQLMSNVDAAYEVAE
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 KDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKY
. ...::: ..: :: ... : :: :. .::: :..::::. .: .:: ::: :.:
NP_004 RGTAYFFKGPHYWITRGFQMQ-GPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEY
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 WRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHT
. .::.. .:: .::. :.: :....:::. : :..:::.: . ..: . . :. .
NP_004 YSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSV
420 430 440 450 460 470
470
pF1KE4 LKSNSWLNC
.::.::..:
NP_004 VKSSSWIGC
480
>>NP_002412 (OMIM: 120353,226600,606963) interstitial co (469 aa)
initn: 1387 init1: 956 opt: 1029 Z-score: 898.3 bits: 175.6 E(85289): 2.7e-43
Smith-Waterman score: 1786; 53.1% identity (79.1% similar) in 478 aa overlap (1-477:1-466)
10 20 30 40 50 60
pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPV
:.:.: :::: .. . .. . .. ...:::::::.::.:..: .: .:..::::
NP_002 MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
:.:...::.:.::.:::: :..::.::..::::::::..: : :.:..::::::: :
NP_002 VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
::::::. :: :.:::...: .::::::... ::.:::::::. .: : ::::::.
NP_002 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
::::. :::::.::::::.::.::.. :: :::::.:::::: ::.. ::::: :
NP_002 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
:. .:.::::.:::..:: . :..:. :. :: :: :.:::..
NP_002 TFSGDV---QLAQDDIDGIQAIYGRSQN-------PVQPIGPQ--TPKACDSKLTFDAIT
250 260 270 280
310 320 330 340 350 360
pF1KE4 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
:.:::...:::: . : . : ::..:: :::.::.:..:::: ...: : .::::..
NP_002 TIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKY
290 300 310 320 330 340
370 380 390 400 410
pF1KE4 WAIRGNEVRAGYPRGIHT-LGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSME
::..:..: :::. :.. .::: ::..::::.:... .:::::: .::::.:: . ::.
NP_002 WAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMD
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE4 PGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
::.::.::.::::: :.:::: . :::::: :. : .:::..:.. :.:::.::
NP_002 PGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRK
410 420 430 440 450 460
NP_002 N
>>NP_002418 (OMIM: 250400,600108,602111) collagenase 3 p (471 aa)
initn: 1663 init1: 867 opt: 1023 Z-score: 893.1 bits: 174.6 E(85289): 5.2e-43
Smith-Waterman score: 1669; 49.5% identity (77.6% similar) in 477 aa overlap (4-477:6-471)
10 20 30 40 50
pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTS---MNLVQKYLENYYDLEKDVKQFVRRK
: .:.: . : : :: ... .: : ......::..:: .. .....
NP_002 MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYH-PTNLAGILKEN
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 DSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLT
.. .....::::.:.:::::::::..::.::.::::::::::.. .:: :: : .::
NP_002 AASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 YRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFD
:::::::::. .. :..: .::.::: .::::.:.::..: :::::::...:::::::::
NP_002 YRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 GPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEAL
::...::::. :::. .::::::::: ::... : :::::::::.:::::: :: . ::
NP_002 GPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 MYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALS
:.:.: . : ..: : .::..:::::::: ..:. : .: :: .:::.::
NP_002 MFPIY-TYTGKSHFMLPDDDVQGIQSLYGPGDEDPN---------PKHPKTPDKCDPSLS
240 250 260 270 280
300 310 320 330 340 350
pF1KE4 FDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIF
.::...:::: .::::: ::: .... :: : .:::: ::. .::::: :.::.:::
NP_002 LDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIF
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE4 KGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKR
.: .:::. : .. :::. : ::.: :.::.::. .. .:: .: .. ::.:.
NP_002 RGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTN
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE4 NSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWL
. :. .:. : :::::: .:.:::.:. :..:::.: :.:.. ........ .:: :
NP_002 HIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSIL
410 420 430 440 450 460
pF1KE4 NC
:
NP_002 WC
470
>>NP_002415 (OMIM: 120355) neutrophil collagenase isofor (467 aa)
initn: 1607 init1: 816 opt: 973 Z-score: 850.0 bits: 166.6 E(85289): 1.3e-40
Smith-Waterman score: 1708; 50.5% identity (77.4% similar) in 477 aa overlap (1-477:4-464)
10 20 30 40 50
pF1KE4 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDS
.:.::.:::: : . .:.:... .. : :: :::..:.: .. : .:.. .
NP_002 MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKT----VQDYLEKFYQLPSNQYQSTRKNGT
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 GPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYR
. .:.:..:::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::
NP_002 NVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYR
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 IVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGP
: ::::.: . :. :.. :...: ..:: :.:. .::::: :.: :.::: :::::
NP_002 IRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 GNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMY
...::::. :: ::.:::::: .: ::. ... :::::::::.:::::: ::.. ::::
NP_002 NGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMY
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 PLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFD
: : .. . . . : ::::.:::..:: . :. :: : :.: :::.:.::
NP_002 PNY-AFRETSNYSLPQDDIDGIQAIYGLSSN----PIQPTGPSTPKP-----CDPSLTFD
240 250 260 270 280
300 310 320 330 340 350
pF1KE4 AVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKG
:..:::::::.::::.:::. . . :...:: ::::::.:..:::: ..::.:.:::
NP_002 AITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKG
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE4 NQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNS
::.::. : .. :::. : . ::: .:. ::::. ..::::::.:..::.:..:.
NP_002 NQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQF
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE4 MEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
::::.::.:. ::::.::.::::.. ::. :.: :: :..::.. ..:.::::
NP_002 MEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC
410 420 430 440 450 460
NP_002 RYG
>>NP_005931 (OMIM: 185261) stromelysin-3 preproprotein [ (488 aa)
initn: 797 init1: 371 opt: 916 Z-score: 800.5 bits: 157.5 E(85289): 7.5e-38
Smith-Waterman score: 916; 42.8% identity (63.0% similar) in 397 aa overlap (87-460:75-460)
60 70 80 90 100
pF1KE4 SGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVG--------HFRTFPGIPK
.: ::::::: . . : . .
NP_005 RRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGR
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE4 WRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREH
:.:: :::::. . .: .. : ... .::::: .::::::....::.:::::.:: :
NP_005 WEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWH
110 120 130 140 150 160
170 180 190 200 210 220
pF1KE4 GDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT-KDTTGTNLFLVAAHEIGHSLGLF
:: ::::::..::::. : .::.::: :: :: : ::.:. :::::.:: :::
NP_005 GDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQ
170 180 190 200 210 220
230 240 250 260 270
pF1KE4 HSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPP-PD-SPETP-LVP------TE
:.. ..::: .: :. :: :: :.: ::: : : . .:: : : .:
NP_005 HTTAAKALMSAFYTFRYPLS---LSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNE
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE4 PVPPEPGTPAN-CDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELH-LISSFWPSL
.: :: .: . :. :::::::.:::...:: :: .:.: : : : .:
NP_005 IAPLEPDAPPDACEA--SFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGL
290 300 310 320 330
340 350 360 370 380 390
pF1KE4 PSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVR-KIDAAIS-D
:: ::::.: .. ...:.: :.:. :.. : : . ::. :: . ::.
NP_005 PSPVDAAFE-DAQGHIWFFQGAQYWVYDGEKPVLG-PAPLTELGL---VRFPVHAALVWG
340 350 360 370 380 390
400 410 420 430 440 450
pF1KE4 KEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEF-GFFYFFTGS
:::: ::: :::: . .. :.. : :. :. :.:::.:.. :. ::. :
NP_005 PEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR-ATDWRGVPSEIDAAFQDADGYAYFLRGR
400 410 420 430 440 450
460 470
pF1KE4 SQLEFDPNAKKVTHTLKSNSWLNC
.:::
NP_005 LYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
460 470 480
>>NP_001291371 (OMIM: 120355) neutrophil collagenase iso (444 aa)
initn: 1663 init1: 805 opt: 909 Z-score: 795.1 bits: 156.4 E(85289): 1.5e-37
Smith-Waterman score: 1644; 51.4% identity (78.2% similar) in 444 aa overlap (34-477:10-441)
10 20 30 40 50 60
pF1KE4 LPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPVVKK
.. :::..:.: .. : .:.. .. .:.:
NP_001 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEK
10 20 30
70 80 90 100 110 120
pF1KE4 IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTP
..:::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::: ::::
NP_001 LKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 DLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAH
.: . :. :.. :...: ..:: :.:. .::::: :.: :.::: :::::...:::
NP_001 QLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAH
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 AYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSL
:. :: ::.:::::: .: ::. ... :::::::::.:::::: ::.. ::::: : ..
NP_001 AFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AF
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 TDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLR
. . . : ::::.:::..:: . :. :: : :.: :::.:.:::..:::
NP_001 RETSNYSLPQDDIDGIQAIYGLSSN----PIQPTGPSTPKP-----CDPSLTFDAITTLR
220 230 240 250 260
310 320 330 340 350 360
pF1KE4 GEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAI
::::.::::.:::. . . :...:: ::::::.:..:::: ..::.:.:::::.::.
NP_001 GEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWAL
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE4 RGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFP
: .. :::. : . ::: .:. ::::. ..::::::.:..::.:..:. ::::.:
NP_001 SGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEPGYP
330 340 350 360 370 380
430 440 450 460 470
pF1KE4 KQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
:.:. ::::.::.::::.. ::. :.: :: :..::.. ..:.::::
NP_001 KSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
390 400 410 420 430 440
>>XP_011541137 (OMIM: 120355) PREDICTED: neutrophil coll (444 aa)
initn: 1663 init1: 805 opt: 909 Z-score: 795.1 bits: 156.4 E(85289): 1.5e-37
Smith-Waterman score: 1644; 51.4% identity (78.2% similar) in 444 aa overlap (34-477:10-441)
10 20 30 40 50 60
pF1KE4 LPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLEKDVKQFVRRKDSGPVVKK
.. :::..:.: .. : .:.. .. .:.:
XP_011 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEK
10 20 30
70 80 90 100 110 120
pF1KE4 IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTP
..:::.:.::.:::: . .::..:.:::::::: : : :: :::..:.::::: ::::
XP_011 LKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 DLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAH
.: . :. :.. :...: ..:: :.:. .::::: :.: :.::: :::::...:::
XP_011 QLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAH
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 AYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSL
:. :: ::.:::::: .: ::. ... :::::::::.:::::: ::.. ::::: : ..
XP_011 AFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY-AF
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 TDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLR
. . . : ::::.:::..:: . :. :: : :.: :::.:.:::..:::
XP_011 RETSNYSLPQDDIDGIQAIYGLSSN----PIQPTGPSTPKP-----CDPSLTFDAITTLR
220 230 240 250 260
310 320 330 340 350 360
pF1KE4 GEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAI
::::.::::.:::. . . :...:: ::::::.:..:::: ..::.:.:::::.::.
XP_011 GEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWAL
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE4 RGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFP
: .. :::. : . ::: .:. ::::. ..::::::.:..::.:..:. ::::.:
XP_011 SGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEPGYP
330 340 350 360 370 380
430 440 450 460 470
pF1KE4 KQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
:.:. ::::.::.::::.. ::. :.: :: :..::.. ..:.::::
XP_011 KSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
390 400 410 420 430 440
477 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:58:31 2016 done: Sun Nov 6 00:58:33 2016
Total Scan time: 9.230 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]