Result of FASTA (omim) for
pFN21AE4456
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4456, 475 aa
1>>>pF1KE4456 475 - 475 aa - 475 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7198+/-0.000461; mu= 15.4043+/- 0.028
mean_var=65.8514+/-13.473, 0's: 0 Z-trim(109.4): 49 B-trim: 33 in 1/49
Lambda= 0.158049
statistics sampled from 17508 (17552) to 17508 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.564), E-opt: 0.2 (0.206), width: 16
Scan time: 8.270
The best scores are: opt bits E(85289)
XP_011531105 (OMIM: 143450,609015) PREDICTED: trif ( 474) 3068 708.9 7.6e-204
NP_000174 (OMIM: 143450,609015) trifunctional enzy ( 474) 3068 708.9 7.6e-204
XP_016859428 (OMIM: 143450,609015) PREDICTED: trif ( 481) 2993 691.8 1.1e-198
NP_001268442 (OMIM: 143450,609015) trifunctional e ( 452) 2834 655.5 8.4e-188
NP_001268441 (OMIM: 143450,609015) trifunctional e ( 459) 2531 586.5 5.4e-167
XP_016873172 (OMIM: 203750,607809) PREDICTED: acet ( 301) 345 87.9 4.1e-17
XP_016873171 (OMIM: 203750,607809) PREDICTED: acet ( 301) 345 87.9 4.1e-17
XP_006713186 (OMIM: 604054) PREDICTED: 3-ketoacyl- ( 272) 331 84.7 3.4e-16
XP_011531952 (OMIM: 604054) PREDICTED: 3-ketoacyl- ( 279) 331 84.7 3.5e-16
NP_000010 (OMIM: 203750,607809) acetyl-CoA acetylt ( 427) 257 67.9 6.1e-11
NP_005882 (OMIM: 100678,614055) acetyl-CoA acetylt ( 397) 199 54.7 5.5e-07
NP_006102 (OMIM: 604770) 3-ketoacyl-CoA thiolase, ( 397) 197 54.2 7.6e-07
NP_001290182 (OMIM: 100678,614055) acetyl-CoA acet ( 426) 194 53.6 1.3e-06
NP_001123882 (OMIM: 604054) 3-ketoacyl-CoA thiolas ( 331) 192 53.1 1.4e-06
XP_006713185 (OMIM: 604054) PREDICTED: 3-ketoacyl- ( 364) 189 52.4 2.5e-06
NP_001598 (OMIM: 604054) 3-ketoacyl-CoA thiolase, ( 424) 189 52.4 2.8e-06
XP_006718898 (OMIM: 203750,607809) PREDICTED: acet ( 337) 163 46.5 0.00014
XP_016873170 (OMIM: 203750,607809) PREDICTED: acet ( 337) 163 46.5 0.00014
XP_005271160 (OMIM: 184755,613724) PREDICTED: non- ( 463) 155 44.7 0.00066
NP_001180546 (OMIM: 184755,613724) non-specific li ( 466) 155 44.7 0.00067
NP_001180529 (OMIM: 184755,613724) non-specific li ( 503) 155 44.7 0.00071
NP_001180528 (OMIM: 184755,613724) non-specific li ( 523) 155 44.7 0.00074
NP_002970 (OMIM: 184755,613724) non-specific lipid ( 547) 155 44.7 0.00077
XP_011540237 (OMIM: 184755,613724) PREDICTED: non- ( 399) 139 41.0 0.0073
>>XP_011531105 (OMIM: 143450,609015) PREDICTED: trifunct (474 aa)
initn: 3068 init1: 3068 opt: 3068 Z-score: 3780.6 bits: 708.9 E(85289): 7.6e-204
Smith-Waterman score: 3068; 100.0% identity (100.0% similar) in 473 aa overlap (3-475:2-474)
10 20 30 40 50 60
pF1KE4 MTTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN
360 370 380 390 400 410
430 440 450 460 470
pF1KE4 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
420 430 440 450 460 470
>>NP_000174 (OMIM: 143450,609015) trifunctional enzyme s (474 aa)
initn: 3068 init1: 3068 opt: 3068 Z-score: 3780.6 bits: 708.9 E(85289): 7.6e-204
Smith-Waterman score: 3068; 100.0% identity (100.0% similar) in 473 aa overlap (3-475:2-474)
10 20 30 40 50 60
pF1KE4 MTTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN
360 370 380 390 400 410
430 440 450 460 470
pF1KE4 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
420 430 440 450 460 470
>>XP_016859428 (OMIM: 143450,609015) PREDICTED: trifunct (481 aa)
initn: 2993 init1: 2993 opt: 2993 Z-score: 3688.1 bits: 691.8 E(85289): 1.1e-198
Smith-Waterman score: 2993; 100.0% identity (100.0% similar) in 462 aa overlap (3-464:2-463)
10 20 30 40 50 60
pF1KE4 MTTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN
360 370 380 390 400 410
430 440 450 460 470
pF1KE4 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
::::::::::::::::::::::::::::::::::::::::::::
XP_016 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQVRYSGVIGPSRESFSW
420 430 440 450 460 470
XP_016 ND
480
>>NP_001268442 (OMIM: 143450,609015) trifunctional enzym (452 aa)
initn: 2834 init1: 2834 opt: 2834 Z-score: 3492.6 bits: 655.5 E(85289): 8.4e-188
Smith-Waterman score: 2834; 100.0% identity (100.0% similar) in 438 aa overlap (38-475:15-452)
10 20 30 40 50 60
pF1KE4 PFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDGVRTPFLL
::::::::::::::::::::::::::::::
NP_001 MTLVSGWLLYGWIIAVQTKTKKTLAKPNIRNVVVVDGVRTPFLL
10 20 30 40
70 80 90 100 110 120
pF1KE4 SGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFS
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 DKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDL
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 NKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYAL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 RSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAA
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 NSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKA
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 GLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSL
350 360 370 380 390 400
430 440 450 460 470
pF1KE4 GHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
410 420 430 440 450
>>NP_001268441 (OMIM: 143450,609015) trifunctional enzym (459 aa)
initn: 2531 init1: 2531 opt: 2531 Z-score: 3119.1 bits: 586.5 E(85289): 5.4e-167
Smith-Waterman score: 2929; 96.8% identity (96.8% similar) in 473 aa overlap (3-475:2-459)
10 20 30 40 50 60
pF1KE4 MTTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDG
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 VRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA
::::::::::: ::::::::::::::::::::::::::::::::::
NP_001 VRTPFLLSGTS---------------GLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREA
60 70 80 90 100
130 140 150 160 170 180
pF1KE4 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKM
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKP
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNN
350 360 370 380 390 400
430 440 450 460 470
pF1KE4 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
410 420 430 440 450
>>XP_016873172 (OMIM: 203750,607809) PREDICTED: acetyl-C (301 aa)
initn: 464 init1: 118 opt: 345 Z-score: 428.3 bits: 87.9 E(85289): 4.1e-17
Smith-Waterman score: 469; 33.5% identity (59.6% similar) in 319 aa overlap (159-471:20-299)
130 140 150 160 170 180
pF1KE4 KTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLN
::.::::.: ::.:: .: .
XP_016 MFYKEVKDKLLQGRQYWVQDVMVAGGMESMSNVPYVMNR---------G
10 20 30 40
190 200 210 220 230 240
pF1KE4 KAKSMGQRL-SLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYAL
.. : .: .:: : .... .. :: :. : . ..: ::: ::.
XP_016 STPYGGVKLEDLIVK----------DGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAI
50 60 70 80 90
250 260 270 280 290 300
pF1KE4 RSHSLAKKAQDEGLL-SDVVPFKVPGK---DTVTK-DNGIRPSSLEQMAKLKPAFIKPYG
:.. .: : . : . ..:.: : : :.:.: :. . .. .. ::: .: : :
XP_016 NSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENG
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE4 TVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPK
::::::.: :.:::.:...:. . : .. : : . : .. .: : . ..:.::.
XP_016 TVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPID-FPIAPVYAASM
160 170 180 190 200
370 380 390 400 410 420
pF1KE4 VLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWG
::. .:: .:: .: .:::: .:::.: .. : : .: : :
XP_016 VLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEID----------------P-QKVNING
210 220 230 240 250
430 440 450 460 470
pF1KE4 GSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
:..:::::.: .: :.: .. :.. :.:::.. : .:: . ::...
XP_016 GAVSLGHPIGMSGARIVGHLTHALKQ--GEYGLASICNGGGGASAMLIQKL
260 270 280 290 300
>>XP_016873171 (OMIM: 203750,607809) PREDICTED: acetyl-C (301 aa)
initn: 464 init1: 118 opt: 345 Z-score: 428.3 bits: 87.9 E(85289): 4.1e-17
Smith-Waterman score: 469; 33.5% identity (59.6% similar) in 319 aa overlap (159-471:20-299)
130 140 150 160 170 180
pF1KE4 KTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLN
::.::::.: ::.:: .: .
XP_016 MFYKEVKDKLLQGRQYWVQDVMVAGGMESMSNVPYVMNR---------G
10 20 30 40
190 200 210 220 230 240
pF1KE4 KAKSMGQRL-SLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYAL
.. : .: .:: : .... .. :: :. : . ..: ::: ::.
XP_016 STPYGGVKLEDLIVK----------DGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAI
50 60 70 80 90
250 260 270 280 290 300
pF1KE4 RSHSLAKKAQDEGLL-SDVVPFKVPGK---DTVTK-DNGIRPSSLEQMAKLKPAFIKPYG
:.. .: : . : . ..:.: : : :.:.: :. . .. .. ::: .: : :
XP_016 NSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENG
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE4 TVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPK
::::::.: :.:::.:...:. . : .. : : . : .. .: : . ..:.::.
XP_016 TVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPID-FPIAPVYAASM
160 170 180 190 200
370 380 390 400 410 420
pF1KE4 VLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWG
::. .:: .:: .: .:::: .:::.: .. : : .: : :
XP_016 VLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEID----------------P-QKVNING
210 220 230 240 250
430 440 450 460 470
pF1KE4 GSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
:..:::::.: .: :.: .. :.. :.:::.. : .:: . ::...
XP_016 GAVSLGHPIGMSGARIVGHLTHALKQ--GEYGLASICNGGGGASAMLIQKL
260 270 280 290 300
>>XP_006713186 (OMIM: 604054) PREDICTED: 3-ketoacyl-CoA (272 aa)
initn: 538 init1: 148 opt: 331 Z-score: 411.7 bits: 84.7 E(85289): 3.4e-16
Smith-Waterman score: 550; 40.5% identity (67.2% similar) in 262 aa overlap (224-474:29-270)
200 210 220 230 240 250
pF1KE4 GQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLA
:: ... .: :..:: .:: .:: :.. :
XP_006 MSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKA
10 20 30 40 50
260 270 280 290 300
pF1KE4 KKAQDEGLL-SDVVPFKVPGKD--------TVTKDNGIRPSS-LEQMAKLKPAFIKPYGT
.::..: . ...:: . .: :::.:.:::::. .: .::::::: : :.
XP_006 ARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKD-GS
60 70 80 90 100 110
310 320 330 340 350 360
pF1KE4 VTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKV
.::.::: ..:::.:.:. . :: .: . ::.. :. : : . .::.:: : .
XP_006 TTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPP-DIMGIGPAYAIPVA
120 130 140 150 160 170
370 380 390 400 410 420
pF1KE4 LEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGG
:.:::::..:.: ::..:::..: . . .: :. ::: :: : ::
XP_006 LQKAGLTVSDVDIFEINEAFASQ---------AAYCVE-------KLRLPP-EKVNPLGG
180 190 200 210
430 440 450 460 470
pF1KE4 SLSLGHPFGATGCRLVMAAANRLRKEGGQ-YGLVAACAAGGQGHAMIVEAYPK
...::::.: :: : :.. :.:...: . ::.:. : . :.: : . : ::
XP_006 AVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFE-YPGN
220 230 240 250 260 270
>>XP_011531952 (OMIM: 604054) PREDICTED: 3-ketoacyl-CoA (279 aa)
initn: 538 init1: 148 opt: 331 Z-score: 411.5 bits: 84.7 E(85289): 3.5e-16
Smith-Waterman score: 550; 40.5% identity (67.2% similar) in 262 aa overlap (224-474:36-277)
200 210 220 230 240 250
pF1KE4 GQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLA
:: ... .: :..:: .:: .:: :.. :
XP_011 ESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKA
10 20 30 40 50 60
260 270 280 290 300
pF1KE4 KKAQDEGLL-SDVVPFKVPGKD--------TVTKDNGIRPSS-LEQMAKLKPAFIKPYGT
.::..: . ...:: . .: :::.:.:::::. .: .::::::: : :.
XP_011 ARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKD-GS
70 80 90 100 110 120
310 320 330 340 350 360
pF1KE4 VTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKV
.::.::: ..:::.:.:. . :: .: . ::.. :. : : . .::.:: : .
XP_011 TTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPP-DIMGIGPAYAIPVA
130 140 150 160 170 180
370 380 390 400 410 420
pF1KE4 LEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGG
:.:::::..:.: ::..:::..: . . .: :. ::: :: : ::
XP_011 LQKAGLTVSDVDIFEINEAFASQ---------AAYCVE-------KLRLPP-EKVNPLGG
190 200 210 220
430 440 450 460 470
pF1KE4 SLSLGHPFGATGCRLVMAAANRLRKEGGQ-YGLVAACAAGGQGHAMIVEAYPK
...::::.: :: : :.. :.:...: . ::.:. : . :.: : . : ::
XP_011 AVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFE-YPGN
230 240 250 260 270
>>NP_000010 (OMIM: 203750,607809) acetyl-CoA acetyltrans (427 aa)
initn: 640 init1: 250 opt: 257 Z-score: 317.4 bits: 67.9 E(85289): 6.1e-11
Smith-Waterman score: 649; 31.9% identity (60.9% similar) in 445 aa overlap (34-471:21-425)
10 20 30 40 50 60
pF1KE4 ILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDGVRT
: . .. .. ..::....::.:...::
NP_000 MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRT
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 PFLLSGTSYKDLMPHD-LARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAAL
: . : . .:.: :. :. : ......::: : .:.:.: . . .:.:.:
NP_000 P-IGSFLGSLSLLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVL
60 70 80 90 100
130 140 150 160 170 180
pF1KE4 GAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRK
:::. .:: :.. .: :. .:. . . :. ::.::::.: ::.:: .:
NP_000 GAGLPISTPCTTINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNR----
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 LMLDLNKAKSMGQRL-SLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLE
... : .: .:: : .... .. :: :. : . ..: :
NP_000 -----GSTPYGGVKLEDLIVK----------DGLTDVYNKIHMGSCAENTAKKLNIARNE
170 180 190 200 210
250 260 270 280 290
pF1KE4 QDEYALRSHSLAKKAQDEGLL-SDVVPFKVPGK---DTVTK-DNGIRPSSLEQMAKLKPA
:: ::. :.. .: : . : . ..:.: : : :.:.: :. . .. .. ::: .
NP_000 QDAYAINSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTV
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE4 FIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGP
: : :::::::.: :.:::.:...:. . : .. : : . : .. .: : . ..:
NP_000 FQKENGTVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPID-FPIAP
280 290 300 310 320
360 370 380 390 400 410
pF1KE4 TYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLE
.::. ::. .:: .:: .: .:::: .:::.: .. : : .
NP_000 VYAASMVLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEID---------------P--Q
330 340 350 360 370
420 430 440 450 460 470
pF1KE4 KFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
: : ::..:::::.: .: :.: .. :.. :.:::.. : .:: . ::...
NP_000 KVNINGGAVSLGHPIGMSGARIVGHLTHALKQ--GEYGLASICNGGGGASAMLIQKL
380 390 400 410 420
475 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:59:50 2016 done: Sun Nov 6 00:59:52 2016
Total Scan time: 8.270 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]