Result of FASTA (omim) for
pFN21AE4445
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4445, 461 aa
1>>>pF1KE4445 461 - 461 aa - 461 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8106+/-0.000334; mu= 20.7491+/- 0.021
mean_var=69.4440+/-13.530, 0's: 0 Z-trim(115.5): 15 B-trim: 0 in 0/55
Lambda= 0.153906
statistics sampled from 25993 (26007) to 25993 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.305), width: 16
Scan time: 8.560
The best scores are: opt bits E(85289)
NP_000138 (OMIM: 230000,612280) tissue alpha-L-fuc ( 466) 3321 746.5 3.5e-215
XP_016856394 (OMIM: 230000,612280) PREDICTED: tiss ( 365) 2379 537.2 2.7e-152
XP_005245878 (OMIM: 230000,612280) PREDICTED: tiss ( 341) 2377 536.8 3.5e-152
NP_114409 (OMIM: 136820) plasma alpha-L-fucosidase ( 467) 1860 422.1 1.6e-117
XP_011539469 (OMIM: 230000,612280) PREDICTED: tiss ( 255) 1798 408.1 1.4e-113
>>NP_000138 (OMIM: 230000,612280) tissue alpha-L-fucosid (466 aa)
initn: 3321 init1: 3321 opt: 3321 Z-score: 3984.1 bits: 746.5 E(85289): 3.5e-215
Smith-Waterman score: 3321; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:6-466)
10 20 30 40 50
pF1KE4 MRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGV
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 FIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEW
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 ADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 LYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYW
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 NSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSID
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 KFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 WLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTK
370 380 390 400 410 420
420 430 440 450 460
pF1KE4 ITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
430 440 450 460
>>XP_016856394 (OMIM: 230000,612280) PREDICTED: tissue a (365 aa)
initn: 2377 init1: 2377 opt: 2379 Z-score: 2855.1 bits: 537.2 E(85289): 2.7e-152
Smith-Waterman score: 2379; 96.8% identity (98.0% similar) in 348 aa overlap (114-461:18-365)
90 100 110 120 130 140
pF1KE4 YQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSP
.:.. .::::::::::::::::::
XP_016 MTSRLFPLHQGLQTGQRDWSSASFLRPMRYVVLTTKHHEGFTNWPSP
10 20 30 40
150 160 170 180 190 200
pF1KE4 VSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVS
50 60 70 80 90 100
210 220 230 240 250 260
pF1KE4 AKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQN
110 120 130 140 150 160
270 280 290 300 310 320
pF1KE4 CSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQT
170 180 190 200 210 220
330 340 350 360 370 380
pF1KE4 VSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWY
230 240 250 260 270 280
390 400 410 420 430 440
pF1KE4 TSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLP
290 300 310 320 330 340
450 460
pF1KE4 PSAVPAEFAWTIKLTGVK
::::::::::::::::::
XP_016 PSAVPAEFAWTIKLTGVK
350 360
>>XP_005245878 (OMIM: 230000,612280) PREDICTED: tissue a (341 aa)
initn: 2377 init1: 2377 opt: 2377 Z-score: 2853.1 bits: 536.8 E(85289): 3.5e-152
Smith-Waterman score: 2377; 99.7% identity (100.0% similar) in 337 aa overlap (125-461:5-341)
100 110 120 130 140 150
pF1KE4 GFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVG
.:::::::::::::::::::::::::::::
XP_005 MRRRRYVVLTTKHHEGFTNWPSPVSWNWNSKDVG
10 20 30
160 170 180 190 200 210
pF1KE4 PHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLV
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE4 NSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNC
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE4 EDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNI
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE4 GPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIF
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE4 LHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWT
280 290 300 310 320 330
460
pF1KE4 IKLTGVK
:::::::
XP_005 IKLTGVK
340
>>NP_114409 (OMIM: 136820) plasma alpha-L-fucosidase pre (467 aa)
initn: 1074 init1: 929 opt: 1860 Z-score: 2230.9 bits: 422.1 E(85289): 1.6e-117
Smith-Waterman score: 1860; 54.9% identity (77.7% similar) in 461 aa overlap (4-460:8-466)
10 20 30 40 50
pF1KE4 MRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVF
: : : ::::::.: :. :. : : :::.: ::::::.::::.:
NP_114 MRPQELPRLAFPLLLLLLLLLPPPPC--PAHSATRFDPTWESLDARQLPAWFDQAKFGIF
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 IHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWA
:::::::::..:::::::.:: : :.: .::.:::::.:.: :::: :::.::. ..::
NP_114 IHWGVFSVPSFGSEWFWWYWQKEKIPKYVEFMKDNYPPSFKYEDFGPLFTAKFFNANQWA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 DLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKR-NIRYG
:.:::.::::.:::.::::::: : : :::::. : ::.::.: :: .:.:.: ..:.:
NP_114 DIFQASGAKYIVLTSKHHEGFTLWGSEYSWNWNAIDEGPKRDIVKELEVAIRNRTDLRFG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 LYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYW
::.::.::::::.: :....:. ..: .::.::::.:::.:.:...::::. :: ::
NP_114 LYYSLFEWFHPLFLEDESSSFHKRQFPVSKTLPELYELVNNYQPEVLWSDGDGGAPDQYW
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 NSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSID
:::.::.::::.:::. ::.::::: . :.:::.:.: :...: : :::: : .::
NP_114 NSTGFLAWLYNESPVRGTVVTNDRWGAGSICKHGGFYTCSDRYNPGHLLPHKWENCMTID
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 KFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGK
:.::::::. ..:: :....::.::: ::: :.::::: :: : .:.::: .:.
NP_114 KLSWGYRREAGISDYLTIEELVKQLVETVSCGGNLLMNIGPTLDGTISVVFEERLRQMGS
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 WLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSA--VYAIFLHWPENGVLNLESP-ITTS
::..:::::: .. :: : . : .:::::: . ::::::.:: .: : : : .
NP_114 WLKVNGEAIYETHTWRSQNDTVTPDVWYTSKPKEKLVYAIFLKWPTSGQLFLGHPKAILG
360 370 380 390 400 410
420 430 440 450 460
pF1KE4 TTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
.:.. .:: :.: . ..:... :::: .: ...:.. ::.:
NP_114 ATEVKLLGHGQPLNWISLEQNGIMVELPQLTIHQMPCKWGWALALTNVI
420 430 440 450 460
>>XP_011539469 (OMIM: 230000,612280) PREDICTED: tissue a (255 aa)
initn: 1798 init1: 1798 opt: 1798 Z-score: 2160.0 bits: 408.1 E(85289): 1.4e-113
Smith-Waterman score: 1798; 100.0% identity (100.0% similar) in 255 aa overlap (207-461:1-255)
180 190 200 210 220 230
pF1KE4 YHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWN
::::::::::::::::::::::::::::::
XP_011 MPELYDLVNSYKPDLIWSDGEWECPDTYWN
10 20 30
240 250 260 270 280 290
pF1KE4 STNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDK
40 50 60 70 80 90
300 310 320 330 340 350
pF1KE4 FSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKW
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE4 LSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKI
160 170 180 190 200 210
420 430 440 450 460
pF1KE4 TMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
220 230 240 250
461 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:05:44 2016 done: Sun Nov 6 01:05:45 2016
Total Scan time: 8.560 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]