Result of FASTA (omim) for
pFN21AE4440
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4440, 457 aa
1>>>pF1KE4440 457 - 457 aa - 457 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.7272+/-0.000382; mu= -6.6237+/- 0.024
mean_var=310.9435+/-61.020, 0's: 0 Z-trim(122.7): 12 B-trim: 0 in 0/57
Lambda= 0.072733
statistics sampled from 41353 (41374) to 41353 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.785), E-opt: 0.2 (0.485), width: 16
Scan time: 12.370
The best scores are: opt bits E(85289)
NP_001266 (OMIM: 118910) chromogranin-A isoform 1 ( 457) 2994 327.5 4.6e-89
XP_011534672 (OMIM: 118910) PREDICTED: chromograni ( 457) 2994 327.5 4.6e-89
NP_001288619 (OMIM: 118910) chromogranin-A isoform ( 306) 1237 143.0 1.1e-33
NP_001030025 (OMIM: 300029,300455,300834,304020,31 (1152) 322 47.4 0.00024
>>NP_001266 (OMIM: 118910) chromogranin-A isoform 1 prep (457 aa)
initn: 2994 init1: 2994 opt: 2994 Z-score: 1720.0 bits: 327.5 E(85289): 4.6e-89
Smith-Waterman score: 2994; 100.0% identity (100.0% similar) in 457 aa overlap (1-457:1-457)
10 20 30 40 50 60
pF1KE4 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE
370 380 390 400 410 420
430 440 450
pF1KE4 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
:::::::::::::::::::::::::::::::::::::
NP_001 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
430 440 450
>>XP_011534672 (OMIM: 118910) PREDICTED: chromogranin-A (457 aa)
initn: 2994 init1: 2994 opt: 2994 Z-score: 1720.0 bits: 327.5 E(85289): 4.6e-89
Smith-Waterman score: 2994; 100.0% identity (100.0% similar) in 457 aa overlap (1-457:1-457)
10 20 30 40 50 60
pF1KE4 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE
370 380 390 400 410 420
430 440 450
pF1KE4 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
:::::::::::::::::::::::::::::::::::::
XP_011 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
430 440 450
>>NP_001288619 (OMIM: 118910) chromogranin-A isoform 2 p (306 aa)
initn: 1237 init1: 1237 opt: 1237 Z-score: 726.1 bits: 143.0 E(85289): 1.1e-33
Smith-Waterman score: 1678; 66.7% identity (67.0% similar) in 457 aa overlap (1-457:1-306)
10 20 30 40 50 60
pF1KE4 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELK--
70 80 90 100 110
130 140 150 160 170 180
pF1KE4 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KE4 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG
NP_001 ------------------------------------------------------------
250 260 270 280 290 300
pF1KE4 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS
.::::::::::::::::::::::::::::::
NP_001 -----------------------------GRSEALAVDGAGKPGAEEAQDPEGKGEQEHS
120 130 140
310 320 330 340 350 360
pF1KE4 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG
150 160 170 180 190 200
370 380 390 400 410 420
pF1KE4 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE
210 220 230 240 250 260
430 440 450
pF1KE4 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
:::::::::::::::::::::::::::::::::::::
NP_001 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
270 280 290 300
>>NP_001030025 (OMIM: 300029,300455,300834,304020,312610 (1152 aa)
initn: 296 init1: 175 opt: 322 Z-score: 199.1 bits: 47.4 E(85289): 0.00024
Smith-Waterman score: 322; 27.4% identity (55.1% similar) in 405 aa overlap (71-450:715-1101)
50 60 70 80 90
pF1KE4 SDTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKEL-QDLALQGAKERAHQQKKHSG
:.:. :: :.. : .:... .....
NP_001 EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGD
690 700 710 720 730 740
100 110 120 130 140 150
pF1KE4 FEDELSEVLENQSSQAELKEAVEEPSSKDVME-KREDSKEAEKSGE--ATDGARPQALPE
:.: : :..... : :: :. : :.:. :..:: . .: . :
NP_001 REEE--EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETE
750 760 770 780 790 800
160 170 180 190 200
pF1KE4 PMQESKAEGNN-------QAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQG
: : ::.. .. ::.::::::. . . . .. : . ::...: .:
NP_001 GRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG
810 820 830 840 850 860
210 220 230 240 250 260
pF1KE4 LVDREKGLSAEPGWQAKREEEEEEEEEA--EAGEEAVPEEEGPTVVLNPHPSLGYKEIRK
:.: . : : ... : :::: : : :: :::: . . . : : ..
NP_001 ----EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGE--GEEEGEGEGEEEE
870 880 890 900 910
270 280 290 300 310 320
pF1KE4 GESRSEALAVDGAGK----PGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSG
::...: . .: :. : :..: ::.::.:... . :::: : .: . :
NP_001 GEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEE------GEGEGEEEG
920 930 940 950 960 970
330 340 350 360 370 380
pF1KE4 ELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGF
: : :: . : :... .. .. .: .:.. ::.:: : . . . .... :
NP_001 EGEGEEGEGEGEEEEGEGEGEEEEGEEE--GEEEGEGEEEGEGEGEEEEEGEVEGEVEGE
980 990 1000 1010 1020
390 400 410 420 430
pF1KE4 RGPGP-QLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGS-------ANRRPEDQELE
.: : . ..: . . :. . : . : ::..::::. :.: . .: .
NP_001 EGEGEGEEEEGEEEG--EEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYK
1030 1040 1050 1060 1070 1080
440 450
pF1KE4 SLSAIEAELEKVAHQLQALRRG
..: :.. .. :.
NP_001 KVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRLLKNGPSGSKKFWNNVLP
1090 1100 1110 1120 1130 1140
457 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:37:53 2016 done: Sun Nov 6 00:37:55 2016
Total Scan time: 12.370 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]